Top similar games like Project: Vaccine A:

Gather resources by day, build and recruit by noon, defend your village by night! A new minimalism sandbox survival with countless new ideas – Craft Hero

Build walls, turrets and summon allies to survive hordes of enemies in this top-down sandbox base builder.

Kingdom is a 2D sidescrolling strategy/resource management hybrid with a minimalist feel wrapped in a beautiful, modern pixel art aesthetic.

Bestion is a game that combines Roguelike tower defense elements with automated factory construction. Players are required to construct their own factory on a planet and protect the kernel from monster attacks.

Fight, upgrade, explore, and build your way out of a dangerous planet in this 2D pixel art side scroller. Stream of foes will keep you on your toes while beating them will reward you with much needed resources.

Defend your castle from the attacks of the night creatures. Collect coins, interact with the elements of the game, discover, explore, learn and survive for 30 days or try again.

Outpost brings the perfect mix between survival and roguelite gameplay. Start the game in a randomly generated environment and try to adapt, and make it through as many nights as possible. How long can you survive?

Step into the world of Defend from Candyland! where retro tower defense meets strategic depth. Plant and upgrade trees, use powerful buffs, and reveal enemy paths to shield Eden from waves of candy invaders. Master the challenge now!

An open-ended factory management game with RTS and tower defense elements.

The Last Drop is a pixel art top-down shooter where you control the last water droplet on Earth. Battle waves of enemies with unique weapons, customize the map, and compete on the online leaderboard.

Unleash your creativity and strategic prowess in Forts, the exhilarating physics-based RTS! Design, construct, and customize imposing fortresses, bristling with devastating firepower, and blast your opponent’s buildings to rubble!

A Byte War is a real time strategy game where you lead a race of block-based machines against a machine threat from another dimension. Construct buildings from blocks arranged in various patterns and leverage your machines to convert the world around you.

A brutal godlike village sim that melds the god game, management, and tower defense genres! Fight off hoards of monsters at night, and expand your village in the day time. Inspired by games like Black and White, Rimworld, and Dwarf Fortress but not quite like any of them.

Crash land on a hostile planet where you'll have to build the strongest defenses if you wish to live to escape from it. But be warned... this planet is merciless. Build strong, and smart; else physics may flood or destroy your only hopes of survival.

Acid Planet is a caustic blend of horde-survival, tower-defense and strategy. Build, fight and evolve to survive against rampaging swarms of monsters and fearsome Kaiju.

As a Taoist from the Heavenly Master's Mansion, you will come down the mountain to experience various demons and monsters on this land. You need to personally build a camp, search for food, establish defenses, and do everything you can to survive.

Kingdom Eighties is a short story-based standalone expansion set in the Kingdom universe. An epic singleplayer adventure of micro-strategy and base building. Defend your town against the mysterious Greed, and discover the secrets of your family lineage!

Defend your Nexus by placing mirrors and buildings on the path of your projectiles. Deflect, empower, manage and solve each map using your creative and strategic mind.

Defend your castle in this fast-paced tower defense/action hybrid game with stunning pixel art graphics! Play as alchemically enhanced warrior Bellator, set traps, build towers, craft powerful weapons, and defend your home! The fate of the castle lies in your hands!

Grand Attrition is an RTS/tower defense survival game with RPG elements that boasts innovative game mechanics where you can take control of everything in battles, from map terrain to enemy units. Combine a wide variety of playable units, side grades, and talents to ensure no battle is the same.

Base Raid is a 2D base build and defence strategy game. In the game your goal is to build the best base to crush the enemy before it crushes you. You have a specific amount of in-game money to build your base and use it to fight against enemy bases.

About：The solar system was invaded by aliens of unknown origin. The earth has fallen. As the commander of the surviving space fleet, return to the solar system from outer space and save the earth.

Dive into 1BIT CASTLE: REMAKE, a strategic action-packed tower defense game. Choose heroes and perks to fight off evil monsters. Enjoy captivating pixel art while protecting your treasures in this addictive adventure with endless mode!

Build your defense base to repel alien invaders. Atahion is a strategy and tactical defense game in which you have to extract resources, build defense towers and use bonuses to complete the mission.

Are you worthy of being a king? Test your mettle in this city-builder and resource management game as you develop your kingdom. Face challenges at every turn and transform your village into something mighty. Protect your subjects. Slay your enemies. Be a king!

Embark on an adventure with Loot Express Delivery Service, a 2D pixel art game. As the commander, your goal is to retrieve valuable items from a distant planet. Utilize your skills and strategy to complete missions and guide your company to prosperity.

Dig! Dig! Dig! Manage the small underground Dwarf base and make it as rich as possible before they meet their inevitable doom. Purchase before May 11th and save!

Refactor is a hard-core tower defense game that combines modular building, route planning, and element composition.

[[h2]Rogue elements[/h2] + Free Layout + BattleMastery + Turn-based March]What kind of different experience will it bring?Will you be able to hold on to a tower caught in a tidal wave of enemy attacks? may be the answer you're looking for.

Defend the energy cores from ever increasing enemy waves by destroying their spawn gates. Build tower mazes on Hex grid. Adapt them to dynamic changes in the terrain. Face quirky bosses. Design your own levels and share them on the Steam Workshop.

Once a year Grandma cleans her bassement. Join her in this addictive demon blasting tower defence game. Rescue your possessed grandchildren.

Amber trail is a pixel art 2D side scrolling real time strategy mixed with hack'n slash action. Manage resources and defend your settlement from incoming enemies.

{{An RTS inspired by the classics of the past!}} Making up for it's subpar retro graphics with fun gameplay and modern multi-threaded tech enabling huge battles to run smooth... Featuring singleplayer challenges, skirmish, sandbox, 10-player multiplayer & workshop modding.

Explore a fantasy ocean-punk world, braving the deep with steam-powered marvels. Discover mysterious underwater treasures, but scarcity and ecological crises test survival. Rise, build, confront foes in this pixel-art ocean survival journey!