Top similar games like Patient Zero:

A roguelite horde-survival bullet heaven with QUINTILLIONS of bullets over QUINTILLIONS of hordes. Mix weapons with items, modify, control chaos at terminals and break through tightening waves.

You are a punk in a retro bullet-heaven space roguelite. Fly your ship, blast swarms with auto-fire and aimed shots, grow stronger, and stack a wild loadout. Dash through the void, complete objectives, reach rifts to push your run into tougher tiers, and unlock permanent upgrades between runs.

Cut down Thousands of enemies, from the undead to the mysterious creatures of the night to save the world from the impending doom, Rune Break is a Fantasy Rogue-lite where you fight hordes of enemies with casual elements.

Genome Guardian: Prologue is the first 20 waves of the full game's first mode & difficulty. This is a roguelite shooter where you defend yourself from microscopic aliens using various upgrades & builds. Combine & create 70 bioweapons, and try 7 turrets & 10 perks from the base game!

Slime Rush! Jump into a thrilling hack-and-slash adventure with Leshy and the Magic Book! Wreck relentless slimes, unleash crazy magic combos, power up with runes, and reclaim the Red Panda Temple! Get ready to bash, blast, and dominate!

Shatter overwhelming cube swarms in a fast arena-survival roguelite. Aim your evolving arsenal, conquer five hazardous zones, destroy their Guardians, and climb five Fracture difficulty tiers—solo or in two-player local co-op.

Juicy army is the sweetest action roguelike set in a dream universe where you'll have to fight an army of juicy creatures!

Pilot mechs as you slaughter hordes of a diverse cast of alien quacks in this survival roguelike. Build your arsenal from a variety of mechs, power ups and items to survive in ever-changing scenarios.

Tear through hordes of soul-hungry creatures across dying planets before the universe collapses. Gather relics, chain explosive abilities, and bend the laws of physics in this chaotic objective-based action rogue-lite.

Fight monsters with coins and descend by elevator. In this first-person roguelike, coins are both currency and ammo — survive while deciding whether to spend or shoot.

"Break Through The Illusion" is a dungeon barrage shooting game. The protagonist Mick needs to try to pass one room after another, make full use of the specific weapons and limited bullets in his hand to kill the monsters in these rooms, in order to reach the boss room for the final battle.

Tankmageddon is a fast-paced roguelike tank game where you play as Ed, a pilot and mechanic on an Earth facing invasion. A ruthless A.I. has built a tank factory on the Moon and plans to wipe out humanity. Face hordes of enemy machines and use their parts to defeat them.

Echoes of Elpis is a twin-stick shooter sci-fi roguelike. Upgrade weapons, discover new tech, and uncover a secret past as you battle through Elpis on an epic treasure hunt.

Dive into exhilarating combat in this roguelite, top-down shooter where survival is key! Face relentless hordes of monstrous foes, and conquer epic boss battles. Play solo or team up in co-op to race against time and see if you have what it takes to survive this mayhem of blood butts and guts!

Ma vie en rogue is a roguelike spanning multiple themed dungeons and worlds bringing advancements such as a mini-map, first-person view, and paperdoll customization to the genre. 

Prepare for epic battles between gods and Hades in this top-down action roguelite! Choose your deity, unleash powerful combos, and fight against underworld enemies. Feel the adrenaline for 15 minutes and restore order in the underworld.

Manaballs is an online survival game with roguelike, extraction and farming elements. Venture into the woods, gather resources, build bases, and engage with players through voice chat. Team up to conquer dungeons, craft weapons, and raid enemy bases for that sweet loot.

This is a unique roguelike action game where you command a dynamic fish swarm. Evolve different weaponized fish breeds, and combine abilities to transform your school from vulnerable prey into an unstoppable force that dominates the abyss. Survive relentless waves of aquatic creatures.

Roguelite Overpowered Wizard Simulator & Dungeon Crawler. Slay hundreds of cultists using the power of ancient cards and your magical arsenal. Choose from a diverse set of cards to create unique, game-breaking builds and shoot down the horde trying to stop you from climbing the tower of babel.

A fast-paced roguelite where speed is your greatest weapon. Dash through deadly rooms, master the parry, discover powerful synergies, and build your way through the Void.

“DigRogue” is a solo-play mining 3D roguelite. Stranded on an unknown planet with minimal supplies, you must mine resources and gather enemy materials to upgrade your gear. Defeat the planet’s bosses, using their unique organs to upgrade your spaceship, and begin your long journey back to Earth.

Magical Girl Guardians is a 1-4 player co-op survivorlike where you play as a magical girl. Defeat cute monsters, protect the city, upgrade your abilities and save the day!

SURVIVE COUNTLESS HORDES, BE A ONE MAN ARMY, DIE AND RETURN STRONGER. Halftime Heroes is a Survival Rogue Action RPG game with short and intense matches where you learn spells, level up, acquire loot and fight bosses. Each time you die you may upgrade or unlock several features.

Start with one bullet. End with hundreds. Crystalyn is a fast-paced top-down bullet-hell looter shooter about pushing your build to its absolute limits. Fight monsters, defeat bosses, and turn their loot into unstoppable firepower.

Fight through endless hordes in trials bestowed by constellation patrons. Upgrade skills, collect relics, and craft broken builds in true roguelite fashion! Rediscover the fantasy behind the words hack and slash and bullet heaven. Will you survive the densest monster Survivor-like ever created?

The Element Of is an element bending roguelite dungeon crawler set in a strange fantasy world. Choose from a variety of elements all with their unique playstyles to fight through floors of enemies and gain rewards that make you and your element stronger.

In this fast paced twin-stick roguelite platformer, you play as an unnamed child ascending an ominous clocktower in pursuit of their lost memories. Harvest and sacrifice souls to grow your power in order to challenge procedural encounter rooms and intimidating bosses!

COMBINE WEAPONS in the microscopic roguelite turret shooter with macroscopic depth. Survive 6 modes using an astounding array of turrets, perks, mutations and power-ups on this psychedelic journey to the heart of the abyss. Shmup Mode turns it into a vertical shoot 'em up!

Grab, Throw, Build, Explore, Upgrade, Fuse, Shoot, and Loot in this surreal, high-energy adventure where breaking the limits and reaching further is encouraged!

A new adventure for Shiren and Koppa begins!

Bullets that spawn more bullets! Collect dragons to fight with you. Level up and merge them. Create unique builds to survive hordes of enemies in this 3D roguelike bullet hell survival game!