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STEM Defense
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The top results based on the latest update are Hormone Wars - Tower Defense [Score: 1.0], Villages on Wheels [Score: 1.0] and Surging Matrix [Score: 1.0] The top rated games you can find here are Emberward [SteamPeek Rating: 8.1] ranked #16, Rogue Tower [SteamPeek Rating: 7.2] ranked #6 and Nordhold: Origins [SteamPeek Rating: 6.4] ranked #18 Also don't forget to check the newest releasesCard Conquest [Release date: 2026-09-25] ranked #22, Emberward [Release date: 2026-09-17] ranked #16 and Endless Defense [Release date: 2026-08-02] ranked #23 While it is tempting to play with the newest and the best, there might be some other gems in the results, like Emberward [SteamPeek Rating: 8.1] ranked #16, Nordhold: Origins [SteamPeek Rating: 6.4] ranked #18 and Isle of Arrows [SteamPeek Rating: 5.5] ranked #19.
Engage in epic battles against microscopic foes in 'STEM Defense', a strategic tower defense adventure set on a hex-grid. Harness the immune system's power, BUILD your defenses and fend off waves of pathogens, unlock potent cells and upgrades, and evolve your defenses for a grand survival showdown!
Do you like Tower Defense games with Strategy elements? Well, look no further! We've got exactly what you're looking for! Get ready to defend your settlement from enemies using a huge arsenal of towers!
Expand your moving village while monsters try to tear it down in this strategic horde survival. Combine blessings, level-ups, orbs and buildings to create the ultimate survival machine!
Dawn of Defense blends RTS, Tower Defense, and Roguelite progression. In a last defense, lead your tribe against the Empire: Command warriors in battle, fortify defenses, and build an economy as you fight to reclaim your ancestral homeland.
Hexguardian is a roguelite, tower defense game where you build your own maps with hexagonal tiles! Build and upgrade towers, recruit armies, learn spells, construct wonders and place hexagonal tiles to create a path to enhance your defenses. With plenty of game modes and talents to unlock!
Rogue Tower is a tower defense game with roguelike elements and a continuously expanding path which you can influence. Unlock, build, upgrade, expand, defend.
Build defences, explore an all-encompassing fog and pray you can fight off the massive hordes of Ruin. Engage with an expansive unlock system and survive in a world that changes with your decisions. ‘Monuments to Ruin’ is a roguelite, tower defense game set in a world ravaged by a suffocating fog.
Tiny Kings is the whimsical medieval base builder where your dreams of building and managing a pint-sized kingdom come true! Unleash your inner ruler and build your kingdom, manage your citizens' tasks, and dominate the siege to become the ultimate ruler.
Tower Knight is a deck-building & tower defense strategy game. Build your deck to strengthen your position, level up your knight, and win by capturing enemy towers.
Expand TD is a tower defense roguelite. Explore the map between waves, build your defenses, and discover useful locations, strange encounters, hidden rewards, and dangerous threats on every run.
Defend the Obsidian Tower in a roguelike tower defense on procedurally generated hex paths. Build crossbows, flamethrowers, Tesla coils and mortars, combine fire, poison, ice and lightning, draft run cards between waves, and spend banked XP on permanent upgrades.
Wandering Monolith is a Roguelike, Tower Defense game with Deckbuilding elements.[/img]Each playthrough is divided into these stages: Summon your towers - Strategically place your towers on the battlefield. Expand board - Watch as the board grows and changes with every decision you make.
Cube Duty is a Cube-Powered City Builder where every throw shapes your kingdom. Every cube can become a building, resource or unit. Grow intricate production chains, recruit powerful armies, and defend your Castle against waves of enemies and epic bosses!
Eversiege is a roguelike, tower defense in which you'll defend a castle in procedurally generated terrain. Establish a production, build defending buildings and survive waves of enemies coming from everywhere! After defeat, buy new buildings, unlock new leaders and prepare to fight again.
