Top similar games like Infect and Destroy:

Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.

Dead State is a narrative-driven survival RPG set at the dawn of the undead apocalypse. Drawing inspiration from classic RPGs like Fallout, X-Com, and Suikoden, Dead State combines strategic, turn-based combat with base building mechanics, character creation, and social management.

Become the plague in an asymmetrical player verses simulation battle for immortality. Infect populations, collapse economies, and harvest the dead to fuel your path to lichhood; only if you can conquer an adaptive world fighting to survive.

Dead Earth is an open world survival game, choose what you want to do in this world, build a small base, hunt for food, survive and explore the open world, play the game your way, ohh... and try to stay off the menu.

Survive the onslaught, manage your ammo, and endure in Final Redoubt, a relentless survival shooter where every bullet, every swing, and every decision counts!

A campy, crazy pixelart zombie apocalypse arcade sim where you're the bad guy. Drop your virus and spread it across the globe while you unlock a whole horde of bizarre undead to do your bidding.

Flesh Eaters is retro style single player RTS zombie survival game with resource gathering and crafting. Zombies are everywhere! You must gather resources to build barricades, upgrade weapons and armour and explore the city under the siege of the dead

The island of Eden-Nadir, has fallen to a vicious mind consuming fungal parasite. Fight through the ashes of humanity to track down the truth behind the infection as one of four playable survivors before the outbreak spreads throughout the world.

Rescue survivors and construct cities in the clouds in this post-apocalyptic simulation and role-playing game. Escape from frenzied zombies and a mysterious mist permeating through the air.

No More Room in Hell 2 is an intense 8 player zombie shooter. Overcome the endless undead. Avoid infection. Survive hell together.

Can you survive the ultimate zombie apocalypse? Build your deck and take on a customizable Encounter Deck made from Mission, Zombie, Danger, and Location cards. Every choice matters as you face relentless threats in a collapsing world. Adapt, strategize, and prove your survival instincts!

Darkness is coming. How long can YOU survive? Build your base by day, defend it by night. Play in online or local co-op. Stay alive as long as you can.

"Kill Me If You Can" combines RPG, and construction for a survival defense against zombies. Explore by day for growth, and at night, build defenses against incoming zombies. With unique skills per character, control a team, not just one, for dynamic gameplay.

You are the last survivor in a world overrun by a virus. Travel by train to a safe zone, loot abandoned houses, trade what you find, and fight off zombies. Use your earnings to buy fuel and weapons. A single-player, offline survival journey.

Restore power to fragmented islands in a post-apocalyptic base-building sandbox. Start from a hidden cave with 1,200+ items, rebuild infrastructure, earn settlement trust, and trade, loot or negotiate—while defending power stations with turrets from enemy waves every 7 days. ⚡🛡️

Warranted Humanity is a post-apocalyptic 2D side scroller where choices matter. Fight different infected and rival factions, scavenge, skill up, craft, manage your shelter and other survivors, all in a race against time to ensure humanity’s survival before everyone is irreversibly infected.

Help Amy survive the Vile Demons in Hell in order to find the Portal and Ascend to Heaven.

Kill all the damn zombies in different game modes!

A Huge Wave of Zombies Are Coming! Control hundreds of swarming zombies to conquer the entire city!

Without Pain - is a dynamic 2D shooter with surviving elements where you will have to fight against various types of monsters.

Play as a lethal virus infecting various organs in your host's body while trying to outsmart the immune cells that seek to eliminate you and your kind. Generate clones and watch them propagate, infecting cells and taking down bosses.

Third-person wave survival shooter where you protect your base, and eliminate annoying Karens that want to speak to the manager. Protect your supplies, build traps and construct your defenses. Eliminate all the annoying customers! This is your chance to get back at Karens for old' times sake.

Have you ever thought or imagined how our world would look like after an apocalyptic event? What would we do if some of us were to survive? What world would we live in and what challenges would we face? What would you do?

Scientists made a new discovery about the Backrooms. Noclipping out of bounds in normal reality was a myth for long, but now it can be real! Now they are looking for subjects to test it on civil people. There are already scientists inside, so you have nothing to worry about, they say. Or do you?

Zomboard is a post-apocalyptic colony sim and base defense game. Start with a few survivors, build your settlement, and fortify defenses to survive overwhelming zombie hordes.

You'll play as a survivor in a world overrun by zombies. Explore and interact with other survivors, making tough choices about whether to help or exploit them. Defend against zombies, collect resources, craft, and fortify your shelter. Use strategy to escape this world and return to safety.

Find your way out of the most horrifying forest in this eventful story, packed with adventures and the ultimate horror that you never faced before.

Convicted is a 2D top-down asymmetrical multiplayer horror game inspired by SCP and Space Station 13. Escape a secret Soviet facility full of dangerous anomalies, be part of the lab and try your best at containing them, or even play as the anomalies themselves and hunt down the other survivors!

Dark Survival is a horror survival game with a mix of the classic survival mechanics of find the items around the map to survive and the scary sounds and monsters of a horror game.

Barricade Protocol: Survive in the world's last bastion, the Vera Hospital. Farm on the rooftops, generate power on balconies, and transform patient rooms into shops to build your own vertical city within the hospital corridors.

Manage a zombie colony. Mine, build, master new technologies, do everything to capture these pitiful people and their juicy brains!