Top similar games like Regen Protocol:

Astra Industria is a sci-fi factory builder set on colossal player-constructed space megastructures with the addictive growth of incremental games. Extract resources, craft advanced components, and automate deep-space production through a vast tech tree.

Build and expand an orbital station in this idle/incremental space colony sim. Manage crew, resources, refinery chains, research and ship expeditions as you progress from Earth orbit toward new planets.

A sudden, devastating strike has reduced your interstellar voyage to ruins. As the sole survivor in X SPACE, you must rebuild your space base from scratch, assemble a versatile fleet, and pilot your massive mobile fortress into the depths of the universe.

A survival engineering game where you build life support habitats, mine resources, and automate production chains on a radiation heavy planet. No rescue. No support. Just engineering.

Defend against endless waves of deadly red cubes in this futuristic idle tower defense game. Upgrade your towers, deploy mini-towers, speed up time, and rotate the battlefield in full 360°. Infinite levels. Infinite upgrades. No mercy.

Factory management and sandbox base building in zero-g environment. Survive, expand and then dominate space industrial market. Build large scale resource processing plant completely from nothing.

Exovia is a physics-based mining and automation sandbox in space. Survey asteroids, engineer zero-G logistics without conveyor belts, and design complex Newtonian factories. Turn floating chaos into perfect order and experience true inner peace as you solve one satisfying problem and then the next.

Yuri’s Resolve is a single-player factory-building game set in Mars' orbit. Salvage wreckage, mine Phobos, construct manufacturing systems, and forge a path back home. Operate from the immersive cockpit of your ship as Yuri’s Resolve delivers a bold, innovative take on the factory building genre.

The ultimate space capital ship combat compendium is the evolution of hard core space combat sims. The only game of its kind currently in existence.

Build an automated factory on a true-scale Mars streamed from real NASA terrain. Mine, smelt and belt resources, run trains between outposts, master chemistry, and grow from a lone lander into a planet-spanning industry while the real Martian weather does its worst.

Build the most efficient intergalactic factory in space simulation strategy game Dyson Sphere Program! Harness the power of stars, collect resources, plan and design production lines and develop your interstellar factory from a small space workshop to a galaxy-wide industrial empire.

A sci-fi colony management sim with a focus on exploration, expansion, and survival. Rebuild your underground facility, manage colonists and robots, and uncover the mysteries of an alien world light-years from Earth. Dig deep, expand across the surface, and shape your new home.

Welcome to Trappist-1, 40.7 light-years from Earth. Fly your Ark, a colossal spaceship and mobile base. Explore the solar system and establish thriving colonies. Uncover the mysteries of Trappist in this story-driven colony builder.

The day has come… Humanity has been attacked by an alien race.You have space bases at your disposal. Use them to launch battleships and take over the alien mothership.

Star Trek: Prelude is a space-based game that builds defense towers on earth to defend against alien invaders called Black Ember.

Build factories, solve puzzles, and send robots to explore the desert planet of Drath. With each release comes a new planet with stranger challenges, smarter enemies, and more advanced tech. It will take a logical mind, cunning, and a yearning for adventure to succeed. Do you have what it takes?

Guide pioneering settlers among Venusian clouds in this space colonisation city builder. Grow food, collect energy, mine resources, balance buoyancy and weight to stay afloat in the treacherous Venusian atmosphere, and build a self-sufficient colony while navigating storms and acidic clouds.

Valdis est un hybride dynamique tower defense et third-person shooter en univers sci-fi. Défendez le noyau énergétique d’une station spatiale contre des vagues de zombies, combinez tourelles et éléments, déclenchez des réactions dévastatrices et survivez avec votre fusil à pompe !

Rionag: Survey Fleet is a top-down starship builder and logistics game where it's your job to balance the needs of the crews with cutting-edge equipment on board. Unlock tech that adds new capabilities for your ships to go through hazardous environments, enabling you to explore new worlds.

A 2D side-scrolling sandbox survival game featuring pure random exploration and mining. Mine, gather, study alien life, and build bases. Battle harsh environments and rival alien miners. Embrace unpredictable roguelike survival challenges in an infinitely generated universe.

Build an industrial base among the stars. Gather resources, manufacture ships, research technologies, and explore unknown regions of space. The core gameplay can be played offline, while alliance features add online missions and cooperative construction.

Dig into a mysterious world, build robot colonies, and fight to dominate interdimensional rifts. Automate your way to total control.

Hostile Mars is a factory-building game focused on combat! Explore an open world and discover new tech to unlock powerful weapons and structures. Create efficient supply chains using delivery bots. Salvage destroyed enemies for resources. Design your base to withstand increasing waves of enemies!

HAS Galactics is a top-down factory builder. Design your own rocket, automate your production lines, balance your reputation between the Galactic Factions and complete daring missions. Start from a humble beginning… to a thriving galactic mega-factory!

The Last Starship is a 2D space construction game where you design and upgrade your starship. Choose your path: pirate hunter, miner, engineer, spacebus driver, and more, whilst exploring vibrant star systems. Enjoy a growing sandbox world, with regular free updates. Your cosmic adventure awaits!

Frontier Control: Invasion is a Real-Time Strategy survival game in which you play the commander of a human space colony under the attack of outer space robots. Build your base, train your colony, and fight herds of enemies and bosses.

Defend your tower and protect the dwarf's treasure from marauding creatures in this roguelike tower defense game. Explore the region, collect resources and choose the right upgrades. But be careful, don't leave your fortress empty for too long.

Embark on a sci-fi survival adventure on Halley's Comet as a retired astronaut on a top-secret mission. Build, manage limited resources, and survive the desolate space environment to complete your mission.

Startron is an ASCII-based space colony sim where you can mine, harvest, build and automate your way across a procedurally generated cosmos. Lead a crew of sentient cats (or dogs) as they take their first steps out and discover the mysteries of the cosmos.

Facteroids is a 3D factory building game about asteroid mining in space. Prospect, mine and manage your production lines in a variety of scenarios and procedurally generated worlds across the entire Solar system.

Your spacecraft has crash landed on an alien planet. Explore this unknown world, mine the resources, build your base, grow farms, craft equipment, fight off the alien lifeforms and survive.

A strategy tower defence where you create the towers! Gather resources, build towers, defeat bugs, and survive. Unlock new weapons, create towers, gather resources, and die. Don't fall short of the Company's expectations... these resources are worth more than any life, including yours.

Galactic Simulator 3 is a space exploration and evolution sim inspired by the Fermi Paradox and Great Filter theory. Scan uncharted star systems, gather resources and samples, establish outposts and stargates, and witness the rise and fall of civilizations across an ever-evolving galaxy.

Grid Miner is a real-time strategy puzzle game where you mine asteroids to gather resources and expand your space station. Unlock new tools and utilities as you progress through levels. Maintain your quotas and learn more about your employer and coworkers at Hypergo Industries.

Dive into a factory-building game with the focus on just that – building huge space factories! Design sprawling multi-level factories and satisfying production lines without limits. Tackle progressively challenging automation goals at your own pace, without the threat of enemies.

Build, launch, and survive. Design your own rover and automated robot workforce to conquer the harsh Martian climate, fulfill Mission Control directives, and uncover the secrets of the red planet in Heng Mar Mission.