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The top results based on the latest update are Loopstructor:Prologue [Score: 1.0], Nano Organism [Score: 0.9] and Propa. [Score: 0.9] The top rated games you can find here are Plague Inc: Evolved [SteamPeek Rating: 10.5] ranked #29, Creeper World 3: Arc Eternal [SteamPeek Rating: 8.2] ranked #9 and Yokai Art: Night Parade of One Hundred Demons [SteamPeek Rating: 6.3] ranked #13 Also don't forget to check the newest releases Infinite Evo TD [Release date: 2026-06-26] ranked #20, Zero Bugs Given [Release date: 2026-05-14] ranked #16 and Yokai Art 2: Tales of the Nine-Tails [Release date: 2026-04-26] ranked #24 While it is tempting to play with the newest and the best, there might be some other gems in the results, like Wireworks [SteamPeek Rating: 5.5] ranked #12, Yokai Art: Night Parade of One Hundred Demons [SteamPeek Rating: 6.3] ranked #13 and Dungeon Warfare 3 [SteamPeek Rating: 5.1] ranked #14.
Fight ever-mutating bacteria and viruses, collect gene modules from fallen pathogens, evolve and strengthen your immune system, unlock a variety of medical interventions, and create powerful synergistic builds to survive an ever-escalating infection.
《Loopstructor:Prologue》 is a strategy game that combines tower defence with Roguelike.Unlike traditional tower defense game, the towers in the game are vehicles that move along ‘loops’.You need to create defence loop and build battle trains to defend against enemy attacks.
Nano Organism - is a real-time strategy game, you control nano cells to control the entire organism, lots of puzzles, dynamic progression, lots of research, achievements, free choice of development direction and progression.
In this RTS game, control your virus to replicate and evolve against a powerful immune system. Equip gene segments to create unique viral armies. Use tactics to eliminate immune cells or achieve escape. Develop strategies for domination and enjoy endless strategic fun!
This is a strategy game that combines tower defense with Roguelike. Unlike traditional tower defense game, the towers in the game are vehicles that move along ‘loops’.You need to create defense loop and build battle trains to defend against enemy attacks.
Strategically position units on a chess-based battlefield, defending territories while earning roguelike upgrade-items for leveling up. Discover over 30 unique equipment pieces that modify units, allowing for exciting customization and ensuring endless excitement and replayability.
Life on the Edge is an educational tower defense game. You play as a cell struggling to survive waves of bacteria and the COVID-19 virus. Protect your cell and build an understanding of cell biology at the same time!
BALL MACHINE is real-time strategy driven by pinball. Launch creature marbles, gather red, green, and blue paint energy, and buy units, cartridges, upgrades, structures, and tactical tools. Command the battlefield against the standard AI or asynchronous builds formed from your own past decisions.
This is a innovative roguelike TD game made with the 『CliCli』. No need for path planning or tower combos—just one tower! With almost 100 weapons, you’ll be mowing down foes and dominating the battlefield. Enjoy the rush and let off some steam!
Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.
Strategically position units on a chess-based battlefield, defending territories while earning roguelike upgrade-items for leveling up. Discover over 30 unique equipment pieces that modify units, allowing for exciting customization and ensuring endless excitement and replayability.
"Infectonator : Survivors" is a Randomized Permadeath Survival Simulator that combines RTS, Tower Defense, Roguelike, and Management-Simulation gameplay. The goal is to lead a group of survivors in a struggle to stay alive and find rescue in a zombie apocalyptic world.
Design your defenses, build your module board, and manage your wires. Combine signals and create synergies to empower your weapons and survive in this base-defense roguelike auto-battler.
By accident, you broke the seal of the mysterious book, which contains an enormous magical power that allows users to control any Yokai by defeating them and recording their names. This godly power is too much which alerts all the Yokai. You must find your own way to defeat them and survive.
Forge invincible defenses with lethal traps and devious machines, and crush relentless waves of adventurers in the ultimate tower defense showdown!
A roguelike tower defense where every run reshapes your strategy. Build your team of towers, combine more than 80 artifacts, and explore a pixel-art world while taking on ever tougher challenges and bosses.
