Top similar games like Genome Guardian 2:

Fast paced Top-down shooter! Smartly use IRCM to evade the constant barrage of bullets and missiles and destroy everything that stands in your way.

Fight for your freedom as you battle through wave after wave of alien adversaries. Destroy enemy fighters and collect XP to raise your level and become more powerful. Combine your skills and abilities with a huge range of power-ups to become the ultimate champion.

Roguelite Overpowered Wizard Simulator. Slay hundreds of cultists using the power of ancient cards and your magical steampunk arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you.

Aggrolotls is a top-down arena roguelike where you play as tiny axolotls and must evolve into a swarm that can take on powerful creatures from the sea. Level up and choose from upgrades that make each round feel unique.

Blast Beam Bang is a top-down roguelite arena shooter where you upgrade and modify active abilities and weapons between waves to create evolving builds and survive relentless robot swarms.

Roguelite Overpowered Wizard Simulator & Dungeon Crawler. Slay hundreds of cultists using the power of ancient cards and your magical arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you from climbing the tower of babel.

Mother Nature has no mercy! Turn bug swarms into fertilizer as a mutated plant. Take root, evolve, and create your garden of death with unique combos. You are the top of the food chain in this chaotic arena!

Collect synergizing items to create an overpowered character to fight hordes of cyclops monsters. Cyclo Chambers is a fast-paced, top-down arena shooter with light rogue-like elements. 150 items to choose from to create frantic combinations. Different runs every time.

Don't get swarmed in this incremental top-down shooter! Unlock new mechanics and upgrades as you defeat more and more enemies. Let drones aid you in combat and use your abilities to become unstoppable.

Ready to tackle the challenge? On Mars, confront countless mutated creatures and mechanical monsters. Choose survivors, weapons, and skills wisely for diverse battles. Employ precise shooting, agile dodging, and strategic use of props and skills to fend off enemy attacks.

Plunder magic from the anonymously-owned public internet in this Roguelite Twin-Stick Shooter. Use the essence you steal to research new weapons or augment the ones you already have, to better battle against the network defenses and steal even more power.

Gunforged is a goofy fantasy roguelite shooter where you create broken builds every run. Forge your guns with randomized gun parts, collect passive abilities, and embed gun-changing runes into your guns to create the ultimate build.

A casual rogue-lite shooter where you can buy upgrades to improve your run and defeat waves of enemies. Shoot tons of bullets and create different builds while trying to be as accurate as you can to get the best rewards!

Mow down endless hordes of enemies in the arena of this dark cyberpunk survival roguelite. Play as a fully modular robot, snapping together multiple weapons and components to craft your perfect build. Collect powerful items to forge game-breaking synergies and annihilate everything in the Pit.

Deepforge Brawl is a dwarven arena roguelite where your weapons fire themselves — you just have to survive. Charge your beard, chug your ale, and dash through goblin hordes across six depths of the mountain. Forge builds from 13 auto-firing weapons, evolve them, and descend until the Maw takes you.

Defend your Lifenode from waves of Scrollers, Trolls, and Doomscrollers in this chaotic 2D arena shooter. Upgrade, survive, and beat the algorithm.

You are the cursor — the last honest user in a machine built to farm your Attention. Auto-fire your way through swarms of cookie banners, tracking pop-ups, and EULAs in a fast, funny survivors-like roguelite. Draft absurd upgrades, cash in your Attention, and survive the Performance Review.

A sepia Roguelike — lead a chained squad through 22 waves. Map events split your line, milestone recruits add firepower. Linked Blink, run upgrades, 19 Evolutions, and a permanent meta tree carry you to the final Boss Hydra.

Survive 20 minutes against waves of ever-evolving enemies. Upgrading your weapons is inevitable — but what if those weapons also hurt you?

A roguelite horde-survival bullet heaven with QUINTILLIONS of bullets over QUINTILLIONS of hordes. Mix weapons with items, modify, control chaos at terminals and break through tightening waves.

Slay Goblins is an arena roguelite where you play a knight fighting off hordes of goblins. Choose from a variety of perks, weapons and items to create unique builds and defend your castle.

JERONIMO is a roguelite shooter where you play as the Eraser against your eternal enemy: the Drawer, a frantic pencil who summons waves from his rolling lab. Wield up to 6 unique weapons, stack broken builds, and crush the hordes. Every enemy is a drawing from my 6-year-old nephew's notebook.

COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

Vault Apocalypse is a top-down, roguelite twin-stick arena shooter where you fight hordes of monsters while assembling powerful, synergistic builds. Pick your weapons, refine your build and destroy the keepers of the vault.

Defend the galaxy from endless cosmic horrors. Dash and blast with fast, burst-based piloting, unleash powerful overdrives, evolve your ship with each unique run, and push your skills to the limit.

A broke bounty hunter. A sarcastic robot. 1,000,000 credit debt. Star Scrap is a chaotic twin stick space roguelite. Blast through increasingly difficult waves of enemies to pay it off.

Kill all enemies, Upgrade, Repeat! Defeat thousands of enemies in this incremental roguelite and become unstoppable as you progress through the game.

The alien hordes have attacked us for no reason. We must throw all our forces to repel our planet from the alien invaders!

SYNTHETIK is an unforgiving tactical shooter rogue-lite where freedom and experimentation is key. Fight in a world overrun by the Machine Legion and their Gods. Experience the next level in gun-play and dive into unparalleled build options and Android upgrades. Can you defeat the Heart of Armageddon?

Core Breach is a fast-paced, twin-stick arcade shooter in a pixel art style. Play as a Trojan worm virus, outmaneuvering and destroying antivirus enemies. Upgrade your worm with powerful attacks and skills as you fight to breach the CPU core and uncover its secrets

Tankron is a top-down wave survival roguelike in which you fight an ever-increasing amount and variety of enemies. Choose from a variety of upgrades to stand a chance. Discover and choose between different tank specializations to enhance your Build.

Defend massive interdimensional portals against relentless alien swarms in this fast-paced sci-fi top-down survival shooter.

Dive into Liminal Descenders, an intense top-down pixel art roguelike "survivor style" action game set within the mysterious Backrooms. Your mission is to survive a limited amount of time in each zone while facing relentless waves of enemies and upgrade your habilities.

Fight versus unlimited hordes of lizards and italian brainrot animals in post-soviet environment.

Apple man Sam versus moustached vegetables. A top-down survivors-like roguelite where you pick a loadout, level up, upgrade your weapons, and loot items to blast through escalating hordes and bosses. Multiple loadouts, endless mode, and leaderboards. Complete quests to unlock items and cosmetics!