One More Tower is a horde survival TD set in a medieval fantasy world. Pioneer an unexplored forest, build your town and defenses, and hold out against the onslaught of enemies. How long can you survive?
Immerse yourself in Nordhold: Origins, a tower defense game with high replayability. Build a medieval Nordic village, develop its economy, and defend it with unique towers and upgrades. Choose heroes and relics, compete on leaderboards, and aim for the Valhalla rank!
Isle of Arrows is a Puzzle Tower Defense game in which you build a fortress in the sky. Place towers, expand the isle, and build your own paths. Can you find the perfect spot for each tile to beat the RNG and defend against waves of invaders?
Stop an endless hoard of crystal-type enemies, with different attributes, from reaching the portal to earth! You can build your own labyrinths, unlock new turrets, upgrade them, unlock abilities, and also gather permanent bonuses.
Dawnhelm Defense is a strategic tower defense game set in a medieval-fantasy world where players must defend the mighty fortress of Dawnhelm from relentless waves of enemy invaders. You will build and upgrade powerful towers and deploy magical abilities to stop hordes of enemies.
Card Conquest is a Tower Defense game with Deckbuilding and Roguelite elements. Combine spells, towers and units to create a deck and defeat your enemies. Spend your resources wisely and find balance between offense and defense. Gather powerful relics that will enhance your cards.
Endless Defense is a roguelite sci-fi tower defense game where every run becomes a new build. Place turrets, choose traits, draw upgrade cards, use special tiles, and evolve your defense to survive endless waves of enemies, elites, and bosses.
Einherjar is a combination RTS and turn-based game, with roguelike elements. Defend against waves of enemies as your territory expands, and the opposition becomes tougher, while building up your base and defending and upgrading your resources.
Block Tower TD 2 is a strategic game in the roguelike style with original innovations. Build worlds from blocks, choose random upgrades, each game will be unique.
Crystal Guardians is a tower defense game with rogue-like elements. Fight of waves and defend the world crystal. Gear up your towers with a powerful combination of items for your strategy. In an ever expanding map, find hidden powers and conquer the enemies.
A frantic roguelite castle defense with deckbuilding elements. The world has fallen to evil. Raise your fantasy castle and survive endless monster hordes. Collect the energy of the fallen and let dark powers tempt you with gifts like knights, wizards, towers and walls. Choose wisely. Grow strong.
The enemy is approaching. What's your strategy? In this fusion of Tower Defense and Autobattler, optimize the power of your turrets, create strong synergies and wisely choose your bonuses... Or your maluses! Will you be able to defend your city against the hordes of furious monsters?
Draw the enemy's path, build powerful towers, and defend your castle against thousands of enemies in this roguelite tower defense game. Conquer procedurally generated maps, unlock permanent upgrades, and grow stronger with every attempt!
In Kingdom’s Path, each battle is your own living battlefield. Every zone you place shifts enemy flow, pushing you to adapt and outsmart them. Towers rise, leaders guide, and no run plays the same. Build, defend, and carve victory from chaos.
Outpost brings the perfect mix between survival and roguelite gameplay. Start the game in a randomly generated environment and try to adapt, and make it through as many nights as possible. How long can you survive?
Tower defense meets alchemy: Brew flasks, throw them at your enemies to counter their special abilities, or empower your towers with them. Defend Khaldoria in a fully voiced campaign built around your magical board game. Play the free demo now!
Terrorformer TD is a tower defense roguelite with a procedurally generated map that YOU shape! Raise or lower tiles, divert enemy paths and funnel monsters into perfectly designed killzones. Randomly drawn cards result in plenty of run variety, as you seek to survive endless waves of enemies.
Hexfall is a planet-scale tower defense game where over 100,000 enemies attack at once. Mine the crust, wire the power and arm a hex world against an armada that fills the sky long before it comes down.
A dark hex board. Shadow-crystal creatures march on your last lantern. Build no towers, build light. Aim emitters, bend beams with mirrors, and cross colors to unleash new effects. Every placement re-traces the whole board. A roguelite tower defense made of pure light.
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