Top similar games like Mutagenesis:

Command swarms of warriors at an unprecedented scale of warfare in this blend of RTS and base-building. Lead ant colonies against the many fearsome threats of the insect world, while building intricate nests, developing pheromone-based tactics, and evolving to meet growing dangers.

ATC is a base building game set in a post-apocalyptic world featuring urban environments. Build a base across several layers with dozens of survivors. Fight other factions for the control of the remaining production centers and explore the world to find long forgotten resources and technologies.

Neo Citizen - Prologue - A management and strategic game in which you will have to manage your resources to the best of your ability. Make connections with the inhabitants, improve the infrastructure and defend yourself from the dangers of a hostile and corrupt world.

Recovery Syndicate is a prequel to Abeyance, in which you are the leader of one of the factions trying to reconstruct the economy of the galaxy. You must build and manage your colony's resources carefully, while watching out for rival factions who are also vying for supremacy.

Build a new civilization out of the chaos of an apocalyptic solar flare as you grow your House from a lone shelter to an industrial metropolis. Take on the burden of preserving life itself and help your people realize their aim: "A future beyond survival." Lead the world of New Cycle.

Settle an untamed wilderness with the might of Dwarven engineering and thoughtful planning! Design and build your colony towards fame and fortune in a deeply-simulated fantasy world. Chill out in peaceful mode with a bustling settlement, or fight for survival against monsters and invasions!

Of Life and Land is a charming settlement-building strategy game paired with a rich simulation experience. Every animal and plant tries to find their place in nature while you lead your villagers to their future. Expand to different regions and trade with local factions to gain needed resources.

Crowded Blue Dot is a game about producing various items to make people happy and growing a city from a small village to a metropolis.

A sci-fi colony sim driven by an intelligent AI storyteller. Generates stories by simulating psychology, ecology, gunplay, melee combat, climate, biomes, diplomacy, interpersonal relationships, art, medicine, trade, and more.

A deep starship colony sim. Build your starship, manage air, water, food, fuel, energy, temperature and psychology to keep your crew alive across vast distances. Closed-loop system in space. Mining, wiring, plumbing, in-ship factory, (alien?) radio signals & translation, diplomacy, combat, and more.

Explore a fantasy ocean-punk world, braving the deep with steam-powered marvels. Discover mysterious underwater treasures, but scarcity and ecological crises test survival. Rise, build, confront foes in this pixel-art ocean survival journey!

Humans are long gone. Will your lumberpunk beavers do any better? A city-building game featuring ingenious animals, vertical architecture, river control, and deadly droughts. Contains high amounts of wood.

In this roman strategy city-builder, you must build a striving city from the ground up, manage resources and people and survive against a plethora of threats (Gods, Hydra, Minotaur, Barbarians and more)!

Land your crew of survivors on an abandoned island and survive! Mine raw materials, grow food, build factories, manufacture products, research new tech, and trade with others. Become an industrial superpower! But this is no easy task, you will be put to the test to keep your settlement alive.

The Final Earth 2 is a vertical sci-fi city builder. Earth is unlivable, so you decide to create a space colony. Gather resources, then build and research your way to a better future! Grow your city from an exploration ship to a huge metropolis, full of advanced technology. What will you build?

Make Mars your own! Take control of the world’s most sophisticated AI (AMI) and terraform the surface of the Red Planet for a city-building experience on a planetary scale. Transform this barren world into a lush paradise and explore the surface for any ancient secrets that may be waiting.

Songs of Syx is a fantasy city-builder where you start off as an insignificant colony and build, scheme, and fight your way towards a metropolis and empire. The mechanics are complex and true to life, where small events can spiral into the collapse of kingdoms. Try the unlimited demo first!

Survive and thrive in a post-apocalyptic future — resources are scarce, but opportunity calls! Build the ultimate disaster proof colony, protect your colonists, and restore civilization to a devastated world.

A strategy simulation based on stories of the first men. Infinite possibilities await your very own Adam and Eve as they embark on a generation-spanning adventure. How will you shape their future?

Build your way to success! Trade your way to the top! Explore your way to infamy! Do it all your way!

Endzone is a post-apocalyptic survival city builder, where you start a new civilization with a group of people after an ecological disaster. Build them a new home and ensure their survival in a shattered world, threatened by constant radiation, toxic rain, sandstorms and droughts.

A simulation-based settlement-building strategy game set in a fantasy world - build and grow from a humble colony to control of your own kingdom!

Build, scavenge, craft, and perform occult rituals to survive in a demon-infested, post-apocalyptic colony simulation. Will you survive Judgment day?

Embark on a space voyage with your ragtag crew of civilians in search of a new home. Build spaceships tile by tile, create optimal gas conditions, manage the needs and moods of their crew, encounter other space-faring groups, and explore the universe in this spaceship colony simulation.

Automate a lunar base as you become the savior of humanity exploring the future on the moon. Mine, craft, research, and trade resources with Earth in this gripping narrative basebuilder.

Build your ship, manage your crew and explore the cosmos whilst trying your best to keep your crew alive and your ship fully functioning. This game utilises an events driven AI and simulated ship systems to ensure gameplay is kept challenging and every game you play has a different story to tell.