Top similar games like Clinical Trial:

Get injected into the microscopic world of BioGun. Face viral threats and winding corridors on your mission to save man’s best friend from the inside. Will you save dog-kind from extinction?

Guide Pronty and its Javelin partner Bront as it defends the once great city of Royla. Explore the deep sea, fight mutant sea creatures, and discover the secrets behind this new Atlantis in this beautiful action-packed adventure.

Drilly Willis has a drill for a head and mad guitar skills. Save music for eternity by fighting your enemies with a one-of-a-kind drillhead weapon, jam songs on your guitar to grant special powers and abilities, and explore an interconnected world of bizarre creatures!

Take to the sky and reunite a fragmented world in this surprisingly wholesome metroidvania! Help Iko adventure across beautiful hand-painted islands, receive letters from a quirky cast of characters, and face powerful monstrous adversaries.

Fall of Gorithia: Nym's Fate is a 2D action adventure set in the ancient land of Gorithia. Go from simple thief to magic wielding warrior as you battle your way through the fallen kingdom on your quest to find your lost brother in this sprawling fantasy world.

Constance is a 2D hand-drawn action adventure featuring a paintbrush-wielding artist, striving to escape from a colorful but decaying inner-world, created by her declining mental health.

Play as Akari, a magical fox imbued with the power of light in this fast paced Metroidvania. Slash and Dash your way through an army of darkness and explore diverse, beautiful worlds.

Explore a strange planet, collect the creatures you find, and then shape-shift into them to expand your world. Build your own path, chat with the locals, and discover the planets sprawling secrets in this quirky metroidvania platformer.

The Chaos Rider finally wakes up after ages. Explore a mysterious island with tons of secrets and treasures to discover ! Fight your way through hordes of enemies and fulfill the dream of the Great Architect. Create your own playstyle, beat bosses and do crazy platforming in this epic adventure game

A cute Hand-Drawn platformer adventure about a brave doggy in a mysterious dreamland where the sun and the moon have stopped moving!

Restore the Sun’s light and end the Eternal Eclipse in this 2D fast-paced action-platformer game inspired by Peruvian cultures. Explore hand-crafted environments, battle and improve your skills to defeat the Four Keepers that stole the power of the Sun.

An exhilarating action-adventure game set in a vibrant retro-futuristic universe. Embark on daring interstellar journeys, uncovering new worlds, and battling formidable alien adversaries. Upgrade your ship and abilities as you explore the vastness of space to save the Galaxy from a hidden threat.

Flow gracefully through a colorful, hand-drawn 2.5D action platformer inspired by Japanese folklore. Engage in acrobatic aerial combat, unlock powerful mystical abilities, and explore an interconnected world of myth as you seek to unravel the mysteries of your origin.

Explore an interconnected world, encounter bizarre enemies and mysterious puzzles in this hand-drawn metroidvania, action adventure. Forge your own path, uncover secrets and master unique powers.

A shape-shifting, pixel-art, story-rich action adventure metroidvania for PC

Florarium is a Metroidvania game focused on exploration and battle. Explore the mysterious world full of unexpected secrets. Battle fierce enemies with your bow. Choose your own path to your goddess in the vast, interconnected world.

Recover scattered gem shards in this puzzle-filled, exploration-driven Metroidvania to restore balance and return home.

Memoria is a hand-drawn 2D Metroidvania where magic is as much about memory as it is about power. You play as a powerful—but aging—sorceress who awakens in a familiar but fragmented world. Only by exploring the world around you can you spark your memories, and remember once again.

8Doors is a story-driven Metroidvania-style action platformer heavily influenced by Korean folktales. Play as ‘Arum’, a brave girl that has entered the realm of the afterlife in search of her father’s soul and guide her through the '8 Doors of Purgatory' to solve the mysteries that lie deep within.

Blast off in a 2D metroidvania adventure bursting with platforming thrills, deep exploration, and explosive action. Assemble a crack team of heroes to save the world in Blast Brigade!

Stoatman is an exciting Metroidvania adventure where you control a brave hero with a magical sword. Explore mysterious lands, discover powerful spells, and battle fantastic creatures in an enchanting fairy-tale world.

"ARO: Tales in the Dome" is a 2D hand-drawn action-adventure game. Play as Aro and explore an elemental world sealed beneath the dome. As the journey unfolds, uncover the hidden conspiracy and face the truth about the world, the dome, and yourself.

Join young Mako as she ventures into a wild world of exploration and finds a mysterious bird companion. Navigate through two distinct realms with your staff and face off against an ancient sentinel in this prologue to the action-packed metroidvania Akatori.

You are Eduardo, a teddy bear thrust into a racial struggle between Bears and Spidz who share the same land. On Eduardo's journey to discover his purpose, he must learn to master ability cards and curry cooking to uncover the hidden root of all evil in this Victorian-inspired fantastical world.

Lead Rolly in his adventure within the wonderful world of Shroomast, and explore its deep semi open-world underground. Goo Keeper is a pure metroidvania with tons of unique bosses, hand-crafted worlds and creatures, and tons of awesome abilities.

The King's pup levels up! Cavalier is a single player hand drawn Metroidvania. Combat enchanted creatures while you explore the expanding map, and restore the magical kingdom in this charming medieval adventure.

Become a brave hero and embark to the dangerous journey though mysterious forbidden lands. Reveal secrets of the legendary past, find the last pieces of gone magic and gain courage to slay the terrible monster!

It's you who can make a change. Use your soul to fight the corruption that leaks in the mysterious and atmospheric universe of Astra. Dive deeply into the essence of this world and navigate around danger leaning on truths and secrets. The Stars are Fading! Soon the darkness will swallow them all.

Unleash your magical spear! Explore a vast inter-connected world, battling enemies sent by Culex, the dark mosquito deity. Throw, recall, and use your spear as a platform through this minimalistic metroidvania made by one developer!

Explore, solve enigmas and fight mutated creatures in a 2D narrative-driven metroidvania with pets, set on the rooftops and the undergrounds of a flooded countryside, enriched by cinematic cutscenes, diverse scenography and memorable characters.

A Norse mythology Metroidvania where an orphan sets out on a journey through interconnected realms. Master tactical combat, discover ancient powers, and unveil the secrets of a dying world in this hand-crafted pixel art adventure.

When a nightmare creeps into reality, the only ones that can help are those whose magical powers we’ve believed in since childhood. A brave teddy bear and his fairy sidekick head to the darker side of “happily ever after” to rescue his owner, Alicia.

Embark on an adventure with Aku, a lovable little white dragon.

"Charlie from the swamp" is a metroidvania game about little frog in a big world.