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Zero Bugs Given is a tower defense / roguelike game designed with the ambition of making every run different from the others. Every wave, a pair of bonus and malus will force you to adapt in the best way you can. Build your defense and try survive as long as you can!
"In 'Random Core Defense,' acquire and enhance cores using limited resources to withstand relentless enemy onslaughts. Defeat powerful bosses and test your strategy to survive until the very end!"
FinalFort is a survival game with defense as the core gameplay, and when the end comes, you use the last human shelter to constantly dig minerals, build walls and various turrets to defend against the endless zombie army.
Gelluloid Domination is a fast-paced, strategic and tactical game where you grow a network of cells. Expand by assimilating nearby cells, fight off pathogens and develop nanoboosts in the lab. Other cells want to propagate their DNA too, so this won't be easy. Can your cells achieve domination?
A tower defense game where mechanics evolve through your choices. Strengthen classic tower defense, blend in other game genres, or abandon tower defense entirely. Each level unlocks a fresh ruleset, making one purchase feel like many games in one.
Star Defence is a unit-placement real-time tower defense game in which you can place any unit you like on a 2D free-form plane. All units in the game, including enemies, are composed of units you place. Place your units in a balance between enemies and allies to develop your civilization.
During the pandemic, would you be curious about how our bodies react to the virus? Are you wondering: "What' is autoimmunity?" "All definitions and thesis of the immunology are too hard to understand!" Don't be afraid! After beating the game, you get all the necessary information and fun!
Flesh Eaters is retro style single player RTS zombie survival game with resource gathering and crafting. Zombies are everywhere! You must gather resources to build barricades, upgrade weapons and armour and explore the city under the siege of the dead
After defeating Fujin and Raijin, Hiro and his allies found peace at his grandfather’s house. One day, Sanbi sensed a distant summon. After tracing the energy, they discovered it came from her true form—the nine-tailed fox. Determined to help, Hiro and his friends set off on a new journey.
The hungry Gooper swarm threatens intergalactic peace. Stop them! Build towers around planets and take control over their orbits. Spin them with all you’ve attached! Collect new towers, powers and upgrades to beat the onslaught of goopers and save the galaxy in this colorful Tower Defense Roguelite!
"Harvest Loop" is a Rougelike game that mainly features farming simulation and management. In the game, you need to use special crops with various abilities to adapt to the changing seasons and fight against the greedy "locust army" to protect the normal operation of the farm.
A lightweight roguelite roulette strategy game where gold is both your weapon and your lifeline. Bet on symbols, build your economy, upgrade your wheel, and survive debt, collectors, and the final boss without losing everything.
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Team up with survivors, customize your character, and combine over 70 weapons and items to defend your central tower against endless waves of enemies. Choose your skills, craft insane synergies, and unleash chaos in intense bullet-hell combat.
Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself.
Immortal Sword is a strategy and role-playing game that combines tower defense, tower pushing, and lightweight rouge. You will defeat various strong enemies in the world of swords and magic, gradually regaining your power.
A roguelike royalelike about warriors from across space and time, fighting to claim a wish from the Star of Aestheta. Strategize your tactics, enhance your troops, and outwit your opponents to rise to the top!
Inspired by Max Brooks' World War Z novel, Z-Collapse takes you into a worldwide zombie apocalypse. As leader of the government of your choosing, make sure your country survives! Dramatic decisions are ahead of you. How do you manage them?
A defensive game that combines hero collection and base building, focusing on real - time strategy and a thrilling sense of combat. Use your wisdom to repel wave after wave of enemy attacks!
Conflict of Lords is an Roguelite Anti-TD game. You will act as the Lord of Foe in Game Development Council, who decided to go his separate way due to a conflict. Invade the newly released game Village Guardian. Summon the Predators to destroy villages. Try your best to overthrow the Overlord!
Envy the Dead is zombie survival roguelike, in which you are leading group of unique, randomly generated characters through destroyed lands, infested with zombies.
Top-down RTS: Collect genes/gear, train warriors into 4-person squads, explore ruins and unlock secrets. Old maps persist; focus on progression to defeat all foes. Enemies drain SAN—use consumables wisely. Mix tactics for bursts; endless builds via loot, traits & 3-choice skills.
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