Top similar games like Slay the Spire 2:

Destiny or Fate is a deck-building roguelite game. Choose a hero, build a deck and a party of mythical creatures, and set out on an endless adventure! Are you ready to make your own destiny, or will you succumb to an evil fate?

Cardseer is a deckbuilding game combining roguelike elements with a sprawling campaign. Choose your hero and fight your way across diverse maps filled with fearsome enemies, all while crafting your deck and collecting powerful artifacts. Can you rise to the challenge?

Poker Quest is a fantasy roguelike where players use a standard 52-card deck to take on fierce enemies in epic battles. Featuring over 20 unique heroes, thousands of items, and deep gameplay that will test even the most experienced players.

Unlike other single player deckbuilder, you are going to fill a bag with black and white stones. Wether you can use your skills depends on the order you pick the stones. Build a unique combo, defeat powerful enemies, and don't forget to use your Prescience!

Reincarnation is a medieval/fantasy themed turn-based RPG card game with unique deck-building, character development and class selection experiences. Devise your attack and defense strategies to defeat monsters and gain rewards. Join the action-packed world of Reincarnation today!

This card game combines elements of roguelike and deckbuilding. During the game, you shall strive ahead, gathering cards to build a unique deck and use it to defeat the enemies getting in your way. You will have to choose between escaping or try to defeat Death, who is relentlessly pursuing you.

Dreamgate is a unique hardcore mix of deck building card battler, roguelite adventure and RPG. Build your deck, explore the Dreamgate world and defeat fearsome foes!

Noyah: Corrupted Memories is a roguelike deckbuilder, in pixel art, with random battle generation, day and night cycle, climate events, advanced rune system, that allows you to create endless possibilities with a single card.

Fuse cards together in this roguelike deckbuilder to unleash their full potential. Discover powerful fusion combinations, craft unique decks, harness the power of ancient runes, and conquer challenging enemies on your quest to restore peace to the realm of Erdia.

We fused card games and roguelikes together to make the best single player deckbuilder we could. Craft a unique deck, encounter bizarre creatures, discover relics of immense power, and Slay the Spire!

Dreamshard is a rogue-like deck-building game where slay the spire meets hearthstone. Explore procedurally generated dungeons, fight monsters, craft a unique deck and defeat your enemies to find the secret of the Dreamshard.

Neurodeck is a psychological deckbuilding card game to challenge your fears. Build your deck & capacities by answering personality tests, visiting rooms or meditating. Face your phobia and defeat them through the power of life-inspired cards.

Folktale Misfits is the card game roguelike where you play as outcasts looking for answers in a whimsical world. Develop strategies and help the misfit heroes unlock their true potential.

Hunt through the wastelands for colossal Beasts in this roguelike deckbuilder. Beware! Beasts grow stronger during battle, allowing them to consume your creatures or counter your spells. Carve profane Gifts from these behemoths and grow stronger to serve your Patron! But serve them to what end?

Spellrune is a singleplayer collectible card game with rogue-like and role-playing elements set in a fantasy world. Take the role of a wizard apprentice, build a powerful spell deck, defeat hordes of creatures and collect magic artifacts.

A combo-based deckbuilding roguelike through a space-time loop: collect cards, receive blessings, add pets to your party, and grow stronger. Chain together cards in the right order for max power, and act before the enemy does. Build synergistic decks, find many secrets, and make BIG numbers!

Dark Mist is a card game that combines elements of the roguelike deckbuilder genre with enemies that appear in waves. Defeat monsters and level up during battle to keep yourself going.

Spliced is a hybrid roguelite deck-builder. Play as a symbiotic ooze, taking the parts and abilities of enemies you defeat. Use cards to battle enemies and navigate the environment.

Explore the galaxy in this deckbuilding, sci-fi roguelike where ship upgrades and crew management are key to your survival. Optimize resource generation, engage in intense turn-based battles, and take on ever-growing threats as you seek out The Signal.

Become a master hacker in this Cyberpunk Roguelike Deckbuilder. Explore the dangers of cyberspace and fight evil corporations. Build and upgrade a deck of powerful programs. Unlock perks and skills, and unleash digital hell on your enemies. Dive Into The Grid!

Dimensionals is an RPG that combines fast paced, action packed tactics with deep rogue-like replayability. Collect powerful heroes and fight epic bosses. Every run is unique, so equip your heroes carefully to pull off insane combos. Dimensionals is a total reimagining of the rogue-like genre!

Iris and The Giant is a fusion of the CCG, RPG and roguelike genres. You play as Iris, who must brave her fears in her imaginary world. Dive into a melancholic and gripping adventure, filled with cute monsters and buried memories. Ready to face your inner demons?

Ancient Gods is a fusion of hero collector and deck-building rogue-lite where you collect your character, fight, and experience exciting events. Any character can use all the cards, combine them with the character's passive for ultimate power on your exploration.

Crystal Soul chambers is a roguelike card game where you must create a group of 3 characters, each one with his own unique card set. Each of the characters has their own abilities related to their personality!

Your deck is your health in BeaureCard, an easy to learn fast-paced roguelike deckbuilder. Strive to deplete your opponents' deck, cleverly using traps, powers, blessings, and curses. Embark on an epic adventure, with exciting events to explore, new cards to acquire, and dangerous demons.

Northwind is a rogue-lite deckbuilder monster-hunting game. Hunt monsters, gather resources, and explore card smelting in Northwind Town. Discover new monsters and unlock town upgrades as you increase your hazard level.

A roguelike deckbuilder where you play as a witch studying wacky schools of magic like Llamamancy and Spookymancy. Summon monsters to fight for you. Scrounge together components to cast powerful spells. Mix and match spell combos as you journey for lost astral knowledge.

Escape a treacherous labyrinthine prison by outsmarting guards in tactical card-based battles. Pick your abilities before each encounter, tailoring your strategy. Defeat guards to steal their skills, navigate deadly traps, and unleash your cunning to secure your freedom.

Call of Zadeus [Zuh-day-us] is an open-world roguelike deckbuilder with a late 90's aesthetic. Travel across a huge procedurally generated world, collect cards, battle enemies, delve into dungeons, and defeat the unimaginable Zadeus!

Embark on a thrilling deckbuilding adventure, fighting your way to the final boss on a journey that's different every time.

Astrea is a DICE-deck-building roguelike that flips the script on deckbuilders by using dice instead of cards and an unique dual “damage” system: Purification vs Corruption. Build a dice pool strong enough to purify Astrea's out-of-control corruption and save the Star System.

Become a giant walking dice, explore dungeons and defy Lady Luck in this dice powered roguelike! Now featuring "Reunion", a free DLC with six brand-new episodes!

Fight your way through an unexplored dungeon in this deck-building, turn-based roguelike focused on dice combinations! Deal with enemies by combining powerful dice on your board, boost their effects with synergies, and risk it all hoping for a good roll.

Dungeons & Degenerate Gamblers is a roguelike deckbuilder where you play blackjack with unique cards from both real life and other card games. Create your deck, battle degenerate gamblers, partake in events throughout the tavern, and strike down the greedy capitalists who are in charge!

Create your own cards in this roguelike deckbuilder by cutting and pasting throughout your deck! Play your customized cards in text-based events and card battles. Journey through an epic medieval fantasy world, making do with limited resources.

Game is a deck building roguelite card game with RPG elements. Save the forest kingdom from the oppression of the Mad King.