Top similar games like Mutagenesis:

Survive and thrive in a post-apocalyptic future — resources are scarce, but opportunity calls! Build the ultimate disaster proof colony, protect your colonists, and restore civilization to a devastated world.

Rebuild civilization in a world consumed by the blight. Manage survivors, defend against the dead, and transform a fragile camp into a thriving frontier settlement.

ATC is a base building game set in a post-apocalyptic world featuring urban environments. Build a base across several layers with dozens of survivors. Fight other factions for the control of the remaining production centers and explore the world to find long forgotten resources and technologies.

Build your spaceship, manage your crew, and explore the cosmos whilst trying to keep your crew alive and your ship fully functioning. This game features simulated ship systems and a lived in universe which creates a challenging, unique and unforgettable experience with every playthrough.

LiF:Forest Village is a city builder with survival aspects in a realistic harsh medieval world. Shape, build and expand your settlement, grow various food to prevent your villagers from avitaminosis and starvation. Possess them for additional micromanagement or simply to wander around.

DUSK OF WAR is a base-building game with resource and human management in a post-apocalyptic world where resources are limited. The game is played in real time and allows you to alternate between base management phases and real-time tactical combat.

New Cycle is a city building game with focus on survival. After an apocalyptic series of solar flares, human society has been thrown into disarray. Establish a settlement and develop it all the way from humble beginnings to industrial metropolis.

There will be challenges to overcome. Execute your strategy and improve your colony’s chances of survival while unlocking the mysteries of this alien world. Are you ready? Mars is waiting for you.

In a collapsing world, safety is a memory. Guide a small group of survivors through the daily struggle of a bleak reality. Manage your shelter, craft essentials, and make soul-crushing choices. In Never Secure, winning isn't the goal—lasting one more day is.

Build, scavenge, craft, and perform occult rituals to survive in a demon-infested, post-apocalyptic colony simulation. Will you survive Judgment day?

Build a colony from scratch, set up production chains, and defend against raids. Manage resources, research technologies, expand your settlement, and survive each escalating wave!

A colony sim set on a starship. Build and manage a spacefaring civilisation, balance oxygen, power, and crew survival, and guide your ship through the final escape from Earth.

Gnomoria is a sandbox village management game where you help lead a small group of gnomes, who have set out on their own, to thrive into a bustling kingdom! Anything you see can be broken down and rebuilt elsewhere.

Commander, lead your army, build the strongest weapons, conquer the harsh weather and enemies, and build a new Eden on the sea!!!!

Crowded Blue Dot is a game about producing various items to make people happy and growing a city from a small village to a metropolis.

Doom falls and civilization collapses entirely. The roaming train becomes the last hope of mankind. You will take charge of the vehicle, manage and equip survivors, allocate food and daily tasks, collect resources to resist zombie swarms. The fate of everyone hinges on your decisions.

Endzone is a post-apocalyptic survival city builder, where you start a new civilization with a group of people after an ecological disaster. Build them a new home and ensure their survival in a shattered world, threatened by constant radiation, toxic rain, sandstorms and droughts.

The world after a nuclear war. Manage the settlement, learn technology, make decisions, produce weapons, ammunition, organize defense, raid for supplies on other areas, do not let residents die, survive the nuclear winter.

Manor Lords is a medieval strategy game featuring in-depth city building, large-scale tactical battles, and complex economic and social simulations. Rule your lands as a medieval lord – the seasons pass, the weather changes, and cities rise and fall.

Frostpunk is the first society survival game. As the ruler of the last city on Earth, it is your duty to manage both its citizens and infrastructure. What decisions will you make to ensure your society's survival? What will you do when pushed to breaking point? Who will you become in the process?

Can you build an entire country? An infrastructure and economy management sim. Lead a nation to prosperity by strategically placing towns and factories. Choose between bidding teams to build connections, while paying attention to citizen feedback on Social Bird to avoid civil unrest.

Recovery Syndicate is a prequel to Abeyance, in which you are the leader of one of the factions trying to reconstruct the economy of the galaxy. You must build and manage your colony's resources carefully, while watching out for rival factions who are also vying for supremacy.

Set in a gritty, fictional 1960s universe, it’s a colony sim & base-building hybrid where you rebuild a war-ravaged region, fortify your defenses, and control key trade routes that every convoy depends on.

Build a city on the back of a Space Whale and learn to coexist as you journey through the stars. Manage intricate supply chains and the needs of your people as you build outposts, meet aliens, and uncover the mysteries of the universe.

Automate a lunar base as you become the savior of humanity exploring the future on the moon. Mine, craft, research, and trade resources with Earth in this gripping narrative basebuilder.