Top similar games like Genome Guardian:

Zombie exterminator is a top-down shooter roguelite where you play a soldier. Combine weapon parts and create unique weapons. Use gadgets and relics to exterminate zombies. Fight against zombies and horrendous creatures.

DPSWTF is a base defense game with roguelike elements, where instead of placing towers, you build the best tower of them all. Combine the best projectiles with effective modifiers and push back the incoming hordes. Research them all to conquer the secrets of the Great North!

Splatter slimes, massacre mutants, and assemble your perfect Gunbot! Survive hordes of enemies in this top-down shooter roguelite by customizing your weapons on the unique upgrade grid, and pick from a wide variety of build-defining modules and wacky base bots for a new experience every run.

Invent your own weapons in this sci-fi Roguelike shooter! Combine any weapon with any upgrade to customize your arsenal. Form a squad of holographic soldiers, redesign their guns too, and slay hordes of cybernetic enemies!

Genome Guardian: Prologue is the first 20 waves of the full game's first mode & difficulty. This is a roguelite shooter where you defend yourself from microscopic aliens using various upgrades & builds. Combine & create 70 bioweapons, and try 7 turrets & 10 perks from the base game!

Become an agent of vengeance in this bullet-heaven action roguelite! You are the lone survivor of your squad, on an alien planet with just your weapon, a jetpack, and the courage to keep fighting. Kill off alien swarms and transform their valuable guts into explosive upgrades and vital utilities.

Plunder magic from the anonymously-owned public internet in this Roguelite Twin-Stick Shooter. Use the essence you steal to research new weapons or augment the ones you already have, to better battle against the network defenses and steal even more power.

Roboholic is a cheerful Rogue-Lite FPS about robots. Use cool guns, unique abilities, and realistic physics to defeat enemies. It's the most dynamic game in its genre, and during battles with robots, you'll recall the fun days of Quake.

Pillage and plunder across the galaxy as part of a crew of Space Vikings in this sci-fi roguelite bullet hell dungeon crawler. Find exotic weapons, upgrade them with powerful augments, explore mysterious alien planets, and unleash viking vengeance on their inhabitants.

Time to Strike is busted build bullet hell roguelike. Create overpowered builds and break the game by collecting powerful weapons, modifying them with whacky mods and discovering crazy synergies!

Fast paced bullet hell roguelike. Upgrade your weapons and abilities as you collect attribute blocks. Highly customisable with lots of combinations. Fight bosses, pick up items and improve your stats. Unlock new items and achievements for the next run through the ever-changing dungeon.

Destroy the enemy base before they can destroy your own. In this single-player MOBA action roguelite bullet-heaven, you play as a viking dinosaur wielding up 4 abilities and weapons at a time. Unlock new warriors and fight along with your soldiers and bring an end on the Alien’s reign.

Cleanup Crew is a fast-paced survival action roguelite. Complete emergent objectives, customize your build and put your skills to the test to survive nerve-wracking hordes of creatures across bizarre worlds. Will you be able to survive until extraction?

Neon Blitz is an electrifying roguelike where you strategically choose from an arsenal of skills and abilities to repel waves of glowing invaders. Invest hard-earned cash in a deep upgrade system, crafting synergistic loadouts of abilities to outlast the relentless neon onslaught.

Ride giant turtles and aim your weapons at hordes of enemies chasing you while you gather as many resources as you can. Pick your upgrades carefully and create strong builds to survive the long road to the Outpost!

Take back your planet from alien invaders! Guns of Gaia is a game that blends survival and base-building elements. Use biotechnology to alter the landscapes, build defenses, set traps, and deploy bait. Nurture creatures, unlock equipment and weapons. Defeat your enemies and conquer your planet!

The alien hordes have attacked us for no reason. We must throw all our forces to repel our planet from the alien invaders!

Face relentless alien hordes, collect their resources and assemble an unstoppable squadron of mechs! In this Action Roguelite, discover game-breaking synergies, mix and match weapons and units, unlock upgrades, harvest and conquer alien planets.

In this fast-paced roguelite vehicle shooter, WW2 is ending, and a secret testing facility is overrun by an unknown alien force. The best pilots of the war are asked to take an experimental hover tank on a perilous mission - To descend into the caverns below the facility and face this new threat.

Aggrolotls is a top-down arena roguelike where you play as tiny axolotls and must evolve into a swarm that can take on powerful creatures from the sea. Level up and choose from upgrades that make each round feel unique.

Roguelite Overpowered Wizard Simulator & Dungeon Crawler. Slay hundreds of cultists using the power of ancient cards and your magical arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you from climbing the tower of babel.

Demons are coming! is a bullet hell rougelite shooter where you fight a high variety of demons that occupied your holy land. Use the upgrades you find to your advantage and create your ideal guns to help you kill the most terrifying monsters.

Nitroverse is a mix of a Rogue Like and a Bullet Hell with persistent level progression and combinable weapons.

The climate crisis is hitting humanity with increasing force - but you're hitting back. Dodge, fight, and level up in arenas around the world. Customize your champion and utilize the full arsenal humanity has at its disposal to show an endless swarm of natural hazards who's boss.

Immerse yourself in a post-apocalyptic wasteland in this intense horde combat shooter that combines roguelike and bullet-hell elements. Battle relentless waves of monstrous foes as you strive to survive and conquer challenging levels. In my game no vampire, survive 20 minutes!

Prepare for an interstellar showdown like no other in a gripping roguelike top-down twin-stick shooter set in the vast depths of space. Pilot your advanced starship, engaging in relentless battles against hordes of alien adversaries. Destroy, Collect, Upgrade, Die, Unlock, Repeat.

Alchementalist is a procedurally generated rogue-lite dungeon crawler featuring spell-crafting. Fight your way through hordes of enemies, mine elemental nodes for materials and craft spell boosts, or even totally new spells, that allow you to manipulate the elements any way you choose!

A sci-fi twin stick shooter stripped down to the bare essentials with focus on smooth controls and satisfying action.

Play as a wizard with a magic shotgun and fight waves of enemies. Each enemy has its own behavior, so you need to think fast and use tactics to win. Defeat all enemies to move to the next round. Upgrade your managun, and choose new powers after each round.

Tankron is a top-down wave survival roguelike in which you fight an ever-increasing amount and variety of enemies. Choose from a variety of upgrades to stand a chance. Discover and choose between different tank specializations to enhance your Build.

Your movement is controlled like a mouse cursor. You will earn money for killing enemies which will let you pay for weapons and spells. Mix and match magics to convert this bullet hell into a bullet heaven.

In this game, you are the bullet hell. Face off against 100 waves of enemies and bosses by collecting a deck of attack cards that activate in real-time to unleash destruction upon everything in sight. There's an insane amount of customizability leading to an infinitely replayable experience.

Run through the universe in this rogue-like-ish space-shooter. Discover the numerous perks/consumables and their synergistic effects. Explore the randomly-generated galaxy to find merchants, unlock spacecrafts, collect Cartridges and checkmark your kills of the various galactic overlords.

The PROLOGUE to Battle Grid. Face relentless alien hordes, collect their resources and assemble an unstoppable squadron of mechs! In this Action Roguelite, discover game-breaking synergies, mix and match weapons and units, unlock upgrades, harvest and conquer an alien planet.

Stay Alive is a game with simple gameplay, designed in retro pixel art style, with elements of mythology and roguelite. Sometimes running away isn't the solution, but sometimes you shouldn't even look back, and giving up isn't always the end.