Top similar games like Genome Guardian: Prologue:

Genome Guardian is a top-down roguelite turret shooter where you defend yourself from hostile aliens at the microscopic level. Combine & discover 70 weapons across 6 modes using an astounding array of turrets, perks, modifiers and power-ups on this vibrant journey to the depths of the abyss.

Combine abilites to create infinite possibilities of spells and decimate thousands of enemies. King Krieg is a top-down arena roguelite where YOU are the KING and you buy mystical items, find powerful guns, and craft new spells

an action-packed arcade shooter that takes you deep into the heart of a computer under siege.You're the system's last line of defense.

Our Tribe Above All is an epic online co-op survival game that masterfully blends survivor combat with online multiplayer. Make crucial strategic decisions and choose to grow in power collectively or isolate yourself for individual gains while fending off relentless hordes.

PlatinumS is a roguelite top-down arena shooter that brings the ultimate hero's party-building experience to life, empowering heroes to conquer dungeons. Players have the option to select from a range of items and buffs to craft their own distinctive builds.

The republic is under attack, but the enemies of freedom are on the run. We've got them right where we want them, folks, as their schemes unravel and their plots are exposed for the whole world to see. We need you to help the 47th president to restore order. Stay vigilant, complete the journey.

Dodge, weave, and unleash a storm of arrows as you battle hordes of enemies in this fast-paced 2D top-down roguelike pixel art style. Hunt for legendary arrowheads, master their unique powers, and become the ultimate treasure hunter!

A cozy time survival roguelite in space. You steer the shippy while the shooting happens automatically. Meet cute NPCs, solve small quests, and fight quirky enemies with satisfying weapons. A shorter experience for people who don't have much time but love playing (and finishing) games.

Swarmhunters is a top-down arena action shooter. The war between human and bugs has become worse - Project Swarmhunters emerged at this situation. You play as the best space soldiers in the galaxy and your mission is to strike the hive and hunt down the Emperor, supreme commander of bugs.

Become an agent of vengeance in this bullet-heaven action roguelite! You are the lone survivor of your squad, on an alien planet with just your weapon, a jetpack, and the courage to keep fighting. Kill off alien swarms and transform their valuable guts into explosive upgrades and vital utilities.

Aliens have taken over humanity and now have the goal to destroy Lexi Lane, the last hope of human resistance. Step into Lexi's "pedal to the metal" shoes. Help the last heroine drive, drift, and blast her way through the alien onslaught and meet her destiny in a last act of defiance and glory.

An eternal loop starts, where each beginning is a challenge. Constantly improve to survive in Eternal Rising, a rogue-lite and bullet-hell where you face relentless enemies that oppose you at every turn. Death is a constant, but with each new attempt, you evolve, ready to face a eternal life.

lone.AI is an upcoming space RPG roguelite. With challenging, relentless gameplay, each run has the potential to boost your ship's power, speed, and more. As a lone AI, fight your way through the solar system and uncover the secret behind the ZOSMA, an alien race that holds power over the system.

DopeMine Arena is a Bullet-Heaven Roguelite. Simple controls and auto-firing weapons put the focus on levelling up and making good choices to survive the onslaught of enemies. Earn coins to increase the stats of your characters. Discover the weapons and items that pair together .

It’s time to cluck around and find out. Gear up and pull on the helmets of the Battle Roosters, a hotshot space brigade of poultry with panache. In this quirky, roguelike, bullet hell adventure you’ll combine weapons, upgrades and killer strategies to recover space’s best taco ingredients. Bwark!

Bullet Hell or Heaven? A rogue-like where you upgrade yourself and your enemies. Strategize around your build choices and dominate the battlefields of Novi Blaster.

Discover the beauty and fragility of life in Survivor Cells, a unique survival game against viruses and bacteria, which strategically combines the elements of roguelite, bullet hell and tower defense in a challenging experience. Your destiny depends on your agility and choices. How far will you get?

Operation Ascension is a Sci-Fi Action Roguelike where endless hordes of enemies charge at you, trying to take your ascendant body. You need to slice through the digital chaos and break free. Unleash your powers. Will you be able to complete the transformation and become an Ascended Being?

Reality Core is a dungeon-crawling, loot-gathering bullet hell with extraction shooter elements. Travel through the multiverse to collect scattered Reality Shards and repair your ship. Face diverse and dangerous enemies, and wield over 100 imaginative weapons.

Dive into exhilarating combat in this roguelite, top-down shooter where survival is key! Face relentless hordes of monstrous foes, and conquer epic boss battles. Play solo or team up in co-op to race against time and see if you have what it takes to survive this mayhem of blood butts and guts!

Defend the body in vaXinator, a fast-paced action roguelike! As the last white blood cell, unleash powerful abilities and antibodies to fight off waves of infections. Test your reflexes in this microscopic battle for survival. How long can you hold the line?

Prepare for an interstellar showdown like no other in a gripping roguelike top-down twin-stick shooter set in the vast depths of space. Pilot your advanced starship, engaging in relentless battles against hordes of alien adversaries. Destroy, Collect, Upgrade, Die, Unlock, Repeat.

As The House of God races towards heaven, Jack blasts their way to the conductor in this chaotic and fast-paced Rogue-Lite.

Viking Survivors is an action roguelite where you wield ancient weapons and unleash Norse fury on endless waves of monsters. Survive the bullet hell, collect mythic weapons, and prove you're the ultimate Viking warrior in this thrilling survival game.

Summon the Dark Lord for revenge! This game combines survival and roguelite elements, where you summon monsters and place totems to defeat monsters and take down the Dark Lord!

Battle time and terror in a shoot & survive extraction roguelite. Select your hero and survive the relentless cosmic surge. Shoot, level up, topple bosses, and amplify your powers to cosmic levels. Embrace the Blastard within and unlock new heroes, powers, and perks to use on future runs.

Shoot alien invaders, upgrade your ship, level up your weapons and save planets to defend against the invasion. Choose your favorite between the different unlockable ships and buy perks between your runs to ensure victory. After you triumph, hunt for achievements and ascend to save more universes

Zombie exterminator is a top-down shooter roguelite where you play a soldier. Combine weapon parts and create unique weapons. Use gadgets and relics to exterminate zombies. Fight against zombies and horrendous creatures.

Tankron is a top-down wave survival roguelike in which you fight an ever-increasing amount and variety of enemies. Choose from a variety of upgrades to stand a chance. Discover and choose between different tank specializations to enhance your Build.

Assemble a limitless arsenal in this survive-em-up roguelite shooter. As a Gun Manufacturer's testing force, your mission is simple: test the latest gun tech and scavenge alien planets. Collect insane weapon parts to invent crazy guns that slay thousands. You may not survive, but your guns will!

Craft and upgrade the ultimate ship and survive an onslaught of enemies in this top down, rogue-lite shooter.

Gacha Fever is a suvivors like in a cute and colorful universe. You will fight waves of monsters with various weapons, from the machine gun to the magical girl wand and the Bubble Tea Canon ! Just be careful of the area !

Void Heart is a frenetic 2D action rogue-lite platformer with a character development system. You will go through various rooms destroying enemies and collecting items that will help you in the battle against the bosses. Enemies will become tougher with each level you complete. No checkpoints.

Sleep Stream is a roguelite survivor game that exquisitely combines the fun factors of roguelite with the tension of survival. Host a bloody livestreaming to fall asleep with synergy combinations and equipment enhancements to match Layla's various personas.