Top similar games like Intelligent Design: An Evolutionary Sandbox:

Gridworld is an artificial life and evolution simulator. Watch creatures evolve through natural selection as they learn to find food, avoid danger, and compete with other creatures for survival.

Play with evolution! Species: ALRE is a scientifically-grounded, emergent simulation of natural selection. Creatures evolve and speciate in response to in-game mutation and selection forces, allowing you to experience and tinker with evolution in real-time.

In Reus, you control powerful giants to shape the planet to your will. You can create mountains, oceans, forests and more. Enrich your planet with plants, minerals and animal life. There is only one thing on the planet that you do not control: mankind, with all their virtues and and all their vices.

Manipulate climate, add plants and evolve creatures in this planet and life sandbox simulation game. From cells to civilizations, spread life throughout the whole planet. Or just enjoy watching your creation burn!

Create virtual lifeforms whose development is shaped by a deep simulation of evolution. Guide them as they fight, mate, and adapt to the environment you have built. All the creatures in the trailer evolved on their own in the game!

Shape worlds with your godly titans. Make symbiotic ecosystems and inspire humanity with your creations. Their achievements unlock new possibilities. Make different planets for different human spirits, and fill the universe with life!

Strategy game about genes and animal species. Evolve, reproduce, expand to new territories, survive, and fight to achieve various goals like biodiversity or dominance in the ecosystem.

Sci-fi idle strategy in isometric view: build structures, gather resources, and trade with ships while exploring your plot of land cell by cell.

Collect, raise and breed an army of beetles to rise up and lay claim to the abandoned lot! The game features a complex genetics simulation and real-time tactics missions with a full campaign.

You have awoken as a small god. As you accumulate the faith and souls of your followers, you will learn incredible new abilities. Protect, guide your people and smite any threats that may arise. The fate of your world is in your hands.

Node Math is a simple, idle-factory game about combining numbers with math operators, unlocking new stuff, and making money go brrr!

Inspired by legendary classics from the ’90s, Craftlings will take you on a journey full of strategic decisions and test your skills in optimizing automated production chains and Craftlings’ paths. Gather, deliver, build, and fight for wealth and glory in the unique, nostalgic world of Craftlings.

Rocket Automashapes is a minimalistic automation game where shapes are produced, combined, and rocketed across the grid! Manage increasingly complex scenarios as you progress from one level to the next.

A relaxing evolution simulation where AI-driven block creatures move in unexpected ways. There are no complex ecosystems—just pure movement learning through a physics engine. Watch as these creatures scurry, stumble, and evolve in their own unique, unpredictable ways.

Lead your space agency in The Search for Life in this authentic strategy simulation game. Investigate the solar system and collect evidence of life. Manage base building, rocket designing, launches, and mission planning to Mars and beyond, leading the way in the future of space exploration.