Top similar games like Cardinal Sequence:

A unique spin on the deckbuilding genre, where you must play cards and use strategy and tactics to activate ceiling mounted flame throwers to defeat the aliens and find out the truth

ASCENDANT VEIL is a sci-fi roguelike deckbuilder where you create powerful card synergies, upgrade your Exosuit with Boosters, and explore mysterious planets filled with ancient ruins, deadly creatures, and cosmic secrets.

A roguelite deck-builder based on "Daifugo". If you can't play a card, you take damage: (Field Total) x (Multiplier). Use battle rewards to customize your deck and special cards in the shop. Strategize and upgrade to defeat even stronger enemies!

Galactic Overlord is a rogue-lite deck-builder.  Travel the galaxy, hone your deck, find strange and powerful artifacts, and defeat the rebels!  Balance your deck carefully to maintain the favor you have with the different factions!

Renegade Run is an immersive deckbuilder that puts you in the pilot seat of an experimental starship. Discover anomalies, carve your path, and face powerful enemies as you battle your way back to Sector 0.

Explore the galaxy in Star Deck, a replayable roguelike card battling sci-fi adventure! Rescue your brother from the Federation, an uncompromising totalitarian presence that rules the galaxy with an iron fist. Endless story loops with unlockable new weapons, cards & items will keep you coming back!

The roguelike auto-battler where your deck prints itself! Supply a brave worker droid with synergistic blueprints to defend the planet against hordes of alien invaders. Combine hundreds of cards with custom upgrades and infinitely stackable modules to discover broken builds.

In this unique roguelike deck-builder, tend your garden and harvest plants for high scores! 100+ plants, 5 gardens, and a wealth of unique weather, animals, and tools — countless builds await!

A strategic sci-fi rogue-lite deck building game, with unique storytelling and strategic elements.

Shuffle chaos. Brew victory. A roguelike deckbuilder where relics, potions, and risky hands rule the table. An arcane twist on Cribbage where potions and relics supercharge your cards and the deck always has an attitude. Choose your build wisely, the cards show no mercy!

A rapidly escalating Minesweeper-inspired roguelike. Gain upgrades, discover new mines, and progress further based on understanding and strategy. Can you avoid running out of probes and clear all the minefields?

A whimsical roguelike deckbuilder with rich card interactions and deep synergies. Strategize through perilous space missions by assembling powerful crewmates and gadgets. Can you beat your objectives before time runs out?

A roguelike deckbuilder set in a glitching network where you build and upgrade your deck, fight enemies that telegraph their moves, and push through endlessly scaling difficulty with no run limit

Solitaire roguelike. Enter flow state while chaining combos of cards. Build the perfect deck, find the broken synergies, forget what time it is.

Disaster Blaster is a roguelite automation card game where you play a questionably sane scientist building the most over-the-top weapon in the universe. Design your blaster’s shooting mechanism and let it rip against hordes of alien enemies across a galaxy of unfortunate planets.

A galactic roguelike adventure wrapped around an extremely satisfying solitaire game about puzzling, planning and organization. Overcome increasingly difficult challenges, make piles of money, and stop an evil tyrant with the help of your eccentric companions!

Build your own fleet in this space roguelike deckbuilder. Pick your faction, draft cards mid-combat from a rotating market, and fight your way through hostile sectors one run at a time. Can you carve a path to victory through Contested Space?

ULTRAMASSIVE is a rogue-like deckbuilding game in a sci-fi setting. Embark on a journey towards the center of the galaxy, craft unique decks, fight hostile aliens, upgrade your space ship and face the unknown.

Aurora Nova is a story-driven, scifi Roguelike deckbuilder where the player is a member of an advanced species struggling to avoid extinction. Upgrade your vessels & their capabilities. Find unique events throughout the galaxy as you prepare to fight the greatest threat the Milky Way's ever seen.

"Pile Goes Up" is a roguelike deck‑builder where you stack cards in order… but you are in hell, and the devil cheats. As rounds progress, your deck destabilizes, piles grow harsher, and devilish tricks escalate. Use the shop, discover synergies, and cheat your way to salvation.

The fusion of deck-building roguelike and tower defense returns, bigger than ever! Build your deck with powerful new cards, unlock unique trinkets, and deploy enhanced towers to overcome relentless waves of enemies and new strategic challenges.

Build game-breaking combos as you ascend through challenging rituals in this strategic deck builder. Master the unique card linking resource system and discover infinite procedural possibilities.

Fox and Shadow is a scifi dual deckbuilding roguelike. Scavenge for resources in a broken city to maintain your crumbling bunker. Combine the mind of a human pilot and the body of a drone to build your cards piece by piece. The world is in ruins, salvage yourself.

Build card queues, clear escalating Nodes, unlock new decks and Modules, and chase satisfying combo turns in a chill glass-and-water deckbuilding roguelike.

Dominoir is a strategic domino roguelike where every tile can trigger explosive combos. Build powerful upgrades, manipulate the board, and chain massive scores in a stylish noir casino. Think Balatro meets Dominoes.

Star Patrol Nova is a sci-fi roguelike deckbuilder. Take control of a team of four Star Rangers with customisable skills, and a deck of cards you can modify between battles.

Explore the fantasy dungeon, use the elements flexibly, experience varied events and use different mechanisms to solve challenges. And, face powerful beings head on.

Build explosive chain reactions with balls, pegs, and cards inside a cursed arcade machine. Place and upgrade special pegs, master physics-driven bounces, and survive stages and bosses that keep rewriting the rules.

Magma Karta is a satisfying strategy card game with roguelite and gambling elements. The rules can switch at any turn, challenging you to adapt your builds and your playstyle.

If the moon was made of blue cheese would you be able to eat it? Stilton's Spire is a brutal, high-stakes roguelike challenge where you build your deck, face relentless enemies, and reach for the moon. Master the cards, conquer the Spire.

Bagatto is a pixel-art poker roguelike. Score with poker hands, multiply them with a growing arsenal of Jokers, and blow past every blind by absurd margins. Buy, sell and stack wild synergies through escalating antes and cunning boss battles — the best trick is the one you build yourself.

This is a hybrid between a card, board, and turn-based single-player game. Play cards in various ways, and discover iconic artifacts. Combine logical possibilities with an aspect of chance. Gradually map the world of this rogue-lite adventure. Walk through the portal and fight!

Odds At Oddity is a blackjack based roguelike deck builder. Manage your power betting deck, create diverse combinations and scale your points as far as you can go!

Match colors to build your own spaceship! Explore space and fight alien spacecrafts while acquiring weapons and upgrading your red ship. Become the space pilot you’ve always wanted to be.

The Galaxy is dangerous. Build your perfect deck, and dominate the skies! SuperNovem is a roguelite deckbuilder packed to the brim with tactical strategy. Fight your way through 100 levels, unlock card upgrades, build your perfect deck and tweak it as much as you want to, and win!

AsTroops is a roguelike card-based space combat game. Build your fleet, choose cards with machine gun, rocket, and electric weapons, and fight real-time battles to break the alien blockade.