Top similar games like Post Apocalypse Microbe Lab:

Idlequarium is a casual simulation game where you raise adorable little fish to earn coins, purchase decorations, and build a fully customized aquarium.The game sits anywhere on your desktop, letting you interact with your live aquarium during work or study breaks.

Watch a tiny diver explore the ocean in the corner of your screen. Collect sea creatures, upgrade equipment, and unlock new diving spots.

"Skytopia" is a charming pixel-style fishing simulation idle game. Decorate a beautiful sky island at the base of your desktop, immerse yourself in a relaxing fishing lifestyle, and hatch and nurture a variety of adorable animals on the island.

"Meet your new hardworking desk companion! Cozy Desktop Pal mines, fishes, and farms while you focus on your work. Help your pal survive by managing their needs, trade resources in the market, and use skill points to transform a tiny worker into a master adventurer."

A relaxing mini aquarium that stays on your desktop corner while you do other stuff — collect fish, upgrade tanks, and enjoy a cozy idle experience.

Cozy Littlequarium is a relaxing aquarium simulator that sits at the bottom of your screen! Take care, breed them, collect and decorate!

A creature collection game that sits at the bottom of your screen & fits easily into your routine. Whether you're working, studying, or relaxing, Whimside is always ready to offer you a cozy escape. Capture rare creatures, create new species & decorate your whimsical space!

"Launch the hook to the sky! Capture the unknown!"Use a specially designed anti-gravity fishing rod to fish for strange flying creatures in the mutated clouds, establish a new era of Earth's ecological atlas, and explore the oddities of civilization in the joy of picking up trash.

Collect over 100 stylish little pets on your desktop! They can freely move along the bottom of your screen, or live in the little houses you've carefully decorated for them. Hmm... or perhaps send them on adventures to earn treats?

This is a group of cute little fish swimming leisurely at the bottom of the screen while you work. The fish swim, grow and earn stars for you. Use them to buy other cute little fish until the bottom of the screen becomes a colorful ocean world! Start a leisure desktop fish farming journey!

Hatch mystery eggs, watch fish grow to reveal their hidden rarity, and collect the rarest ones in a cozy aquarium you can relax with in the background.

In this incremental game, you shoot ducks and earn money. Use your earnings to buy dogs and traps and hire hunters to help you hunt even more ducks. Progress through levels, battle powerful bosses, and work toward making the entire duck population extinct!

Fish Companions is a relaxing idle game that brings colorful life to your desktop. Adopt your own digital fish to keep you company. Raise your companions, unlock aquariums, explore new oceans filled with more fish, and collect them all! Hang out with your friends to enjoy even more companionship!

An idle desktop pet game where pixel RPG heroes patrol the bottom of your screen, collect loot, and level up while you work.

Welcome To The Crater! It's been 100 years of drought, but water has returned and with it a flourishing of new life to find! Discover new creatures, customize your aquarium to perfection, and collect them all! Fish right on your desktop with passthrough or enjoy the scenic views of The Crater!

A relaxing idle fishing game that waits for you at the bottom of your screen. CATCH fish, BUY upgrades, COMPLETE your collection, and DISPLAY them in your aquarium.

"Lofi Aquarium" is a gamified focus tool designed to enhance concentration and relieve stress. As you work, a group of adorable baby fish will keep you company, all set to soothing lofi music. Over time, the fish grow and can be sold for profit. 

Evicted. Broke. One bottle. Flip your way from the curb in this idle incremental game. Pull rare bottles from Crusty Carl’s trash can, upgrade your flip technique, and fight the homeless for that sweet rotisserie chicken

A chill, tamagotchi-like idle creature game in the corner of your screen. Raise creatures, unlock 100+ evolutions, and freely customize your room at your own pace!

Reefling is a calm desktop aquarium that sits in the corner of your screen. Feed your fish with a click, earn shells over time, and collect over 150 pixel-art species. Decorate the tank and watch day turn to night. Your fish never starve and you can't lose, so just relax while you work.

Decorate your own aquariums and care for a variety of fish in Fishlets, a cozy fish-collecting sim! Feed, breed, sell, and collect fish and aquatic critters in the virtual tanks mode. Drop into Adventure mode and progress through 7 unique levels, unlocking even more fish while fending off threats!

Little Aquarium is a relaxing idle game where you grow your own underwater world. Collect rare fish, discover vibrant color variants, and decorate your dream tank!

A cozy desktop companion game where a cute crocodile fishes for you. Catch all kinds of weird fishes, sell them to upgrade his gears or showcase your impressive catches so that friends can be jealous. Automation is there for busy time, and no distractions, so you can focus on work when needed.

《Fluffy Kitchen Saga》A restaurant simulation game located at the bottom of your computer screen, where both staff and customers are fluffy little animals! They’ll keep you company while you work/study. Let’s run a restaurant full of fluffiness!

Build a living pond where every fish has a unique genetic code. Breed for rare traits, balance oxygen and hunger, unlock new species, and watch your ecosystem compose its own soundtrack in real time. Part sim, part idle game, part science experiment gone beautifully wrong.

A one-button game where failure is progress, inaction is a choice, and luck is never entirely fair. Discover every egg, stage, secret, and animal while putting your fortune to the test. It’s a piece of cakegg!

"Internet Fisherman" is an idle fishing game with Steam Community trading, where you can obtain rare fish every 2 hours and add them to your Steam inventory. Players can feed fish to cats to increase affection, and will appear on the affection leaderboard to compete with other players.

Mango’s Fisharium is a short incremental game about catching unique fishes and displaying them in the Fish Aquarium. Designed to be completed in around 4 hours.

Raise your own virtual pet right on your desktop. Choose your favorite, take care of your companion, play together, train for battle, and help them evolve! They will always be there, keeping you company while you work, play, or browse.

Sit back and relax with Neko Station, a cozy 2D Pixel Art Desktop Idle Game! Manage your very own 'cat train,' decorating it with the perfect furniture to attract a diverse cast of feline customers. Pick them up at various stations and build friendships in this heartwarming adventure.

Here’s a cute, chubby black cat. All it wants to do is quietly go fishing. “Right in the corner of your desktop!” Collect fish to fill up the cat’s encyclopedia, earn money, and dress it up in adorable outfits!

Brewbie’s Alchemy Desk is a cozy idle simulation about potions and tiny magical helpers. On your enchanted desk, you’ll meet the adorable Brewbies—little spirits who happily run your workshop while you relax. Decorate your desk however you like and enjoy a slow, healing moment of magic.

Meet Lofelia, your dreamy desktop companion who writes books as you work, study or game. In this cozy clicker game, every time you press a key Lofelia continues to write her stories. How will you decorate Lofelia's Cozy Corner?

A chill idle-fishing desktop toy in the corner of your screen. Buy upgrades, catch rare fish, and customize your avatar at your own pace!