Top similar games like Medusa Frontier:

LithoBreak is a survival factory-builder grounded in real physics and engineering. Build and automate a lunar colony, explore in first-person, and survive constant orbital threats – all while you Play with Science

Untethered is a space survival-sandbox set in our own cosmic backyard. Explore zero-gravity environments, build and operate realistic space stations, and fight to stay alive in the unforgiving realm of deep space.

Red Planet: Survive is a first person survival game for Microsoft Windows. Surviving in the harsh conditions of the Red Planet will be hard, but if you are strong enough, you will succeed. Find the best way to survive, but be careful, since each wrong step will ensure your demise. The environment is your main enemy.

Explore, dig for resources, and build factories in a vibrant open world with quests for both technological and magical progression. Inspired by classic old-school Minecraft modpacks and featuring many new and unique features.

Go to the Moon to explore its harsh nature and mysterious anomalies. Build your own lunar base, craft equipment, extract valuable resources and make many discoveries. Overcome the challenges of extreme lunar conditions, an oxygen-free atmosphere and much more unknown...

An open world survival and automation game. Engineer Alpha combines an infinite editable world, building and connecting of automated machinery, and RPG style player progression.

First Person, Exploring, Surviving, Hunting, Foraging, Buiding, Hoarding, Looting, Prepping, Crafting Work against Time and Survive, Storms, Earthquakes, Nuclear Events, Radical Weather, and much more

An open world survival game set in space.

You were deep in uncharted space on a research mission. Disaster struck. Together with your friends, explore a mysterious asteroid field and mine whatever resources possible to build what you need to survive.

INTERASTRA is a fully immersive first-person sci-fi survival adventure game set in outer space. Discover unknown planets differing in weather conditions, resources, and various mysteries. Craft necessary equipment, launch, and control space rockets, explore the universe, and survive among the stars.

A space survival crafting mining base building and star system building game. Craft rockets to create planets and Dyson Rings, mine and craft advanced materials, terraform the terrain, manage electricity, farm food, and more as you watch the star system evolve into stunning, ever-changing views.

Total Miner is an open world voxel sandbox game. It is primarily designed for creative RPG game builders, but also has two action/adventure style game modes where you can just jump in and play.

Terraform a dead planet back to life in this open world survival crafting game. Explore ruins, gather resources, print machines, drive modular vehicles, grow forests, biomes, and ecosystems and create life and make it thrive with your own hands.

WarpedSpace is a sci-fi survival adventure game set in deep space. A massive, open environment full of wonder and peril awaits you!

Interstellar Rift is an open world starship simulator with an emphasis on ship construction and multi-player interaction. Survive in a hostile galaxy with your own custom designed and constructed starship. Invite other players to join your crew or fight them across the galaxy!

Play as an astronaut on our moon in the future. Your task is to prepare the moon for future colonies by terraforming. Collect resources, explore procedurally generated caves, build buildings and create a second world for you and our earth.

Explore alien planets with carefully designed ecosystems, weather, resources, dangers and unique phenomena. Hunt animals for food and collect resources to craft equipment and repair devices on your ship. Escape each unique planet and unlock crew members and new ships.

RealmCraft is an immersive 3D sandbox VR adventure in a blocky world, blending creativity and survival. Explore a vast procedurally generated open world, mine resources, craft tools, and build anything. Fight hostile mobs, find treasures, and enjoy smooth, intuitive VR gameplay.

The ultimate block building game.

A sandbox survival game, set on life-sized voxel planets with realistic physics with the possibility to shape your own building blocks. From your custom made furniture, walls to vehicle parts. You shape the blocks which can then be used to build buildings, spacecraft and aircraft.

Set on small procedurally generated planets, PoliPlanet is a unique first-person city building game. Discover new planets, gather resources, craft, explore, and build.

Space Engineers 2 is a sandbox about engineering and colonization where you build ships, stations, and planetary bases in a fully destructible world. Begin the story of Miro and Ivan Sokol, expand humanity’s foothold in the Almagest system, and fight to survive.

TerraTech Worlds is an open world, build-craft adventure game, set on an uncharted alien world. Play solo or with friends, explore your surroundings, craft unique vehicles, construct automated bases, and battle your way through hazards and enemies to harness the power of your environment

A realistic prehistoric survival game where you play as Homo habilis or Homo erectus. Craft primitive tools, build shelter, hunt massive beasts, and survive the harsh forces of nature in a vast multiplayer world.

FAR NORTH SURVIVAL is an open-world survival game set in the unique setting of a vast ice-bound area beyond the Arctic Circle.

Abiotic Factor is a survival crafting experience for 1-6 players set in the depths of an underground research facility. Caught between paranormal containment failure, a military crusade, and chaos from a dozen realms, the world’s greatest minds must survive against the universe’s biggest threats.

Validate credentials, provide travel, and catch baddies while maintaining your warp gate station on the dangerous fringe of the galaxy.

Triton Survival is an open world survival game about exploration, construction, engineering, and fighting on planets. Embark on this interstellar adventure and conquer the galaxy. Are you ready?

Planet Explorers is an open world sandbox adventure RPG game set on a distant planet. The game uses a new OpenCL calculated voxel system to allow players to change the terrain in any way, create new objects such as weapons, vehicles, objects, and do it anywhere.

Explore, Adventure, Craft, Build, Survive. How will you shape your world? Astral Terra is a Smooth Voxel, Procedurally Generated Open World game with RPG and Survival Elements!

After a mysterious accident you are left are stranded, floating through space on a piece of a space station. Craft supplies and Hubs to expand what is now your home. But be warned space is a dangerous places where one mistake can mean certain death. Can you defy the odds and survive in space?

You’ve crash-landed on Earth in 2702. Craft, dig, fight through a vast and colorful post-apocalyptic open world full of wonder, generated cities, dungeons, aliens, mechs, and an underworld. Find love. Or beat the ultimate Underlord!

100000 years after the apocalypse, a mysterious entity guides you to build a factory on a desert island...