Top similar games like Genome Guardian:

Roboholic is a cheerful Rogue-Lite FPS about robots. Use cool guns, unique abilities, and realistic physics to defeat enemies. It's the most dynamic game in its genre, and during battles with robots, you'll recall the fun days of Quake.

Zombie exterminator is a top-down shooter roguelite where you play a soldier. Combine weapon parts and create unique weapons. Use gadgets and relics to exterminate zombies. Fight against zombies and horrendous creatures.

Prepare for an interstellar showdown like no other in a gripping roguelike top-down twin-stick shooter set in the vast depths of space. Pilot your advanced starship, engaging in relentless battles against hordes of alien adversaries. Destroy, Collect, Upgrade, Die, Unlock, Repeat.

Tankron is a top-down wave survival roguelike in which you fight an ever-increasing amount and variety of enemies. Choose from a variety of upgrades to stand a chance. Discover and choose between different tank specializations to enhance your Build.

Cleanup Crew is a fast-paced survival action roguelite. Complete emergent objectives, customize your build and put your skills to the test to survive nerve-wracking hordes of creatures across bizarre worlds. Will you be able to survive until extraction?

Discover the beauty and fragility of life in Survivor Cells, a unique survival game against viruses and bacteria, which strategically combines the elements of roguelite, bullet hell and tower defense in a challenging experience. Your destiny depends on your agility and choices. How far will you get?

Play an arena shooter roguelite where you build your own ship and survive through enemies' attack. You can even customize individual weapons, turning each one into a unique and formidable tool of destruction.

Physics-Based Ragdoll Roguelike up to 4 players with Endless action to survive > Get items and discover powerful transformations to increase your power to survive the invading alien horde and save indie games.

an action-packed arcade shooter that takes you deep into the heart of a computer under siege.You're the system's last line of defense.

Run through the universe in this rogue-like-ish space-shooter. Discover the numerous perks/consumables and their synergistic effects. Explore the randomly-generated galaxy to find merchants, unlock spacecrafts, collect Cartridges and checkmark your kills of the various galactic overlords.

An eternal loop starts, where each beginning is a challenge. Constantly improve to survive in Eternal Rising, a rogue-lite and bullet-hell where you face relentless enemies that oppose you at every turn. Death is a constant, but with each new attempt, you evolve, ready to face a eternal life.

Void Heart is a frenetic 2D action rogue-lite platformer with a character development system. You will go through various rooms destroying enemies and collecting items that will help you in the battle against the bosses. Enemies will become tougher with each level you complete. No checkpoints.

Swarmhunters is a top-down arena action shooter. The war between human and bugs has become worse - Project Swarmhunters emerged at this situation. You play as the best space soldiers in the galaxy and your mission is to strike the hive and hunt down the Emperor, supreme commander of bugs.

Dive into this action roguelite as a brave Possum, shooting down crowds of crazy beasts. Drink cactus booze, ride your train through the deserts, and feel the thrill of bloody shootouts! Whistling bullets, explosions, flying arrows, mines, fire, and acid — bring this chaos under control!

Operation Ascension is a Sci-Fi Action Roguelike where endless hordes of enemies charge at you, trying to take your ascendant body. You need to slice through the digital chaos and break free. Unleash your powers. Will you be able to complete the transformation and become an Ascended Being?

Mechanophagia is a challenging bullet hell shooter with roguelite elements, set in a dark and gritty sci-fi world. Blast through waves of fleshy aberrations and defeat monstrous bosses. Can you outmaneuver the relentless enemy onslaught and save the robots from their inevitable extinction?

You are Earth's last line of defense in a relentless alien invasion. Experience intense 3D top-down roguelite action. Outsmart, outgun and survive smarter, increasingly menacing foes with a versatile arsenal in diverse landscapes. Every run escalates the challenge - adapt, evolve, dominate!

