Top similar games like Patient Zero:

Cut down Thousands of enemies, from the undead to the mysterious creatures of the night to save the world from the impending doom, Rune Break is a Fantasy Rogue-lite where you fight hordes of enemies with casual elements.

Genome Guardian: Prologue is the first 20 waves of the full game's first mode & difficulty. This is a roguelite shooter where you defend yourself from microscopic aliens using various upgrades & builds. Combine & create 70 bioweapons, and try 7 turrets & 10 perks from the base game!

Fight through endless hordes in trials bestowed by constellation patrons. Upgrade skills, collect relics, and craft broken builds in true roguelite fashion! Rediscover the fantasy behind the words hack and slash and bullet heaven. Will you survive the densest monster Survivor-like ever created?

Become a possessed gun in this bullet heaven rogue-lite, mowing down hordes of Eldritch minions with chaotic firepower. Harvest souls, hoard artifacts, and craft insane builds to slay gods and break free.

Camelot is under threat! Merlin Survivors is a game where rogue-like action meets fast-paced survival challenges. Take control of legendary characters like Merlin, Arthur, Lancelot, and Morgana, and fight against relentless waves of enemies. Master each character.

Slime Rush! Jump into a thrilling hack-and-slash adventure with Leshy and the Magic Book! Wreck relentless slimes, unleash crazy magic combos, power up with runes, and reclaim the Red Panda Temple! Get ready to bash, blast, and dominate!

Slay hordes of enemies on thrilling missions to save the humanity from a looming demon onslaught.

Juicy army is the sweetest action roguelike set in a dream universe where you'll have to fight an army of juicy creatures!

Tear through hordes of otherworldly creatures and defeat their ruler before the universe ends. Travel between planets, gather powerful relics, and shape the galaxy to your whim in this objective-based action rogue-lite.

Tankmageddon is a fast-paced roguelike tank game where you play as Ed, a pilot and mechanic on an Earth facing invasion. A ruthless A.I. has built a tank factory on the Moon and plans to wipe out humanity. Face hordes of enemy machines and use their parts to defeat them.

Pilot mechs as you slaughter hordes of a diverse cast of alien quacks in this survival roguelike. Build your arsenal from a variety of mechs, power ups and items to survive in ever-changing scenarios.

Fight monsters with coins and descend by elevator. In this first-person roguelike, coins are both currency and ammo — survive while deciding whether to spend or shoot.

Ma vie en rogue is a roguelike spanning multiple themed dungeons and worlds bringing advancements such as a mini-map, first-person view, and paperdoll customization to the genre. 

This is a unique roguelike action game where you command a dynamic fish swarm. Evolve different weaponized fish breeds, and combine abilities to transform your school from vulnerable prey into an unstoppable force that dominates the abyss. Survive relentless waves of aquatic creatures.

Dive into exhilarating combat in this roguelite, top-down shooter where survival is key! Face relentless hordes of monstrous foes, and conquer epic boss battles. Play solo or team up in co-op to race against time and see if you have what it takes to survive this mayhem of blood butts and guts!

Prepare for epic battles between gods and Hades in this top-down action roguelite! Choose your deity, unleash powerful combos, and fight against underworld enemies. Feel the adrenaline for 15 minutes and restore order in the underworld.

Manaballs is an online survival game with roguelike, extraction and farming elements. Venture into the woods, gather resources, build bases, and engage with players through voice chat. Team up to conquer dungeons, craft weapons, and raid enemy bases for that sweet loot.

Roguelite Overpowered Wizard Simulator & Dungeon Crawler. Slay hundreds of cultists using the power of ancient cards and your magical arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you from climbing the tower of babel.

Magical Girl Guardians is a 1-4 player co-op survivorlike where you play as a magical girl. Defeat cute monsters, protect the city, upgrade your abilities and save the day!

SURVIVE COUNTLESS HORDES, BE A ONE MAN ARMY, DIE AND RETURN STRONGER. Halftime Heroes is a Survival Rogue Action RPG game with short and intense matches where you learn spells, level up, acquire loot and fight bosses. Each time you die you may upgrade or unlock several features.

“DigRogue” is a solo-play mining 3D roguelite. Stranded on an unknown planet with minimal supplies, you must mine resources and gather enemy materials to upgrade your gear. Defeat the planet’s bosses, using their unique organs to upgrade your spaceship, and begin your long journey back to Earth.

Summon an army of clouds in this roguelite bullet heaven survivors-like inspired by Korean folklore! Recruit and fuse cloud companions, befriend shrine visitors, and uncover the mystery of the moon goddess!

A new adventure for Shiren and Koppa begins!

In this fast paced twin-stick roguelite platformer, you play as an unnamed child ascending an ominous clocktower in pursuit of their lost memories. Harvest and sacrifice souls to grow your power in order to challenge procedural encounter rooms and intimidating bosses!

COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

Gum Flesh is a turn based roguelike that takes place on the back of a celestial monster. Use your wits and fragile supplies to take on strange plants and fauna on a planet where you are definitely not welcome. The air is different here. Your body is starting to change.

Grab, Throw, Build, Explore, Upgrade, Fuse, Shoot, and Loot in this surreal, high-energy adventure where breaking the limits and reaching further is encouraged!

Trapped by a cursed artifact, you must survive an ever-changing dungeon in this fast-paced roguelike runner. Harness powerful magic, defeat enemies, dodge traps, and battle bosses. Die, revive, and grow stronger with permanent upgrades. Can you escape the dungeon's eternal cycle?

Enter the Gungeon is a bullet hell dungeon crawler following a band of misfits seeking to shoot, loot, dodge roll and table-flip their way to personal absolution by reaching the legendary Gungeon’s ultimate treasure: the gun that can kill the past.