Top similar games like Slime Virus Defense:

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Build, Upgrade, and then Move your Towers in this unique twist on the Tower Defence genre. With Rogue-Lite mechanics every run offers new strategies, and every death unlocks new upgrades. Grow. Evolve. Destroy the Robots!

"In 'Random Core Defense,' acquire and enhance cores using limited resources to withstand relentless enemy onslaughts. Defeat powerful bosses and test your strategy to survive until the very end!"

We've traveled to the past to conquer these fertile lands. Now, you must defend them from the blood cult intent on taking it for themselves. Be careful though: from where their blood is spilled, ancient magicks empower whomever is still alive.

Tower defense / Roguelike / Sci-Fi / Pixel Art game with boomer games aesthetics. Mine resources and shoot those disgusting aliens right in their faces. Unlock new technology, develop new strategies and explore the planet. A modern old-school Pixel Art experience with the vibe of 90s classics.

Build your defense base to repel alien invaders. Atahion is a strategy and tactical defense game in which you have to extract resources, build defense towers and use bonuses to complete the mission.

Raise a fallen keep by day, and hold it through the dark. Villagers with names and tempers fell timber and work the fields — then take up spears when night comes. A dark fantasy settlement-builder defense game.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

Build your own towers from modular units, adapt mid battle, and master custom defenses in this Build-a-Tower Defense.

Scrap Bastion is a strategy tower defense game where you manage your city, equipping it to survive the waves of mutant creatures, testing your planning and decision making capacities at every turn. Watch out, as time is crucial to win!

The ultimate mash-up of Real-time Strategy and Tower Defense!

Customize your Ships, Upgrade your fleet, and Command your way to victory in this ruthless rogue-lite tower defense/real time strategy hybrid. Take on an enemy that learns from your moves and adjusts its own path. Do you have what it takes to persevere?

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

A strategic tower-defense where you control powerfull drones. Unlock new tower and use specific technologies to defend your base on Thukothea!

Prepare for the onslaught! Chromatrix is a retro tower defense game where color and placement are everything. Upgrade and customize your turrets to counter shifting enemy-types and map configurations. Manage your resources and craft the perfect defense against any attack!

Command your forces to victory in this intense tower defense experience! Strategically deploy your defenses to fortify your position and funnel the enemies through intricate mazes. Carefully allocate your resources and adapt your tactics to counter waves of relentless enemy drones!

Defend your planet from relentless stream of incoming asteroids in this fast-paced 2D tower defence game. Strategically place defensive buildings and upgrade your arsenal to protect your world from destruction!

Build whimsical defenses, wield powerful relics, and command magical snow guardians to survive the infernal chaos. Can you hold the line through endless nights and defeat the Frost fallen King?

Defend your Nexus by placing mirrors and buildings on the path of your projectiles. Deflect, empower, manage and solve each map using your creative and strategic mind.

Embark on an adventure with Loot Express Delivery Service, a 2D pixel art game. As the commander, your goal is to retrieve valuable items from a distant planet. Utilize your skills and strategy to complete missions and guide your company to prosperity.

This is a 2D defense game that depicts the near future that may arise from climate change. Unlike the defense game, which is automatically attacked by traditional turrets, it is an attractive game that requires you to defeat the enemy by operating the turret directly with limited power.

Totally Defenceless is a wave-based tower defence game. You will need to protect your energy cores from the invading alien bugs by strategically constructing a maze of towers to alter their path to your advantage.

A strategic tower defense game where your arsenal evolves across time. Build base defenses and experiment by merging towers together to discover powerful new units. Manage your resources carefully, adapt your tactics, and survive enemy waves from the Stone Age to the far future.

The hungry Gooper swarm threatens intergalactic peace. Stop them! Build towers around planets and take control over their orbits. Spin them with all you’ve attached! Collect new towers, powers and upgrades to beat the onslaught of goopers and save the galaxy in this colorful Tower Defense Roguelite!

A roguelike tower defense where every run reshapes your strategy. Build your team of towers, combine more than 80 artifacts, and explore a pixel-art world while taking on ever tougher challenges and bosses.

The ULTIMATE tower defense onslaught is back. Bigger, deadlier, and more action-packed. Build autonomous defenses, deploy tactical drones, and unleash devastating support abilities in this epic, old-school RTS-inspired sci-fi adventure.

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

You are a Portal Guardian. It is your job to help protect the secret gateways to the Realm. Your people have been kept safe and unaware for centuries, but something dark and relentless has been stirring... Unleash the fury of your towers and magic to defend the portal and the realm or all is lost!

Space Base is an action-packed tower defence game, where you aim to protect your planets from the incoming forces of enemy ships and aliens by any means necessary. Build up your defences as stronger and stronger waves of enemies arrive to reach the highest score possible.

An epic, challenging tower defense game with an emphasis on strategy and replayability. Summon gems of immense magical potency and harness their unique abilities against a seemingly endless horde of monsters. The archdemon seeks to swallow the world, and you must journey to stand against her.

Mechanical Trap is a 2D horizontal tower defense game with gravity effects, with a variety of defense towers to collect and use together, a rich map, each enemy has a different way of restraining, and each defense tower has a different function.It's challenging. Do you dare to accept the challenge?

Intercept the surging waves of pixels with a variety of units! Experience the ultimate fixed-route tower defense! Summon a wide variety of units to defend and conquer the battlefield. Where and when you deploy, upgrade or replace your units is up to you. Discover synergies and hone your strategy.

We fused deck-building roguelikes and tower defenses in a way never seen before - deploy your towers, collect valuable trinkets and cast powerful spells to defend yourself against the Salkoth!