Top similar games like The Binding of Isaac, The Binding of Isaac: Rebirth:

Skelly Selest is a score-attack hack slash dash run 'n' gun-athon. Venture into the procedurally generated perdition depths of Hell to purge the evil taint of the Deamonica Netherlords and their fiendly followers.

Reynard is a mixture of procedurally generated action RPG and a Tower Defense genre with roguelike elements. It has been influenced by classics such as The Legend of Zelda and an indie classic - The Binding of Isaac.

Seedovia is a rogue-like dungeon crawler where you traverse room after room, fighting challenging monsters. Chain your weapons, collect game-changing passive upgrades, and equip items to create unique builds and become increasingly more powerful.

ScourgeBringer is a fast-paced free-moving roguelite platformer. Help Kyhra to explore the unknown and slash her way through ancient machines guarding the seal of her past, and maybe the redemption of humanity.

Ever dreamt of being a space potato? Now’s your chance! Space Gladiators is a 2D hand-drawn roguelite platformer following a bunch of captives fighting their way out of a planet prison. Defeat hordes of aliens in the gladiatorial arenas and earn your freedom!

Never Split the Party is an ultra social rogue-like! You're one of four adventurers joining together to explore a procedurally generated dungeon, amass powerful upgrades, and cooperate with your fellow adventures to conquer and crush the evil dungeon champions!

Straimium Immortaly is a shmup roguelike dungeoncrawler. Explore the butts-hard procedurally generated Cubicus battling beasties, looting endless item and weapon upgrades and defeating huge boss meanies in your vengeful quest to eradicate the Queeni Emperess.

Happy hour has arrived! Become the NecroBouncer and toss out rowdy guests in a roguelike adventure through the nightclub dungeon. Raise the dead, discover hundreds of relics, ban enemies and gobble up their powers. It’s one hell of a good time!

Scarlett's Dungeon is a retro-inspired action RPG dungeon crawler with roguelite elements. Explore randomly generated dungeons, fight monsters, and collect loot in beautifully crafted pixel art reminiscent of the Game Boy Advance era. Test your skills as you dive deep into ever-changing challenges!

In Enlightenment, you play in a roguelike action-shooter with a fast-paced challenging journey deep into a underground complex called "the Ark". Players will be tested by large varieties of enemies in a procedurally-generated dungeon, and become stronger by learning from the inevitable deaths.

Eko and the Bewitched Lands is a randomly generated Action Adventure RPG with Rogue-like and Puzzle elements. Help Eko rescue the Princess from the Dark Queen. During your journey you will find different weapons, abilities and artifacts that will change the way you play.

Lab Remnants is a monochromatic roguelike full of secrets and challenges. Play as an artificially made creature and make your way through your own creators to escape from their crazy experiments.

The ROGUELITE that feels like a ROGUELIKE. Praised for its fantastically generated dungeons, real-time combat and surprising amount of content and depth. One of the BEST GAMES OF THE YEAR according to PC Gamer and VICE Waypoint.

Dodge enemies' attacks, activate lethal traps and customize your hero in StormEdge. Brace yourself for the dangerous Elemental Storms that will put your skills to the test!

Star of Providence is a top down action shooter with procedurally generated elements. Explore a large, abandoned facility in search of incredible power, fighting dangerous foes and gaining new weapons and upgrades as you progress.

Shapes & Shots is a Roguelite Shooter Bullet-hell, where you can control time as you make your way through a twisted and delusional universe. Your enemies will merge, creating infinite combinations to try to overwhelm you: only your skills, combined with upgrades you choose, can lead you to victory.

Dungreed is a 2D side-scrolling action game with 2D Rogue-LITE elements. You become an adventurer exploring a continuously evolving dungeon to prevent the town from being destroyed. Eliminate enemies, use a variety of weapons and magic, eat food, and defeat evil in the dungeon!

Risk of Rain is an action platformer with roguelike elements. With permanent death as a primary feature, players will have to play their best to get as far as possible. Fight on a mysterious planet with randomly spawning enemies and bosses, either alone or with 3 friends in online co-op.

Live the life of space captain Flinthook! Armed with your mighty hookshot, your uncanny slow-motion powers and your trusty blasma pistol, plunder and fight your way through an infinite variety of randomly-assembled spaceships for treasure, loot and fame!

The Last Strand is randomly generated twin stick shooter. You will play a pirate trying to escape a boat and seek vengeance, fighting enemies, helping NPC, discovering secrets and finding items.

By night, delve deep into your subconscious and discover powerful artifacts to conquer your nightmares. By day, explore the city of Redhaven and build relationships to unlock the power of your dreams. DREAM. DIE. WAKE. REPEAT.

SURVIVE in a transforming arena against ALIEN OGRES in this ROGUELIKE BULLET-HELL 💥 MODIFY your gun, make smart upgrade decisions and master your spaceship's controls to conquer the OGRE CHAMBERS !

Rush Rover is a 2D top-down shooter game. Compared to other similar games of the genre, the shooting experience is closer to traditional shoot'em up games. It includes random map generation, unique weapons, lots of different enemies, exciting boss battles and a dynamic chiptune soundtrack.

Vile is an action rogue-lite about fighting demonic creatures and other horrors throughout a vile world. Fight enemies and/or complete random objectives given to you in procedurally-generated dungeons to put a stop to the creatures forever! Collect souls, find new weapons, new artifacts, and battle EPIC bosses!

Risk the Dark is an action-filled top-down roguelite set in harrowing darkness. Struggle to escape a shadowy, monster-infested cave while battling threat after threat. Using a variety of weapons, melee, as well as interactions with NPCs and items, light your way and Risk the Dark.

Roguely is a fantasy themed top-down shooter pixel art action roguelite with some bullet hell thrown in. Fight and dodge your way through the randomly generated maps to rescue your friends. Find upgrades along the way and save up arcane fragments for permanent blessings from the gods.

Roguelike bullet hell shooter, where you fend off waves of attacking monsters in a constantly transforming arena. You are rewarded with upgrades to your vulnerable spaceship if you survive long enough.

Rogue Legacy 2 is what you'd get if you mashed Rogue Legacy and a sequel together. Every time you die, your children will succeed you, and each child is unique. Your daughter might be a Colourblind Archer, and your son could be a Pacifistic Chef. Either way, one of them is getting conscripted.

Modest Kind is a Rogue-lite Initiation Adventure. Ever heard of Entropy, The Selfish Gene and Schrödinger's cat? This action-heavy, story-driven top-down dungeon crawler will put your knowledge to the test. Your Path to Enlightment begins now.

Get ready to face Yokais of all shapes and sizes! A challenging platformer Roguelike that brings you up close to all Eastern legends as you go through procedurally generated levels!