Top similar games like Post Apocalypse Microbe Lab:

CELESTAY is a calm idle building game where you fish for materials and grow your home toward the sky. In a world sunk beneath the sea, you stack pieces of a house and spend quiet days fishing and watching the stars. The higher you build, the more constellations and memories fill your world.

Koishi’s Fishing Journal is a Touhou Project fan-made desktop idle fishing game. Fish with Koishi, collect fish and rare merfolk, cook dishes with your catch and precious ingredients, sell them for profit, and unlock new species as Koishi enjoys her quiet fishing life on your desktop.

Idlequarium is a casual simulation game where you raise adorable little fish to earn coins, purchase decorations, and build a fully customized aquarium.The game sits anywhere on your desktop, letting you interact with your live aquarium during work or study breaks.

Watch a tiny diver explore the ocean in the corner of your screen. Collect sea creatures, upgrade equipment, and unlock new diving spots.

A small desktop game where every keystroke and click takes Claire another step through a dream. Keep it in a corner of your screen, collect items, customize Claire and her surroundings, and enjoy music and ambient sounds while you work.

In this casual idle simulator, you take care of charming pixel-art fish, collect coins to buy decorations that provide uniques bonusses, and create your dream Pixel Aquarium!

A relaxing idle swimming game where you catch fish, unlock new locations and characters, customize your swimmer, and enhance your abilities with helpful pets and power-ups.

Raise your own virtual pet right on your desktop. Choose your favorite, take care of your companion, play together, train for battle, and help them evolve! They will always be there, keeping you company while you work, play, or browse.

"Fishful Days" is a casual idle game. you can buy fish fry and let them grow in the background; once they reach adulthood, they will continuously produce fish for you! You can also buy multiple fish tanks to achieve snowballing growth. It also offers rich fish tank customization features.

Tiny pixel monsters live along the bottom of your screen, and climb on top of your windows. Hatch eggs, merge twins to evolve them, and collect over 1,000 looks across 95 forms while you work. Pet them, toss them a treat, and watch them make friends.

A relaxing mini aquarium that stays on your desktop corner while you do other stuff — collect fish, upgrade tanks, and enjoy a cozy idle experience.

Make some lemonade and set sail in this cozy fishing incremental game. Catch weird fish across colorful locations, upgrade your gear, rebuild Starlight Cove back to its former glory, and defeat the evil shark that stole your grandfather's greatest treasure years ago.

Cozy Littlequarium is a relaxing aquarium simulator that sits at the bottom of your screen! Take care, breed them, collect and decorate!

A creature collection game that sits at the bottom of your screen & fits easily into your routine. Whether you're working, studying, or relaxing, Whimside is always ready to offer you a cozy escape. Capture rare creatures, create new species & decorate your whimsical space!

a tiny wizard lives at the edge of your screen and rebuilds his tower while you work. you set the spells he casts, he catches falling stars in a jar and keeps going while the game is closed. about two weeks to the ending

A cozy and relaxing desktop companion game filled with adorable cats. Welcome a variety of cats into your family, care for them, and enjoy everyday life together.

"Launch the hook to the sky! Capture the unknown!"Use a specially designed anti-gravity fishing rod to fish for strange flying creatures in the mutated clouds, establish a new era of Earth's ecological atlas, and explore the oddities of civilization in the joy of picking up trash.

Collect over 100 stylish little pets on your desktop! They can freely move along the bottom of your screen, or live in the little houses you've carefully decorated for them. Hmm... or perhaps send them on adventures to earn treats?

This is a group of cute little fish swimming leisurely at the bottom of the screen while you work. The fish swim, grow and earn stars for you. Use them to buy other cute little fish until the bottom of the screen becomes a colorful ocean world! Start a leisure desktop fish farming journey!

Hatch mystery eggs, watch fish grow to reveal their hidden rarity, and collect the rarest ones in a cozy aquarium you can relax with in the background.

Fish Companions is a relaxing idle game that brings colorful life to your desktop. Adopt your own digital fish to keep you company. Raise your companions, unlock aquariums, explore new oceans filled with more fish, and collect them all! Hang out with your friends to enjoy even more companionship!

An idle desktop pet game where pixel RPG heroes patrol the bottom of your screen, collect loot, and level up while you work.

An idle fishing game that lives on the edge of your screen. A tiny fisherman works your real weather, your real nights and your real moon, and pulls up something rare when you least expect it. 120 species. Forty of them are riddles, not jackpots.

Welcome To The Crater! It's been 100 years of drought, but water has returned and with it a flourishing of new life to find! Discover new creatures, customize your aquarium to perfection, and collect them all! Fish right on your desktop with passthrough or enjoy the scenic views of The Crater!

"Skytopia" is a charming pixel-style fishing simulation idle game. The witch Alice will decorate a beautiful sky island at the base of your desktop, immerse yourself in a relaxing fishing lifestyle, and hatch and nurture a variety of adorable animals on the island.

《Fluffy Kitchen Saga》A restaurant simulation game located at the bottom of your computer screen, where both staff and customers are fluffy little animals! They’ll keep you company while you work/study. Let’s run a restaurant full of fluffiness!

A relaxing idle fishing game that waits for you at the bottom of your screen. CATCH fish, BUY upgrades, COMPLETE your collection, and DISPLAY them in your aquarium.

"Lofi Aquarium" is a gamified focus tool designed to enhance concentration and relieve stress. As you work, a group of adorable baby fish will keep you company, all set to soothing lofi music. Over time, the fish grow and can be sold for profit. 

Reefling is a calm desktop aquarium that sits in the corner of your screen. Feed your fish with a click, earn shells over time, and collect over 150 pixel-art species. Decorate the tank and watch day turn to night. Your fish never starve and you can't lose, so just relax while you work.

Sit back and relax with Neko Station, a cozy 2D Pixel Art Desktop Idle Game! Manage your very own 'cat train,' decorating it with the perfect furniture to attract a diverse cast of feline customers. Pick them up at various stations and build friendships in this heartwarming adventure.

A chill, tamagotchi-like idle creature game in the corner of your screen. Raise creatures, unlock 100+ evolutions, and freely customize your room at your own pace!

An idle fishing game at the edge of your desktop. Visit six alien seas, collect 120 species in 700+ forms, and unlock in-game foil cards. Decorate your aquarium, cook 150 dishes for strange guests, breed fish, and send takeout by rocket while you work or unwind.

Decorate your own aquariums and care for a variety of fish in Fishlets, a cozy fish-collecting sim! Feed, breed, sell, and collect fish and aquatic critters in the virtual tanks mode. Drop into Adventure mode and progress through 7 unique levels, unlocking even more fish while fending off threats!

Still Waters is a cozy idle aquarium at the bottom of your screen - the kind you can reach into. Grab fish, toss them, collect them, and let a little ocean keep you company while you work, study or chill.

Little Aquarium is a relaxing idle game where you grow your own underwater world. Collect rare fish, discover vibrant color variants, and decorate your dream tank!