Top similar games like Genome Guardian: Prologue:

COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

Battle increasingly deadly hordes in an action-packed survivors-like with tower defense elements. Create unique builds, unlock and place towers, upgrade your character, and fight to defend the Kingdom of Stellara.

Become an agent of vengeance in this bullet-heaven action roguelite! You are the lone survivor of your squad, on an alien planet with just your weapon, a jetpack, and the courage to keep fighting. Kill off alien swarms and transform their valuable guts into explosive upgrades and vital utilities.

Fight hordes of Covenant & Flood in this new game mixing Roguelite & Bullet Heaven for hours of mindless fun!

Gacha Fever is a suvivors like in a cute and colorful universe. You will fight waves of monsters with various weapons, from the machine gun to the magical girl wand and the Bubble Tea Canon ! Just be careful of the area !

A fast-paced action roguelike where explosive combat fuels 'Blitz' ultimates—a rage mode that dominates the battlefield. Endure relentless battles, enhance your arsenal, and evolve powerful abilities. Each run opens new tactical possibilities in this intense arena shooter.

Discover the beauty and fragility of life in Survivor Cells, a unique survival game against viruses and bacteria, which strategically combines the elements of roguelite, bullet hell and tower defense in a challenging experience. Your destiny depends on your agility and choices. How far will you get?

Swarmhunters is a top-down arena action shooter. The war between human and bugs has become worse - Project Swarmhunters emerged at this situation. You play as the best space soldiers in the galaxy and your mission is to strike the hive and hunt down the Emperor, supreme commander of bugs.

Summon an army of clouds in this auto-battler survivors-like bullet heaven inspired by Korean folklore! Recruit cloud companions, collect relics, befriend shrine visitors, and survive against the monster hordes!

Combine abilites to create infinite possibilities of spells and decimate thousands of enemies. King Krieg is a top-down arena roguelite where YOU are the KING and you buy mystical items, find powerful guns, and craft new spells

"Spell Disk Survivor" is one of the game modes in "Spell Disk" where you survive against the endless waves of enemies. Craft overpowering builds using synergizing items and unlock new powers!

President 47 is a controversial, action-packed shooter that thrusts you into a political revolution. Fight through three epic stages against media moguls and corrupt officials using firearms, explosives, your fists. If you enjoy high-octane gameplay with a political edge, this game is a must-play!

Galactic Pawns is an action-packed roguelite bullet hell, where you eliminate high-profile targets across war-torn planets. Master a vast arsenal, upgrade your abilities, and adapt to ever-changing battlefields in a fight for galactic order.

Invasion Survivors is a fast-paced bullet heaven and bullet hell arena shooter with roguelike elements. Explore a colorful and chaotic world where survival depends on your skills, quick reflexes, and every choice you make.

Movement is your weapon. A sci-fi action roguelike and shmup combined, in Gunlocked 2 you'll pilot and upgrade a state-of-the-art warship against endless waves of deadly aliens. Deep customization, branching paths, and tons of unlockables offer endless replayability!

You just have to kill the bugs and critters before they kill you, so you can kill the bugs EVEN BETTER. Defeat the 3 floors and their bosses to win the game! Fight through procedurally maps made of handcrafted rooms, in this action RPG shooter with heavy roguelike and bullet-hell elements.

Our Tribe Above All is an epic online co-op survival game that masterfully blends survivor combat with online multiplayer. Make crucial strategic decisions and choose to grow in power collectively or isolate yourself for individual gains while fending off relentless hordes.

It’s time to cluck around and find out. Gear up and pull on the helmets of the Battle Roosters, a hotshot space brigade of poultry with panache. In this quirky, roguelike, bullet hell adventure you’ll combine weapons, upgrades and killer strategies to recover space’s best taco ingredients. Bwark!

Shoot alien invaders, upgrade your ship, level up your weapons and save planets to defend against the invasion. Choose your favorite between the different unlockable ships and buy perks between your runs to ensure victory. After you triumph, hunt for achievements and ascend to save more universes

Bullet Hell or Heaven? A rogue-like where you upgrade yourself and your enemies. Strategize around your build choices and dominate the battlefields of Novi Blaster.

Challenge your creativity in thrilling roguelite arena survival!

Tankron is a top-down wave survival roguelike in which you fight an ever-increasing amount and variety of enemies. Choose from a variety of upgrades to stand a chance. Discover and choose between different tank specializations to enhance your Build.

A cozy time survival roguelite in space. You steer the shippy while the shooting happens automatically. Meet cute NPCs, solve small quests, and fight quirky enemies with satisfying weapons. A shorter experience for people who don't have much time but love playing (and finishing) games.

A roguelite top-down shooter where you create a ring of guns around you to mow down thousands of enemies! Upgrade your guns with insane mods and experiment with the endless possibilities. You may be an adorable dog, but that won't stop you from raining death upon your enemies!

DUCKLYTE is a top-down shooter with roguelite elements where you play as a constipated little duck trying to stay alive as long as possible in a randomly generated farm with progressively stronger enemies.

Roguelite Overpowered Wizard Simulator & Dungeon Crawler. Slay hundreds of cultists using the power of ancient cards and your magical arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you from climbing the tower of babel.

You thought you landed alone. You were wrong. Now you must defend yourself against waves of enemies in order to survive. Vanquish thousands of foes, master your abilities, call in reinforcements, and survive in a quest to become a true Defender.

Zombie exterminator is a top-down shooter roguelite where you play a soldier. Combine weapon parts and create unique weapons. Use gadgets and relics to exterminate zombies. Fight against zombies and horrendous creatures.

Collect synergizing items to create an overpowered character to fight hordes of cyclops monsters. Cyclo Chambers is a fast-paced, top-down arena shooter with light rogue-like elements. 150 items to choose from to create frantic combinations. Different runs every time.

Prologue version of the game Gatekeeper. Gatekeeper: Infinity is a fast-paced rogue-lite shooter where you'll search for the stolen Heart of the Universe and battle machine enemies! Play solo or join forces with friends in co-op mode.

Survive the void in this retro-futuristic roguelike space shooter! Dodge intense bullet-hell patterns, upgrade your ship, and scavenge for survival in a galaxy full of chaos. Every run is a new fight for existence.