Top similar games like The Binding of Isaac: Rebirth:

Never Split the Party is an ultra social rogue-like! You're one of four adventurers joining together to explore a procedurally generated dungeon, amass powerful upgrades, and cooperate with your fellow adventures to conquer and crush the evil dungeon champions!

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Toroom is a dungeon crawler roguelike-like top-down shooter, where the protagonist just wants to come back to his bedroom after waking up in a world of fantasy. Fight your way through multiple biomes, clear rooms full of enemies, get as much loot as possible and defeat the bosses in your way.

Straimium Immortaly is a shmup roguelike dungeoncrawler. Explore the butts-hard procedurally generated Cubicus battling beasties, looting endless item and weapon upgrades and defeating huge boss meanies in your vengeful quest to eradicate the Queeni Emperess.

Lab Remnants is a monochromatic roguelike full of secrets and challenges. Play as an artificially made creature and make your way through your own creators to escape from their crazy experiments.

Skelly Selest is a score-attack hack slash dash run 'n' gun-athon. Venture into the procedurally generated perdition depths of Hell to purge the evil taint of the Deamonica Netherlords and their fiendly followers.

Explore 6 x 6 x 6 = 216 rooms of randomly generated hazards and enemies while collecting the necessary artefacts. Hundreds of monsters are roaming inside, guarding the sword shards — the last known thing to be capable of defeating the demonic castle owner.

Risk of Rain is an action platformer with roguelike elements. With permanent death as a primary feature, players will have to play their best to get as far as possible. Fight on a mysterious planet with randomly spawning enemies and bosses, either alone or with 3 friends in online co-op.

Spelunky is a unique platformer with randomized levels that offer a challenging new experience each time you play. Journey deep underground and explore fantastic places filled with all manner of monsters, traps, and treasure.

Worm Slayer is a Fast-Paced Bullet Hell Roguelike where you must fight your way through the dungeon that is the Worm King's den to finally reach and then defeat the Worm King.

Legend of Dungeon is a randomly generated action RPG Beat'em'up with heavy Rogue-like elements, striking visuals, and dynamic music.

Phobias have awoken in this dark roguelike shooter One by One! Dive into procedural dungeons, unlock forbidden equipment, unleash the might of your soul and strike down bosses to save the world.. or is it late?

Little Adventures is a randomly generated Dungeon crawler, with heavy Rogue-like elements. Throughout the game players will find shops and upgrades which helps, to fight mysterious creatures throughout 5 randomly generated levels.

Spirits Abyss is a roguelite platformer with destructible terrain. Cast into the Abysm you must explore its diverse depths battling phantasmic meanies and plundering its useful treasures to find a way home... but does something nestle beyond the realmic veil of death?

Sealer of Dungeons is an action-shooter with Rogue-lite elements. Play Sealers on their journey, you will find great treasures and abilities to seal the unknown evil above. Gather precious loot, discover hidden secrets, and chat with merchants to get powerful items. Seal the dungeon, save the world!

Wizard of Legend is a no-nonsense, action-packed take on wizardry that emphasizes precise movements and smart comboing of spells in a rogue-like dungeon crawler that features over a hundred unique spells and relics!

A challenging action RPG with deep souls-like combat and rogue-like elements. Explore a dreadful dungeon and fight smart enemies that will plan and collaborate between themselves to defeat you.

Enter the Gungeon is a bullet hell dungeon crawler following a band of misfits seeking to shoot, loot, dodge roll and table-flip their way to personal absolution by reaching the legendary Gungeon’s ultimate treasure: the gun that can kill the past.

Crawl is the local multiplayer dungeon crawler where your friends control the monsters! Battle through dungeons and power up your hero - if a friend kills you they take your place and it’s their turn to crawl. It's a race to gain enough XP and loot to take on the hulking final boss!

Caveblazers is a challenging and brutal roguelike platformer. Journey into a mysterious cave, fighting orcs and goblins with an abundance of weapons and magical items! Make friends along the way, then watch in despair as they are crushed in to a bloody pulp under a troll's fist.

Sons of Valhalla is a strategy and base-building game set in the Viking Age. Build fortresses and lay siege to enemy strongholds, gather warriors and board longboats, and engage in personal combat as you raid and conquer across England.

Nuclear Throne is a post-apocalyptic roguelike-like top-down shooter. Not 'the final hope of humanity' post-apocalyptic, but 'humanity is extinct and mutants and monsters now roam the world' post-apocalyptic. Fight your way through the wastelands with powerful weaponry, collecting radiation to mutate some new limbs and abilities.

In a cold, dark future dominated by mega-corporations, a small lonely planet on the edge of habitable space is the site of a shadowy research facility specializing in necrotic tissue reactivation. You are a scientist who has suddenly awoken to the realization that you are the lone survivor.

Dungreed is a 2D side-scrolling action game with 2D Rogue-LITE elements. You become an adventurer exploring a continuously evolving dungeon to prevent the town from being destroyed. Eliminate enemies, use a variety of weapons and magic, eat food, and defeat evil in the dungeon!

Woodpunk is an exhilarating roguelike bullet hell retro pixel art shooter in a medieval Woodpunk universe, where the primary energy resource is WOOD.

Curse of Argion is a randomly generated, rogue-like, dungeon crawler in which a small hero must climb a tower full of dangerous traps and enemies to fight a curse that threatens to infect the world of Argion.

Afflicted by severe amnesia, you drift deep into the Common Dream. You scour for the lost pages of the Necronomicon, while clinging on to any little purpose you have left. Faced with mad dreamers, horrible abominations and eldritch deities, you feel drawn to the dark Abyss deep within.

Dungeon of the Endless is a Rogue-Like Dungeon-Defense game, in which the player and their team of heroes must protect the generator of their crashed ship while exploring an ever-expanding dungeon, all while facing waves of monsters and special events as they try to find their way out...

Reynard is a mixture of procedurally generated action RPG and a Tower Defense genre with roguelike elements. It has been influenced by classics such as The Legend of Zelda and an indie classic - The Binding of Isaac.

Hell Can Wait is a diabolic action-roguelike that combines the furious, fast-paced combat of a bullet-hell shooter with the deep strategy of a deck-building card game. With over 250 cards to unlock, find the perfect combo to send the demon hordes back to Hell!