Top similar games like Clinical Trial:

Get injected into the microscopic world of BioGun. Face viral threats and winding corridors on your mission to save man’s best friend from the inside. Will you be the vaccine to save dog-kind from extinction?

Flow gracefully through a colorful, hand-drawn 2.5D action platformer inspired by Japanese folklore. Engage in acrobatic aerial combat, unlock powerful mystical abilities, and explore an interconnected world of myth as you seek to unravel the mysteries of your origin.

Restore the Sun’s light and end the Eternal Eclipse in this 2D fast-paced action-platformer game inspired by Peruvian cultures. Explore hand-crafted environments, battle and improve your skills to defeat the Four Keepers that stole the power of the Sun.

LAPIN is a 2D precision platformer game featuring a group of brave rabbit explorers. Break through life-threatening obstacles with precise controls, and embark on an adventure filled with new encounters and stunning landscapes!

Blast off in a 2D metroidvania adventure bursting with platforming thrills, deep exploration, and explosive action. Assemble a crack team of heroes to save the world in Blast Brigade!

A cute Hand-Drawn platformer adventure about a brave doggy in a mysterious dreamland where the sun and the moon have stopped moving!

MONOWAVE is a whimsical puzzle-adventure platformer about the humane power of emotions. Explore beautiful landscapes and empathize with their quirky denizens to restore harmony in an emotionally turbulent universe.

You are a small fire spirit born in a world of perishing spirits. Driven by someone's desperate voice, you embark on an adventure to find the 'First Flame'. Explore the peculiar, hand-drawn world of Solateria, defeat powerful enemies, and uncover the secrets of the world.

Legends of Ethernal is a 2D single-player action adventure game where you need to explore beautiful hand-crafted environments, solve clever puzzles and battle tough creatures to uncover the truth about your parents’ disappearance.

Guide Pronty and its Javelin partner Bront as it defends the once great city of Royla. Explore the deep sea, fight mutant sea creatures, and discover the secrets behind this new Atlantis in this beautiful action-packed adventure.

When a nightmare creeps into reality, the only ones that can help are those whose magical powers we’ve believed in since childhood. A brave teddy bear and his fairy sidekick head to the darker side of “happily ever after” to rescue his owner, Alicia.

Join young Mako as she ventures into a wild world of exploration and finds a mysterious bird companion. Navigate through two distinct realms with your staff and face off against an ancient sentinel in this prologue to the action-packed metroidvania Akatori.

Rose, a former outlaw, travels through the spirit realm of the Underwest. Take up the once-forgotten skills of the gunslinger in this Action-Platformer adventure, and journey along the breathtaking landscapes on a quest to rescue your daughter’s spirit.

Akatori is an epic metroidvania where you wield your staff to fight, jump, and explore diverse realms across different eras. Join Mako on her journey to build friendships, face formidable foes, and uncover ancient gods while discovering her true self.

A shape-shifting, pixel-art, story-rich action adventure metroidvania for PC

Lead Rolly in his adventure within the wonderful world of Shroomast, and explore its deep semi open-world underground. Goo Keeper is a pure metroidvania with tons of unique bosses, hand-crafted worlds and creatures, and tons of awesome abilities.

Drilly Willis has a drill for a head and mad guitar skills. Save music for eternity by fighting your enemies with a one-of-a-kind drillhead weapon, jam songs on your guitar to grant special powers and abilities, and explore an interconnected world of bizarre creatures!

Play as android MIO in this mesmerizing metroidvania where you explore the Vessel, an enormous technological ark overgrown with machines gone rogue. Uncover its secrets, enhance MIO's abilities, and save the spaceship and its residents from oblivion.

Chiaroscuro is a 2D adventure platformer with metroidvania elements. Explore a world that has fallen into darkness and discover the Lights to illuminate your forgotten past.

Misspell is a 2D action-adventure Metroidvania where you explore the island of Melanor, hiding the secret of a magical catastrophe. Improve skills, use a living vine for combat, and unlock new locations. Dive into a vibrant fantasy world with unique characters and unforgettable adventures!

Embark on a story-rich 2D Metroidvania adventure with breathtaking hand-drawn art, playing as miser-turned-hero Ebenezer Scrooge in a reimagined Victorian-fantasy based on Charles Dickens’ classic novel, A Christmas Carol. Enlist the help of ghosts to save the people of London before it’s too late.

PlayBound tells the story of Kelvin, a boy whose parents have become fatally boring. Strap on your velcro light-up kicks and equip your POG slammers, because it's time to save the world from certain lameness!

Explore an interconnected world, encounter bizarre enemies and mysterious puzzles in this hand-drawn metroidvania, action adventure. Forge your own path, uncover secrets and master unique powers.

"Charlie from the swamp" is a metroidvania game about little frog in a big world.

Enter the prehistoric world dominated by primal reptiles. Evolve by slaying savage enemies and bosses with the combination of melee & ranged combat, primitive traps, and elemental magic. Explore the vast handpainted world and uncover its history.

Battle your way through a living planet in Rebel Transmute, a sprawling 2D action-exploration epic! Embody Moon Mikono as you explore, reprogram your abilities, duel twisted sci-fi experiments, rebel against colonizers, and search for your long lost mother.

Embark on an epic adventure full of perils and secrets. Explore distinct forsaken lands of Devetlam and fight your way by jumping on your enemies or showering them with a plethora of magic spells. An open-world platforming action inspired by the classics.

A 2D Hand Drawn, high-intense metroidvania, telling how two brave women helped to build the Tower of Babel and faced their annihilation.

In Micetopia you play as a brave mouse who must fight, jump and explore its way through a world of mystery. Overcome enemies, gain new powers, and rescue your compatriots from the clutches of their captors. Do you have what it takes for the elder to bestow upon you the title “Hero of Micetopia?”

Embark on a short and emotional journey through a cursed cave in this 2D hand-drawn platformer with action and metroidvania elements. Uncover a touching story about regrets and the value of living the moment

Explore the depths of the ocean in this 2D-Puzzle-Metroidvania! Control the water levels and switch between various robots to solve the ancient puzzles of Atlantis.

Discover the world of Nahucan in this 2D action platformer. You are Itorah, the only human in this strange place. Explore, fight and survive to uncover your past and save Nahucan from its biggest threat, a mysterious plague!

Embark on an epic journey through Dante's 9 circles of hell as clumsy angel Dumbriel, whose mission is to reclaim the souls you lost. Explore angelic and infernal skills, collect shards, craft items, and battle formidable creatures in this Metroidvania-style action adventure.

Take to the sky and reunite a fragmented world in this surprisingly wholesome metroidvania! Help Iko adventure across beautiful hand-painted islands, receive letters from a quirky cast of characters, and face powerful monstrous adversaries.