Top similar games like Mutagenesis:

New Cycle is a city building game with focus on survival. After an apocalyptic series of solar flares, human society has been thrown into disarray. Establish a settlement and develop it all the way from humble beginnings to industrial metropolis.

Neo Citizen - Prologue - A management and strategic game in which you will have to manage your resources to the best of your ability. Make connections with the inhabitants, improve the infrastructure and defend yourself from the dangers of a hostile and corrupt world.

ATC is a base building game set in a post-apocalyptic world featuring urban environments. Build a base across several layers with dozens of survivors. Fight other factions for the control of the remaining production centers and explore the world to find long forgotten resources and technologies.

Stake your claim in this colony building sim and survive a turbulent Medieval age. Construct a multi-storey fortress in a land reclaimed by wilderness, defend against raids, and keep your villagers happy as their lives are shaped by the world around them.

Inspired by the god games of old, Fata Deum lets you mold settlements and townsfolk in your image. Will you raise the settlements to splendor, or spur them on to violent debauchery and demons? Watch as a living world grows under your whims.

Recovery Syndicate is a prequel to Abeyance, in which you are the leader of one of the factions trying to reconstruct the economy of the galaxy. You must build and manage your colony's resources carefully, while watching out for rival factions who are also vying for supremacy.

Automate a lunar base as you become the savior of humanity exploring the future on the moon. Mine, craft, research, and trade resources with Earth in this gripping narrative basebuilder.

Explore a fantasy ocean-punk world, braving the deep with steam-powered marvels. Discover mysterious underwater treasures, but scarcity and ecological crises test survival. Rise, build, confront foes in this pixel-art ocean survival journey!

Crowded Blue Dot is a game about producing various items to make people happy and growing a city from a small village to a metropolis.

A sci-fi colony sim driven by an intelligent AI storyteller. Generates stories by simulating psychology, ecology, gunplay, melee combat, climate, biomes, diplomacy, interpersonal relationships, art, medicine, trade, and more.

Build a city on the back of a Space Whale and learn to coexist as you journey through the stars. Manage intricate supply chains and the needs of your people as you build outposts, meet aliens, and uncover the mysteries of the universe.

Lead your noble family in this medieval colony sim, facing off against class conflict, religious struggle, and political treachery. Tend to your people’s needs, uncover the lost knowledge of a fallen empire, and engage in nefarious plots against your enemies.

Of Life and Land is a charming settlement-building strategy game paired with a rich simulation experience. Every animal and plant strives to find its place in nature while you lead your villagers to their future. Expand to different regions and trade with local factions to gain needed resources.

Survive and thrive in a post-apocalyptic future — resources are scarce, but opportunity calls! Build the ultimate disaster proof colony, protect your colonists, and restore civilization to a devastated world.

Become the hive mind of a robot ant colony in Microtopia! Use pheromone trails to create, automate and optimize supply chains for your ants to follow. Collect resources, produce goods, feed your queen, grow your colony and fly out to expand the species!

Command swarms of warriors at an unprecedented scale of warfare in this blend of RTS and base-building. Lead ant colonies against the many fearsome threats of the insect world, while building intricate nests, developing pheromone-based tactics, and evolving to meet growing dangers.

Settlements Rising is a medieval city building and colony management game. It offers a lively colony experience with simulated villagers, dozens of professions and resources, natural disasters, and raids, while providing full control over the colony through trade, production chains and datas.

Settle an untamed wilderness with the might of Dwarven engineering and thoughtful planning! Design and build your colony towards fame and fortune in a deeply-simulated fantasy world. Chill out in peaceful mode with a bustling settlement, or fight for survival against monsters and invasions!

Land your crew of survivors on an abandoned island and survive! Mine raw materials, grow food, build factories, manufacture products, research new tech, and trade with others. Become an industrial superpower! But this is no easy task, you will be put to the test to keep your settlement alive.

Songs of Syx is a fantasy city-builder where you start off as an insignificant colony and build, scheme, and fight your way towards a metropolis and empire. The mechanics are complex and true to life, where small events can spiral into the collapse of kingdoms. Try the unlimited demo first!

The Wandering Village is a city-building simulation game on the back of a giant, wandering creature. Build your settlement and form a symbiotic relationship with the colossus. Will you survive together in this hostile, yet beautiful post-apocalyptic world, contaminated by poisonous plants?

The Final Earth 2 is a vertical sci-fi city builder. Earth is unlivable, so you decide to create a space colony. Gather resources, then build and research your way to a better future! Grow your city from an exploration ship to a huge metropolis, full of advanced technology. What will you build?

A deep starship colony sim. Build your starship, manage air, water, food, fuel, energy, temperature and psychology to keep your crew alive across vast distances. Closed-loop system in space. Mining, wiring, plumbing, in-ship factory, (alien?) radio signals & translation, diplomacy, combat, and more.

An open-world colony sim based on stories of the first men. Infinite possibilities await your very own Adam and Eve as they embark on a generation-spanning adventure. How will you shape their future?