Top similar games like Bioprototype:

Summonsters is a roguelike auto-battler game where you buy summons and combine artifacts to survive against oncoming enemies. Utilize summons that fight on your behalf to defeat bosses and elites. To ensure survival, strategically combine artifacts to forge powerful legendary artifacts.

Dear candidate, start your free probation period as manager of Hell! Punish sinners by using our deck-building system, constructing fiendish towers to manage underworld hordes. Good luck!

Midnight Heaven is a roguelite shooter where you fight against hordes of deep space creatures. Vision is limited. Enemies are endless. The chance of survival is low. Only the fittest will survive. Create your own build from a variety of items and devices, allocate stats, be the fittest, and survive.

Fight the underground creatures of Argion to free the land from a curse. You have to fight your way through several dungeons full of dangerous creatures and bosses. Try to utilise, level up and combine many different weapons and passive items to stand a chance of defeating them all.

Disaster Blaster is a roguelite automation card game where you play a questionably sane scientist building the most over-the-top weapon in the universe. Design your blaster’s shooting mechanism and let it rip against hordes of alien enemies across a galaxy of unfortunate planets.

Bioweaver is an RPG game with the main content of treasure hunting and character building. You can use basic programming logic to deeply customize your skill sets, and you can also create organs with different attributes and functions with the special crafting system.

In 2060, nanoweapons leaked from an Antarctic ancient ruin transformed Earth lifeforms into deadly bioweapons. As human forces retreat, you—a top frontline commander—are tasked with leading experimental 3rd-gen mech units to defend the most critical zone until civilians evacuate to near-Earth orbit.

Dear candidate, we are pleased to invite you to take up the position of manager of Hell. You will punish sinners by using our deck-building computer system to construct hellish towers capable of keeping the endless hordes of the underworld in check. Best of luck!

Welcome to the brutal wasteland!​​ Survival here is a deadly slot machine - spin to build combos and fend off hordes. Every pull could save you... or doom you.

Overture is an action-adventure roguelike which draws heavy inspiration from hits such as Diablo, Realm of The Mad God, Zelda, and The Binding of Isaac. Explore vast randomly generated dungeons and slay hordes of cunning enemies!

Auto Chess Souls is a casual strategy adventure game that combines auto-chess and roguelike elements. Through consecutive choices, your team grows increasingly stronger. Explore the unknown tower, collect powerful equipment, create unique powerful combinations. Embark on this exciting adventure now!

《Infinity Tao》is a Rogue Lite game set in the Ancient Chinese Immortal Cultivation setting. Raise your realm, build powerful Magic Treasures combinations and Synergies, kill thousands of monster and win the 30 minute game.

Fhtagn Simulator is a Cthulhu Roulette Deckbuilder. Set up card slots on roulette to maximize card's value. Collect evil creatures, spells, items and environment to build your deck. Your ultimate mission is to sacrifice spirit collected by cards to unseal the ancient gods that have come to earth!

A hardcore roguelite card game where deck-building strategies are at the core of everything! With a vast array of cards, random dungeons, a wealth of encounter events, and diverse enemies, it awaits your exploration and challenge.

Arcane Trigger is a bullet-building roguelike where every shot is crafted before it's fired. Forge over 220 bullets, shape their effects with 150+ magical seals, and master infinite synergies in this endlessly replayable strategic shooter.

Embark on an epic saga in Asgard's Fall, a norse Survivors-like Roguelite. Fight your way through hordes of creatures and let the gods feel your relentless wrath. How will your saga unfold?

Build a powerful deck, cast spells on the fly, battle evolving enemies, find game-changing artifacts, make friends or make enemies, just make it to Eden.

In "Glingdom," you're a hero in a medieval world, battling enemies and bosses with a deck of cards. Beat enemy waves and bosses, buy cards to strengthen your deck, and unlock new cards. Each deck offers unique challenges.

Stop the Crawl is a roguelike autobattler where you assemble a deck of monsters to defeat the invading heroes. Discover which monsters work well together, strengthen them with items, and create an unstoppable team.

Meow Legion is a game about assembling an army of cats to defend against waves of enemies.A top-down roguelite shooter game where you hire cats and level them up to fight mice from the evil Mousy Empire!

A top-down shooter roguelike where your cards are your ammo. Build powerful hands with Poker and Tarot cards to unleash unique attacks in real-time. Master strategic deckbuilding and bullet-hell action. A new build, a new battle, every run.

Just King is an action auto-battler with roguelike elements. Assemble your party to venture into different lands fighting fearsome kings and their deadly armies. Use your loot to hire and upgrade mighty heroes... or the bard.

Battle against hordes of enemies, conquer Boss encounters, and explore various character and skill combinations in this time-based auto-attacking Roguelite in your quest to become stronger and defeat the most menacing of creatures that lay in wait at the end of each run.

Hello everyone, this is my second game "Meta Card 2". Based on the rich card entries of the first generation, it innovatively incorporates the concept of projectiles. Through the strategic combination of cards and projectile targeting, the control of movement is replaced.

Bubble Survivor is a hack-and-slash game that combines Roguelike elements with team-based gameplay. You will summon like-minded heroes to conquer challenges and defeat the malevolent slimes, restoring light to the world!

Mystic Explorer is a treasure rogue game. Players will play the role of treasure hunter in search of treasure chests in the siege of monsters, defeat the ever stronger enemies, and bring back your own archive treasures.

DEFRAG is a game about cleansing corrupted sectors and refining them through optimization to build a stronger system. Collect resources, adjust configurations, and complete your build as you progress.

Crop Rotation is a farming-theme card drafting game. Cards are played automatically so you can focus on the deck building and building synergies.

In Nine Lives Ninja: Survive you are a cat (who also happens to be a ninja) forced to fight for your lives against hordes of evil woodland creatures. Choose which abilities to focus on, which attributes to increase, and see if you can survive to fight another day.

Survive a nightmare-tainted world in this thrilling roguelike! With dozens of characters, hundreds of weapons/items, and build freedom, challenge limits across maps. Slay monsters, level up, collect gold, upgrade gear—can you endure the Nightmare Tide?

Simulation Room is a fast-paced 2D auto-battler with deck-building mechanics. Unleash powerful program combos, upgrade abilities, summon allies, and equip weapons. Control the battlefield by altering terrain and weather, using gadgets to outsmart enemies. Every move counts—strategize and dominate!

Sidequest Survivors is a bullet-heaven roguelite where you control wacky characters, mow down waves of magical creatures, and tackle sidequests. Choose from a variety of weapons and create builds that match your playstyle.

Building on the rich card entries of the first generation, this game innovatively incorporates the concept of projectiles. With strategic card combinations and projectile aiming and bouncing features, it guarantees you a refreshing, one-of-a-kind experience with no alternatives online!