Top similar games like Mycelium Conquest: Mitosis:

A deep biological network automation game where you grow a living mycelial network across an alien planet. Consume the local flora and creatures, build biological production chains, and evolve from a tiny spore into a cosmic entity that consumes worlds.

Planet Gemini is a factory-building and tower defense game. After crash-landing on two planets during an interdimensional journey, fend off waves of enemies and research a portal to survive.

Desynced is a sci-fi strategy game with fully customizable units and behaviors. Gather, build, research, and explore the unknown. Alone or with friends, unveil the mystery of an AI on the edge of self-awareness and uncover the hidden truth in this blend of strategy, automation, and exploration.

CircuitVeil is a Single-player / Multiplayer isometric factory game where you boot an artificial mind. Mine the substrate, build production lines, specialize as Engineer, Defender, or Prospector, and send your factory's output through the off-world transfer beam.

Automate your factory to fuel a planet-splitting laser drill. Mass-produce mechanized combat units, deploy them in tactical auto-battles to conquer enemy outposts, and route their resources back to your expanding mega-factory. Grow your army and destroy the Runaway Artificial Superintelligence (RAS)

Build a factory from hand-crafted beginnings to a nuclear-powered megabase. Mine, automate, electrify, ride steam trains across deserts and reach the atomic age — alone or in online co-op. A cozy top-down automation game across 5 tiers and 5 biomes.

Factorio is a game about building and creating automated factories to produce items of increasing complexity, within an infinite 2D world. Use your imagination to design your factory, combine simple elements into ingenious structures, and finally protect it from the creatures who don't really like you.

NuTREEnts is a strategic tower defense roguelike about growing and expanding your forest. Plant saplings, fend off bugs, and explore a desolate planet while you grow a mighty colony of trees!

Techtonica is a first-person factory automation game with a gripping mystery about mining your way out from the depths of an alien planet. Explore bioluminescent caves, mold destructible terrain, construct a massive subterranean factory. Dig your way toward answers & discover the secrets of Calyx.

Take the helm as a new Station Commander and exploit an alien star system in this stunning space-station factory automation game. Amass resources and construct starships using increasingly advanced manufacturing and expand your station in a hostile universe.

A Planet of Mine Mastermine Edition is a cozy 4X game with mass strategy! Choose your winning gang, mastermine resources, and build your base and tools to boost your technology and conquer space! Unless your neighbors don’t see it that way… Trade, peace or clash: your planet, your choice!

Factory Trashcension is a first-person open-world factory creation and optimization game with unlimited possibilities. Play with your friends and design efficient factories to TRASHCEND without worries and explore a v a p o r w a v e inspired universe!

Build a sophisticated robot factory optimized to perfection in an infinite voxel world. Mine and harvest resources, automate your production lines and manage complex systems while researching your way to become the galaxy’s leading robotics megacorp.

Builderment is a casual factory builder, where you are sent to far away planets to keep Earth going with fresh resources. Establish your base, then mine, build, transport, and ultimately design an automated operation that will save your home one shipment at a time!

An open-ended factory management game with RTS and tower defense elements.

Dig sand with a shovel and process into iron, silicon and more. Craft and merge better tools and machines to build solar panels to power them. Research new machines to automate everything in multi-story factories. Play alone or with friends to survive in the desert and turn it into a solar farm.

Grow a small colony into a vast, world-spanning civilization. Play solo or with friends as you gather resources, build cities, manage colonist needs, explore uncharted lands, establish logistics, raise armies, forge alliances, and wage wars—all in a living world.

Build a formidable factory and go dungeoning alone or with friends. Solve logic puzzles and automate resource collection and crafting, or venture into dungeons filled with dangers and rewards. Find your own ideal gameplay balance, as any unique path will advance the story!

One More Turret is an automation and tower defense strategy game with interesting innovations. Gather resources and enemy loot to construct intricate factory while defending against relentless monster waves. Can you strike the perfect balance between production and defense?

Rebuild hope in a world that was lost in the fog. Lead your Pioneers across the isles of Pagonia, unite scattered tribes, raise thriving communities and discover the history of your people as you reclaim your world in the new story campaign.

A fantasy city builder where you build up your army of minions to take on monsters, bandits and even entire armies! Recruit a wide range of minions to help you gather resources, craft weapons and armor, and develop your colony into the stronghold it was always meant to be.

In a nuclear apocalypse, you have to use your engineering skills to save as many survivors as possible. Defending, mining, crafting, creating production lines, and building an underground city for the survivors is your goal in this 2d side-scrolling automation game.

Harness the power of automation in this factory game set on a rogue planet in the far reaches of the solar system. Dig down and explore the depths of an alien world, exploit its resources across complex production chains, and travel towards the core to uncover its deepest secrets.

Good Company is an in-depth management sim about building a trail-blazing tech corporation. Assemble complex production lines, manage employee logistics, and sell high-quality products on the market to become the best company in the whole county!

Build a settlement in a realm recovering from the Fracture, a calamity that nearly destroyed the realm. Choose from several unique races, establish a new kingdom, and survive in a land filled with magic and strange creatures. Farm the land, fish the seas, or raid rival kingdoms for their treasures.

Mine, build, upgrade, and extract. Scavenge the stars in a resource-management sim focused on base building and survival. Gather materials, construct facilities, and order units to thrive in a hostile galaxy. Fortify your temporary base and secure your haul for a clean escape before it’s too late.

The depths of Ashenburrow are alive. Wildlife hunts, feeds, breeds and dies — with or without you. Survive, craft, build. But remember: you are not alone underground.

​Immerse yourself in ancient Egypt with PyramidValley, a management game where you develop your pharaonic city by constructing iconic monuments and gathering various resources to ensure prosperity.

A relaxing industry/factory builder where you build, manage, automate, optimize, and expand an industrial village by exploiting various resources to create items.

OpenTTD is a business simulation game in which players earn money by transporting passengers and cargo via road, rail, water, and air. It is an open-source remake and expansion of the 1995 Chris Sawyer video game Transport Tycoon Deluxe.

Be sure to become the King of the Kingdom of Jerusalem!

Factoriant is a factory builder where you construct an underground ant factory. As a queen ant, dig tunnels, carry food, and hatch worker ants to automate your production. Defend your nest from threats like birds and humans, and build a subterranean ant colony.

You and allies, avian inhabitants of Sanctree City, build structures and production lines on the tree, crafting weapons to fend off subterranean insects. Defense is just the start—dig deeper, destroy nests, fortify new defenses against escalating threats for an impregnable stronghold.

Cat Island is a colony survival game with voxel building and multiplayer! You start off with nothing and must grow your island with the help of a couple cat friends. Gather resources, complete building contracts, and expand your colony to do the labor for you!

The FPS with the most advanced gun building system ever made. Master the art of stacking as you battle robots, design a base, experiment with procedural superpowers, and save entire planets from annihilation.

Build your star system. Arm nine planets. Then raid real commanders while they sleep — and watch them raid you back. Asynchronous 1v1 base battles, clan wars, and a loot economy where your ore is never safe.