Top similar games like Project: Vaccine A:

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Gather resources by day, build and recruit by noon, defend your village by night! A new minimalism sandbox survival with countless new ideas – Craft Hero

Planet Gemini is a factory building and tower defense game. On two planets that crash-landed during a dimension trip, survive against incoming enemies and research on a portal to escape.

Defend the energy cores from ever increasing enemy waves by destroying their spawn gates. Build tower mazes on Hex grid. Adapt them to dynamic changes in the terrain. Face quirky bosses. Design your own levels and share them on the Steam Workshop.

Defend your castle from the attacks of the night creatures. Collect coins, interact with the elements of the game, discover, explore, learn and survive for 30 days or try again.

Embark on an adventure with Loot Express Delivery Service, a 2D pixel art game. As the commander, your goal is to retrieve valuable items from a distant planet. Utilize your skills and strategy to complete missions and guide your company to prosperity.

Do you like Tower Defense games with Strategy elements? Well, look no further! We've got exactly what you're looking for! Get ready to defend your settlement from enemies using a huge arsenal of towers!

Build defenses to protect your mining sites from the hostile native alien species. Explore the planet and discover the true reasons you've been sent here for. A true old school pixel-art experience.

This is a pixel-style classic tower defense game. You need to summon souls to fend off enemy attacks, and each type of soul has its unique skill tree. You can also build your own maze in the game to prevent enemy invasions.

Battle friends over air, land and sea in this epic WW2-themed battle strategy game.

Nova Lands: Emilia's Mission is a prologue chapter of the main game, Nova Lands. Learn your way around the planet you've landed on, build your base, and automate it with your helpful bots!

Kingdom is a 2D sidescrolling strategy/resource management hybrid with a minimalist feel wrapped in a beautiful, modern pixel art aesthetic.

The Last Drop is a pixel art top-down shooter where you control the last water droplet on Earth. Battle waves of enemies with unique weapons, customize the map, and compete on the online leaderboard.

A Byte War is a real time strategy game where you lead a race of block-based machines against a machine threat from another dimension. Construct buildings from blocks arranged in various patterns and leverage your machines to convert the world around you.

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

Step into the world of Defend from Candyland! where retro tower defense meets strategic depth. Plant and upgrade trees, use powerful buffs, and reveal enemy paths to shield Eden from waves of candy invaders. Master the challenge now!

Defend your Nexus by placing mirrors and buildings on the path of your projectiles. Deflect, empower, manage and solve each map using your creative and strategic mind.

Outpost brings the perfect mix between survival and roguelite gameplay. Start the game in a randomly generated environment and try to adapt, and make it through as many nights as possible. How long can you survive?

Delve into the mystical art of summoning alongside Feylin, the last of the Ancients. Begin your journey as her new apprentice and learn how to summon minions, outwit your enemies, collect relics to enhance your powers and overcome the dreadful obstacles set in your path.

Build walls, turrets and summon allies to survive hordes of enemies in this top-down sandbox base builder.

Keyclash is a simple tower defense roguelike about building on keyboard keys and surviving as long as possible.

Crash land on a hostile planet where you'll have to build the strongest defenses if you wish to live to escape from it. But be warned... this planet is merciless. Build strong, and smart; else physics may flood or destroy your only hopes of survival.

Fight, upgrade, explore, and build your way out of a dangerous planet in this 2D pixel art side scroller. Stream of foes will keep you on your toes while beating them will reward you with much needed resources.

Action adventure strategy game with tower defense, in a fantasy world, use your own combat skills, weapons, and the power of your partners to survive. Face the ultimate fate with your unique combat style.

The ultimate mash-up of Real-time Strategy and Tower Defense!

An open-ended factory management game with RTS and tower defense elements.

Go head to head with other players in a Bloon-popping battle for victory. From the creators of best-selling Bloons TD 5, this all new Battles game is specially designed for multiplayer combat, featuring the ability to control bloons directly and send them charging past your opponent's defenses.

All kinds of enemies entered the battlefield! Build your defenses against hordes of enemies!

Build whimsical defenses, wield powerful relics, and command magical snow guardians to survive the infernal chaos. Can you hold the line through endless nights and defeat the Frost fallen King?

Upgrade and evolve, expand your territory, and build mighty defense towers to repel hordes of monsters.

{{An RTS inspired by the classics of the past!}} Making up for it's subpar retro graphics with fun gameplay and modern multi-threaded tech enabling huge battles to run smooth... Featuring singleplayer challenges, skirmish, sandbox, 10-player multiplayer & workshop modding.

Desperate Place is a strategic tower defense game where you play as a crew member who wakes up early on a damaged colonization starship. Stranded on an unknown planet, you must gather resources, repair the ship, and defend against alien monsters to survive and escape.

Get ready to face the lands of Deitra. Choose your class and fight to change your destiny.

Bestion is a game that combines Roguelike tower defense elements with automated factory construction. Players are required to construct their own factory on a planet and protect the kernel from monster attacks.

Open a diner on a desert planet, grow exotic ingredients, create a menu for intergalactic palates and deal with powerful factions. Free Appetiser is the prologue to Diner at the End of the Galaxy, where you cook and manage your way to intergalactic riches and glory.