Top similar games like Project: Vaccine A:

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Gather resources by day, build and recruit by noon, defend your village by night! A new minimalism sandbox survival with countless new ideas – Craft Hero

Planet Gemini is a factory building and tower defense game. On two planets that crash-landed during a dimension trip, survive against incoming enemies and research on a portal to escape.

Defend the energy cores from ever increasing enemy waves by destroying their spawn gates. Build tower mazes on Hex grid. Adapt them to dynamic changes in the terrain. Face quirky bosses. Design your own levels and share them on the Steam Workshop.

Defend your castle from the attacks of the night creatures. Collect coins, interact with the elements of the game, discover, explore, learn and survive for 30 days or try again.

Embark on an adventure with Loot Express Delivery Service, a 2D pixel art game. As the commander, your goal is to retrieve valuable items from a distant planet. Utilize your skills and strategy to complete missions and guide your company to prosperity.

Build your own towers from modular units, adapt mid battle, and master custom defenses in this Build-a-Tower Defense.

Do you like Tower Defense games with Strategy elements? Well, look no further! We've got exactly what you're looking for! Get ready to defend your settlement from enemies using a huge arsenal of towers!

Tower defense / Roguelike / Sci-Fi / Pixel Art game with boomer games aesthetics. Mine resources and shoot those disgusting aliens right in their faces. Unlock new technology, develop new strategies and explore the planet. A modern old-school Pixel Art experience with the vibe of 90s classics.

This is a pixel-style classic tower defense game. You need to summon souls to fend off enemy attacks, and each type of soul has its unique skill tree. You can also build your own maze in the game to prevent enemy invasions.

Battle friends over air, land and sea in this epic WW2-themed battle strategy game.

Nova Lands: Emilia's Mission is a prologue chapter of the main game, Nova Lands. Learn your way around the planet you've landed on, build your base, and automate it with your helpful bots!

Be the Gun & the Architect. Arcade-Tower defense hybrid with controller-first design for a snappy tower building and twin-stick shooting. Every kill feeds the machine. Adapt to roguelike chaos with unique items and synergies. Can you build the ultimate defense & survive the Derp?

You are a Portal Guardian. It is your job to help protect the secret gateways to the Realm. Your people have been kept safe and unaware for centuries, but something dark and relentless has been stirring... Unleash the fury of your towers and magic to defend the portal and the realm or all is lost!

Build, gamble, and most of all survive in this roguelike tower defense where everything is a tile. Use the slot shop to draft towers and physical upgrade tiles to buff your grid. With hundreds of unique synergies, will you hit the jackpot or let the enemies break your base? Play the odds today!

Kingdom is a 2D sidescrolling strategy/resource management hybrid with a minimalist feel wrapped in a beautiful, modern pixel art aesthetic.

The Last Drop is a pixel art top-down shooter where you control the last water droplet on Earth. Battle waves of enemies with unique weapons, customize the map, and compete on the online leaderboard.

A Byte War is a real time strategy game where you lead a race of block-based machines against a machine threat from another dimension. Construct buildings from blocks arranged in various patterns and leverage your machines to convert the world around you.

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

Step into the world of Defend from Candyland! where retro tower defense meets strategic depth. Plant and upgrade trees, use powerful buffs, and reveal enemy paths to shield Eden from waves of candy invaders. Master the challenge now!

Defend your Nexus by placing mirrors and buildings on the path of your projectiles. Deflect, empower, manage and solve each map using your creative and strategic mind.

Outpost brings the perfect mix between survival and roguelite gameplay. Start the game in a randomly generated environment and try to adapt, and make it through as many nights as possible. How long can you survive?

Delve into the mystical art of summoning alongside Feylin, the last of the Ancients. Begin your journey as her new apprentice and learn how to summon minions, outwit your enemies, collect relics to enhance your powers and overcome the dreadful obstacles set in your path.

A maze-building tower defense where tower placement is everything. Force enemies the long way around, build choke points, push through lava, and adapt as levels change beneath you. No spells, no card modifiers. Just planning, placement, and a cat stuck in a jar.

In this top-down, multiplayer, co-op game, you must protect your Core Crystal by any means necessary. Build up your defenses, explore, refine, and upgrade to reach your goal. Play alone or with up to 8 people.

Build walls, turrets and summon allies to survive hordes of enemies in this top-down sandbox base builder.

Keyclash is a simple tower defense roguelike about building on keyboard keys and surviving as long as possible.

Crash land on a hostile planet where you'll have to build the strongest defenses if you wish to live to escape from it. But be warned... this planet is merciless. Build strong, and smart; else physics may flood or destroy your only hopes of survival.

Fight, upgrade, explore, and build your way out of a dangerous planet in this 2D pixel art side scroller. Stream of foes will keep you on your toes while beating them will reward you with much needed resources.

Action adventure strategy game with tower defense, in a fantasy world, use your own combat skills, weapons, and the power of your partners to survive. Face the ultimate fate with your unique combat style.

Become a Tsar! Create your own settlement and expand it into a stronghold to protect your people in a handcrafted side-scroller pixel art adventure game. Construct your town, gather resources, and fight enemies like a real tsar.

The ultimate mash-up of Real-time Strategy and Tower Defense!

An open-ended factory management game with RTS and tower defense elements.

Go head to head with other players in a Bloon-popping battle for victory. From the creators of best-selling Bloons TD 5, this all new Battles game is specially designed for multiplayer combat, featuring the ability to control bloons directly and send them charging past your opponent's defenses.