Top similar games like Microbes and Machines:

Destroy hordes of strange machines that have invaded the forest. Yawnoc is a chaotic top-down shooter roguelite focused on immersion into the world of Conway's Game of Life and other cellular automata.

Cyberscape is a top down round based action game with some rougelike elements. Play as different heroes with unique abilities and fight against the evil robot army. Level up and complete achievements to unlock new items and fight your way through different locations.

Cards and Guns is a top-down arena shooter roguelite, where you’ll have to defeat hordes of creatures. Choose from a variety of cards and upgrades to create unique builds and survive to the end.

Fight through hordes of burnt CDs, flying TVs, and faceless suits in this frantic, run-based, twin-stick shooter. Forget firing bullets, though - you'll be flinging vinyl records, throwing drumsticks and swinging guitars to fend off the enemies of music and maybe, just maybe, survive the night.

Grid-based action roguelike where you face chaotic encounters against computer viruses. Build and upgrade your antivirus using a vast array of commands and add-ons in order to survive.

Danger Gazers is a post-apocalyptic roguelite top-down shooter where you pave your own path. The choices you make will decide your fate, it will either turn you into the new ruler or... the ashes to be windswept away.

Hyperspace Dogfights is a juicy jet-combat roguelite in which you blast, dodge and slice your way through masses of technologically inferior baddies. Your jet evolves differently on each run and becomes stronger and weirder by gathering some of the 300+ available items.

Metallophobia is a dystopian roguelike top-down shooter. Each playthrough is a new procedurally generated map, with unique designs and challenges. Upgrade your robot with new guns and modules as you progress, and create your own unique build.

"Guardians Of Restoration" is a top-down robot action game that combines action and bullet hell elements. Level up within a set time to enjoy thrilling battles against various bosses. Each boss randomly possesses one of three traits, ensuring a unique and exciting experience every time you play.

Crush, smash, and eat thousands of enemies showing humanity what the meaning of destruction is! Kaiju Catastrophe is an arcade game with roguelite mechanics. Mutate devastating weapons, unlock permanent evolutions, and wreak havoc with a variety of monsters to tear humanity apart!

A tactical action game where you are backed up by an AI controlled recruit shooting mutated villains. Complete missions, operate tasks, and unlock new weapons and items and skills and put a stop to the Ooze Mutations taking over the city

Spent Shells is a high score top-down shooter with roguelike-y randomized elements. Players dive in to an everchanging dungeon to harvest a crystalized power source that will get them home. Fight through the dungeon using a variety of weapons, characters, upgrades, and your own skill! Each run ea...

PERMUTER is a synthwave-style autobattler inspired by Geometry Wars 3's Pacifism mode. Control an agile ship, weave through enemies, buy and stack game-changing upgrades, choose your build carefully to gain synergy bonuses, and defeat the challenging elite bosses.

lone.AI is an upcoming space RPG roguelite. With challenging, relentless gameplay, each run has the potential to boost your ship's power, speed, and more. As a lone AI, fight your way through the solar system and uncover the secret behind the ZOSMA, an alien race that holds power over the system.

Enter the human body with A Way To Die! Play as a disease that attempts to infect its host by contaminating organs and mutating! Discover new ways to win every time you play with all the different diseases!

Drawn into your PC by an antivirus, control a multi barrel tank in this Action Roguelike, 2D Shooter. Defeat motherboard viruses to unlock new zones. The 'UPGRADE MACHINE' grants enhancements every 1-10 seconds. Use points to add upgrades in this Arcade, Top-Down Adventure.

Stel is a spaceship action-adventure game with procedurally generated elements. Fight dangerous foes, improve your ship and explore the different levels to decipher a mysterious problem, the Quantum are disappearing...

Stellar Space is a new take on a classic arcade game with a modern, rogue-like, form for new players to enjoy!

You’re being Bounty-Hunted! Run, Build your ship piece-by-piece and make it work with the parts you find, Destroy outposts and waves of fleets, and Pick your battles carefully to overcome your hunters in this Fast-Paced Top-Down Action Roguelite Shooter.

Extinction 1306 is a top-down roguelike shooter. You are the sole survivor after a failed experiment. You must fight off mutant insects, explore the abandoned lab, level up and find upgrades to improve your skills, and defeat bosses to reach a final threat standing in between you and saving Earth.

Woodpunk is an exhilarating roguelike bullet hell retro pixel art shooter in a medieval Woodpunk universe, where the primary energy resource is WOOD.

Retrofuturistic bullet-hell roguelike where you play as a rogue time traveler, fighting through hundreds of historical foes! Every run reshapes history itself— Shoot weapons from different eras, use time-manipulating skills, and create unique builds to survive until you reach the end of all time!

A self-inflicted bullet hell that combines retro sci-fi with the sounds and sights of the disco era

Nanokeeper is a short roguelite where your towers are your last line of defense. Add, attack, and conquer the arena!

Rush Rover is a 2D top-down shooter game. Compared to other similar games of the genre, the shooting experience is closer to traditional shoot'em up games. It includes random map generation, unique weapons, lots of different enemies, exciting boss battles and a dynamic chiptune soundtrack.

BroodStar is a classic arcade shmup with roguelike elements. Acquire crazy item combos, encounter strange events and fight challenging bosses on a quest to destroy the living planet, the BroodStar.

Cosmic Cursor fuses simple mouse-based controls with a challenging, reactive bullet hell for the ultimate pick-up-and-play roguelike experience.

"Steel Knight's ARMIS" is a roguelike robot game. Lead the rebellion through five chapters, fighting against the Imperial Army and Earth Federation. Customize and upgrade your robot to survive the intense battles ahead.

Zombie exterminator is a top-down shooter roguelite where you play a soldier. Combine weapon parts and create unique weapons. Use gadgets and relics to exterminate zombies. Fight against zombies and horrendous creatures.

Fast paced bullet hell roguelike. Upgrade your weapons and abilities as you collect attribute blocks. Highly customisable with lots of combinations. Fight bosses, pick up items and improve your stats. Unlock new items and achievements for the next run through the ever-changing dungeon.

Explore a cyberpunk universe where monkeys rule. Challenge the fearsome Cyber Monkeys as you take on the role of a hero armed with a living shark weapon.

Splatter slimes, massacre mutants, and assemble your perfect Gunbot! Survive hordes of enemies in this top-down shooter roguelite by customizing your weapons on the unique upgrade grid, and pick from a wide variety of build-defining modules and wacky base bots for a new experience every run.

Blast through waves of enemies, collect powerups and test your skills against challenging bosses. It is a modern take on classic space shooters, blending accessible gameplay with roguelite progression. Compete for the top spot on the global leaderboards in 15 minute runs.

Elsie is a technicolour, hyperkinetic, rogue-like action-platformer filled with procedurally generated levels, an army of robots to blast through, and a wide scope of items & weaponry to make each run unique. Master countless magitek weapons and abilities in order to embrace the chaos.