Top similar games like The Binding of Isaac:

Spelunky is a unique platformer with randomized levels that offer a challenging new experience each time you play. Journey deep underground and explore fantastic places filled with all manner of monsters, traps, and treasure.

Reynard is a mixture of procedurally generated action RPG and a Tower Defense genre with roguelike elements. It has been influenced by classics such as The Legend of Zelda and an indie classic - The Binding of Isaac.

Modest Kind is a Rogue-lite Initiation Adventure. Ever heard of Entropy, The Selfish Gene and Schrödinger's cat? This action-heavy, story-driven top-down dungeon crawler will put your knowledge to the test. Your Path to Enlightment begins now.

Skelly Selest is a score-attack hack slash dash run 'n' gun-athon. Venture into the procedurally generated perdition depths of Hell to purge the evil taint of the Deamonica Netherlords and their fiendly followers.

Journey to the dark heart of the Edgewood Home for Lost Children in this fiendishly difficult action RPG!When her teacher stepped out of the classroom a month ago, Cordy never imagined he would be gone for good. Now her fellow students have turned on each other as the school descends into chaos.

Play as the titular Archer Hero in this procedurally generated roguelike, as he sets off to climb the mysterious tower that suddenly appeared one day. Conquer the numerous floors, defeat the monsters that lurk in the shadows and solve the puzzles of this enigmatic tower.

Worm Slayer is a Fast-Paced Bullet Hell Roguelike where you must fight your way through the dungeon that is the Worm King's den to finally reach and then defeat the Worm King.

In Enlightenment, you play in a roguelike action-shooter with a fast-paced challenging journey deep into a underground complex called "the Ark". Players will be tested by large varieties of enemies in a procedurally-generated dungeon, and become stronger by learning from the inevitable deaths.

Nuclear Throne is a post-apocalyptic roguelike-like top-down shooter. Not 'the final hope of humanity' post-apocalyptic, but 'humanity is extinct and mutants and monsters now roam the world' post-apocalyptic. Fight your way through the wastelands with powerful weaponry, collecting radiation to mutate some new limbs and abilities.

Risk of Rain is an action platformer with roguelike elements. With permanent death as a primary feature, players will have to play their best to get as far as possible. Fight on a mysterious planet with randomly spawning enemies and bosses, either alone or with 3 friends in online co-op.

Vile is an action rogue-lite about fighting demonic creatures and other horrors throughout a vile world. Fight enemies and/or complete random objectives given to you in procedurally-generated dungeons to put a stop to the creatures forever! Collect souls, find new weapons, new artifacts, and battle EPIC bosses!

Conquer the forces of Death in A Wizard’s Lizard, an action RPG for Windows, Mac, and Linux. Explore ever-changing dungeons, filled with powerful weapons and items. Battle back the hordes of evil. Rescue villagers to improve your town and increase your power for your next trek into the dungeon.

Battle Planet - Judgement Day is a planetary rogue-lite top-down shooter. You are one of the universe's 3 most wanted criminals on the run, fighting your way through hordes of aliens, military and police units. There is only one way to reclaim your freedom - destroy them all...

Eternal Step is a deviously difficult, rogue-like action adventure game.

In this fast-paced rogue-lite, your health points are your only resource: sacrifice them to acquire vampiric powers and devour your enemies to heal yourself! Beware: every drop of blood counts in this frantic race to defeat the apostles of the Cult of the Sun!

Danger Gazers is a post-apocalyptic roguelite top-down shooter where you pave your own path. The choices you make will decide your fate, it will either turn you into the new ruler or... the ashes to be windswept away.

Straimium Immortaly is a shmup roguelike dungeoncrawler. Explore the butts-hard procedurally generated Cubicus battling beasties, looting endless item and weapon upgrades and defeating huge boss meanies in your vengeful quest to eradicate the Queeni Emperess.

ScourgeBringer is a fast-paced free-moving roguelite platformer. Help Kyhra to explore the unknown and slash her way through ancient machines guarding the seal of her past, and maybe the redemption of humanity.

By night, delve deep into your subconscious and discover powerful artifacts to conquer your nightmares. By day, explore the city of Redhaven and build relationships to unlock the power of your dreams. DREAM. DIE. WAKE. REPEAT.

Star of Providence is a top down action shooter with procedurally generated elements. Explore a large, abandoned facility in search of incredible power, fighting dangerous foes and gaining new weapons and upgrades as you progress.

Hollow Mine is a roguelike hack-and-slash dungeon crawler. Explore mysterious mines where levels are generated randomly every play. Fight enemy hordes and tough bosses. You can choose from various weapons and abilities to upgrade your character and create your own combination.

A simple, action-packed, arcade bullet hell game with progression system and some roguelite elements, where almost everything is a square! There are 100 randomized waves of enemies to beat, which includes 4 deadly boss encounters.

Dungreed is a 2D side-scrolling action game with 2D Rogue-LITE elements. You become an adventurer exploring a continuously evolving dungeon to prevent the town from being destroyed. Eliminate enemies, use a variety of weapons and magic, eat food, and defeat evil in the dungeon!

The ROGUELITE that feels like a ROGUELIKE. Praised for its fantastically generated dungeons, real-time combat and surprising amount of content and depth. One of the BEST GAMES OF THE YEAR according to PC Gamer and VICE Waypoint.

Cast spells, dash around hordes of enemies, and assemble powerful combos as you explore procedurally generated dungeons. Chaos Caster is an action roguelike focused on strategy, playstyle variety, and replayability.

Sealer of Dungeons is an action-shooter with Rogue-lite elements. Play Sealers on their journey, you will find great treasures and abilities to seal the unknown evil above. Gather precious loot, discover hidden secrets, and chat with merchants to get powerful items. Seal the dungeon, save the world!

Aura of Worlds is a chaotic, creative tactics rogue-lite platformer. Explore multiple dangerous worlds where you utilize creative abilities & wield the environment to your advantage. Blast, dash, grapple, fight, and charm your way through ever-changing labyrinths & outwit powerful guardians!

Hecaton is futuristic action rogue-like set on Titan, a terraformed moon of Saturn. Play as a Bounty Hunter and fight your way through an army of space pirates. Brave the surface of Titan and begin your descent to find the Pirate Base and your ultimate goal.

Animal Rogues is a dark rogue-lite dungeon crawler bullet-hell with rpg elements. You play as an animal who fights against one possessed beast after another! Discover unique interactable objects such as slot machines, dices.. Collect magical items and level up to become more and more powerful!

Tower defense reimagined! Dead Ground is a procedurally generated tower defense game with rogue-like elements. Each playthrough will offer randomly generated guns, skills and augments. You'll have to travel, collect scrap, water, manage your inventory and upgrade your base to survive!