Top similar games like The Binding of Isaac:

Animal Rogues is a dark rogue-lite dungeon crawler bullet-hell with rpg elements. You play as an animal who fights against one possessed beast after another! Discover unique interactable objects such as slot machines, dices.. Collect magical items and level up to become more and more powerful!

Sealer of Dungeons is an action-shooter with Rogue-lite elements. Play Sealers on their journey, you will find great treasures and abilities to seal the unknown evil above. Gather precious loot, discover hidden secrets, and chat with merchants to get powerful items. Seal the dungeon, save the world!

In Enlightenment, you play in a roguelike action-shooter with a fast-paced challenging journey deep into a underground complex called "the Ark". Players will be tested by large varieties of enemies in a procedurally-generated dungeon, and become stronger by learning from the inevitable deaths.

The ROGUELITE that feels like a ROGUELIKE. Praised for its fantastically generated dungeons, real-time combat and surprising amount of content and depth. One of the BEST GAMES OF THE YEAR according to PC Gamer and VICE Waypoint.

Skelly Selest is a score-attack hack slash dash run 'n' gun-athon. Venture into the procedurally generated perdition depths of Hell to purge the evil taint of the Deamonica Netherlords and their fiendly followers.

Reynard is a mixture of procedurally generated action RPG and a Tower Defense genre with roguelike elements. It has been influenced by classics such as The Legend of Zelda and an indie classic - The Binding of Isaac.

Seedovia is a rogue-like dungeon crawler where you traverse room after room, fighting challenging monsters. Chain your weapons, collect game-changing passive upgrades, and equip items to create unique builds and become increasingly more powerful.

Worm Slayer is a Fast-Paced Bullet Hell Roguelike where you must fight your way through the dungeon that is the Worm King's den to finally reach and then defeat the Worm King.

Modest Kind is a Rogue-lite Initiation Adventure. Ever heard of Entropy, The Selfish Gene and Schrödinger's cat? This action-heavy, story-driven top-down dungeon crawler will put your knowledge to the test. Your Path to Enlightment begins now.

A rogue-like dungeon crawler where each playthrough offers a unique experience. Play as a small hero climbing a tower filled with deadly traps, cunning enemies, and powerful bosses. Face a dark curse threatening the world, uncover secrets, and collect upgrades in a constantly changing labyrinth.

ScourgeBringer is a fast-paced free-moving roguelite platformer. Help Kyhra to explore the unknown and slash her way through ancient machines guarding the seal of her past, and maybe the redemption of humanity.

Play as the titular Archer Hero in this procedurally generated roguelike, as he sets off to climb the mysterious tower that suddenly appeared one day. Conquer the numerous floors, defeat the monsters that lurk in the shadows and solve the puzzles of this enigmatic tower.

Roguely is a fantasy themed top-down shooter pixel art action roguelite with some bullet hell thrown in. Fight and dodge your way through the randomly generated maps to rescue your friends. Find upgrades along the way and save up arcane fragments for permanent blessings from the gods.

Hollow Mine is an action roguelite that combines mining, crafting, and intense 2D top-down combat. Explore unpredictable, ever-changing mines, battle fierce enemy hordes, and confront tough bosses. Engage, die, learn, and repeat as you uncover new challenges with every run.

Star of Providence is a top down action shooter with procedurally generated elements. Explore a large, abandoned facility in search of incredible power, fighting dangerous foes and gaining new weapons and upgrades as you progress.

Battle Planet - Judgement Day is a planetary rogue-lite top-down shooter. You are one of the universe's 3 most wanted criminals on the run, fighting your way through hordes of aliens, military and police units. There is only one way to reclaim your freedom - destroy them all...

By night, delve deep into your subconscious and discover powerful artifacts to conquer your nightmares. By day, explore the city of Redhaven and build relationships to unlock the power of your dreams. DREAM. DIE. WAKE. REPEAT.

Shapes & Shots is a Roguelite Shooter Bullet-hell, where you can control time as you make your way through a twisted and delusional universe. Your enemies will merge, creating infinite combinations to try to overwhelm you: only your skills, combined with upgrades you choose, can lead you to victory.

In this top-down roguelike shooter game you go through levels of enemies to defeat [???] which escaped from [???]. You do this with the help of weapons and items you find on the way. You can equip up to two weapons. Mix and match the weapons and items you find to make combos that work together!

In this fast-paced rogue-lite, your health points are your only resource: sacrifice them to acquire vampiric powers and devour your enemies to heal yourself! Beware: every drop of blood counts in this frantic race to defeat the apostles of the Cult of the Sun!

Lab Remnants is a monochromatic roguelike full of secrets and challenges. Play as an artificially made creature and make your way through your own creators to escape from their crazy experiments.

Shapes & Shots is a Roguelite Shooter Bullet-hell, where you can control time as you make your way through a twisted and delusional universe. Your enemies will merge, creating infinite combinations to try to overwhelm you: only your skills, combined with upgrades you choose, can lead you to victory.

A simple, action-packed, arcade bullet hell game with progression system and some roguelite elements, where almost everything is a square! There are 100 randomized waves of enemies to beat, which includes 4 deadly boss encounters.

Ever dreamt of being a space potato? Now’s your chance! Space Gladiators is a 2D hand-drawn roguelite platformer following a bunch of captives fighting their way out of a planet prison. Defeat hordes of aliens in the gladiatorial arenas and earn your freedom!

Shadow of the Depth is a top-down action Roguelite game. Delve into a dungeon world of light and shadow to eradicate the monsters that ravage your home. Be prepared to step into the abyss before you!

Straimium Immortaly is a shmup roguelike dungeoncrawler. Explore the butts-hard procedurally generated Cubicus battling beasties, looting endless item and weapon upgrades and defeating huge boss meanies in your vengeful quest to eradicate the Queeni Emperess.

Fast paced bullet hell roguelike. Upgrade your weapons and abilities as you collect attribute blocks. Highly customisable with lots of combinations. Fight bosses, pick up items and improve your stats. Unlock new items and achievements for the next run through the ever-changing dungeon.

You are Zildo, the janitor of a company where employees have been replaced by robots. Enraged, you decide to destroy all of them and reclaim your place. Explore procedurally generated worlds, find weapons, and use power-ups to win.

Cast spells, dash around hordes of enemies, and assemble powerful combos as you explore procedurally generated dungeons. Chaos Caster is an action roguelike focused on strategy, playstyle variety, and replayability.

Barbarization is a roguelite dungeon crawler with elements of bullet hell and RPG. Loot weapons, rare items, and special ability cards to build a unique character each run. Face enemy hordes and challenging bosses to claim new territories and expand your civilization.

Rush Rover is a 2D top-down shooter game. Compared to other similar games of the genre, the shooting experience is closer to traditional shoot'em up games. It includes random map generation, unique weapons, lots of different enemies, exciting boss battles and a dynamic chiptune soundtrack.

Dungeon of Insanity is an action-adventure roguelike that puts the hero inside a dungeon full of enemies, traps, gold, and crazy characters. Face the undead, find treasures, save the princess, beat up the necromancer.