Top similar games like Isolate ME!:

The Apocalypse Begins! Select a supernatural being and plunge the world into chaos. Defeat countless enemies, turn them into minions, destroy everything in your path and upgrade your creature with many different skills. Ascend to become ultimate Apocalypse Lord!

Delve into the mystical depths of the Emerald Forest in this captivating roguelike. You play as a courageous fox, wielder of powerful spells, the last bulwark against the growing corruption.

Get ready for the ultimate space challenge! In this top-down action roguelite you’ll pilot your ship through a low-gravity environment, dodging obstacles and fighting enemies along the way. But be careful, one wrong move could mean the end of your journey. Are you ready to take on the challenge?

Go on a campaign to dethrone the kaiser! Build an army, strengthen yourself with powerful artefacts and defeat the forces he sends to stop you. Kaiser is a casual roguelike game where you fight thousands of enemies in an attempt to become the new kaiser.

Crush, smash, and eat thousands of enemies showing humanity what the meaning of destruction is! Kaiju Catastrophe is an arcade game with roguelite mechanics. Mutate devastating weapons, unlock permanent evolutions, and wreak havoc with a variety of monsters to tear humanity apart!

Mystic Labyrinth is a top-down 2D twin stick shooter rogue-lite game. Choose from multiple starting classes and use swords, spears, axes and magic to conquer the many themed floors of the labyrinth.

Slimenator is a roguelite where you battle endless waves of slimes trying to overtake the world! Choose and customize up to six powerful skills, along with rare relics and accessories, as you craft the ultimate build to survive the slime apocalypse and outlast the ever-growing swarm!

Retro rally racing with a simulation twist

Dungeon Core is a roguelite top-down shooter where you get to explore the sewers and beyond to ultimately reach an old underground research facility. Old nuclear waste has caused dangerous mutations in creatures due to a failed experiment. You set out to destroy the abandoned nuclear core.

Tribe of Werewolves is a rogue-lite survival game where you fight against hordes of creatures using various weapons and spells. Survive as a bloodthirsty werewolf and save all the tribe members!

CHAT CHAMPIONS is an interactive pixel battle simulator built for live streaming on Twitch.

Assume control of a courageous adventurer and blaze through monster infested mazes. Dance with death as you balance fighting with scavenging for loot and power in this classic-arcade inspired roguelike.

Srogue is a snake roguelite where you play as a snake and defeat enemies in order to feast and grow. Unlock new ways to play by gaining experience and choosing items to alter your snake. The goal is to survive as long as possible.

Be the defender of innocence, the last remaining virtue in this land, and prevail against the evildoers! Sentinel of Innocence is a survival game with tower defense and rogue-lite elements.

Mine, fight monsters, upgrade your gear, obtain rare items, unlock new powers and mine some more in the massive follow-up to the popular title "Haste-Miner 2". Eternamine offers a casual yet engaging gameplay experience, expand your mining empire and discover the secrets that lie beneath the earth.

Slimekeep is a fast-paced rogue-like with unique decision making and intriguing player freedoms, where you kill and capture various slimes to stop the corruption that has infected the land. Venture through procedurally generated levels, and stop the slime king before it's too late.

Fend off hordes of enemies in this arcade tower defense roguelite with autobattler elements. Build up a team of powerful synergies and become unstoppable.

Mighty Meow is an action RPG with base-building. Rescue adorable animals from dungeons overrun by evil AI robots. While you are fighting relentless foes, your furry friends will be crafting powerful gear for you back at your base. Explore dangerous dungeons, manage resources and expand your base.

COVID SIMULATOR is an outbreak simulation that visualizes how quickly Covid-19 spreads, becoming a disaster. The game is an open sandbox where you can add (or remove) Covid mandates and see what happens! Create your workplace, enact your mandates, and roll the dice with your workers.

BulletGarden is a 2D vertical shooting gamewhere you explore a planet where the seeds you sow blossom into weapons.You can handle about 300 different types of weapons,each with its own unique characteristics.

Vanquish the ever-growing hordes, Command your army, grow in strength and numbers, and conquer your enemy's castles in this casual top-down roguelite.

Scrap Bastion is a strategy tower defense game where you manage your city, equipping it to survive the waves of mutant creatures, testing your planning and decision making capacities at every turn. Watch out, as time is crucial to win!

School Fighter is a top-down arena roguelite shooter where you play as a student who fights off school enemies using paper airplanes. You have access to a school shop, unique perks, and an upgrade station to help you create a powerful character and overcome the school nightmare!

Shoot your way through an endless stream of enemies! GLORP is an action roguelike where you must upgrade your skills and weapons to become overpowered

Destroy hordes of strange machines that have invaded the forest. Yawnoc is a chaotic top-down shooter roguelite focused on immersion into the world of Conway's Game of Life and other cellular automata.

Survive the hordes of monsters as long as you can. Fight, upgrade your skills, loot equipments, die, rince and repeat.

Modest Kind is a Rogue-lite Initiation Adventure. Ever heard of Entropy, The Selfish Gene and Schrödinger's cat? This action-heavy, story-driven top-down dungeon crawler will put your knowledge to the test. Your Path to Enlightment begins now.

Blast off through space, dodge asteroids, and beat bosses!