Top similar games like The Binding of Isaac:

Spelunky is a unique platformer with randomized levels that offer a challenging new experience each time you play. Journey deep underground and explore fantastic places filled with all manner of monsters, traps, and treasure.

Fast paced bullet hell roguelike. Upgrade your weapons and abilities as you collect attribute blocks. Highly customisable with lots of combinations. Fight bosses, pick up items and improve your stats. Unlock new items and achievements for the next run through the ever-changing dungeon.

Vile is an action rogue-lite about fighting demonic creatures and other horrors throughout a vile world. Fight enemies and/or complete random objectives given to you in procedurally-generated dungeons to put a stop to the creatures forever! Collect souls, find new weapons, new artifacts, and battle EPIC bosses!

Straimium Immortaly is a shmup roguelike dungeoncrawler. Explore the butts-hard procedurally generated Cubicus battling beasties, looting endless item and weapon upgrades and defeating huge boss meanies in your vengeful quest to eradicate the Queeni Emperess.

In this fast-paced rogue-lite, your health points are your only resource: sacrifice them to acquire vampiric powers and devour your enemies to heal yourself! Beware: every drop of blood counts in this frantic race to defeat the apostles of the Cult of the Sun!

Animal Rogues is a dark rogue-lite dungeon crawler bullet-hell with rpg elements. You play as an animal who fights against one possessed beast after another! Discover unique interactable objects such as slot machines, dices.. Collect magical items and level up to become more and more powerful!

Skelly Selest is a score-attack hack slash dash run 'n' gun-athon. Venture into the procedurally generated perdition depths of Hell to purge the evil taint of the Deamonica Netherlords and their fiendly followers.

Risk of Rain is an action platformer with roguelike elements. With permanent death as a primary feature, players will have to play their best to get as far as possible. Fight on a mysterious planet with randomly spawning enemies and bosses, either alone or with 3 friends in online co-op.

In this top-down roguelike shooter game you go through levels of enemies to defeat [???] which escaped from [???]. You do this with the help of weapons and items you find on the way. You can equip up to two weapons. Mix and match the weapons and items you find to make combos that work together!

Cast spells, dash around hordes of enemies, and assemble powerful combos as you explore procedurally generated dungeons. Chaos Caster is an action roguelike focused on strategy, playstyle variety, and replayability.

Play as the titular Archer Hero in this procedurally generated roguelike, as he sets off to climb the mysterious tower that suddenly appeared one day. Conquer the numerous floors, defeat the monsters that lurk in the shadows and solve the puzzles of this enigmatic tower.

Lab Remnants is a monochromatic roguelike full of secrets and challenges. Play as an artificially made creature and make your way through your own creators to escape from their crazy experiments.

Bull et Hell is a roguelike top down shooter. But everything is on Bullet Time, outnumbered and outgunned, shoot your enemies, and maneuver through a chaotic storm of slow-motion bullets.

The Last Strand is randomly generated twin stick shooter. You will play a pirate trying to escape a boat and seek vengeance, fighting enemies, helping NPC, discovering secrets and finding items.

WarSphere is a fast-paced, roguelike top-down shooter. As a spherical death robot, you blast, dash and loot your way through procedurally generated worlds. It's all about the pew pew.

A roguelike tower defense game with a dash of deckbuilding. Choose a reward, improve your build, survive the next wave, repeat. Highly replayable, difficult, and addictive. You'll want just one more wave, just one more run!

Never Split the Party is an ultra social rogue-like! You're one of four adventurers joining together to explore a procedurally generated dungeon, amass powerful upgrades, and cooperate with your fellow adventures to conquer and crush the evil dungeon champions!

Folly Of The Wizards is a comedic 2D roguelike action game that puts you in the shoes of a clumsy wizard apprentice. Join a wacky wizard cult and use unique spells to defeat enemies, explore procedurally generated dungeons, and save the world from chaos.

Worm Slayer is a Fast-Paced Bullet Hell Roguelike where you must fight your way through the dungeon that is the Worm King's den to finally reach and then defeat the Worm King.

Super House of Dead Ninjas is an action arcade game with roguelite elements. Race against a 30 second timer as you descend floor after foe-filled floor and attempt to unlock the secrets of this deadly tower!Play as the fearsome Crimson Ninja, wielding an arsenal of deadly ninja weapons and attacks.

In this fast-paced action roguelike, mutant cats hidden from the world for years find that life outside is so cool, they don’t want to go back home. For that, you'll have to fight through and conquer the heart of the zombie-infested County of Ravinbrook. It's the only way to Catland

BATTLECASTER is a challenging fast paced arena roguelike. Defend yourself against unrelenting enemies and overcome difficult encounters. Use abilities strategically to control the ring of combat.

Fight your way through randomly generated dungeons in this hardcore rouge-lite game. Discover your favorite character from a group of unique heroes and get powerful weapons or power-ups to save beautiful princesses in need.

Star Bind is an increasingly fast-paced action dungeon crawler where you'll need to shoot, dodge, loot, learn, and improve to escape a bizarre simulation.

Action RPG Roguelike. Evolve your abilities and push yourself through a procedurally generated level. Think hard about your choices, itemize well and use your skills to reach the end.

In this game, you are the bullet hell. Face off against 100 waves of enemies and bosses by collecting a deck of attack cards that activate in real-time to unleash destruction upon everything in sight. There's an insane amount of customizability leading to an infinitely replayable experience.

Orbit Express is a physics-based roguelike game. Pilot your delivery spacecraft through a procedurally generated galaxy, creating a unique challenge every time you play. Avoid collisions, upgrade your craft, mind your fuel, and master your flying skills, all for a minimum wage!

Dodge and destroy robots with knights, level-up by evading bullets, explore randomized dungeons, and unlock game-changing relics. Do this in one attempt to become the King.

Roguelike bullet hell shooter, where you fend off waves of attacking monsters in a constantly transforming arena. You are rewarded with upgrades to your vulnerable spaceship if you survive long enough.

Randotura is a top-down action roguelike with inventory management. Dive into bullet hell action and collect unique modifiers, all in a selfmade dungeon.

Blast your enemies! Create the ultimate build! Travel to the edge of space, in this epic rogue-lite action packed bundle of chaos inspired by slay the spire & FTL.

Rogue Runner is a fast-paced Rogue-like, third-person shooter - action and platformer. You must run to break through the possibility you're stuck in. As you run you will discover different possibilities. Run, Kill, Die, Improve and Repeat to break the cycle!

Elementum is a spell-crafting roguelike with bullet-hell elements. Fight your way out by defeating a wide range of enemies and discover a variety of spells and items to customize your build and play style!