Top similar games like Microbes and Machines:

Destroy hordes of strange machines that have invaded the forest. Yawnoc is a chaotic top-down shooter roguelite focused on immersion into the world of Conway's Game of Life and other cellular automata.

Cyberscape is a top down round based action game with some rougelike elements. Play as different heroes with unique abilities and fight against the evil robot army. Level up and complete achievements to unlock new items and fight your way through different locations.

Cards and Guns is a top-down arena shooter roguelite, where you’ll have to defeat hordes of creatures. Choose from a variety of cards and upgrades to create unique builds and survive to the end.

Fast paced Top-down shooter! Smartly use IRCM to evade the constant barrage of bullets and missiles and destroy everything that stands in your way.

Fight through hordes of burnt CDs, flying TVs, and faceless suits in this frantic, run-based, twin-stick shooter. Forget firing bullets, though - you'll be flinging vinyl records, throwing drumsticks and swinging guitars to fend off the enemies of music and maybe, just maybe, survive the night.

Grid-based action roguelike where you face chaotic encounters against computer viruses. Build and upgrade your antivirus using a vast array of commands and add-ons in order to survive.

Danger Gazers is a post-apocalyptic roguelite top-down shooter where you pave your own path. The choices you make will decide your fate, it will either turn you into the new ruler or... the ashes to be windswept away.

Hyperspace Dogfights is a juicy jet-combat roguelite in which you blast, dodge and slice your way through masses of technologically inferior baddies. Your jet evolves differently on each run and becomes stronger and weirder by gathering some of the 300+ available items.

Addicting action-roguelite top-down shooter with a smooth circle fighting jagged enemies in a crisp neon look. Combine powerful and upgradable abilities to craft devastating builds while facing challenging and clever foes in procedurally generated mazes.

Metallophobia is a dystopian roguelike top-down shooter. Each playthrough is a new procedurally generated map, with unique designs and challenges. Upgrade your robot with new guns and modules as you progress, and create your own unique build.

Fight hordes of Covenant & Flood in this new game mixing Roguelite & Bullet Heaven for hours of mindless fun!

Crush, smash, and eat thousands of enemies showing humanity what the meaning of destruction is! Kaiju Catastrophe is an arcade game with roguelite mechanics. Mutate devastating weapons, unlock permanent evolutions, and wreak havoc with a variety of monsters to tear humanity apart!

Regulators is a tactical top-down shooter where you lead a team of mercenaries to clear the city from mutating villains using your weapons, gadgets, special super powers and intelligence.

Rejected as heir after losing your will, you must survive on an abandoned amusement-park planet. Gather ingredients, craft food-guns, shoot, eat, and grow stronger to reclaim your lost legacy.

Spent Shells is a high score top-down shooter with roguelike-y randomized elements. Players dive in to an everchanging dungeon to harvest a crystalized power source that will get them home. Fight through the dungeon using a variety of weapons, characters, upgrades, and your own skill! Each run ea...

PERMUTER is a synthwave-style autobattler inspired by Geometry Wars 3's Pacifism mode. Control an agile ship, weave through enemies, buy and stack game-changing upgrades, choose your build carefully to gain synergy bonuses, and defeat the challenging elite bosses.

Don't get swarmed in this incremental top-down shooter! Unlock new mechanics and upgrades as you defeat more and more enemies. Let drones aid you in combat and use your abilities to become unstoppable.

Overkill Squad is a ultra high-speed top-down shooter roguelike built around intense 1-minute combat arenas. Choose your fighter, unleash overwhelming firepower, defeat brutal bosses, and collect relics to dominate every run.

lone.AI is a space RPG roguelite. With challenging, relentless gameplay, each run has the potential to boost your ship's power, speed, and more. As a lone AI, fight your way through the solar system and uncover the secret behind the ZOSMA, an alien race that holds power over the system.

Enter the human body with A Way To Die! Play as a disease that attempts to infect its host by contaminating organs and mutating! Discover new ways to win every time you play with all the different diseases!

A roguelike with unique curses, 60+ cards, incredible shots and power-ups. No two attempts are ever the same.

Drawn into your PC by an antivirus, control a multi barrel tank in this Action Roguelike, 2D Shooter. Defeat motherboard viruses to unlock new zones. The 'UPGRADE MACHINE' grants enhancements every 1-10 seconds. Use points to add upgrades in this Arcade, Top-Down Adventure.

GLASS x CANNON is a risky top down shooter roguelike. You are always very low health so you'll have to dodge and use blood to survive. Collect items and get stronger to defeat a powers, crossing into our world.

Stel is a spaceship action-adventure game with procedurally generated elements. Fight dangerous foes, improve your ship and explore the different levels to decipher a mysterious problem, the Quantum are disappearing...

Stellar Space is a new take on a classic arcade game with a modern, rogue-like, form for new players to enjoy!

Deepest Well is a roguelike where you fight off waves of enemies in a descending well with destructible terrain. Get upgrades after each wave and make insane builds to break the game!

You’re being Bounty-Hunted! Run, Build your ship piece-by-piece and make it work with the parts you find, Destroy outposts and waves of fleets, and Pick your battles carefully to overcome your hunters in this Fast-Paced Top-Down Action Roguelite Shooter.

Extinction 1306 is a top-down roguelike shooter. You are the sole survivor after a failed experiment. You must fight off mutant insects, explore the abandoned lab, level up and find upgrades to improve your skills, and defeat bosses to reach a final threat standing in between you and saving Earth.

Woodpunk is an exhilarating roguelike bullet hell retro pixel art shooter in a medieval Woodpunk universe, where the primary energy resource is WOOD.

A self-inflicted bullet hell that combines retro sci-fi with the sounds and sights of the disco era

Retrofuturistic bullet-hell roguelike where you play as a rogue time traveler, fighting through hundreds of historical foes! Every run reshapes history itself— Shoot weapons from different eras, use time-manipulating skills, and create unique builds to survive until you reach the end of all time!

Roguelike Shooter Where Your Bullets Hurt You!

Pilot an agile star fighter to tear down alien megastructures under fire, then pull off a high-stakes heist from within before everything explodes. When you die time rewinds, sending you back to Moonbase Alpha—your hub for reinvention. Spend your bounty on explosive upgrades, ready for the next run.

Nanokeeper is a short roguelite where your towers are your last line of defense. Add, attack, and conquer the arena!

Rush Rover is a 2D top-down shooter game. Compared to other similar games of the genre, the shooting experience is closer to traditional shoot'em up games. It includes random map generation, unique weapons, lots of different enemies, exciting boss battles and a dynamic chiptune soundtrack.