Top similar games like Cartridge Defense:

Classic RTS gameplay fused with a modern roguelike. Shape your build each run by assembling an evolving arsenal of powerful units and facilities. Harvest resources, build out your base. Raise your army and call down orbital strikes to overcome the forces threatening your survival.

Galactic Garrison is a sci-fi, turn-based tower defense game where you defend your base from relentless alien waves on Mars. Deploy soldiers, build barricades, and upgrade defenses to withstand attacks. Earn powerful reward cards to gain strategic advantages and outmaneuver your enemies.

Beneath Oresa, a fighting roguelike deckbuilder, takes you deep within the city to confront your foes. As a strategist, choose your cards, upgrades, and artifacts wisely, but as a fighter, turn their positioning to your advantage.

Tower Knight is a deck-building & tower defense strategy game. Build your deck to strengthen your position, level up your knight, and win by capturing enemy towers.

Garden of Wandering Souls is a roguelike tower defense where you strategize using random cards and tiles to prevent lost souls from becoming truly lost.

A Roguelike Tower Defense game set on a user controlled procedurally generated island. Select unique cards and relics that enhance your towers abilities, crafting powerful builds to defend against the growing hordes of enemies.

Strategic roguelike tower defense game where you fortify your defense line by stacking cards in deckforts, play various cards on enemies and deployable grids, and receive general contributions to your defense from altar structures.

Hexistence is a Tower Defense Deck Builder based on four universal elements: Matter, Energy, Space & Time. Place powerful permanents and play wondrous spells to defend the Hexistower from the waves of mobs sent by the Void!

Refactor is a hard-core tower defense game that combines modular building, route planning, and element composition.

Build twisting mazes with tetromino blocks and deploy unique towers in this engaging roguelite tower defense game!

Cards of Prophecy combines Tower Defense, Deckbuilding, and Roguelike elements, with huge inspiration from Trading Card Games. Build an ever evolving deck to summon monsters and use powerful spells. Fuse, defend, open card packs, create new strategies. Repeat.

Sphere – Flying Cities is a sci-fi citybuilder which combines strategy, simulation, and survival elements in an extraordinary and immersive scenario. Rebuild and protect a society in a unique and hostile environment. Pay the price for your decisions and be prepared to lose everything.

Electromaze Defense is a classic tower defense game where you create your own maze. With a wide variety of maps, towers and upgrades, Electromaze Defense will keep you hooked for hours on end! Can you build the perfect maze?

Haxity is a cyberpunk, PvP, action deck-builder. Draft your deck, modify your fighter and outsmart your opponent in intense Head-to-Head battles. Fight online, challenge your friends or terminate the AI. Slot, hack and execute, welcome to Haxity!

Build your deck, re-write your cards, and join in epic space battles! Heat Death is a single-player deckbuilder which takes card customization and power scaling to the extreme, as you battle against sentient stars and black holes.

DEFEND 99 is a rogue-lite tower defense game with deckbuilding and autochess elements. Place your turrets, roll for upgrades and balance your economy in the hope of defending your network of the elite from an array of digital attackers. Can you hold off all ninety nine waves?

A roguelike deckbuilding card game, and a free entry to the Net. Build your perfect deck and defeat your very first boss!

H.I.V.E. is a roguelite autochess game where the player leads the Clone revolution. It's the year 2424 a technology corporation has created the H.I.V.E. clones to take care of sanitation tasks. But now these beings have gained awareness and are taking over the city. Lead the clones to victory.

Combine word wizardry and superior strategy in this roguelike deckbuilding adventure. Craft a unique deck of letter cards throughout each journey, collect rewards from your victories, and each adventure unlocks new cards.

"Atman Rebel Flame" is a cyberpunk card-building game that supports multiplayer battles with no external numerical growth to ensure fairness . Choose your hero and support cards, elevate your phase and select talents, defeat opponents and claim victory!

"Tech Disorder" merges turn-based strategy, Roguelike elements & deckbuilding in a cyberpunk world. Outwit foes with tactical plays and card combos.

A roguelike deckbuilding card game where you control, and buff your objects to defeat all kinds of funny sci-fi enemies.

WAGON is a 1-bit card game where you make tough decisions to try and survive winter on the Oregon Trail.

packet.Breach() is a roguelike tower defense where you deploy hacker programs to manipulate and redirect projectiles to attack your enemies. Build your deck and join a hacker faction, or choose to remain unaffiliated and become a legend.

System Crash is a story-driven cyberpunk collectible card game inspired by Blade Runner and Neuromancer. When corporations own everything and the line between man and machine is blurred, your only option is to fight to survive!

Cyber Tower is a tower defense game emphasizing grid movement and path construction. As a military commander, customize your defense with various towers and strategic paths. Stop waves of virus-infected autonomous vehicles from invading your city!

Space Grid Tournament lets you take part in the most spectacular sport of the future. Spawn your robotic players, fight to take control over every tile of the field, and lead your team to glorious victory. Fast, tactical, and brutal shot of fantastic sport emotions!

Toads of the Bayou: Prologue is a chapter of the main game, Toads of the Bayou. Introducing 'The Sister', a toad missionary sent by her order to purify the bayou. Synergise card effects, build a settlement and engage in a challenging mix of turn-based tactics and roguelike deckbuilding.

扮演古代七位大侠中的一位，争夺武林第一的宝座。

Sky Escort is a rogue-like card game featuring TD and management. Players roleplay an airborne mercenary,escorting clients' cargo to earn rewards. Buildcard decks, recruit crew members, and customize arms to enrich gameplay. Multiple factions can be chose from, each with unique combat style.

Welcome to Technotopia, a city-builder card game. Take on the role of an AI designed to build a perfect city. Build districts, meet the needs of diverse communities and maintain the delicate balance between factions vying for control over you!

As head of your clan, face opposite tribes in strategic solo missions and PvP battles. Build and improve your deck of cards, make the right tactical choices, and place your soldiers on the battlefield so that they destroy the enemy. Can you lead your people to victory?

Tower defense meets deck building in Deck Defense. Defending against the blobs is no easy feat. Will you prioritise fortifying your tower defenses or expanding the map? Build your deck with over 70 cards to choose from.

Dive into a world of retro-futuristic aesthetics and high-voltage gameplay in this innovative turn-based strategy game. Every turn unfolds with intriguing possibilities as players combine moves, creating unique and complex strategies on the electrifying hexagonal battlefield.

A retrowave tower defense game where the player must manage their arsenal of sentries to fight off waves of synths, stop their invasion, and take the fight to their home.