Top similar games like Siege of Centauri:

Classic Tower Defense meets space exploration. Build turrets on mining platforms, harvest enemies to build more defenses, and mine Dark Energy to travel the stars. As a sentient AI, you must upgrade your tech, scan planets, and find a new home for humanity before Earth fades away.

Rise of Mutant Swarms is a strategy survival tower-defense game where you defend the base against waves of evolving mutant enemies. Place and upgrade turrets, adapt to enemy abilities, and make critical decisions as the pressure rises with every wave.

Cubic Annihilation is a fast-paced RTS that demands skill and tactical thinking. Build your own faction by crafting a custom loadout of units, structures, and modifiers, then command cubic armies across land, sea, and air in tight, real-time combat.

Join our machine legion to conquer the world.

Sci-fi tower defense meets ARPG-like hero combat. Build towers then fight alongside them with your hero as you battle through a campaign to uncover the fate of a colonization effort on a distant planet.

A planetary tower defense where enemies attack across land, air, and space. Build layered defenses, manage resources, and survive an escalating alien invasion.

Do you like Tower Defense games with Strategy elements? Well, look no further! We've got exactly what you're looking for! Get ready to defend your settlement from enemies using a huge arsenal of towers!

Lead the Mobile Infantry in this RTS game set in the Starship Troopers film universe. Balance your army composition with a diverse set of unit types, overcome line-of-sight and line-of-fire challenges through tactical positioning, and use special abilities to smash the Arachnid hordes!

Take on the role of commander and protect Earth from the relentless Drone invasion in this exciting tower defense game. Strategize and strengthen your defenses by utilizing a variety of towers, abilities, and elemental upgrades. It's up to you to lead the charge and save humanity from destruction.

Defend your base by placing towers strategically, forming interconnected systems that depend on one another. Adapt your strategy to different environments and enemy waves, exploiting their weaknesses. In System Status: SuperCritical, resources are scarce and critical failure is always an option.

Battle for galactic dominance in this real-time 4X strategy game with unrivaled scale! You’ll explore, expand, exploit, and exterminate through military force, diplomacy, trade, culture, influence, and other underhanded tactics.

Build your towers, plan your efforts, watch out for changing paths and strike back against the alien invaders in this challenging tower defense game!

Assume control of an evil intergalactic megacorporation in this sci-fi tower defense. Build a mining infrastructure on alien moons and exoplanets, exploit their precious resources, and defend your operation against defiant natives.

The last days of man are at hand.. Two years after the Infinite War the once great warring nations now lie in ruins, and humanity’s hope for a brighter future is nothing but a bitter memory. A new, seemingly unstoppable enemy, supported by the zealots of The Order, now seeks to eradicate mankind: UEF, Aeon Loyalist, and Cybran alike.

Rule the battlefield from orbit! Crystal Nexus: Alien Siege is a hybrid deckbuilding tower-defense game that puts you in charge of outposts on hostile alien planets. Look down on the battlefield from your space station and deploy towers, weapons, and buffs from the cards you’ve collected!

Lead an unlikely team of commando scientists behind enemy lines to fight Nazis, uncover arcane mysteries, and wield experimental technology to turn the tide of WWII in this real-time tactical stealth adventure.

An atmospheric tower-defence strategy game about holding back an oozing toxic Tide. A distant mining colony has awakened a living flood that seeps from breaches in the ground. Dig for resources, raise the land for defence, and burn your way to seal the breeches. Can you survive the Biletide?

On planets occupied by robots, mine resources and escape while fending off their attacks! The Ark's survival is entirely in your hands. Many elite crews with abilities will assist you in your mission. The various turret modules are always doing their best to defend your base without your attention.

Command humanity’s last defenses in a cinematic sci-fi tower defense game. Build tactical towers, upgrade your arsenal, deploy soldiers, and survive waves of hostile AI forces led by VAELRA.

Taur is an action-strategy sci-fi game. Control the Prime Cannon and unlock all of its powerful weapons and abilities. Build turrets, droids, aircraft and more as you fight to protect the homeworld of the Tauron droids against a relentless invasion. Will your Taur stand against the Imperion warmachine?

The ULTIMATE tower defense onslaught is back. Bigger, deadlier, and more action-packed. Build autonomous defenses, deploy tactical drones, and unleash devastating support abilities in this epic, old-school RTS-inspired sci-fi adventure.

A sci-fi low-poly tower defense game. Design your defense against waves of aliens using a wide arsenal of different towers.

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

Fight battles through human history, defeat your enemies and save humanities future! The Unwanted War lets you follow history itself and take influence on humanities ultimate fate. Are you going to use your knowledge and power for good or will you bring doom over the human race?

Fight for control of a frontier world. Gather resources, build your base, and command your forces in battle. Survive long enough to unleash your ultimate weapon - THE EPIC.

Engineered to Purpose is a new tower defence game where you custom-design towers to defend your base, with millions of builds to explore and refine. Set in the far future, E2P's story of posthumanism, family, and change will open new worlds to explore and survive.

Millennium Conflict: a real-time strategy game set in space where you must act fast to stop attackers from conquering your universe. With 40 levels, weapon upgrades, and new generals to recruit, it's up to you as the only surviving male to lead your troops to victory.

A unique 3D tower defense game set on randomly generated planets! Place towers to defend against 360-degree attacks, protect mining outposts, and survive intense meteor waves. Earn resources, and face endless replayability with dynamic challenges every playthrough!

In Sins of a Solar Empire: Trinity, you are the leader of a civilization embroiled in a galactic war, fighting for the survival of your entire race against relentless foes.

Defend humanity from the Athral Vanguard in Athralis Tower Defense. As the S.O.D.S. Commander, deploy manned turrets and advanced equipment from orbit to stop alien invasions. Experience intense sci-fi tower defense action and strategic gameplay.

The Elgem Nexus is under attack! Protect it by killing enemies, upgrading gems, and discovering powerful combinations. Not all gems grow the same, and the randomness creates infinite replayability in this element-themed tower defense game.

A classic tower defense game with ordinary graphics didn't fascinate you? Well, let's give a try and see how long you can defend! Show your commanding skills and prove no enemy can break your defense! Be a hero and save humanity with the LAST DEFENSE!

Sudden Strike is back! The beloved Real Time Strategy series returns, this time with bigger battlefields, more units, better graphics, new scenarios and legendary commanders – making Sudden Strike 4 more tactical and realistic than ever before!

Co-op and Single player Tower Defense genre.

Destroy. Salvage. Repair. Upgrade. PROFIT! A real-time tactical experience where you command your own mercenary outfit of mechs and mercs and adventure through randomly generated missions filled with rewards, glory, and bitter defeat.

Button Pop is a 3D Tower defense game fused with Button mashing chaos. Construct the deadliest defense strategies by unlocking powerful traps and turrets across a variety of terrains, while building your very own button with the rewards of your adventures!