You are alone. Your squad is dead. You have your weapon, a jetpack, and a fistful of courage. Fend off murderous alien hordes and transform their precious guts into explosive upgrades, utilities and relics. Become an overpowered agent of vengeance in this bullet-heaven action roguelike.

Battle time and terror in a shoot & survive extraction roguelite. Select your hero and survive the relentless cosmic surge. Shoot, level up, topple bosses, and amplify your powers to cosmic levels. Embrace the Blastard within and unlock new heroes, powers, and perks to use on future runs.

Alchementalist is a procedurally generated rogue-lite dungeon crawler featuring spell-crafting. Fight your way through hordes of enemies, mine elemental nodes for materials and craft spell boosts, or even totally new spells, that allow you to manipulate the elements any way you choose!

In this fast-paced roguelite vehicle shooter, WW2 is ending, and a secret testing facility is overrun by an unknown alien force. The best pilots of the war are asked to take an experimental hover tank on a perilous mission - To descend into the caverns below the facility and face this new threat.

Archons is a unique roguelike/survivor where you control two characters, the Archons. Master the mechanics and upgrade your Archons with different arsenal of weapons to blast your way through the parasites and gigantic bosses.

"Spell Disk Survivor" is one of the game modes in "Spell Disk" where you survive against the endless waves of enemies. Craft overpowering builds using synergizing items and unlock new powers!

Go on an exciting journey through space in this lovingly designed indie rogue-lite space shooter. Gather ressources, craft new equipment and level up your pilot to set against the hordes of alien enemies. Party up with companions that will make your journey less lonely and help you on your path.

Roguelite Overpowered Wizard Simulator & Dungeon Crawler. Slay hundreds of cultists using the power of ancient cards and your magical arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you from climbing the tower of babel.

Blast hordes of alien ships into junk. Collect the scrap to upgrade your ship into an unstoppable force of destruction. Unlock new characters and weapons and upgrade your stats between runs.

Blast robots to bits in this action rogue-lite shooter which focuses on satisfying gunplay and thousands of fun builds! Mechs invented "Mood Solution" to replicate their creators, but lords got possessed by emotions. Fight with friends or by yourself to annihilate hordes of deadly bots.

A cozy time survival roguelite in space. You steer the shippy while the shooting happens automatically. Meet cute NPCs, solve small quests, and fight quirky enemies with satisfying weapons. A shorter experience for people who don't have much time but love playing (and finishing) games.

Master gravity-defying flight mechanics and time-bending powers in this bullet hell rogue-lite where strategic depth meets intense gameplay. Unravel synergistic upgrades and enhancements as you stop the alien invasion from ever happening. Are you ready to dominate the skies?

Blast your way through robotic hordes in this auto-battler arena shooter. Use auto-firing guns and drones, timely dashes and special abilities to reach The Void where a randomly constructed final Conservator awaits convergence. Spend your Cogs wisely among the shops to create unique builds!

DUCKLYTE is a top-down shooter with roguelite elements where you play as a constipated little duck trying to stay alive as long as possible in a randomly generated farm with progressively stronger enemies.

An action rogue-like about garden plants fighting back against the hungry pests that threaten their home. Spend the day blasting through hedges to find loot, but take care to make it back before dark! Gather synergistic items, confront formidable bosses, and play as several unique characters!

As The House of God races towards heaven, Jack blasts their way to the conductor in this chaotic and fast-paced Rogue-Lite.

Aliens have taken over humanity and now have the goal to destroy Lexi Lane, the last hope of human resistance. Step into Lexi's "pedal to the metal" shoes. Help the last heroine drive, drift, and blast her way through the alien onslaught and meet her destiny in a last act of defiance and glory.

Maiden Gear : Dynamic Visual Novel crossed with Strategic Roguelike Shooter! Currently in development, Maiden Gear strives to combine the two into a singular unique experience. Beautiful robot maids, deadly weapons, authority in dystopia -- What if all things could be remade?