Top similar games like Genome Guardian: Prologue:

COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

Micron Survivor is a survival game with rogue-lite elements where you play as alien microorganisms under the microscope. Evolve, unlock research objectives, find symbiotic weapons, upgrade your builds, and fight hordes of terrestrial organisms to rule the microcosm.

Rob o Bot is a survivors-like action game where you fight hordes of robots that began acting on their own after a mysterious virus infected a new generation of machines. Survive waves of enemies, upgrade your gear, and take back control before the machines take over.

Challenge your creativity in thrilling roguelite arena survival!

Fight hordes of Covenant & Flood in this new game mixing Roguelite & Bullet Heaven for hours of mindless fun!

The farm is under attack! Fight against an alien invasion as Hamdy, an armed scarecrow. In this top-down arena roguelike, build your loadout with up to 6 weapons, grow stronger after each wave, and survive until the very end.

Battle increasingly deadly hordes in an action-packed survivors-like with tower defense elements. Create unique builds, unlock and place towers, upgrade your character, and fight to defend the Kingdom of Stellara.

Discover the beauty and fragility of life in Survivor Cells, a unique survival game against viruses and bacteria, which strategically combines the elements of roguelite, bullet hell and tower defense in a challenging experience. Your destiny depends on your agility and choices. How far will you get?

Swarmhunters is a top-down arena action shooter. The war between human and bugs has become worse - Project Swarmhunters emerged at this situation. You play as the best space soldiers in the galaxy and your mission is to strike the hive and hunt down the Emperor, supreme commander of bugs.

Summon an army of clouds in this roguelite bullet heaven survivors-like inspired by Korean folklore! Recruit and fuse cloud companions, befriend shrine visitors, and uncover the mystery of the moon goddess!

Combine abilites to create infinite possibilities of spells and decimate thousands of enemies. King Krieg is a top-down arena roguelite where YOU are the KING and you buy mystical items, find powerful guns, and craft new spells

"Spell Disk Survivor" is one of the game modes in "Spell Disk" where you survive against the endless waves of enemies. Craft overpowering builds using synergizing items and unlock new powers!

Survivors-like game with ONLINE CO-OP (1–4 PLAYERS). The man who had always played by the rules was dead.! Mafia Hero: Streets of Survival is an online co-op auto-shooter roguelite for up to 4 players. Build your criminal empire, craft powerful builds, and battle massive bosses.

President 47 is a controversial, action-packed shooter that thrusts you into a political revolution. Fight through three epic stages against media moguls and corrupt officials using firearms, explosives, your fists. If you enjoy high-octane gameplay with a political edge, this game is a must-play!

Movement is your weapon. A sci-fi action roguelike and shmup combined, in Gunlocked 2 you'll pilot and upgrade a state-of-the-art warship against endless waves of deadly aliens. Deep customization, branching paths, and tons of unlockables offer endless replayability!

Reality is collapsing into the Null, a digital void that consumes entire sectors of existence. As the last surviving pilot, you dive into corrupted space to fight through hostile anomalies, recover lost data, and uncover the force behind the collapse before everything is erased.

You just have to kill the bugs and critters before they kill you, so you can kill the bugs EVEN BETTER. Defeat the 3 floors and their bosses to win the game! Fight through procedurally maps made of handcrafted rooms, in this action RPG shooter with heavy roguelike and bullet-hell elements.

Face the relentless legions of hell in this fast-paced top-down roguelike. Loot powerful weapons, level up your stats, and survive the bullet hell chaos. How long can you stay alive in the inferno?

Our Tribe Above All is an epic online co-op survival game that masterfully blends survivor combat with online multiplayer. Make crucial strategic decisions and choose to grow in power collectively or isolate yourself for individual gains while fending off relentless hordes.

Blast your way through infinite hordes while completing objectives in this chaotic twin-stick looter shooter with frantic juicy combat. Upgrade gear, recruit heroes, tackle cumulative escalating challenges in your quest for the build of ultimate destruction.

It’s time to cluck around and find out. Gear up and pull on the helmets of the Battle Roosters, a hotshot space brigade of poultry with panache. In this quirky, roguelike, bullet hell adventure you’ll combine weapons, upgrades and killer strategies to recover space’s best taco ingredients. Bwark!

Survive in the deep void of the galaxy against thousands of invaders! Nebula is a challenging bullet hell, twin stick shooter where you have to face endless waves of space enemies. Additional map resources and space drones can provide you a support but be wary, they can as well become a deadly trap.

Shoot alien invaders, upgrade your ship, level up your weapons and save planets to defend against the invasion. Choose your favorite between the different unlockable ships and buy perks between your runs to ensure victory. After you triumph, hunt for achievements and ascend to save more universes

Bullet Hell or Heaven? A rogue-like where you upgrade yourself and your enemies. Strategize around your build choices and dominate the battlefields of Novi Blaster.

Tankron is a top-down wave survival roguelike in which you fight an ever-increasing amount and variety of enemies. Choose from a variety of upgrades to stand a chance. Discover and choose between different tank specializations to enhance your Build.

A single player 2D anime rogue-lite RPG. Join an new born duck girl's adventure in a aggressively cute world. Beat up cute wild creatures and level up to different bird classes as you explore this place.

A roguelite top-down shooter where you create a ring of guns around you to mow down thousands of enemies! Upgrade your guns with insane mods and experiment with the endless possibilities. You may be an adorable dog, but that won't stop you from raining death upon your enemies!

DUCKLYTE is a top-down shooter with roguelite elements where you play as a constipated little duck trying to stay alive as long as possible in a randomly generated farm with progressively stronger enemies.

A cute, chaotic roguelite arena-survivor: play a panda holding off endless waves of cats. Auto-fire your weapons, dodge the swarm, cast active skills, and stack relics, upgrades, and synergies into game-breaking builds that clear the screen in a single sweep.

Roguelite Overpowered Wizard Simulator & Dungeon Crawler. Slay hundreds of cultists using the power of ancient cards and your magical arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you from climbing the tower of babel.

You thought you landed alone. You were wrong. Now you must defend yourself against waves of enemies in order to survive. Vanquish thousands of foes, master your abilities, call in reinforcements, and survive in a quest to become a true Defender.

Zombie exterminator is a top-down shooter roguelite where you play a soldier. Combine weapon parts and create unique weapons. Use gadgets and relics to exterminate zombies. Fight against zombies and horrendous creatures.