Top similar games like Alchemia: Creatio Ex Nihilo:

Slay your enemies, explore a wicked fantasy realm and unleash crazy combinations of items, artefacts and arcane spells! Break the time loop that grips the Wicked Lands in the ultimate fusion of turn-based tactics, deck-building, and rogue-lites!

Craft demonic essences and brew powerful potions in this diabolical roguelike deckbuilder. Summon 150+ demons to defend your land against heavenly forces. Discover rare relics and ingredients to form the most potent synergies.

Folktale Misfits is the card game roguelike where you play as outcasts looking for answers in a whimsical world. Develop strategies and help the misfit heroes unlock their true potential.

Discover infinite cards in this roguelike deckbuilder. Every card is unique, every run a new experience. Craft, combine, and build your deck completely freely to defeat enemies and bosses, or take on cleverly designed puzzle challenges!

Crownkeep is a roguelike deckbuilder that mixes minesweeper with dungeon crawling. Fight your way through deadly grid-based dungeons with one card in your hand. Build up your deck, forge powerful combos, and defy the madness that devoured the realm.

Craft a legendary deck and lead your troops to protect the Kingdom for the glory of the Han Dynasty in this fast-paced deck-building strategy roguelike. The Kingdom is on the verge of disaster against the Yellow Turbans rebellion, and only you – and your skills as a general – stand in their way!

This isn't a casino. This is war! Command the crew, upgrade your deck and collect rule-bending Booty. Discover devastating combinations and destroy your enemies as you navigate a branching map full of encounters, islands and treasure.

A chance-based roguelike deckbuilder with silly, chaotic dragons. Spin the roulette wheel to multiply your card effects, manipulate the odds, and unleash ridiculous combo turns. Build a synergistic deck, outsmart RNG, and climb your way to the Boss Dragons.

A roguelike alignment deck builder. Where you align your runes to cast spells to defeat enemies. Build your deck and craft your spells to meet the challenges ahead. Feed and grow your companion to aid in battle. Before it's too late, journey to the center of the maze and restore the Pattern Ring.

A unique solo quest card combat adventure with 500+ cards, drafting, roguelike and puzzle modes of play. The campaign features a unique MULTI-CLASSING SYSTEM and 50 boss fights plus hundreds of encounters.

Immerse yourself in a first-person 3D roguelike deckbuilder where cards are your only weapon. Build complex synergies and use cards to physically unlock doors, chests, and interact with the environment while fighting to survive the Crypt's powerful and strange enemies.

Your world is abruptly erased. Only the Oneiron Expanse remains; a Plane where your mental state evokes lethal potential. Embark on a deckbuilding odyssey where every card is a fragment of your will. Find the Dreamwright and dream your reality back into being... before your memories fade

Fuse cards together in this roguelike deckbuilder to unleash their full potential. Discover powerful fusion combinations, build decks with potent synergies, harness abilities from ancient runes, and defeat challenging enemies on your quest to restore peace to the realm of Erdia.

Atomic Souls is a tactical roguelite deckbuilder which has you playing as an awoken remnant of the old world. Journey through the new world, encounter bizarre creatures, assemble the perfect deck, discover powerful artifacts, and fulfill your destiny!

Poker Quest is a fantasy roguelike where players use a standard 52-card deck to take on fierce enemies in epic battles. Featuring over 20 unique heroes, thousands of items, and deep gameplay that will test even the most experienced players.

Embark on a thrilling deckbuilding adventure, fighting your way to the final boss on a journey that's different every time.

Tactical Roguelike Deckbuilder with ability-based combat, fueled by card synergies. Build a powerful deck to support your hero. Use abilities to wipe out hordes of enemies. Discover powerful combos within the near-endless variety of composite cards.

TAROGUE is a challenging Tarot Roguelike Deckbuilder. You are The Fool. 🃏 Craft your deck, discover synergies, and uncover the secrets of the four factions; Wands, Cups, Swords, and Coins. Dive into the occult and unravel the mysteries of Kings, Queens, and Aces. Welcome to the Courts!

Card of Fate is a roguelike deckbuilder where you wander the path to Heaven or Hell. Construct a powerful deck, find legendary relics, and defeat the guardians of the afterlife. Will you master the celestial arts of the Angel or the devastating fury of the Demon?

Devise the ultimate spell rotation and watch it obliterate your opponents. In this roguelike autobattler, arrange your spells into devastating combos and customize them with build-defining runestones. Draft spells, sequence your skillbar, slot your runes, and assemble your Broken Build!

Through Hell and Back is a timeline based roguelike deckbuilding game. Place your spells on the Timeline to outsmart your enemies. Choose your power ups carefully, trade spells and upgrade the Timeline to unleash devastating combos.

CELESTIAL 9 is a roguelike fusing Teochew lore & 'Mu Shi' poker. Forge pacts with deities! In a deadly gamble challenging the Sunken Sovereigns, use strategy to unleash epic combos and keep your family's last incense burning!

Memoria Arcana is a mystical memory roguelike where hidden pairs become powerful poker hands. Discover game-changing Arcana, craft clever Zodiac combos and overcome strange Curses in endlessly satisfying runs.

A roguelike deckbuilder where you cook your strategy. As a Cook, manage your Hero’s Appetite and Cholesterol, and build powerful combos with food cards and kitchen tools.

Hell Hold’em is a dark turn-based RPG where every encounter is a battle of strategy, manipulation, and survival. Descend into the underworld to rescue an unjustly condemned soul. Face demons in twisted turn-based duels where every hand is a trap. To survive, you'll have to cheat better than they do.

Travel back to darker times, and enjoy a roguelike deckbuilder adventure, set in XVI Century. Discover the secrets of alchemy and fight mythical beasts. Hermetica combines card tactical combat and potion crafting, with a unique medieval art style.

A deckbuilding (kinda) roguelike with Tetris-like unit management and turn-based battles.

A roguelike deckbuilding game about assembling adventuring parties and running an Adventurers’ Guild. Combine hero, weapon, and item cards to form teams that meet each commission’s needs, earn gold and reviews, uncover relics, and build the realm’s most powerful and beloved guild.

Unleash devastating combos with unique dual cards in this combat roguelite deckbuilder. Battle deadly foes, adapt your deck, and conquer the Everglyph Trials.

The 10-rats-in-a-trenchcoat roguelike deckbuilder. Recruit a rag-tag team of rats, craft a curated deck for each, and discover devastating multi-deck combos. Build your team & masterfully pilot multiple unique decks to take down increasingly difficult enemies.

Play quick card duels, open booster packs, discover new cards and build the best deck to face your next opponent. Duel Champions offers a highly replayable singleplayer TCG experience. Ready to duel?

A roguelite deckbuilder where the courageous spit back. Build powerful Companion and Structure synergies, unleash absurd spit combos, and stand up to bullies, bizarre foes, legendary monsters, and the unexpected.

Perfect Teams is a Rogue Like deckbuilder in which you have to assemble a team of three characters, each one with unique cards and unique powers, to explore different universes and fight the corruption caused by the fusion. What will be your Perfect Team ?

Fight your way through the lands of the magical kingdom in this turn-based, roguelike deck builder game. Fight your enemies by combining powerful poker combinations, enhance their effects, endow them with new properties, find magical relics and choose new classes for your hero.

Wizard Hand is a magical deckbuilder game where solitaire meets roguelike. You play solitaire by using your magical cards to uncover dazzling combos and accumulate magical points with the help of enchantments, crafting, and a collection of powerful artifacts.