Top similar games like Genome Guardian:

Genome Guardian: Prologue is the first 20 waves of the full game's first mode & difficulty. This is a roguelite shooter where you defend yourself from microscopic aliens using various upgrades & builds. Combine & create 70 bioweapons, and try 7 turrets & 10 perks from the base game!

Become an agent of vengeance in this bullet-heaven action roguelite! You are the lone survivor of your squad, on an alien planet with just your weapon, a jetpack, and the courage to keep fighting. Kill off alien swarms and transform their valuable guts into explosive upgrades and vital utilities.

It’s time to cluck around and find out. Gear up and pull on the helmets of the Battle Roosters, a hotshot space brigade of poultry with panache. In this quirky, roguelike, bullet hell adventure you’ll combine weapons, upgrades and killer strategies to recover space’s best taco ingredients. Bwark!

Swarmhunters is a top-down arena action shooter. The war between human and bugs has become worse - Project Swarmhunters emerged at this situation. You play as the best space soldiers in the galaxy and your mission is to strike the hive and hunt down the Emperor, supreme commander of bugs.

Shoot alien invaders, upgrade your ship, level up your weapons and save planets to defend against the invasion. Choose your favorite between the different unlockable ships and buy perks between your runs to ensure victory. After you triumph, hunt for achievements and ascend to save more universes

Astragene is a roguelite shooter where you will have to survive each level facing hordes of aliens. Improve your abilities, choose new upgrades, and create reactions by generating combinations of powerful elements. Each game will be different, will you be able to adapt?

Galactic Pawns is an action-packed roguelite bullet hell, where you eliminate high-profile targets across war-torn planets. Master a vast arsenal, upgrade your abilities, and adapt to ever-changing battlefields in a fight for galactic order.

Survive in the deep void of the galaxy against thousands of invaders! Nebula is a challenging bullet hell, twin stick shooter where you have to face endless waves of space enemies. Additional map resources and space drones can provide you a support but be wary, they can as well become a deadly trap.

You are military volunteer. what? you did not volunteer? It's too late! You are already in the middle of the battlefield. kill the alien for the humanity! Marine Survivors is simple action rogue lite game. kill aliens, earn exp gem, upgrade your weapon. unlock various collection.

A roguelite top-down shooter where you create a ring of guns around you to mow down thousands of enemies! Upgrade your guns with insane mods and experiment with the endless possibilities. You may be an adorable dog, but that won't stop you from raining death upon your enemies!

A fast-paced action roguelike where explosive combat fuels 'Blitz' ultimates—a rage mode that dominates the battlefield. Endure relentless battles, enhance your arsenal, and evolve powerful abilities. Each run opens new tactical possibilities in this intense arena shooter.

Gacha Fever is a suvivors like in a cute and colorful universe. You will fight waves of monsters with various weapons, from the machine gun to the magical girl wand and the Bubble Tea Canon ! Just be careful of the area !

Rocket Rats is a survivors-like game where you defeat cheese-based astral bodies in space – as a rat! Clear waves of enemies, collect cheese, upgrade your gear, and conquer the moon!

Battle increasingly deadly hordes in an action-packed survivors-like with tower defense elements. Create unique builds, unlock and place towers, upgrade your character, and fight to defend the Kingdom of Stellara.

Battle time and terror in a shoot & survive extraction roguelite. Select your hero and survive the relentless cosmic surge. Shoot, level up, topple bosses, and amplify your powers to cosmic levels. Embrace the Blastard within and unlock new heroes, powers, and perks to use on future runs.

This is a 2D Pixel Top-Down Space Shooter Game. The game implemented Rogue-Lite elements, like the survivor series.

Fight hordes of Covenant & Flood in this new game mixing Roguelite & Bullet Heaven for hours of mindless fun!

Can you survive the Empire's onslaught? Avoid the attacking enemies and upgrade your ship to last long enough to escape in this space survivorslike.

lone.AI is a space RPG roguelite. With challenging, relentless gameplay, each run has the potential to boost your ship's power, speed, and more. As a lone AI, fight your way through the solar system and uncover the secret behind the ZOSMA, an alien race that holds power over the system.

Combine abilites to create infinite possibilities of spells and decimate thousands of enemies. King Krieg is a top-down arena roguelite where YOU are the KING and you buy mystical items, find powerful guns, and craft new spells

Survive the neon space chaos in this fast-paced top-down arcade shooter with a twist of Asteroids. Blast through swarms of geometric enemies, complete quirky quests, and upgrade your ship with absurd weapons in a Jetsons-style galaxy brimming with danger, glow, and humor.

Microscopic SurvivalEmbark on a microscopic survival journey where you eat or be eaten.Simple controls meet strategic evolution in this unique roguelike RPG._Hunt the weak, flee the strong, and evolve your way to become the apex predator of this endless micro universe.

DUCKLYTE is a top-down shooter with roguelite elements where you play as a constipated little duck trying to stay alive as long as possible in a randomly generated farm with progressively stronger enemies.

Alien Slayers is a roguelite time survival game where you hunt down hostile alien creatures on various planets. Grab your weapon and survive to the end to become the strongest alien.

Code of Shadows is a real-time roguelite where XP never sleeps and time obeys you. Pause on demand, evolve mid-fight, command support drones, and shut rift-spawned hordes across shifting dimensions.

Robot Arena Survivors is a single-player arena auto-shooter where you're fighting against waves of hostile robots using a powerful arsenal made of hover tank units. Customize your own set of abilities and dismantle your enemies to claim your fame into the leaderboards.

Movement is your weapon. A sci-fi action roguelike and shmup combined, in Gunlocked 2 you'll pilot and upgrade a state-of-the-art warship against endless waves of deadly aliens. Deep customization, branching paths, and tons of unlockables offer endless replayability!

Zurararush!!! is a twin-stick shooter that you can play easily! Wear a wig as a weapon and defeat the virus that mutated inside your body! Power up your character and wig and become stronger! Defeat a lot of enemies and feel good! It's an arcade-style casual game that you'll want to play every day.

Discarded is action rougelike, arena shooter where you face waves of relentless enemies. You’re alone and outgunned - move fast, shoot faster, dodge the bullets and upgrade on the fly. Keep up with the pressure or get shredded like the rest.

Survive the all-consuming darkness! Against Twilight is a casual game where your choices can make you stronger to finish off thousands of creatures that appear in the twilight.

Tankron is a top-down wave survival roguelike in which you fight an ever-increasing amount and variety of enemies. Choose from a variety of upgrades to stand a chance. Discover and choose between different tank specializations to enhance your Build.

Roguelite Overpowered Wizard Simulator. Slay hundreds of cultists using the power of ancient cards and your magical steampunk arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you.

Bound Survivor is a 2D pixel top-down roguelike action game. Combine weapons with “bond” tags to trigger powerful synergies and create your own combat style. Every run offers fresh challenges!

Kill all enemies, Upgrade, Repeat! Defeat thousands of enemies in this incremental roguelite and become unstoppable as you progress through the game.

When alien beings decide to invade and conquer Earth, they don't expect such a powerful enemy: A very angry farmer, join him in the battle against dangerous and lethal aliens and win back the farm that is rightfully yours.