Top similar games like Ex Vitro:

Simona's Requiem is a retro-styled platformer Inspired by old action-adventure games but with a modern touch. Pick up the scythe as Simona and slash your way to the Fisher King who has hidden behind the moon.

Overplasma is a combat, platforming and exploration game in alien worlds where you must face challenging enemies and obstacles as a space explorer who was in the wrong place at the wrong time!

Chiaroscuro is a 2D adventure platformer with metroidvania elements. Explore a world that has fallen into darkness and discover the Lights to illuminate your forgotten past.

Rosemarie, an alien princess from the planet Nimola seeks genocide on the evil monsters who killed her mother and people. Can you find and kill all 28 target threats?

Explore, solve puzzles, and fight your way through over 100 screens and return your pumpkin pals!

Hunt down massive beasts and, upon destroying them, shapeshift into their forms in order to use their powers to save or destroy the world. Players with less violent intent can find secret paths to complete Mable without killing anything, including bosses.

Dungeon exploring Wizard action! Learn spells, defeat bosses and escape the evil in this 2D metroidvania.

Mainasutto: I'm Not Alone is a metroidvania about time and choice-making, set on a dream-like world, where decision making is crucial for our protagonists to save their timeline.

Play as Captain Grisham, and uncover the secrets of Planet 4-514 in this thrilling prequel to Side Scape!

Story driven Metroidvania-ish challenging platformer with cute hand-drawn graphics and a focus on exploration.

Explore, fight, and platform through a world of deadly plants as a lone potato, Tater Spud, in search of powerups and the answers behind the flora that was once safe.

Genopanic is a pixel-art, Metroidvania-inspired adventure-platformer. Explore corridors of the space station, teeming with secrets and dangers, and engage in boss fights. Solve puzzles and uncover hidden mysteries in the dark atmosphere of a sci-fi research complex. Discover the truth with each step

Explore, fight, and discover new spells and abilities in the world of Shifted Heart! Customize your build to your liking and save the province of Shutterweld, and perhaps the rest of the world, from certain doom.

Last souls is a 2D side-scrolling Metroidvania soulslike game.The player controls a mysterious caped character and explores a labyrinthine, dark and cold world.

BIOMORPH is a dark metroidvania game where you become the creatures that you kill! Solve ingenious puzzles and navigate a stunning hand-drawn world. Meet quirky characters, rebuild a city, and uncover the secrets of a sprawling, fallen civilization… and of your own mysterious origins.

MindSeize is a 2D Metroidvania game set in a Sci-Fi-universe. Transfer your mind to a robot and rescue your beloved one!

Astronite is a 1bit metroidvania that combines action, exploration, puzzles and platforms. Recover the planet where you and yours lived before it was invaded by strange creatures.

Marko: Beyond Brave is an action-packed Metroidvania adventure. Wander through lush forests and crumbling castles, battle corrupted creatures, and escape intricate traps. Jump, slash, and shoot your way through challenging foes and mighty bosses inspired by Slavic myths and legends.

Explore a mysterious castle in this pixel perfect metroidvania and take on the Shadow King! Upgrades, secrets, combat, and more!

A love letter to classic NES games! Explore an ever-expanding, challenging maze filled with countless secrets.

Battle your way through a living planet in Rebel Transmute, a sprawling 2D action-exploration epic! Embody Moon Mikono as you explore, reprogram your abilities, duel twisted sci-fi experiments, rebel against colonizers, and search for your long lost mother.

After Shadows is a metroidvania with roguelike elements. Get into a distant post-apocalyptic future, where all of humanity became extinct. Explore the abandoned Fortress, look for traps and hide from Dark Monster who is chasing you.

Explore a dystopian future in this Metroidvania platformer in which you use glitchy abilities to launch yourself and enemies across the level at high speeds, create temporary platforms, and more in your search to uncover the secrets of your origin in The Forum.

Dreeg is a dimension shifting platforming adventure game where you move between 3 parallel dimensions at will to solve puzzles and take on robotic enemies. Customize Dreeg's armor to gain power and unlock new abilities and upgrades for your energy weapon system as you take on the psychotic Xel'xan.