Top similar games like Patient Zero: Plague Idle:

SynthetiCell BioClicker is an Idle incremental simulator where you bring to life a colony of synthetic automaton cells. Inspired by the classic 'Game of Life' by mathematician John Horton Conway (1970) about the evolution of an organism. Can you guide your colony to prosperity?

From 0 to Hero investing simulation game. Start as a dead end job worker and work your way to financial freedom. Supports both minmaxing and relaxing playstyles.

Grow food. Smash it into bites. Feed Fred. An active incremental game about one very hungry creature. Discover stranger foods, cook better meals, and hire Friends to keep food coming from every location. Recycle Fred's waste into fertilizer and watch his weight climb.

Manage a colony of living cells in a strategy game built from real biology. Build phospholipid membranes, place organelles, import nutrients, fight viruses, detect cancer, and divide your cells to grow. No tutorials. No lectures. Learn by keeping the cell alive.

A relaxing idle city-builder where a single hut grows into a sprawl of millions. Build production chains, let your civilisation expand while you're away, and Ascend to push the whole world up an order of magnitude.

Do you need more RAM? Of course you do. Everybody does. Get RAM Downloader and improve your quality of life. The clicker / idler, that gets you all the RAM you need. It's easy. You click Download. RAM increases. You live a happier life.

A condensed incremental experience, where you build a colony to collect and merge bigger and bigger fruits. Combine game-changing technologies and special upgrades to find the best synergies and take your cash flow to another dimension.

Apiary in Flow is an incremental game with automation elements where you place bees inside a hive to build efficient honey-gathering chains. Unlock new bee types and spend your harvest on permanent skill tree upgrades!

Build a living ant colony that can stay on your desktop while you work. Hatch unusual ants, place nest and food rooms, collect coins, and expand from a glass habitat into drawers, pipes, walls, roots, and the forgotten depths below.

Idle Cosmos Clicker is a space-themed idle simulation where you grow the universe from asteroids to black holes. Produce, automate, and evolve resources while unlocking planets, stars, and galaxies. A relaxing yet deep incremental experience with endless progression.

A cute incremental clicker where you bonk bugs for profit. Earn money, unlock upgrades, acquire powerful skills, and recruit helpers to automate the bonking until you’re truly unstoppable. Satisfying and Relaxing!

An idle game where you gather resources and grow your city. Sit back and watch your city expand!

Giant Horse Feeding is a silly alien colony simulator where you feed a horse & collect its droppings to build an alien empire. Automate production, unlock bizarre technologies, and create an endless recycling loop where horse droppings become the foundation of your civilization.

Slay giant bosses and turn the hollow wasteland into the almighty kingdom! Endlessly rewarding incremental game where you collect fountains of rare loot, unleash crazy combos and watch the monsters fall under your knees. Boss Rush that keeps on going when you're gone!

An incremental game about flipping bottles, unlocking and upgrading unique abilities, and turning simple bottle flips into increasingly satisfying moments.

Goblin Smasher is an addictive idle/incremental game where you crush endless hordes of goblins. Sweep your mouse to blast goblins, explore a massive skill tree, equip your heroes, collect relics, and become an unstoppable force!

Click, topple and profit! Knock over tiny wandering Humans, hire Animals to cause chaos, collect mountains of coins and grow your ridiculous empire. Unlock powerful Rebirth upgrades, defeat Bosses and turn a peaceful board into a glorious mess of falling people.

Stolen Legacy!! Click, hustle, invest. From nobody to legend!

Pirate Treasure Hunt is a short incremental treasure hunting game. Explore islands, uncover rare treasures and ancient artifacts, upgrade your expedition and become the richest pirate on the seas.

Incremental clicker/idle and narrative game where you crush empty cans, sell the aluminum, upgrade your equipment, and buy factories and automatic presses to automate the process. Discover what happened to your wife and son as you try to save Aluminum City from an evil villain.

Build a cosmic energy empire in this colorful incremental sci-fi game. Click, automate production, unlock technologies, explore distant planets, collect artifacts, raise cosmic pets, and ascend to unlock permanent upgrades.

The company is falling apart, and you're both the HR cleaning up the mess and the CEO profiting from it. Optimize people, rebuild workflows, automate production, and watch the numbers go up.

A chill idle game in the corner of your screen. Popups spawn. Close them. Earn money. Buy upgrades. Repeat.

Start with a single sickle and a tiny field. Cut and sell grass, automate your workforce, optimize supply chains, and build a sprawling incremental empire.

Start with one donut. End with a multidimensional bakery empire. Click, automate, expand, unlock the Research Lab, run a Storefront, and break through to the Donut Hole. A layered idle game that keeps unfolding new systems until your mouse screams for mercy.

Billion Bounces is a short incremental game with bouncing balls, bumpers, and one goal: earn coins, buy upgrades, and watch the economy slowly fall apart.

A Minesweeper-inspired incremental where every cell you dig pays. Run short shifts, buy upgrades between them, and work your way up a seven-floor company tower — glaciers, volcanoes, deep space, a casino on top. Mines? That's what insurance is for.

Weedcraft Inc explores the business of producing, breeding and selling weed in America, delving deep into the financial, political and cultural aspects of the country's complex relationship with this troublesome and promising plant.

What if you had it in your power to rid the world of disease, to improve the lives of millions, to ease suffering and cure the sick… and earn a tidy profit? As the head of your own Pharmaceutical Conglomerate you have this power resting in your hands. Will you use it for good?

You start with a tiny mech factory, a pile of scrap, and one goal: make money. Manufacture parts, assemble mechs, and take on questionable contracts for clients who don't ask about ethics, just excellent margins. Grow your factory, upgrade your tech tree, and build the ultimate mech: TITAN.

Explore an old operating system in this incremental game about software that pays its users. Type stories, earn money, upgrade your software, and unlock new programs. Discover how lucrative the Screen Saver OS can be!

Dive into the world of machine learning! Node Factory is a node-based automation incremental game where you harvest resources and train neural networks. Manage your economy, optimize your grid, and automate your way to a multi-Centillion dollar tech empire.

Start as a small content creator and build your own YouTube empire. Upgrade your PC, produce videos, earn money and grow your channel into a massive content factory.

Fracture Field is an idle/incremental quarry mining game. Shatter rocks with timed swings then invest your earnings into upgrades. Build a fleet of drones to automate your empire, bomb tough layers, and unlock powerful prestige upgrades on your journey to master the quarry.

Incremental game where you play as a frustrated rich MMO veteran promising to make the next WoW killer. How far will you get before cashing out?

Build a drug empire with your last $50. Buy production, upgrade it, and hire workers to automate.