Top similar games like Diffusion:

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

Defend your Nexus by placing mirrors and buildings on the path of your projectiles. Deflect, empower, manage and solve each map using your creative and strategic mind.

A Byte War is a real time strategy game where you lead a race of block-based machines against a machine threat from another dimension. Construct buildings from blocks arranged in various patterns and leverage your machines to convert the world around you.

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

Build, Upgrade, and then Move your Towers in this unique twist on the Tower Defence genre. With Rogue-Lite mechanics every run offers new strategies, and every death unlocks new upgrades. Grow. Evolve. Destroy the Robots!

A Roguelike Tower Defense in space with missions to conquer. Can you hold against the spreading alien bosses? Build and upgrade towers against the corruption. Choose your technologies and warpspeed your way to victory.

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

You are isolated on a small meteor and need to build a fire to escape before being destroyed by aliens. Use your limited space to create machines and obtain more and more resources. Enjoy this mix of puzzles, tower defense and incremental gameplay.

Build your defense base to repel alien invaders. Atahion is a strategy and tactical defense game in which you have to extract resources, build defense towers and use bonuses to complete the mission.

A pixelated 2.5D RTS meets tower defense as you battle mutated ants in a short campaign. Build walls, place turrets, and hold the line to reclaim Earth's surface in this tactical fight for survival where placement of everything matters.

Embark on an adventure with Loot Express Delivery Service, a 2D pixel art game. As the commander, your goal is to retrieve valuable items from a distant planet. Utilize your skills and strategy to complete missions and guide your company to prosperity.

The goblin tribes of the realm have united against you and the power of the Eye of the Void. Build towers, fortify walls, construct gold mines to gather resources, and cast powerful spells to fend off waves of determined goblins and their allies who seek to destroy you.

Space Base is an action-packed tower defence game, where you aim to protect your planets from the incoming forces of enemy ships and aliens by any means necessary. Build up your defences as stronger and stronger waves of enemies arrive to reach the highest score possible.

An Urban Survival RPG! Crafting, Exploring and Defending in a desolate metropolis haunted by the mysterious dreamers. Lead a team of 4 survivors through this urban desert of skyscrapers and high-rises, where the streets are crowded with the mutated victims of a strange disease.

Build & defend a small remote mining base on Taichin XI from the alien hordes. Deploy defenses, upgrade your turrets and get ready for the nightfall. The Unearthened is a classic Idle Tower Defense game where you build towers and prepare for the invasion.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

You control a small colony in the underground of an unknown planet. Mine resources, build a base, explore the world and technology. Supply your colonists with oxygen, food and energy so that they can carry out their tasks.

A survival RTS game about exploring the vast cosmos, the many planets inhabiting it and their countless secrets. You'll need to explore, gather resources and research new technologies in order to survive, thrive, and eventually build a colony on a bizarre, foreign world.

TAVU is a PvE RTS game with a tactical combat system. Build your bases and defend them against waves of enemy attacks. Upgrade your units and destroy enemy bases to gain new territories and resources.

Turn-based space battle tactical/strategic game

A strategic tower-defense where you control powerfull drones. Unlock new tower and use specific technologies to defend your base on Thukothea!

Gutfarm is a top-down 2D pixel art game that blends farming, tower defense, and survival elements. On this alien island, you will expand and grow your farm by planting crops, unlocking genetically mutated varieties, defending against waves of monster attacks, collecting relics, and more!

Bestion is a game that combines Roguelike tower defense elements with automated factory construction. Players are required to construct their own factory on a planet and protect the kernel from monster attacks.

Firewall, vaccine, cleaner... Place various blocks to protect your CPU! Vaccine A is a sandbox defense game, filled with parody of various programs.

A game of base building and colony simulation in a world where night is permanent. Survive, build, explore, repel enemy raids and tend to the needs of your workers and your king.

Tiny Battles is a tactical action auto-battler where battles take place automatically in the arena.

Stellar Initiative is a roguelike tower defense game where you land on the planet and use your orbit ship to deliver buildings and support you with fire. Complete missions, install new upgrades, discover powerful artifacts, and find the best strategy!

The ultimate mash-up of Real-time Strategy and Tower Defense!

Step into the shoes of the last standing drop of water, tasked with defending against the relentless assault of evil sponges determined to absorb every remaining drop. Although you stand alone, you possess all the water knowledge needed to create impressive structures and fend off your enemies.

Land on unique planets to survive the horrors that await in this adventure survival RPG. Use the spoils to upgrade defensive buildings and explore the galaxy further. Can you survive the hunt all alone?

Build your factory by day, then fight relentless hordes by night in this unique blend of factory-building and rogue-like mayhem. Gather resources and upgrade your arsenal with Magic, Guns and Tesla Coils?!

Scrap Bastion is a strategy tower defense game where you manage your city, equipping it to survive the waves of mutant creatures, testing your planning and decision making capacities at every turn. Watch out, as time is crucial to win!

Defend the energy cores from ever increasing enemy waves by destroying their spawn gates. Build tower mazes on Hex grid. Adapt them to dynamic changes in the terrain. Face quirky bosses. Design your own levels and share them on the Steam Workshop.

The hungry Gooper swarm threatens intergalactic peace. Stop them! Build towers around planets and take control over their orbits. Spin them with all you’ve attached! Collect new towers, powers and upgrades to beat the onslaught of goopers and save the galaxy in this colorful Tower Defense Roguelite!