Top similar games like The Lizard Problem:

A Roguelike Tower Defense in space with missions to conquer. Can you hold against the spreading alien bosses? Build and upgrade towers against the corruption. Choose your technologies and warpspeed your way to victory.

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

Survive as long as possible in Fried Panic! Buy weapons, abilities, and even donut producing machines. Fight through waves of eggs, lemons, chicken drumsticks, and much more, all in a top down pixel art style.

Try to survive in infinite asteroid cloud as long as possible in reworked tower defence style. FInd your own playstyle and beat your own records or chillout with original ambient soundtracks. Build, explore, think - everything to create your own colony in this cold space.

Delve for materials, machines and curiosities in this game inspired by Dungeon Keeper and Pikmin.

Snowbound is a roguelite farming game with tower defense elements. Build your farm, survive the night with a range of defenses, and complete missions to progress deeper into the forest.

TEOM is a roguelite strategy game that draws inspiration from the tower defense genre to innovate it through dynamic levels, interactive elements, and high replayability. Follow Aiden and his friends on an unexpected journey through this vibrant world.

Mana Fortress is a roguelite base defense strategy game. Build up your arsenal of towers and spells to keep your fortress safe from waves of enemies while you gather enough mana and resources to ensure victory.

Prepare for an epic battle in this captivating tower defense game! Build, defend, and triumph as you strategically place towers, manage resources, and upgrade your arsenal to fend off relentless waves of enemies.

Dive into the whimsical world of Tinker Tactics, a unique blend of roguelike deckbuilding and tower defense. Craft the perfect deck to build the most efficient engines for your toy towers, then fend off waves of malfunctioning toy robots.

A base-building, Roguelike Action/Turn-based Strategy (RATS) game, in a forest invaded by a million Rats. As the powerful Spirit of Vengeance, you must save the adorable Villagers! Explore a randomly generated world, expand your village, and exterminate the Rats!

Ready for some chaos? Command 5 characters in this Roguelite Tower Defense! Build your dream team, crush enemies, and have a blast with adorable pixel art!

Cluckmech Oasis, a top-down shooting Roguelike tower defense game. Play as the Warcluck and lead your team of animal heroes in a fight for survival. Collect, build and upgrade defenses, and engage in intense battle against waves of plant enemies.

Endless horde mode tower defense with permanent and per-run progression. Unlock dozens of towers, survive and become dauntless.

Ice Fighter is a fast-paced Tower Defense-like game where you battle enemies, scavenge for resources, manage upgrades, and build defenses. Melt enemies during the night and gather resources during the day.

Fight your way through a large variety of rooms, enemies, and bosses. Collect unique items each floor, developing your stats and creating interesting item combos with terrifyingly powerful synergies! Play to enjoy the rush, or piece together the story through the various endings and hidden messages!

Bioguard is a tower defense roguelite with a biological theme. Help the immune system using a variety of towers, skills and special cards. Develop your strategy to protect your body from invading pathogens and prevent their passage to vital organs!

SUPRACORE is a roguelike base building game. Build your base, upgrade it and defend against ongoing waves of enemies to gather more resources and expand your Core!

OBA DOBA is a Roguelike RTS/Tower Defense that is fast, funny, and frantic. Defend your base with towers and fighters while managing your resources and upgrades. Build up your arsenal of structures, abilities, and passives to defeat the evils that await. Build, rebuild, and survive! (hopefully)

Classic tower defense meets roguelike adventure where you control the hero! Dive into procedurally generated levels filled with unique waves of enemies. Create powerful synergies with a variety of game-changing skills, relics, weapons, and traits to defend your kingdom. Every run is a new challenge!

A living ant tower defense, upgrade abilities to increase competitiveness. Combine different ant species to form an aerial defense and kamikaze attacks. Deploy ants to collect honey. Breed ants to expand your territory and compete against red fire ants to save the natural environment of the island.

As the kingdom's most promising pioneer, embark on a legendary journey to tame the frontier! Build thriving towns across various landscapes, fending off waves of diverse enemies until you establish a firm foothold and have explored everything the eye can see!

The adventure in the mysterious world of the Wall continues! Pilot your robospider into its depths, uncover lost artifacts and technologies, upgrade your exosuit and spider, and battle the horrors lurking in the dark. Unravel the mysteries buried in the depths of the Wall!

A real-time strategy game combining deck-building mechanics. Summon soldiers to control a 3x3 battlefield and deal damage by completing lines using Tic-Tac-Toe rules. Make quick decisions and build your deck strategically to protect the kingdom’s resources.

Combine chemicals, prepare potions, and battle hordes of zombified scientists in this action-packed, chemistry-themed roguelike. You'll fight your way through a procedurally generated lab, exploding enemies and vaporising various vermin in order to purchase upgrades and drill for new elements.

Defend your castle, mine for minerals, and level up your wizarding powers in this thrilling action-roguelike game. Grab your wand and prepare to fight off magical foes in this epic battle for survival!

Combination of roguelike and strategy in one side view game. Defend yourself against constantly attacking Elms while researching procedural research branches. Destroy the enemy or lose

A valiant knight embarks on a perilous quest to find a mystical portal that will lead him back to his homeland. Clad in gleaming armor and wielding his trusted fork, he traverses treacherous landscapes only to be haunted by none other than...cows.

Explore the mysterious Wall World on your giant robospider: mine for valuable resources, upgrade your equipment to fight off hordes of monsters, and discover exotic biomes in-between attacks. Will you be able to survive and learn the secrets of the Wall World?

Baa! Get ready to protect the lambs! Whether you go solo or invite your friends, construct a sturdy home to shield your little ones from the dangers in the forest. Start building your family now and prove the power of the sheep! Baa!

The hungry Gooper swarm threatens intergalactic peace. Stop them! Build towers around planets and take control over their orbits. Spin them with all you’ve attached! Collect new towers, powers and upgrades to beat the onslaught of goopers and save the galaxy in this colorful Tower Defense Roguelite!

Build your ship, escape the swarm, survive for as long as you can. When you are finally defeated, upgrade your technologies to survive longer next time. Escape from Zeta Aurigae is a sci-fi ship builder with rich meta progression.

ANTD is a tower defense game where you’ll defend your picnic set against waves of relentless ants. Unlike most games in the genre, ANTD stands out by having no predefined routes. Instead, players must create their own intricate layers of defense to guide enemies strategically.

Cook Fest is a unique combination of tower defense and cooking genres. Create and design your own complex maze. Cook and serve dishes to satisfy your customers & unlock new recipes. With unexpected roguelite elements & fast-paced gameplay, you can play solo or in chaotic co-op with your fellow chef!

Face endless, unpredictable waves of unique geometric enemies by building and customizing a powerful base designed to withstand the chaos. Unleash the Quantum Decimator to obliterate gigantic bosses in this one-of-a-kind top-down tower defense where strategy meets action!

Protect your kingdom in a game that combines Tower Defense and Action RPG. Build your perfect defense with towers, skills, hero, upgrades, and research to face 200+ different enemies. Evolve your hero, unlock new abilities, and expand your inventory to prepare for the greatest challenges!