Top similar games like Genome Guardian:

Genome Guardian: Prologue is the first 20 waves of the full game's first mode & difficulty. This is a roguelite shooter where you defend yourself from microscopic aliens using various upgrades & builds. Combine & create 70 bioweapons, and try 7 turrets & 10 perks from the base game!

Micron Survivor is a survival game with rogue-lite elements where you play as alien microorganisms under the microscope. Evolve, unlock research objectives, find symbiotic weapons, upgrade your builds, and fight hordes of terrestrial organisms to rule the microcosm.

Become an agent of vengeance in this bullet-heaven action roguelite! You are the lone survivor of your squad, on an alien planet with just your weapon, a jetpack, and the courage to keep fighting. Kill off alien swarms and transform their valuable guts into explosive upgrades and vital utilities.

Rob o Bot is a survivors-like action game where you fight hordes of robots that began acting on their own after a mysterious virus infected a new generation of machines. Survive waves of enemies, upgrade your gear, and take back control before the machines take over.

It’s time to cluck around and find out. Gear up and pull on the helmets of the Battle Roosters, a hotshot space brigade of poultry with panache. In this quirky, roguelike, bullet hell adventure you’ll combine weapons, upgrades and killer strategies to recover space’s best taco ingredients. Bwark!

Swarmhunters is a top-down arena action shooter. The war between human and bugs has become worse - Project Swarmhunters emerged at this situation. You play as the best space soldiers in the galaxy and your mission is to strike the hive and hunt down the Emperor, supreme commander of bugs.

Shoot alien invaders, upgrade your ship, level up your weapons and save planets to defend against the invasion. Choose your favorite between the different unlockable ships and buy perks between your runs to ensure victory. After you triumph, hunt for achievements and ascend to save more universes

Astragene is a roguelite shooter where you will have to survive each level facing hordes of aliens. Improve your abilities, choose new upgrades, and create reactions by generating combinations of powerful elements. Each game will be different, will you be able to adapt?

COMBINE WEAPONS in the microscopic shooter with macroscopic depth. BUILD YOUR NANOBOT from hundreds of parts. SURVIVE the microbial onslaught once more in this psychedelic dive to the Abyss, full of mutations, minerals, anomalies and powerup polyps. SHMUP mode turns it into a vertical shoot 'em up!

Orangino is a top-down roguelike shooter where you play a heroic orange on a mission to rescue his kidnapped love from a horde of mischievous vegetables. Equip a wild mix of medieval, modern, and magical weapons, and upgrade your skills to survive chaotic waves of enemies.

Become the galaxy’s deadliest hunter! Wield 7 weapons at once, unleash ricochet chaos, and conquer alien worlds in this fast-paced roguelite. Survive 10 minutes of madness, trigger your Rage, and slay the boss. Master unique Signature Weapons and craft your ultimate build!

You are military volunteer. what? you did not volunteer? It's too late! You are already in the middle of the battlefield. kill the alien for the humanity! Marine Survivors is simple action rogue lite game. kill aliens, earn exp gem, upgrade your weapon. unlock various collection.

The farm is under attack! Fight against an alien invasion as Hamdy, an armed scarecrow. In this top-down arena roguelike, build your loadout with up to 6 weapons, grow stronger after each wave, and survive until the very end.

Survive in the deep void of the galaxy against thousands of invaders! Nebula is a challenging bullet hell, twin stick shooter where you have to face endless waves of space enemies. Additional map resources and space drones can provide you a support but be wary, they can as well become a deadly trap.

A roguelite top-down shooter where you create a ring of guns around you to mow down thousands of enemies! Upgrade your guns with insane mods and experiment with the endless possibilities. You may be an adorable dog, but that won't stop you from raining death upon your enemies!

Ironfall is a high-octane Action Roguelite where medieval steel meets futuristic firepower. Mow down thousands of mechanical demons, collect powerful loot, and craft unique builds in a world of burning metal. Can you survive the descent and reclaim the shattered fortress?

