Top similar games like Microbes and Machines:

Destroy hordes of strange machines that have invaded the forest. Yawnoc is a chaotic top-down shooter roguelite focused on immersion into the world of Conway's Game of Life and other cellular automata.

Beyond Lost Planets is an intense Roguelike Dungeon Crawler Bullet Hell. Fight through enemies and bosses across procedural worlds. Everything from weapons and bullets to powerup and companions is represented with cards. Grow absurdly powerful and create wild, unique synergies every run!

Cyberscape is a top down round based action game with some rougelike elements. Play as different heroes with unique abilities and fight against the evil robot army. Level up and complete achievements to unlock new items and fight your way through different locations.

Cards and Guns is a top-down arena shooter roguelite, where you’ll have to defeat hordes of creatures. Choose from a variety of cards and upgrades to create unique builds and survive to the end.

Fast paced Top-down shooter! Smartly use IRCM to evade the constant barrage of bullets and missiles and destroy everything that stands in your way.

Fight through hordes of burnt CDs, flying TVs, and faceless suits in this frantic, run-based, twin-stick shooter. Forget firing bullets, though - you'll be flinging vinyl records, throwing drumsticks and swinging guitars to fend off the enemies of music and maybe, just maybe, survive the night.

Grid-based action roguelike where you face chaotic encounters against computer viruses. Build and upgrade your antivirus using a vast array of commands and add-ons in order to survive.

Rob o Bot is a survivors-like action game where you fight hordes of robots that began acting on their own after a mysterious virus infected a new generation of machines. Survive waves of enemies, upgrade your gear, and take back control before the machines take over.

Danger Gazers is a post-apocalyptic roguelite top-down shooter where you pave your own path. The choices you make will decide your fate, it will either turn you into the new ruler or... the ashes to be windswept away.

A cyberpunk roguelike arcade shooter. Hack through hostile cyberspace across three escalating sectors, pick hacking programs from a randomised loadout, and blast through ICE before the trace meter catches you.

A roguelite space shooter based around the classic arcade game. Shoot asteroids, ships, and take down the mothership in a multi-stage boss fight, avoiding lasers and explosions. Upgrade your ship during and after your run in this casual simple roguelite.

Metallophobia is a dystopian roguelike top-down shooter. Each playthrough is a new procedurally generated map, with unique designs and challenges. Upgrade your robot with new guns and modules as you progress, and create your own unique build.

Hyperspace Dogfights is a juicy jet-combat roguelite in which you blast, dodge and slice your way through masses of technologically inferior baddies. Your jet evolves differently on each run and becomes stronger and weirder by gathering some of the 300+ available items.

You are a circle in a sharp world. Fight jagged enemies in a neon twin-stick bullet-hell roguelite, build devastating ability combos, and grow from fragile to unstoppable through shifting neon labyrinths.

Crush, smash, and eat thousands of enemies showing humanity what the meaning of destruction is! Kaiju Catastrophe is an arcade game with roguelite mechanics. Mutate devastating weapons, unlock permanent evolutions, and wreak havoc with a variety of monsters to tear humanity apart!

Regulators is a tactical top-down shooter where you lead a team of mercenaries to clear the city from mutating villains using your weapons, gadgets, special super powers and intelligence.

Gunclone Arena is a top-down looter-shooter roguelite. Fight as a super-clone that can wield 6 weapons, a Beam and Shield in a dystopian TV show! Loot thousands of weapon variants with ricochet, detonate, shock, pierce and more. Stack build-changing Mods. Notice: Escape is grounds for perma-recycle.

Irradiant Skies is an arcade roguelite blending brick-breaking and bullet-parrying combat. Reflect enemy attacks, chain powerful upgrades, and master unique ships as you ascend through waves of enemies.

Rejected as heir after losing your will, you must survive on an abandoned amusement-park planet. Gather ingredients, craft food-guns, shoot, eat, and grow stronger to reclaim your lost legacy.

Spent Shells is a high score top-down shooter with roguelike-y randomized elements. Players dive in to an everchanging dungeon to harvest a crystalized power source that will get them home. Fight through the dungeon using a variety of weapons, characters, upgrades, and your own skill! Each run ea...

PERMUTER is a synthwave-style autobattler inspired by Geometry Wars 3's Pacifism mode. Control an agile ship, weave through enemies, buy and stack game-changing upgrades, choose your build carefully to gain synergy bonuses, and defeat the challenging elite bosses.

Don't get swarmed in this incremental top-down shooter! Unlock new mechanics and upgrades as you defeat more and more enemies. Let drones aid you in combat and use your abilities to become unstoppable.

Bakorila is an action roguelike focused on dash-based combos. Climb destructible towers, defeat enemies with lethal dashes while performing wall jumps, and use your weapon to survive increasingly dangerous threats. Build your loadout, defeat bosses, and help Bakko return to his homeland.

Overkill Squad is a ultra high-speed top-down shooter roguelike built around intense 1-minute combat arenas. Choose your fighter, unleash overwhelming firepower, defeat brutal bosses, and collect relics to dominate every run.

BotNet is a 2D bullet hell roguelike where you play as malware trying to infect the world. Collect powerful items along the way, discover synergies, and make your virus unstoppable.

80 waves. 8 bosses. 17 logs that will make you question everything you've been defending. Locus Protocol is a twin-stick bullet heaven with an adaptive AI Director and a horror story hidden inside a cozy geometric shell.

A roguelike bullet-hell shooter where table tennis meets ancient mythology. Wield your paddle to strike enemies with bouncing balls, retrieve them to attack again, and craft powerful builds through strategic upgrades.

lone.AI is a space RPG roguelite. With challenging, relentless gameplay, each run has the potential to boost your ship's power, speed, and more. As a lone AI, fight your way through the solar system and uncover the secret behind the ZOSMA, an alien race that holds power over the system.

Enter the human body with A Way To Die! Play as a disease that attempts to infect its host by contaminating organs and mutating! Discover new ways to win every time you play with all the different diseases!

A roguelike with unique curses, 60+ cards, incredible shots and power-ups. No two attempts are ever the same.

Drawn into your PC by an antivirus, control a multi barrel tank in this Action Roguelike, 2D Shooter. Defeat motherboard viruses to unlock new zones. The 'UPGRADE MACHINE' grants enhancements every 1-10 seconds. Use points to add upgrades in this Arcade, Top-Down Adventure.

GLASS x CANNON is a risky top down shooter roguelike. You are always very low health so you'll have to dodge and use blood to survive. Collect items and get stronger to defeat a powers, crossing into our world.

Stel is a spaceship action-adventure game with procedurally generated elements. Fight dangerous foes, improve your ship and explore the different levels to decipher a mysterious problem, the Quantum are disappearing...

Stellar Space is a new take on a classic arcade game with a modern, rogue-like, form for new players to enjoy!