Top similar games like Patient Zero:

“DigRogue” is a solo-play mining 3D roguelite. Stranded on an unknown planet with minimal supplies, you must mine resources and gather enemy materials to upgrade your gear. Defeat the planet’s bosses, using their unique organs to upgrade your spaceship, and begin your long journey back to Earth.

Pilot mechs as you slaughter hordes of a diverse cast of alien quacks in this survival roguelike. Build your arsenal from a variety of mechs, power ups and items to survive in ever-changing scenarios.

Circuit Runner is a fast-paced cyberpunk game where you collect resources to escape a dystopian tower. Use active and passive skills to outwit enemies and overcome obstacles. Compete on Leaderboards for ultimate bragging rights in this thrilling race for freedom.

Grimstone Survivor is a unique 3D top-down roguelite genre adventure that immerses you in the heart of a fantasy world. You must hone your combat skills and think strategically to survive in this world full of dangerous creatures.

The game is a Dungeon Crawler, where the player must survive the succeeding dungeons and defeat Impeficus on his throne.

Cut down Thousands of enemies, from the undead to the mysterious creatures of the night to save the world from the impending doom, Rune Break is a Fantasy Rogue-lite where you fight hordes of enemies with casual elements.

A co-op roguelike for 1-4 players with missions and levels that include classic gameplay of pinball, brick breaker, mini-golf and soccer combined with ninjas, stats, power-ups, and enemies. Build your clan, crush the darkness.

Manaballs is an online survival game with roguelike, extraction and farming elements. Venture into the woods, gather resources, build bases, and engage with players through voice chat. Team up to conquer dungeons, craft weapons, and raid enemy bases for that sweet loot.

SULFUR is a modern old-school action-adventure: Outsmart enemies, find treasure, improve weapons, harness powers. Delve deeper, find answers, make it end.

Skull Scavenger is an unforgiving top down extraction rogue like. Drift across a procedural map, slam into enemies, collect new weapons and Escape to stash your loot. Pack the ultimate nap sack, master the underworld, Defeat all 3 greater demons and the devil in one run to end your cyclical hell.

"Touhou ~Red Empress Devil." is a bullet-hell shooting roguelike action game. Set in The Scarlet Devil Mansion, the inhabitants of Gensokyo go on a rampage!

Don’t be fooled by its cuteness. Rightfully, Beary Arms is a bullet hell, roguelite that will punish and reward you. Augment weapons to create unique weapon builds, pick rewards as you explore levels, alter mechanics to your benefit and peril, fight, die, become stronger, and do it all over again.

Dive into exhilarating combat in this roguelite, top-down shooter where survival is key! Face relentless hordes of monstrous foes, and conquer epic boss battles. Play solo or team up in co-op to race against time and see if you have what it takes to survive this mayhem of blood butts and guts!

Fast-paced top-down shooter in a world abandoned by mankind. To replicate their creators, mechs invented "Mood Solution", but lords got possessed by emotions. Fight with friends or by yourself to annihilate hordes of deadly bots. Modify your Guns and uncover the Emotional Abilities. Choices Matter.

Step into an exciting journey in Cats Guns & Robots, a rogue-like action game where you are the last hope for the world. In this outlaw-like action game, surviving enemy attacks in each room will require careful choices of upgrading your character abilities and features of weapons in your inventory.

Trapped in a deadly gameshow, in order to survive, you will need to fight mutated creatures, use crazy weapons & abilities, collect treasures, avoid sinister traps and obtain insane power-ups in this Top-Down, Twin-Stick Shooter with a wacky FMV/Low-CGI style and multiple Single+Multiplayer modes.

Mech Survivor Elite is a time-based survival game featuring action-packed gameplay and roguelite elements.

Full Mojo Rampage is a rogue-like game that takes place within the confines of the Voodoo reality. In this realm only the most powerful rites and powers can provide a safeguard against evil. Dying is not the end, only the beginning to becoming a stronger voodoo soul!

Roguelite Overpowered Wizard Simulator & Dungeon Crawler. Slay hundreds of cultists using the power of ancient cards and your magical arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you from climbing the tower of babel.

In this fast paced twin-stick roguelite platformer, you play as an unnamed child ascending an ominous clocktower in pursuit of their lost memories. Harvest and sacrifice souls to grow your power in order to challenge procedural encounter rooms and intimidating bosses!

Gum Flesh is a turn based roguelike that takes place on the back of a celestial monster. Use your wits and fragile supplies to take on strange creatures and fauna on a planet where you are definitely not welcome. The air is different here. Your body is starting to change.

Rain down hell on the robot army in DUST & NEON, an award-winning best-in-class post-apocalyptic shooter where twitchy-finger gunslingers are rewarded with fame and glory.

SURVIVE COUNTLESS HORDES, BE A ONE MAN ARMY, DIE AND RETURN STRONGER. Halftime Heroes is a Survival Rogue Action RPG game with short and intense matches where you learn spells, level up, acquire loot and fight bosses. Each time you die you may upgrade or unlock several features.

A charming 3D roguelite platformer about a normal day in the life of a knight! Sharpen the spear and make the Dragon run in fear! Oh, and also try to manage a date with princesses & princes you rescue.

Prepare for epic battles between gods and Hades in this top-down action roguelite! Choose your deity, unleash powerful combos, and fight against underworld enemies. Feel the adrenaline for 15 minutes and restore order in the underworld.

Juicy army is the sweetest action roguelike set in a dream universe where you'll have to fight an army of juicy creatures!

Star Bind is an increasingly fast-paced action dungeon crawler where you'll need to shoot, dodge, loot, learn, and improve to escape a bizarre simulation.

LightBear is a randomly generated action RPG whackathon with heavy Rogue-like elements. Players will lose their vision the further from the starting point they get. Don't be deceived by its appearance, this game will challenge you to no end. Watch out for 100's of randomized monsters.

Genome Guardian: Prologue is the first 20 waves of the full game's first mode & difficulty. This is a roguelite shooter where you defend yourself from microscopic aliens using various upgrades & builds. Combine & create 70 bioweapons, and try 7 turrets & 10 perks from the base game!

Assemble a limitless arsenal in this survive-em-up roguelite shooter. As a Gun Manufacturer's testing force, your mission is simple: test the latest gun tech and scavenge alien planets. Collect insane weapon parts to invent crazy guns that slay thousands. You may not survive, but your guns will!

Void Soul Awakening is a 3rd person action rogue-lite that fuses the heart-pounding elements of hack and slash mechanics with the intensity of a shooter. In a world of unrelenting action and adventure, you are casted as an immortal vessel struggling to escape from the clutches of an undead prison.