Top similar games like Slime Virus Defense:

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Build, Upgrade, and then Move your Towers in this unique twist on the Tower Defence genre. With Rogue-Lite mechanics every run offers new strategies, and every death unlocks new upgrades. Grow. Evolve. Destroy the Robots!

"In 'Random Core Defense,' acquire and enhance cores using limited resources to withstand relentless enemy onslaughts. Defeat powerful bosses and test your strategy to survive until the very end!"

Build defenses to protect your mining sites from the hostile native alien species. Explore the planet and discover the true reasons you've been sent here for. A true old school pixel-art experience.

Build your defense base to repel alien invaders. Atahion is a strategy and tactical defense game in which you have to extract resources, build defense towers and use bonuses to complete the mission.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

Scrap Bastion is a strategy tower defense game where you manage your city, equipping it to survive the waves of mutant creatures, testing your planning and decision making capacities at every turn. Watch out, as time is crucial to win!

The ultimate mash-up of Real-time Strategy and Tower Defense!

Customize your Ships, Upgrade your fleet, and Command your way to victory in this ruthless rogue-lite tower defense/real time strategy hybrid. Take on an enemy that learns from your moves and adjusts its own path. Do you have what it takes to persevere?

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

A strategic tower-defense where you control powerfull drones. Unlock new tower and use specific technologies to defend your base on Thukothea!

Prepare for the onslaught! Chromatrix is a retro tower defense game where color and placement are everything. Upgrade and customize your turrets to counter shifting enemy-types and map configurations. Manage your resources and craft the perfect defense against any attack!

Defend your Nexus by placing mirrors and buildings on the path of your projectiles. Deflect, empower, manage and solve each map using your creative and strategic mind.

This is a 2D defense game that depicts the near future that may arise from climate change. Unlike the defense game, which is automatically attacked by traditional turrets, it is an attractive game that requires you to defeat the enemy by operating the turret directly with limited power.

Embark on an adventure with Loot Express Delivery Service, a 2D pixel art game. As the commander, your goal is to retrieve valuable items from a distant planet. Utilize your skills and strategy to complete missions and guide your company to prosperity.

Totally Defenceless is a wave-based tower defence game. You will need to protect your energy cores from the invading alien bugs by strategically constructing a maze of towers to alter their path to your advantage.

Space Base is an action-packed tower defence game, where you aim to protect your planets from the incoming forces of enemy ships and aliens by any means necessary. Build up your defences as stronger and stronger waves of enemies arrive to reach the highest score possible.

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

An epic, challenging tower defense game with an emphasis on strategy and replayability. Summon gems of immense magical potency and harness their unique abilities against a seemingly endless horde of monsters. The archdemon seeks to swallow the world, and you must journey to stand against her.

The hungry Gooper swarm threatens intergalactic peace. Stop them! Build towers around planets and take control over their orbits. Spin them with all you’ve attached! Collect new towers, powers and upgrades to beat the onslaught of goopers and save the galaxy in this colorful Tower Defense Roguelite!

Mechanical Trap is a 2D horizontal tower defense game with gravity effects, with a variety of defense towers to collect and use together, a rich map, each enemy has a different way of restraining, and each defense tower has a different function.It's challenging. Do you dare to accept the challenge?

We fused deck-building roguelikes and tower defenses in a way never seen before - deploy your towers, collect valuable trinkets and cast powerful spells to defend yourself against the Salkoth!

Build your factory by day, then fight relentless hordes by night in this unique blend of factory-building and rogue-like mayhem. Gather resources and upgrade your arsenal with Magic, Guns and Tesla Coils?!

A Roguelike Tower Defense in space with missions to conquer. Can you hold against the spreading alien bosses? Build and upgrade towers against the corruption. Choose your technologies and warpspeed your way to victory.

A wave-based action game, where you fight to survive for as long as you can.

Coastal Defense is a fast paced, casual top-down tower defense game inspired by real-world coastal defense structures. Buy and upgrade your coastal defenses to defeat incoming navies!

Be the villain in this Reverse Tower Defense. Send waves after waves of troops to break the enemy defenses. Summon, upgrade your troops and conquer the whole world.

If I would categorize "BattleField BattleFront," it would be summarized as a RTSTD (real-time strategy tower defense) game.

Relaxing, casual single-Player Tower Defense Game for breaks in life.

A Byte War is a real time strategy game where you lead a race of block-based machines against a machine threat from another dimension. Construct buildings from blocks arranged in various patterns and leverage your machines to convert the world around you.

A minimalist sci-fi tower defense. Buy soldiers and upgrade them, defeat waves of enemies, hold your lines.

1-person Topdown strategy game. Plant seeds to defend enemy and grow roots. Terraforming the planets!

Get ready for an epic pixel art showdown ! Dive into the heart of tower defense chaos as you battle against scrumptious calorie-packed enemies, all on massive, sprawling maps. With an extensive arsenal of towers at your disposal, it's time to defend against the ultimate sweet tooth invasion!