Top similar games like Xenomycology:

Build up your defenses and ward off any threats to your expedition in this rogue-like tower defense game. Manage your resources well and make sure no to overstay your welcome on this planet, or be prepared to face a never-ending onslaught of crustaceans...

Build your defense base to repel alien invaders. Atahion is a strategy and tactical defense game in which you have to extract resources, build defense towers and use bonuses to complete the mission.

Refactor is a hard-core tower defense game that combines modular building, route planning, and element composition.

A brutal godlike village sim that melds the god game, management, and tower defense genres! Fight off hoards of monsters at night, and expand your village in the day time. Inspired by games like Black and White, Rimworld, and Dwarf Fortress but not quite like any of them.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

A strategic tower-defense where you control powerfull drones. Unlock new tower and use specific technologies to defend your base on Thukothea!

Frontera is a fantasy city builder and colony sim where you start with a small camp at the edge of a dark forest. Build up your settlement and economy to attract more settlers. Form a military to clear the forest, and claim it for yourself!

Scrap Bastion is a strategy tower defense game where you manage your city, equipping it to survive the waves of mutant creatures, testing your planning and decision making capacities at every turn. Watch out, as time is crucial to win!

Make your own metropolitan utopia! Stores, mansions, towers--anything goes!

Build amongst the stars in Starport Delta, a light sci-fi strategy game that focuses on survival. Station Commanders across the universe will turn to you for guidance to expand, defend, and survive. Help them build a thriving station, but watch out, there are many dangers hiding in space...

Engage in the construction of your station from a variety of different modules. Create your space fleet. Protect your base from enemies...

Stellar Initiative is a roguelike tower defense game where you land on the planet and use your orbit ship to deliver buildings and support you with fire. Complete missions, install new upgrades, discover powerful artefacts and find the best strategy!

Tendrils and Plates is an Open World Sci-Fi Space Survival Shooter RPG under development by a solo indie developer. You begin in a scout starship and learn to survive in a hostile solar system. Build your base and take on missions in space and on numerous ground locations.

After a nuclear war life on the surface became impossible. A 300m thick radioactive fog covered the Earth. We are looking for bold active people to manage the process of restoring life on Earth. Join!

Build, Upgrade, Reset, Repeat

Grow a city with your transport system in this minimal logistic management game!

Build, arrive, and move into new regions and planets in the depths of space. Whether you will establish a colony and trade or train soldiers and fight, everything is in your hands.

Helle's Undersea City Project - Bringing Air to The Garden - Grow and expand the land with air, aiming to rebuild the undersea city with a lone girl, Hele! A new type of undersea city-building simulation game!

Desktopia is a city-builder game which simulates an evolving, medieval-esque village along the bottom of your desktop, allowing you to work, watch, or browse something else while you play.

The ultimate mash-up of Real-time Strategy and Tower Defense!

Create the perfect community for your town of wizards. Forge weapons and defensive towers in preparation for the onslaught of monsters - and pray you survive.

A turn-based strategy game about managing the first human colony on the pumpkin planet.

Kingdom is a 2D sidescrolling strategy/resource management hybrid with a minimalist feel wrapped in a beautiful, modern pixel art aesthetic.

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

Create and customize your own campground in this charming pixel art sim game.

A unique tower defense game. Where you design and build your defense block by block. With many component that can be combined for different effect. To survive in a hostile world.

Make a fantastic, dazzling water park!

Run any store you like to build up your own buzzing business burg!

The Final Earth 2 is a vertical sci-fi city builder. Earth is unlivable, so you decide to create a space colony. Gather resources, then build and research your way to a better future! Grow your city from an exploration ship to a huge metropolis, full of advanced technology. What will you build?

In "Gaia Trek", you will play as Gaia, the shattered will of a planet, and command your spaceship to explore new worlds, collect and refine various resources, build a home on the damaged spacecraft, summon a wide range of monsters, and ultimately, devour other shattered wills to repair yourself.

Invader TD is a side scroller tower defense, where the player is in the role of an alien race with the purpose of infecting and dominating the earth, you must protect yourself from the attacks of the humans, who are trying to destroy you.

An instant strategy science fiction simulation survival sandbox game. Players can control individuals, teams, and manage multiple bases. Players can farm, build, excavate, fight, produce, graze, explore, trade, record and pass on knowledge, and can also fly a spaceship to explore the starry sky.

A brand new business sim! Build cafés, movie theaters, aquariums, and more!

Revolutionize the revolving sushi bar in this fresh new sim!