Top similar games like Genome Guardian 2:

Roguelite Overpowered Wizard Simulator & Dungeon Crawler. Slay hundreds of cultists using the power of ancient cards and your magical arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you from climbing the tower of babel.

Roguelite Overpowered Wizard Simulator. Slay hundreds of cultists using the power of ancient cards and your magical steampunk arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you.

Pilot customizable mechs in an epic battle against hordes of enemiesor dive into intense PvP battles where precision aiming can turn the tide, or let your mech's auto-firing system handle the heat of combat. With rogue-lite elements, each run offers a unique challenge and opportunity for growth.

Fast paced Top-down shooter! Smartly use IRCM to evade the constant barrage of bullets and missiles and destroy everything that stands in your way.

Tankron is a top-down wave survival roguelike in which you fight an ever-increasing amount and variety of enemies. Choose from a variety of upgrades to stand a chance. Discover and choose between different tank specializations to enhance your Build.

Pilot mechs as you slaughter hordes of a diverse cast of alien quacks in this survival roguelike. Build your arsenal from a variety of mechs, power ups and items to survive in ever-changing scenarios.

COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

Join the race for Ether! Mercenary Battle Company: The Reapers is a fast-paced, roguelite, bullet heaven game in a sci-fi setting. Choose your pilots, customize and upgrade your Mecha Robots, and survive against endless swarms of Xeni. Will you survive long enough?

Mother Nature has no mercy! Turn bug swarms into fertilizer as a mutated plant. Take root, evolve, and create your garden of death with unique combos. You are the top of the food chain in this chaotic arena!

Plunder magic from the anonymously-owned public internet in this Roguelite Twin-Stick Shooter. Use the essence you steal to research new weapons or augment the ones you already have, to better battle against the network defenses and steal even more power.

Become a possessed gun in this bullet heaven rogue-lite, mowing down hordes of Eldritch minions with chaotic firepower. Harvest souls, hoard artifacts, and craft insane builds to slay gods and break free.

Grab a gun and take down hostile robots corrupted by synthetic emotions! Combine weapon modifications and wreak havoc in this roguelite shooter. Let your emotions shape combat and alter boss fights! Fight alone or join up with up to 4 players!

Aggrolotls is a top-down arena roguelike where you play as tiny axolotls and must evolve into a swarm that can take on powerful creatures from the sea. Level up and choose from upgrades that make each round feel unique.

Defend massive interdimensional portals against relentless alien swarms in this fast-paced sci-fi top-down survival shooter.

Don't get swarmed in this incremental top-down shooter! Unlock new mechanics and upgrades as you defeat more and more enemies. Let drones aid you in combat and use your abilities to become unstoppable.

A casual rogue-lite shooter where you can buy upgrades to improve your run and defeat waves of enemies. Shoot tons of bullets and create different builds while trying to be as accurate as you can to get the best rewards!

Collect synergizing items to create an overpowered character to fight hordes of cyclops monsters. Cyclo Chambers is a fast-paced, top-down arena shooter with light rogue-like elements. 150 items to choose from to create frantic combinations. Different runs every time.

Gunforged is a goofy fantasy roguelite shooter where you create broken builds every run. Forge your guns with randomized gun parts, collect passive abilities, and embed gun-changing runes into your guns to create the ultimate build.

Genome Guardian: Prologue is the first 20 waves of the full game's first mode & difficulty. This is a roguelite shooter where you defend yourself from microscopic aliens using various upgrades & builds. Combine & create 70 bioweapons, and try 7 turrets & 10 perks from the base game!

Defend your Lifenode from waves of Scrollers, Trolls, and Doomscrollers in this chaotic 2D arena shooter. Upgrade, survive, and beat the algorithm.

"Plasma Drone" is a dynamic action game where you must fight to survive against waves of enemies. By upgrading your drone and weapons, you can effectively eliminate the enemy forces. The game offers 20 levels and a survival mode, which requires speed, precision, and strategy to survive.

Driveloop is a fast-paced driving roguelike shooter. Drift, blast and ram your way through waves of steampunk enemies. Upgrade your vehicle with powerful weapons, recruit unique crew members and survive intense battles as you build the ultimate combat machine. Can you survive the chaos?

Vault Apocalypse is a top-down, roguelite twin-stick arena shooter where you fight hordes of monsters while assembling powerful, synergistic builds. Pick your weapons, refine your build and destroy the keepers of the vault.

Kill all enemies, Upgrade, Repeat! Defeat thousands of enemies in this incremental roguelite and become unstoppable as you progress through the game.

Summon an army of clouds in this roguelite bullet heaven survivors-like inspired by Korean folklore! Recruit and fuse cloud companions, befriend shrine visitors, and uncover the mystery of the moon goddess!

Fight for your freedom as you battle through wave after wave of alien adversaries. Destroy enemy fighters and collect XP to raise your level and become more powerful. Combine your skills and abilities with a huge range of power-ups to become the ultimate champion.

Choose your pilot and build your own custom mecha with 17+ weapons and 55+ attachments, then jump to the battlefield against hundreds of enemies to save spacetime itself in this thrilling sci-fi bullet heaven!

Frontline Frenzy is a fast-paced top-down WW2 roguelite arena shooter where you fight endlessly growing hordes of enemy soldiers in wave-based arenas. Pick your class, level your character and survive the frontline as the battlefield turns into pure chaos.

Invent your own weapons in this sci-fi Roguelike shooter! Combine any weapon with any upgrade to customize your arsenal. Form a squad of holographic soldiers, redesign their guns too, and slay hordes of cybernetic enemies!

Nuclear Throne is a post-apocalyptic roguelike-like top-down shooter. Not 'the final hope of humanity' post-apocalyptic, but 'humanity is extinct and mutants and monsters now roam the world' post-apocalyptic. Can you reach the Nuclear Throne?

Nebula Cleanup Crew is a short top down action roguelite shooter with a focus on hot and cold weaponry. Rescue your crew members as you blast enemies and bosses away with super heated and chilled weapons — freeze foes, overheat them and unleash powerful supertemp special attacks!

Space Warden is top-down shooter in space where whole environment can be destroyed. Use lots of weapons which can burn, stun, damage, explode enemy ships, bases and terrain. Use turrets to defend your base and complete various missions.

Swarmhunters is a top-down arena action shooter. The war between human and bugs has become worse - Project Swarmhunters emerged at this situation. You play as the best space soldiers in the galaxy and your mission is to strike the hive and hunt down the Emperor, supreme commander of bugs.

Hope's Final Defense is an action roguelite where you create a skill deck to fight hordes of enemies. Choose from many game-breaking items and upgrades. Craft overpowered builds and create deadly synergies to fight endless monsters from Negativia. Can you protect humanity's last hope?