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STEM Defense
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The top results based on the latest update are Hormone Wars [Score: 1.1], Surging Matrix [Score: 1.0] and Dawn Of Defense [Score: 1.0] The top rated games you can find here are Emberward [SteamPeek Rating: 7.4] ranked #9, Rogue Tower [SteamPeek Rating: 6.7] ranked #7 and Nordhold: Origins [SteamPeek Rating: 6.4] ranked #14 Also don't forget to check the newest releasesLast Throne [Release date: 2025-08-20] ranked #29, Tiny Kings [Release date: 2025-06-26] ranked #6 and Dawnhelm Defense [Release date: 2025-03-21] ranked #17 While it is tempting to play with the newest and the best, there might be some other gems in the results, like Nordhold: Origins [SteamPeek Rating: 6.4] ranked #14, Isle of Arrows [SteamPeek Rating: 5.5] ranked #16 and Outpost [SteamPeek Rating: 5.8] ranked #25.
Engage in epic battles against microscopic foes in 'STEM Defense', a strategic tower defense adventure set on a hex-grid. Harness the immune system's power, BUILD your defenses and fend off waves of pathogens, unlock potent cells and upgrades, and evolve your defenses for a grand survival showdown!
Do you like Tower Defense games with Strategy elements? Well, look no further! We've got exactly what you're looking for! Get ready to defend your settlement from enemies using a huge arsenal of towers!
Dawn of Defense is a Roguelite Tower Defense game with RTS elements. Surrounded by enemies, your tribe is the last bastion against the Empire. Build towers to fight enemy troops in the trenches, train warriors and retake territory to build on. Reclaim your lands and defeat the baneful Empire!
Hexguardian is a roguelite, tower defense game where you build your own maps with hexagonal tiles! Build and upgrade towers, recruit armies, learn spells, construct wonders and place hexagonal tiles to create a path to enhance your defenses. With plenty of game modes and talents to unlock!
Build defences, explore an all-encompassing fog and pray you can fight off the massive hordes of Ruin. Engage with an expansive unlock system and survive in a world that changes with your decisions. ‘Monuments to Ruin’ is a roguelite, tower defense game set in a world ravaged by a suffocating fog.
Tiny Kings is the whimsical medieval base builder where your dreams of building and managing a pint-sized kingdom come true! Unleash your inner ruler and build your kingdom, manage your citizens' tasks, and dominate the siege to become the ultimate ruler.
Rogue Tower is a tower defense game with roguelike elements and a continuously expanding path which you can influence. Unlock, build, upgrade, expand, defend.
Tower Knight is a deck-building & tower defense strategy game. Build your deck to strengthen your position, level up your knight, and win by capturing enemy towers.
You are the Wandering Monolith, falling from the sky. Summon towers, expand the board, defend your core, and build your deck of upgrades to conquer countless worlds.
Eversiege is a roguelike, tower defense in which you'll defend a castle in procedurally generated terrain. Establish a production, build defending buildings and survive waves of enemies coming from everywhere! After defeat, buy new buildings, unlock new leaders and prepare to fight again.
Card Conquest is a Tower Defense game with Deckbuilding and Roguelite elements. Combine spells, towers and units to create a deck and defeat your enemies. Spend your resources wisely and find balance between offense and defense. Gather powerful relics that will enhance your cards.
Immerse yourself in Nordhold: Origins, a tower defense game with high replayability. Build a medieval Nordic village, develop its economy, and defend it with unique towers and upgrades. Choose heroes and relics, compete on leaderboards, and aim for the Valhalla rank!
Stop an endless hoard of crystal-type enemies, with different attributes, from reaching the portal to earth! You can build your own labyrinths, unlock new turrets, upgrade them, unlock abilities, and also gather permanent bonuses.
Isle of Arrows is a Puzzle Tower Defense game in which you build a fortress in the sky. Place towers, expand the isle, and build your own paths. Can you find the perfect spot for each tile to beat the RNG and defend against waves of invaders?
