Top similar games like Systematic Immunity:

Gish isn't your average hero. In fact, he's not your average anything...you see, Gish is a ball of tar. A Sunday stroll with his lady friend, Brea, goes awry when a shadowy figure emerges from an open manhole and pulls Brea below ground.

The pinnacle of alien evolution, Maw is a cowardly fat blob concerned mostly with snacking and lounging. He can, however, absorb the traits of anything he eats, is virtually indestructible, and can grow to unlimited size. If he wasn't a danger to all life in the universe, he'd make the perfect pet.

Tommy Tronic - an old-skool platformer that isn't trying to be anything else! Jumping, shooting, dodging and exploring is all that's required to help get Tommy to his destination and free his tiny puppy from the clutches of an insane genius school-kid and his brutal sidekick 'Biffa'.

Players will control two very different characters, Death and the Fly. Each character has special skills that must be used to navigate the many traps and puzzles contained in each level. With many interesting ways to die and numerous opponents to face, the player will be challenged and entertained for hours.

A combination of platforming with a gravity gun, BEEP is an amazing physics-platformer. Despite its friendly art style, this is a hardcore platformer in the truest sense.

Two unique characters and a total of 4 islands and 16 levels to explore, Tobe's Vertical Adventure shall bring you back to the 16-bit era.

Run, jump, shoot, fly and explore your way through a massive action-adventure reminiscent of classic 8- and 16-bit games.

Apotheon is a heroic action game set within the vibrant world of Ancient Greek Mythology. Ascend Mount Olympus, wrestle the divine powers from the Pantheon of Gods, and save mankind.

You choose how to play, and the world of Environ adapts around you.

Take control of the Seven Deadly Sins as you forge your destiny on a quest to troll humanity.

Guacamelee! Gold Edition is a Metroidvania-style action-platformer set in a magical Mexican-inspired world. The game draws its inspiration from traditional Mexican culture and folklore, and features many interesting and unique characters.

Annihilate an evil penguin regime in this cinematic platform adventure game offering full solo and co-op campaigns.

Craft your arsenal to avenge your fallen comrades and save the world from the fearsome forces of CLAW!

Somewhere between a platformer, a puzzle game and a great big dollop of pure fun, Fly’N will challenge your skills through more than forty levels set in a luxuriant world. Experiment with the four Buds to save the World-Trees from Dyer, the loony hair-dryer who intends to destroy their Helys!

A modern take on the 16-bit era, A Valley Without Wind 2 blends a variety of mechanics across multiple genres, seamlessly bringing together the best qualities of old-school platform-shooters and turn-based strategy games.

Awakened from his slumber, Beatbuddy journeys through lush hand-painted environments on a quest to save his companions and his own immortality. Beatbuddy interacts with the living breathing environment that pulses to the beat of an original soundtrack, aiding him as he unlocks new paths and solves puzzles.

Daniel was just an average guy. He was a great videogame player, a big fan of sci-fi movies, and a novice RPG player. In the midst of an RPG, he was teleported to a castle. At first, Daniel believed that he was having a massive hallucination.

Zack Zero takes you on an action-packed platform adventure with incredible 3D graphics and the playability and entertainment of classic 2D games. Help Zack Zero save his beloved Marlene, kidnapped by the evil Zulrog in an effort to obtain the powerful substance that will allow him to travel back in time.

Immerse yourself in a gorgeous hand-painted world on a search for your true identity. As the mysterious warrior, Dust, your action-packed journey will take you from peaceful glades to snowy mountaintops and beyond.

Suit up as an operative of the Ark Corporation, sent to the farthest reaches of the universe in search of habitable planets to terraform. However, after the long space journey you awaken from cryosleep to find that your ship has gone way off course and is disabled near a strange new world.

Q.U.B.E: Director's Cut is the definitive version of the brain-twisting first-person puzzler. Using special high-tech gloves to manipulate cubes in the environment, the player solves an array of conundrums - from physics-based challenges; to 3D jigsaws; to platform-based trials.

An award-winning anti-platformer where destruction is the only way to move. Mold yourself into any form by destroying your cells, and traverse a devastated landscape filled with brain-twisting puzzles and bizarre mutations. Are you ready to break the mold?

Ruthless bird versus bird action. Wild animals and the artefacts of a mysterious ancient culture. A game full of challenge and discovery – unlike anything you've played before.

Return to the Golden Age of arcades with a hardcore action platformer that pulls no punches! Possesses all the hallmarks of true classics like Super Ghouls 'N Ghosts (SNES), Rastan Saga (Arcade), Castlevania (NES) and more with precise controls, high challenge, and meticulous design.

From the creator of the Gundemonium Collection comes a thrilling new 2D action-platformer! Help Bunny escape the Devils’ Labyrinth and defeat the 7 Devils in this hilariously over-the-top action-platformer game. Battle through a large, connected map filled with unique enemies, traps, and puzzles.

Shovel Knight: Treasure Trove is the complete Shovel Knight collection, containing all 5 games in the epic saga! Dig, blast, slash, and bash your way through a fantastical, 8-bit inspired world of pixel-perfect platforming, memorable characters, and world-class action-adventure gameplay.

Hard hat tester, Ray, has a bizarre accident and wakes up with a giant pink spaghetti arm sticking out of his brain! With his awesome new powers he can read minds and change the world with stickers but he’s on the run for a crime he didn’t commit. Can you help Ray out of this sticky situation?

From indie Chilean developer ACE Team comes a new side-scrolling action adventure game featuring a complex fighting engine in procedurally generated levels that destines its three warriors to battle a different abyss each time! Choose your hero and also learn to possess your enemies in the abyss…

Crashed and alone on a world mankind tried to leave behind, Darkout challenges players to survive on Illuna, in harsh, procedurally generated biomes, utilizing the game’s sandbox features to build shelters, craft weapons, and research new technologies.You are not alone.

Join Shaun the Sheep and his friends Timmy and Shirley on this epic adventure journeying through caverns, the busy streets of London and through outer space all in search of the green grass of home. Now with new multiplayer modes, controller support, widescreen graphics and much, much more!

Discover the lost treasures of Ukampa in South America as Aban Hawkins searches for his estranged father, world-famous archeaologist, Jim Hawkins. Aban Hawkins races into the frozen tundra of the antarctic, undiscovered temple ruins and the vast caverns of South America in search of his father and the legendary treasure rumored to lie...

Explore the mysterious and beautiful planet Gomi on foot or with your spaceship in this action packed platformer and space shooter hybrid. Your mission is simple, retrieve A.N.N.E and escape.

Freedom Fall is a diabolical down-scrolling platformer set in a prison tower so tall it touches the clouds. Presented with hand painted art, its old school vibe mixes with fast-paced free falling action and a story with both dark wit and heart.