Top similar games like Clinical Trial:

Get injected into the microscopic world of BioGun. Face viral threats and winding corridors on your mission to save man’s best friend from the inside. Will you save dog-kind from extinction?

Guide Pronty and its Javelin partner Bront as it defends the once great city of Royla. Explore the deep sea, fight mutant sea creatures, and discover the secrets behind this new Atlantis in this beautiful action-packed adventure.

Drilly Willis has a drill for a head and mad guitar skills. Save music for eternity by fighting your enemies with a one-of-a-kind drillhead weapon, jam songs on your guitar to grant special powers and abilities, and explore an interconnected world of bizarre creatures!

Fall of Gorithia: Nym's Fate is a 2D action adventure set in the ancient land of Gorithia. Go from simple thief to magic wielding warrior as you battle your way through the fallen kingdom on your quest to find your lost brother in this sprawling fantasy world.

A colour-fuelled 2D Metroidvania. Paint your surroundings as a little lizard exploring a huge hand-crafted world, and restore emotion to a monochrome continent as you discover your true colours.

Become a brave hero and embark to the dangerous journey though mysterious forbidden lands. Reveal secrets of the legendary past, find the last pieces of gone magic and gain courage to slay the terrible monster!

Explore a broken world filled with masks and monsters in this hand-drawn Metroidvania. Fight strange enemies and twisted bosses with your katana and shotgun umbrella, unlock powerful new abilities, and uncover the truth behind the masks of Peaky Circus.

Stoatman is an exciting Metroidvania adventure where you control a brave hero with a magical sword. Explore mysterious lands, discover powerful spells, and battle fantastic creatures in an enchanting fairy-tale world.

Take to the sky and reunite a fragmented world in this surprisingly wholesome metroidvania! Help Iko adventure across beautiful hand-painted islands, receive letters from a quirky cast of characters, and face powerful monstrous adversaries.

Play as Akari, a magical fox imbued with the power of light in this fast paced Metroidvania. Slash and Dash your way through an army of darkness and explore diverse, beautiful worlds.

Explore a strange planet, collect the creatures you find, and then shape-shift into them to expand your world. Build your own path, chat with the locals, and discover the planets sprawling secrets in this quirky metroidvania platformer.

The crazy plan to revive an ancient spirit has finally succeeded. The Chaos Rider is here to restore an age of magic to this fallen world. With a powerful adaptive robotic body and ancient powers, explore, forge alliances, conquer foes and challenges, and uncover countless secrets and wonders.

An exhilarating action-adventure game set in a vibrant retro-futuristic universe. Embark on daring interstellar journeys, uncovering new worlds, and battling formidable alien adversaries. Upgrade your ship and abilities as you explore the vastness of space to save the Galaxy from a hidden threat.

A cute Hand-Drawn platformer adventure about a brave doggy in a mysterious dreamland where the sun and the moon have stopped moving!

Restore the Sun’s light and end the Eternal Eclipse in this 2D fast-paced action-platformer game inspired by Peruvian cultures. Explore hand-crafted environments, battle and improve your skills to defeat the Four Keepers that stole the power of the Sun.

Flow gracefully through a colorful, hand-drawn 2.5D action platformer inspired by Japanese folklore. Engage in acrobatic aerial combat, unlock powerful mystical abilities, and explore an interconnected world of myth as you seek to unravel the mysteries of your origin.

Scratch in a 2.5D world that blends hip hop aesthetics with action/platforming, where urban art has come to life. Explore dynamic environments, face cleaning robots, and uncover secrets of this vibrant world as you reclaim your identity in this intense and colorful adventure.

Explore an interconnected world, encounter bizarre enemies and mysterious puzzles in this hand-drawn metroidvania, action adventure. Forge your own path, uncover secrets and master unique powers.

Constance is a 2D hand-drawn action adventure featuring a paintbrush-wielding artist, striving to escape from a colorful but decaying inner-world, created by her declining mental health.

A shape-shifting, pixel-art, story-rich action adventure metroidvania for PC

Florarium is a Metroidvania game focused on exploration and battle. Explore the mysterious world full of unexpected secrets. Battle fierce enemies with your bow. Choose your own path to your goddess in the vast, interconnected world.

"ARO: Tales in the Dome" is a 2D hand-drawn action-adventure game. Play as Aro and explore an elemental world sealed beneath the dome. As the journey unfolds, uncover the hidden conspiracy and face the truth about the world, the dome, and yourself.

Recover scattered gem shards in this puzzle-filled, exploration-driven Metroidvania to restore balance and return home.

8Doors is a story-driven Metroidvania-style action platformer heavily influenced by Korean folktales. Play as ‘Arum’, a brave girl that has entered the realm of the afterlife in search of her father’s soul and guide her through the '8 Doors of Purgatory' to solve the mysteries that lie deep within.

Blast off in a 2D metroidvania adventure bursting with platforming thrills, deep exploration, and explosive action. Assemble a crack team of heroes to save the world in Blast Brigade!

Throw your shell, swap your abilities, and grow through molting. Choose from nine hermit crab heroes in a 2D side-scrolling action-adventure. Explore shores and sunken ruins, battle bosses, craft and upgrade shells, and discover the stories of Awesome Island.

Memoria is a hand-drawn 2D Metroidvania where magic is as much about memory as it is about power. You play as a powerful—but aging—sorceress who awakens in a familiar but fragmented world. Only by exploring the world around you can you spark your memories, and remember once again.

Join young Mako as she ventures into a wild world of exploration and finds a mysterious bird companion. Navigate through two distinct realms with your staff and face off against an ancient sentinel in this prologue to the action-packed metroidvania Akatori.

Resort adventure of exploration, life-sim and a little action. Your guide is in-game "Brochure" filled with map and activities. Check them off as you go. Learn new skills to unlock new areas. Days at the waterpark, nights at the hotel lounge. No enemies. Just your own pace. A cozy Metroidvania.

You are Eduardo, a teddy bear thrust into a racial struggle between Bears and Spidz who share the same land. On Eduardo's journey to discover his purpose, he must learn to master ability cards and curry cooking to uncover the hidden root of all evil in this Victorian-inspired fantastical world.

Lead Rolly in his adventure within the wonderful world of Shroomast, and explore its deep semi open-world underground. Goo Keeper is a pure metroidvania with tons of unique bosses, hand-crafted worlds and creatures, and tons of awesome abilities.

The King's pup levels up! Cavalier is a single player hand drawn Metroidvania. Combat enchanted creatures while you explore the expanding map, and restore the magical kingdom in this charming medieval adventure.

Unleash your magical spear! Explore a vast inter-connected world, battling enemies sent by Culex, the dark mosquito deity. Throw, recall, and use your spear as a platform through this minimalistic metroidvania made by one developer!