Top similar games like Genome Survivors:

Reject boring stat stacking! We've restructured the gameplay with limited talent resources—talent combinations are just as important as character selection! With 200+ items and 40+ pieces of equipment, what insane builds can you create? —Depth! Difficulty! And high replay value!

A 2D Roguelite survivor featuring streamer parodies. Rescue your followers to stay off the unemployment line, unlock unique characters, stack powerful runes, and become a wrecking ball of total chaos. Learn. Die. Repeat.

A free-form arena-shooter Roguelite with heavy emphasis on building an overpowered character! You play as a little shape that shoots other shapes! Strengthen your character by mixing and matching mods and upgrades, and experiment with a limitless rune upgrade system!

Choose your race and class, create a unique build, and battle relentless hordes in VERAKORIA. Collect experience, unlock powerful upgrades, defeat deadly bosses, and survive the escalating onslaught in this pixel-art action roguelite.

Franco and Apollo is a rogue-lite survival action game with auto-shooting. Fight against hoards of enemies side by side with your robot dog. Combine weapons and characters to get stronger and be able to defeat all the bosses!

Survive procedural fantasy biomes in a 3D top-down bullet-heaven action roguelite with survivors-like build growth. Upgrade auto-fire weapons, earn and upgrade active abilities, unlock powerful ultimates, defeat bosses, and push into Endless Mode.

Survive relentless enemy waves by broadcasting on risky frequencies. Upgrade, adapt, and defend your radio station in this post-apocalyptic top-down survival game.

Shoot your way through endless waves of government drones! Grab loot, level up, unlock pigeons and upgrade to create unique and crazy builds as you fend off mindless government of creatures.

A casual top-down game with simplified roguelike elements, where a ginger cat named Meow battles endless waves of enemies. Gain experience, upgrade your skills, find the most effective combination of abilities, and try to survive as long as possible.

A fast roguelite survival chaos where you destroy endless plague hordes, stack insane upgrades, and break the rules of power.

You play as a speedy raccoon on his quest for snacks. Collect fruits that make you strong and break those sweet trash cans open! Unlock fancy skins and powerful upgrades while enjoying hand-crafted art and music.

Sidequest Survivors is a bullet-heaven roguelite where you control wacky characters, mow down waves of magical creatures, and tackle sidequests. Choose from a variety of weapons and create builds that match your playstyle.

Slay Goblins is an arena roguelite where you play a knight fighting off hordes of goblins. Choose from a variety of perks, weapons and items to create unique builds and defend your castle.

Mow down endless hordes of enemies in the arena of this dark cyberpunk survival roguelite. Play as a fully modular robot, snapping together multiple weapons and components to craft your perfect build. Collect powerful items to forge game-breaking synergies and annihilate everything in the Pit.

Murim Survival is a survival roguelite game where you must survive against constant waves of enemies within a limited time. Explore a dying world, acquire martial arts, equipment, and traits, and be reborn as a hero of Murim.

Geometry Arena 2 distills RPG depth and Roguelite elements into a unique loop of [ Meta-Progression + Endless Challenges ]. Mix and match Weapons, Bodies, Modules, and Pets to craft your game-breaking builds! Minimalist lines, vibrant colors!

Bullet Heaven x Endless Loot! Create Your Own Build in this Roguelite Action RPG.

Blast Head is a meta progression-focused roguelite/bullet heaven with absurd weapons, powerful runes, and non-linear weapon skill trees. Dive into 10–30 minute runs, discover wild synergies, and unleash chaos across alien arenas.

The arena is shrinking. Annihilate endless swarms of angry geometry to climb the global leaderboards in this relentless bullet heaven. Collect Poly shards, upgrade your weapons, and unlock permanent meta-progression to survive the crush in Shape Survivors.

Survive hordes of out-of-control industrial machines in this top-down arena auto-shooter. Earn upgrades as you level up, complete objectives to enhance weapons, and unlock modules to return stronger. Drive through gaps between enemies and push through to face powerful bosses.

"Magic Cat" is a hand-drawn 2D roguelike game. Players play a little black cat mage to fight—each battle a new trial. Leveling up brings surprises; challenges are unique. Facing monster waves, players strengthen magic via choices, move step by step, defeat the ultimate Boss.

A fast-paced arena shooter game with simple controls and strategic battles. Experience a story original to the game, starring the characters of Appraiser (Provisional).

Entropy Survivors is a bullet hell roguelike where you simultaneously control a powerful mech and a sharpshooting space frog, featuring outrageously creative abilities and powerful weapon customization. Save the universe in single player or 2-4 player online co-op!

A fast-paced Bullet Hell roguelike where your "hero" is a heavily armored sewage truck. Drift through thousands of enemies, combine dozens of absurd weapons and passive skills. Upgrade your heavy machinery and survive the shift!

Dustbound is a deckbuilding survivors-like roguelite where you build your deck by finding lost treasure. Between waves of monsters take time to upgrade your cards and shape your character’s build—then dive back into the fight.

Survive waves of bouncing enemies raining from the skies in this fast-paced action roguelite. Play as a superpowered monk, craft game-breaking builds, and conquer the chaos in sub-30-minute runs.

Your choices matter in Froguelike where you play as a frog on a mission to eat all the bugs. Level up, choose new tongues and upgrades, become unstoppable and run straight into the swarm! Unlock all frogs, tongues, items and chapters to become the most powerful frog in the pond.

Play as the Chosen One in this short, unique action roguelike. Prove your worth to the gods to earn gold, buy powerful upgrades, and build destructive combos. Defend the sacred temple and survive the final wave in this thrilling defense game!