Top similar games like Mutagenesis:

Survive and thrive in a post-apocalyptic future — resources are scarce, but opportunity calls! Build the ultimate disaster proof colony, protect your colonists, and restore civilization to a devastated world.

ATC is a base building game set in a post-apocalyptic world featuring urban environments. Build a base across several layers with dozens of survivors. Fight other factions for the control of the remaining production centers and explore the world to find long forgotten resources and technologies.

Build your spaceship, manage your crew, and explore the cosmos whilst trying to keep your crew alive and your ship fully functioning. This game features simulated ship systems and a lived in universe which creates a challenging, unique and unforgettable experience with every playthrough.

LiF:Forest Village is a city builder with survival aspects in a realistic harsh medieval world. Shape, build and expand your settlement, grow various food to prevent your villagers from avitaminosis and starvation. Possess them for additional micromanagement or simply to wander around.

New Cycle is a city building game with focus on survival. After an apocalyptic series of solar flares, human society has been thrown into disarray. Establish a settlement and develop it all the way from humble beginnings to industrial metropolis.

There will be challenges to overcome. Execute your strategy and improve your colony’s chances of survival while unlocking the mysteries of this alien world. Are you ready? Mars is waiting for you.

Build, scavenge, craft, and perform occult rituals to survive in a demon-infested, post-apocalyptic colony simulation. Will you survive Judgment day?

Begin with a handful of survivors after a 17th-century zombie apocalypse and build a growing colony. Shape its organic layout, establish production chains, define ideologies, and pass laws. Thrive by day, defend by night, and test your colony’s resilience against the undead.

Gnomoria is a sandbox village management game where you help lead a small group of gnomes, who have set out on their own, to thrive into a bustling kingdom! Anything you see can be broken down and rebuilt elsewhere.

Commander, lead your army, build the strongest weapons, conquer the harsh weather and enemies, and build a new Eden on the sea!!!!

Crowded Blue Dot is a game about producing various items to make people happy and growing a city from a small village to a metropolis.

The witches are gone. Only their cats remain. Make a new home for them in this feline city-builder. Keep your cats fed and happy, clean their litter box, and give them a cozy life in a world ravaged by magic.

Endzone is a post-apocalyptic survival city builder, where you start a new civilization with a group of people after an ecological disaster. Build them a new home and ensure their survival in a shattered world, threatened by constant radiation, toxic rain, sandstorms and droughts.

Manor Lords is a medieval strategy game featuring in-depth city building, large-scale tactical battles, and complex economic and social simulations. Rule your lands as a medieval lord – the seasons pass, the weather changes, and cities rise and fall.

The world after a nuclear war. Manage the settlement, learn technology, make decisions, produce weapons, ammunition, organize defense, raid for supplies on other areas, do not let residents die, survive the nuclear winter.

Frostpunk is the first society survival game. As the ruler of the last city on Earth, it is your duty to manage both its citizens and infrastructure. What decisions will you make to ensure your society's survival? What will you do when pushed to breaking point? Who will you become in the process?

Can you build an entire country? An infrastructure and economy management sim. Lead a nation to prosperity by strategically placing towns and factories. Choose between bidding teams to build connections, while paying attention to citizen feedback on Social Bird to avoid civil unrest.

Recovery Syndicate is a prequel to Abeyance, in which you are the leader of one of the factions trying to reconstruct the economy of the galaxy. You must build and manage your colony's resources carefully, while watching out for rival factions who are also vying for supremacy.

Set in a gritty, fictional 1960s universe, it’s a colony sim & base-building hybrid where you rebuild a war-ravaged region, fortify your defenses, and control key trade routes that every convoy depends on.

Automate a lunar base as you become the savior of humanity exploring the future on the moon. Mine, craft, research, and trade resources with Earth in this gripping narrative basebuilder.

Architect of Ruin is a completely hand drawn sword and sorcery colony simulation game. Farm, hunt, build, and survive as you rebuild an ancient temple under the gaze of a vengeful god.

Manage your own medieval smithy in Blacksmith Master and supervise the entire process from mining ores and gems to designing and selling finished products. Forge everything from weapons and armor to tools and cooking utensils to fund your craft and become the Blacksmith Master.

A deep starship colony sim. Build your starship, manage air, water, food, fuel, energy, temperature and psychology to keep your crew alive across vast distances. Closed-loop system in space. Mining, wiring, plumbing, in-ship factory, (alien?) radio signals & translation, diplomacy, combat, and more.

Endzone 2 is a post-apocalyptic survival colony builder, where you embark to secure humanity's survival after a cataclysmic disaster. Discover and repopulate the last habitable grounds, while the survival of your people hinges on your wits, foresight, and resilience in a harsh and unforgiving world.

Building and managing a late medieval city is a series of challenges. Build wells to provide drinking water, markets to provide bread and food, and theaters to collect performance tax. Stage mode continues an interesting story and journey, random map mode fills each game with a new experience.