Survive the chaos of deep space in this intense top-down arcade shooter! Crush asteroids, defeat enemy ships, and fight deadly bosses with lightning-fast reflexes.

Gacha Fever is a suvivors like in a cute and colorful universe. You will fight waves of monsters with various weapons, from the machine gun to the magical girl wand and the Bubble Tea Canon ! Just be careful of the area !

A fast-paced action roguelike where explosive combat fuels 'Blitz' ultimates—a rage mode that dominates the battlefield. Endure relentless battles, enhance your arsenal, and evolve powerful abilities. Each run opens new tactical possibilities in this intense arena shooter.

Rocket Rats is a survivors-like game where you defeat cheese-based astral bodies in space – as a rat! Clear waves of enemies, collect cheese, upgrade your gear, and conquer the moon!

Battle time and terror in a shoot & survive extraction roguelite. Select your hero and survive the relentless cosmic surge. Shoot, level up, topple bosses, and amplify your powers to cosmic levels. Embrace the Blastard within and unlock new heroes, powers, and perks to use on future runs.

Face the relentless legions of hell in this fast-paced top-down roguelike. Loot powerful weapons, level up your stats, and survive the bullet hell chaos. How long can you stay alive in the inferno?

This is a 2D Pixel Top-Down Space Shooter Game. The game implemented Rogue-Lite elements, like the survivor series.

Can you survive the Empire's onslaught? Avoid the attacking enemies and upgrade your ship to last long enough to escape in this space survivorslike.

lone.AI is a space RPG roguelite. With challenging, relentless gameplay, each run has the potential to boost your ship's power, speed, and more. As a lone AI, fight your way through the solar system and uncover the secret behind the ZOSMA, an alien race that holds power over the system.

Battle increasingly deadly hordes in an action-packed survivors-like with tower defense elements. Create unique builds, unlock and place towers, upgrade your character, and fight to defend the Kingdom of Stellara.

Combine abilites to create infinite possibilities of spells and decimate thousands of enemies. King Krieg is a top-down arena roguelite where YOU are the KING and you buy mystical items, find powerful guns, and craft new spells

Microscopic SurvivalEmbark on a microscopic survival journey where you eat or be eaten.Simple controls meet strategic evolution in this unique roguelike RPG._Hunt the weak, flee the strong, and evolve your way to become the apex predator of this endless micro universe.

Blast Beam Bang is a top-down roguelite arena shooter where you upgrade and modify active abilities and weapons between waves to create evolving builds and survive relentless robot swarms.

Movement is your weapon. A sci-fi action roguelike and shmup combined, in Gunlocked 2 you'll pilot and upgrade a state-of-the-art warship against endless waves of deadly aliens. Deep customization, branching paths, and tons of unlockables offer endless replayability!

DUCKLYTE is a top-down shooter with roguelite elements where you play as a constipated little duck trying to stay alive as long as possible in a randomly generated farm with progressively stronger enemies.

Alien Slayers is a roguelite time survival game where you hunt down hostile alien creatures on various planets. Grab your weapon and survive to the end to become the strongest alien.

Frontline Frenzy is a fast-paced top-down WW2 roguelite arena shooter where you fight endlessly growing hordes of enemy soldiers in wave-based arenas. Pick your class, level your character and survive the frontline as the battlefield turns into pure chaos.

Robot Arena Survivors is a single-player arena auto-shooter where you're fighting against waves of hostile robots using a powerful arsenal made of hover tank units. Customize your own set of abilities and dismantle your enemies to claim your fame into the leaderboards.

“Wear it. Dodge it. Shoot like crazy! Blow those viruses away with your ZURA!” A fast, funny twin-stick shooter where wigs are your weapons! Stack multiple ZURAs to boost your firepower, chain combos, and dive into short bursts of pure arcade flow as you compete for the top score worldwide!