Dawnhelm Defense is a strategic tower defense game set in a medieval-fantasy world where players must defend the mighty fortress of Dawnhelm from relentless waves of enemy invaders. You will build and upgrade powerful towers and deploy magical abilities to stop hordes of enemies.
Defense Collapse is a strategy game set in a medieval fantasy world. Pioneer the unexplored dark forest, build your town and defenses, and hold out against the massive hordes of enemies. How long can you survive?
Crystal Guardians is a tower defense game with rogue-like elements. Fight of waves and defend the world crystal. Gear up your towers with a powerful combination of items for your strategy. In an ever expanding map, find hidden powers and conquer the enemies.
Block Tower TD 2 is a strategic game in the roguelike style with original innovations. Build worlds from blocks, choose random upgrades, each game will be unique.
Einherjar is a combination RTS and turn-based game, with roguelike elements. Defend against waves of enemies as your territory expands, and the opposition becomes tougher, while building up your base and defending and upgrading your resources.
The enemy is approaching. What's your strategy? In this fusion of Tower Defense and Autobattler, optimize the power of your turrets, create strong synergies and wisely choose your bonuses... Or your maluses! Will you be able to defend your city against the hordes of furious monsters?
In Kingdom’s Path, each battle is your own living battlefield. Every zone you place shifts enemy flow, pushing you to adapt and outsmart them. Towers rise, leaders guide, and no run plays the same. Build, defend, and carve victory from chaos.
Outpost brings the perfect mix between survival and roguelite gameplay. Start the game in a randomly generated environment and try to adapt, and make it through as many nights as possible. How long can you survive?
Terrorformer TD is a tower defense roguelite with a procedurally generated map that YOU shape! Raise or lower tiles, divert enemy paths and funnel monsters into perfectly designed killzones. Randomly drawn cards result in plenty of run variety, as you seek to survive endless waves of enemies.
A Roguelike Tower Defense game set on a user controlled procedurally generated island. Select unique cards and relics that enhance your towers abilities, crafting powerful builds to defend against the growing hordes of enemies.
Rogue Cube Defense is a minimalist roguelite tower defense game with procedurally generated path that you gradually build up. Each run is different as the upgrades you get from leveling up are random. Pick your towers loadout and come up with the best strategy to beat the hordes of enemies.
Last Throne is a tower defense strategy game set in a dark, mist-shrouded world on the brink of collapse. As the ruler of the final kingdom still standing, you must command your defenses, outsmart relentless waves of monstrous creatures, and make crucial tactical decisions to hold your ground.
Castella is a Tower Defense Rogue-like, where you will build a fortress to defend yourself from hordes of monsters besieging your castle. During the game you will unlock and upgrade towers and buildings. You will build walls to block the path and defend your resources and town hall.
The deckbuilder where cards are plants, animals, and insects that can synergize and prey on each other. Place your cards on an expanding board to trigger satisfying chain reactions and shape an interconnected ecosystem.
You're the Tower Marshal at the Elderglen kingdom, and you have a terrible job. Your king really likes to send letters to neighbours. Ones that make them offended enough to send armies at your castle. They're already on the way, so get back to work!
Begin with a handful of survivors after a 17th-century zombie apocalypse and build a growing colony. Shape its organic layout, establish production chains, define ideologies, and pass laws. Thrive by day, defend by night, and test your colony’s resilience against the undead.
Defend attacks from enemies from all directions within a limited time. Only by making full use of the differences in each tower and choosing appropriate random rewards can you survive.
A tower defense game.In the wave after wave of enemy attacks like a tide, constantly configure defense tower ties, player talents, props and equipment, build a powerful defense position, and eliminate the enemy before they fill the map!
Idol Keeper is a 3D one-player turn based game where you have to make many strategic choices as you face demon waves, with many random events guarantying hours and hours of unique gaming time.
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