Top similar games like Adventures of Isabelle Fine: Murder on Rails:

A man who has to go out to find his lost daughter in a forgotten city with a virus outbreak struggles with street gangs and worsening illness to survive

A puzzle platformer with funky physics and mind boggling puzzles requiring out-of-the-box thinking and persistence. Only a few players were able to complete the game. Can you handle it?

A story-driven puzzle adventure with a shared spotlight between two intergalactic freelancers who get dragged into a series of peculiar events happening on a strange alien planet.

Locked away in the most secure prison in the galaxy, with little hope of escape, Gail Pilgrim faces the most difficult ordeals of her life. Her only hope lies in trusting those who she has come to regard as her friends.

Survive through four days at the end of the world in this post-apocalyptic point-and-click thriller where your choices could keep you alive... or not.

Face dinosaurs, solve puzzles and travel back to the time of ginormous lizards and pixelated adventure games.

22XX年、「僕」はモニターだらけの密室に閉じ込められる。モニターに映るのは見知らぬ多彩な人（？）々。会話から少しずつ明らかになる状況とモニターの住人の生活模様。画面越しのSFノベルアドベンチャーです。

Sector Zero is a story-driven sci-fi survival game with light RPG elements. Software engineer Alex wakes up with no memory in an unfamiliar and hostile environment.  Without a weapon he'll have to use his fast reaction and brains to fight the threats that await for him behind every corner.

Nordlicht is an adventure-game where you accompany an unusual family on its fascinating journey to the cold north. During the journey, they encounter mysterious star-signs of the polar night, and have to overcome nature's dangers to confront their fears.

A fast-paced Point-and-Click adventure AND an indie platfomer in one! Join adventurer Ben and wannabe indie darling Dan in a race against time to stop all the Apocalypses happening at the same time.

Journey to another planet and discover its secrets in order to bring your loved one back to life. Experience an adventure, inspired by old school classics like Another World, Heart of Darkness and Flashback.

You buy a laptop with your hands. You find an interactive collection of short stories on your laptop and something else. Or someone? What will all this lead to?

A science fantasy Pixel Novel with arcade puzzles in isometric perspective.

Impact trial: the lost planet is a space adventure videogame where we will have to escape from an inactive planet through the Impact Trial program.

[Adventures of House Cat Cinnamon]*A street cat's tale 2 is a narrative-led puzzle adventure game about the struggles of stray cats.

The dual Viridis, separated between the luxurious Bright City and the dangerous Blind City, where inequality reigns until you, Axel McCoin, an idealistic detective, start a revolution to change the world in this cyberpunk adventure.

In the dark, the girl seems to have returned to her early time, On the way to escape, monsters keep chasing her... She wanna escape, but the end comes before her leaving...

What do you do if you are the only one left aboard a spaceship? Your team has embarked on a mysterious expedition a few years ago, the ship’s machinery has started acting up and it seems there are ghosts wandering about. Luckily, the black hole above you doesn’t pose any problems…yet.

Still reeling from the life-changing events of the previous episode, Gail seeks out a safe haven with her father in the Delta Pavonis system. However, she soon learns that the politics of Planet Leto can be as treacherous and unpredictable as the local weather.

Gods Will Be Watching is a minimalistic “point and click thriller” centered on despair, commitment, and sacrifice as players face intriguing puzzles and tough decisions that will affect their entire crew’s wellbeing.

McPixel 3 is a mind-blowing save-the-day adventure that sees the titular wanna-be hero avert one disaster after another at every turn using unconventional yet entertaining methods of mayhem.

A retro-inspired 2D Action RPG set in the distant future. CrossCode combines 16-bit SNES-style graphics with butter-smooth physics, a fast-paced combat system, and engaging puzzle mechanics, served with a gripping sci-fi story.

After being abducted by brutal soldiers and his kinfolk butchered, Robert Foster finds himself in Union City - a vast metropolis under the tyranny of a fascist AI. Alone, save for the circuit board of his best friend, Foster must discover the sinister truth - and why they specifically came for him.

MindSeize is a 2D Metroidvania game set in a Sci-Fi-universe. Transfer your mind to a robot and rescue your beloved one!

A hilarious point and click graphic adventure in the best spirit of the '90s where you play as a young man and his friends in a personal quest that will turn their passion for progressive rock and UFOs into a real intergalactic mess... If they manage to survive school !

Gear Path is a small platformer Metroidvania-like game with exploring and power-ups. It's perfect for playing while waiting for another game.

Small but tricky indie game to spend your evening on playing. You'll have to determine the cause of a program's critical error and restore its modules by playing mini games and solving puzzles while using the console.

Rocket of Whispers is an award-winning post-apocalyptic adventure that follows two survivors on a journey to launch a space burial for the lost souls of their desolate world. Help them search the snowy wasteland for supplies and the courage to say goodbye.

In Thimbleweed Park, a dead body is the least of your problems. Switch between five playable characters to uncover the surreal secrets of this strange town in a modern mystery adventure game from the creators of Monkey Island and Maniac Mansion. The deeper you go, the weirder it gets.

Breaking the 4th Wall is a point and click adventure game taking place inside a world of comics. Adrian, the main character, deals with daily life struggles and goes out on a journey for self-realization and breaking out of the confines of his world.