Top similar games like Extinction Protocol:

A Tower Defense where the Towers are moving around the enemies. With over 200 towers and endless mode. There is almost infinite strategies.

In this game you have to help the main character to hold on in self-isolation with limited resources. Every day you face a difficult choice: how to eke out your groceries, whose request you should respond to, and who is to be left without a piece of bread.

Exo TD is a true 3D space Tower Defense. Invaders have scouted your planet as their next target, you must protect it by building destructive turrets, orbital defenses, shields, drones and more to defend against the incoming invasion force.

Build your own cardboard fort and defend it against swarms of enemies. Gather resources, craft weapons and set traps. Be creative, improvise and experiment to win.

Deep Sixed is a roguelike space sim that will force you to use strategy, ingenuity and duct tape to keep your ship (and your skull) in one piece as you risk exploring a mysterious nebula protected by dangerous alien creatures.

Manage a group of survivals in this base building game set in a tropical island! Will you be able to escape from the island?

Sands of Supremacy is a singleplayer, side-scrolling strategy/resource management hybrid 2D game set in a desert landscape on an unknown, futuristic planet. The game combines survival, strategy, and resource management elements to create a challenging and engaging gameplay experience.

The Quiet Sleep is a simulation/tower defense game set in your mind. Build out different parts of your personality to keep a handle on your emotions and to achieve your goals!

Deceptively simple... amazingly deep. Creeper World 2 thrusts you into the 14th millennium fighting and enemy that flows and oozes through the terrain. Employ advanced weapons,gravity manipulating repulsors, wormhole like rifts, and your own wit against this never yielding enemy.

The essence of the Heliconian is to manage a mixed crew of renegades aboard the starship Heliconian. Manage the crew member’s actions and the ship’s functions to survive as long as possible while exploring the star system in the hopes of earning upgrades and ultimately a safe haven.

Civitatem is a medieval city builder where you help your villagers raise a new settlement in dangerous lands by making use of their skills and available world resources.

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

The world after a nuclear war. Manage the settlement, learn technology, make decisions, produce weapons, ammunition, organize defense, raid for supplies on other areas, do not let residents die, survive the nuclear winter.

You’ve been hired to make a delivery to planet Miridian V. The trip will be a dangerous yet lucrative journey full of mad robots and unpredictable stellar phenomenon. Name your crew, name your ship, manage your supplies, trade, battle, survive, and make your delivery!

Phoenix Hope is a pixel art 2D real-time, side-view strategy game in which you must develop your colony during the day and repel waves of monsters at night.

60 Seconds! is a dark comedy atomic adventure of scavenge and survival. Collect supplies and rescue your family before the nuke hits. Stay alive in your fallout shelter. Make difficult decisions, ration food and hunt mutant cockroaches. And maybe survive. Or not.

War Birds is a 2.5D World War 2 air combat game, with impressive 3D warplanes and beautiful 2D environments.

Endzone is a post-apocalyptic survival city builder, where you start a new civilization with a group of people after an ecological disaster. Build them a new home and ensure their survival in a shattered world, threatened by constant radiation, toxic rain, sandstorms and droughts.

Survival strategy with indirect control and tower defense elements. Build and manage your medieval town.

A unique tower defense game. Where you design and build your defense block by block. With many component that can be combined for different effect. To survive in a hostile world.

In Home Behind, you take on the role of a refugee cast out from your homeland by a band of rebels. Your home and the peace you enjoyed has been destroyed, and your family has disappeared. Can you survive the struggle, famine, and sickness to make it to the safety of Europe?

Will you survive the struggle with cold, hunger, and nuclear radiation? Everything is up to you, the shelter manager.

Build and design your own fleets and stand opposed to the Particulate in this physics/strategy/RTS/fleet hybrid. Build partially destructible and self repairing ships that interact with enemies less controlled by some scripted logic and more driven by a real time massive physics particle simulation.

Mine gold and electricity in your own space colony, find new inhabitants in space, and eventually make them happy - because the energy of happiness through smile-to-fly technology can be transformed into rocket fuel!

Buoyancy is a city-building strategy game where you build, manage, and move a floating city on an oceanic world. Explore and scavenge resources scattered around the endless waters. Keep your villagers nourished and happy while combating fires, sickness, and pirate attacks.

《大衍江湖》是一款武侠题材，结合经营养成，角色扮演的游戏。玩家将操控一个江湖门派；与江湖上的其他各色各样的门派打交道，或建立贸易或直接攻陷；与其他门派弟子交流，或结交或抢夺；江湖世界上各种随机事件，能获得具体好处同时也伴随着各种风险；门派传承，终有一日，将主宰江湖。

In a world where a robot revolution failed, the last humans search for a way to survive and escape. Beacon of Neyda is a side-scroller strategy game where you have to survive waves of enemies while creating and upgrading your base. Build where you want - Defend what you can.

A brutal godlike village sim that melds the god game, management, and tower defense genres! Fight off hoards of monsters at night, and expand your village in the day time. Inspired by games like Black and White, Rimworld, and Dwarf Fortress but not quite like any of them.