Top similar games like Project: Vaccine A:

FrontierLord is a pixel strategy game to build and guard frontier forts. As lord, build villages, collect wood and ore for production. Place siege gear and wall traps, train troops to repel raiders. Balance building and defense, craft your fort and create your frontier legend.

Defend your castle from the attacks of the night creatures. Collect coins, interact with the elements of the game, discover, explore, learn and survive for 30 days or try again.

Do you like Tower Defense games with Strategy elements? Well, look no further! We've got exactly what you're looking for! Get ready to defend your settlement from enemies using a huge arsenal of towers!

This is a pixel-style classic tower defense game. You need to summon souls to fend off enemy attacks, and each type of soul has its unique skill tree. You can also build your own maze in the game to prevent enemy invasions.

Nova Lands: Emilia's Mission is a prologue chapter of the main game, Nova Lands. Learn your way around the planet you've landed on, build your base, and automate it with your helpful bots!

Battle friends over air, land and sea in this epic WW2-themed battle strategy game.

Kingdom is a 2D sidescrolling strategy/resource management hybrid with a minimalist feel wrapped in a beautiful, modern pixel art aesthetic.

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Delve into the mystical art of summoning alongside Feylin, the last of the Ancients. Begin your journey as her new apprentice and learn how to summon minions, outwit your enemies, collect relics to enhance your powers and overcome the dreadful obstacles set in your path.

Action adventure strategy game with tower defense, in a fantasy world, use your own combat skills, weapons, and the power of your partners to survive. Face the ultimate fate with your unique combat style.

Crash land on a hostile planet where you'll have to build the strongest defenses if you wish to live to escape from it. But be warned... this planet is merciless. Build strong, and smart; else physics may flood or destroy your only hopes of survival.

Become a Tsar! Create your own settlement and expand it into a stronghold to protect your people in a handcrafted side-scroller pixel art adventure game. Construct your town, gather resources, and fight enemies like a real tsar.

Fight, upgrade, explore, and build your way out of a dangerous planet in this 2D pixel art side scroller. Stream of foes will keep you on your toes while beating them will reward you with much needed resources.

Go head to head with other players in a Bloon-popping battle for victory. From the creators of best-selling Bloons TD 6, this all new Battles game is specially designed for multiplayer combat, featuring the ability to control bloons directly and send them charging past your opponent's defenses.

Gather resources by day, build and recruit by noon, defend your village by night! A new minimalism sandbox survival with countless new ideas – Craft Hero

After crash-landing on a mysterious island with no memories of the past, set out to explore the island and scavenge for resources to build automated production lines and repair the damaged ship.

Open a diner on a desert planet, grow exotic ingredients, create a menu for intergalactic palates and deal with powerful factions. Free Appetiser is the prologue to Diner at the End of the Galaxy, where you cook and manage your way to intergalactic riches and glory.

Unleash your creativity and strategic prowess in Forts, the exhilarating physics-based RTS! Design, construct, and customize imposing fortresses, bristling with devastating firepower, and blast your opponent’s buildings to rubble!

You’ll become a fallen star, crashing down onto an island covered in stars. This is a base-building + tower defense game. In a unique 2.5D art style, explore the island, build up your camp, fight the island’s evil forces, and lead the other stars back to the universe.

{{An RTS inspired by the classics of the past!}} Making up for it's subpar retro graphics with fun gameplay and modern multi-threaded tech enabling huge battles to run smooth... Featuring singleplayer challenges, skirmish, sandbox, 10-player multiplayer & workshop modding.

Keyclash is a simple tower defense roguelike about building on keyboard keys and surviving as long as possible.

A Tower Defense game with new mechanics in virtual setting about online dating. Your task is to protect your base preventing spam from getting into your inbox. Build towers in marked places to stop spam.

Build your own towers from modular units, adapt mid battle, and master custom defenses in this Build-a-Tower Defense.

Dragon Lands is an incremental game about creature collection, farming, crafting and automation! Gather and manage resources, expand your lands and upgrade your skills. Collect Dragons to automate your production. Join in this adventure and explore a vibrant world!

Defend the energy cores from ever increasing enemy waves by destroying their spawn gates. Build tower mazes on Hex grid. Adapt them to dynamic changes in the terrain. Face quirky bosses. Design your own levels and share them on the Steam Workshop.

Call upon the Gods of Olympus to defend Atlanta from Ares’ invading hordes in this roguelite tower defense epic. Battle across procedurally generated realms, unlock powerful upgrades, and shape the fate of a new Pantheon!

Embark on an adventure with Loot Express Delivery Service, a 2D pixel art game. As the commander, your goal is to retrieve valuable items from a distant planet. Utilize your skills and strategy to complete missions and guide your company to prosperity.

Inspired by modern science fiction! A modern real-time war game, the screen is in the style of realism, the fast-paced attack effect is easy to fatigue, easy to use and simple to operate, mainly in the traditional style

Tower defense is a Tower defense game containing HQ, Tower, and 3 building that generates resources. In order to build a building, you must have enough resources. Each building can generate different resources. You must protect the HQ from the Enemy

A brutal godlike village sim that melds the god game, management, and tower defense genres! Fight off hoards of monsters at night, and expand your village in the day time. Inspired by games like Black and White, Rimworld, and Dwarf Fortress but not quite like any of them.

Pet Desktop Adventure is a desktop tower defend game. Defeat waves of enemies, get mysterious eggs and collect different pet animals. While you do your own things, adding a little fun to your desktop!

Plant towers, hold the Nexus. A pixel-art tower defense where population caps how wide you can build, gold and mana decide what you build with. Draft augments as you level, spend gems on a permanent power-up tree, and find out how long your walls hold.

A Byte War is a real time strategy game where you lead a race of block-based machines against a machine threat from another dimension. Construct buildings from blocks arranged in various patterns and leverage your machines to convert the world around you.

Pixel Worlds is a free-to-play sandbox MMO where players build worlds, craft items, explore dungeons, farm resources, and trade in a player-driven economy, all within a shared online universe rebuilt as a fresh start for a fair and stable long-term experience.

Touhou Mushroom Defense blends resource gathering, base building, and tower defense into one survival adventure. Collect mushrooms, craft towers, create synergies, and survive for 30 days—or longer!