Top similar games like Patient Zero:

Grab a gun and take down hostile robots corrupted by synthetic emotions! Combine weapon modifications and wreak havoc in this roguelite shooter. Let your emotions shape combat and alter boss fights! Fight alone or join up with up to 4 players!

As a soul lost in limbo you must defeat the greater demons and the devil to end your cyclical hell. Drift across a procedural map, collect new weapons and escape to the hub to stash your loot. Pack the ultimate nap sack for each run and master the brutal underworld bit by bit.

"Reincarnation in Another World" is a roguelite game where you will have traditional barrage and different skills to fight against hordes of monsters. Choose from a variety of traits and power-ups to create a unique build and style to complete the game.

Cut down Thousands of enemies, from the undead to the mysterious creatures of the night to save the world from the impending doom, Rune Break is a Fantasy Rogue-lite where you fight hordes of enemies with casual elements.

Genome Guardian: Prologue is the first 20 waves of the full game's first mode & difficulty. This is a roguelite shooter where you defend yourself from microscopic aliens using various upgrades & builds. Combine & create 70 bioweapons, and try 7 turrets & 10 perks from the base game!

In this thrilling top-down roguelite survival game, you'll face off against hordes of creatures in a desperate battle for survival. You'll need to collect energy to unlock new skills and upgrade existing ones, and every moment counts as you fight your way through waves of monsters.

Slime Rush! Jump into a thrilling hack-and-slash adventure with Leshy and the Magic Book! Wreck relentless slimes, unleash crazy magic combos, power up with runes, and reclaim the Red Panda Temple! Get ready to bash, blast, and dominate!

Grimstone Survivor is a unique 3D top-down roguelite genre adventure that immerses you in the heart of a fantasy world. You must hone your combat skills and think strategically to survive in this world full of dangerous creatures.

Whether you choose magic, swords, or both, make your way through the thousands of monsters attacking you! DunJumb is a colorful 2D medievial survivor game with roguelite elements, in which you create, buy and reinforce a combination of weapons against formidable enemies!

The game is a Dungeon Crawler, where the player must survive the succeeding dungeons and defeat Impeficus on his throne.

Slay thousands of monsters on thrilling missions to save the humanity from a looming demon onslaught.

Juicy army is the sweetest action roguelike set in a dream universe where you'll have to fight an army of juicy creatures!

Tear through hordes of otherworldly creatures and defeat their ruler before the universe ends. Travel between planets, gather powerful relics, and shape the galaxy to your whim in this objective-based action rogue-lite.

Tankmageddon is a fast-paced roguelike tank game where you play as Ed, a pilot and mechanic on an Earth facing invasion. A ruthless A.I. has built a tank factory on the Moon and plans to wipe out humanity. Face hordes of enemy machines and use their parts to defeat them.

Pilot mechs as you slaughter hordes of a diverse cast of alien quacks in this survival roguelike. Build your arsenal from a variety of mechs, power ups and items to survive in ever-changing scenarios.

Dive into exhilarating combat in this roguelite, top-down shooter where survival is key! Face relentless hordes of monstrous foes, and conquer epic boss battles. Play solo or team up in co-op to race against time and see if you have what it takes to survive this mayhem of blood butts and guts!

Prepare for epic battles between gods and Hades in this top-down action roguelite! Choose your deity, unleash powerful combos, and fight against underworld enemies. Feel the adrenaline for 15 minutes and restore order in the underworld.

Manaballs is an online survival game with roguelike, extraction and farming elements. Venture into the woods, gather resources, build bases, and engage with players through voice chat. Team up to conquer dungeons, craft weapons, and raid enemy bases for that sweet loot.

Roguelite Overpowered Wizard Simulator & Dungeon Crawler. Slay hundreds of cultists using the power of ancient cards and your magical arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you from climbing the tower of babel.

Magical Girl Guardians is a 1-4 player co-op survivorlike where you play as a magical girl. Defeat cute monsters, protect the city, upgrade your abilities and save the day!

SURVIVE COUNTLESS HORDES, BE A ONE MAN ARMY, DIE AND RETURN STRONGER. Halftime Heroes is a Survival Rogue Action RPG game with short and intense matches where you learn spells, level up, acquire loot and fight bosses. Each time you die you may upgrade or unlock several features.

“DigRogue” is a solo-play mining 3D roguelite. Stranded on an unknown planet with minimal supplies, you must mine resources and gather enemy materials to upgrade your gear. Defeat the planet’s bosses, using their unique organs to upgrade your spaceship, and begin your long journey back to Earth.

A new adventure for Shiren and Koppa begins!

In this fast paced twin-stick roguelite platformer, you play as an unnamed child ascending an ominous clocktower in pursuit of their lost memories. Harvest and sacrifice souls to grow your power in order to challenge procedural encounter rooms and intimidating bosses!

COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

Not just cute, but also the most challenging roguelike game. Can you reach the depths of the dungeon in under 15 minutes? A blend of Mystery Dungeon and real time attack.

"Towers and Survivors" combines rogue-like action with tower defense. Strategically build and upgrade towers, manage resources, and use various skills. Each choice is key in this engaging, strategy-based game.

Grab, Throw, Build, Explore, Upgrade, Fuse, Shoot, and Loot in this surreal, high-energy adventure where breaking the limits and reaching further is encouraged!

Gum Flesh is a turn based roguelike that takes place on the back of a celestial monster. Use your wits and fragile supplies to take on strange plants and fauna on a planet where you are definitely not welcome. The air is different here. Your body is starting to change.

Mech Survivor Elite is a time-based survival game featuring action-packed gameplay and roguelite elements.

Prologue version of the game Gatekeeper. Gatekeeper: Infinity is a fast-paced rogue-lite shooter where you'll search for the stolen Heart of the Universe and battle machine enemies! Play solo or join forces with friends in co-op mode.