Top similar games like Ants in Space!:

Hallway Defender is a roguelite tower defense where you defend your base from an endless wave of fellow classmates. With over 25 different towers and even more upgrades and effects there are infinite ways to set up your own defenses.

Welcome to the mystical world of Kainga, an unusual roguelite village-builder! Take control of a Thinker and, with the help of your people, grow a unique town to complete short challenges while discovering the world and adapting to the pressures of the environment, beasts and other tribes.

Archie is an easy-to-learn puzzle, a reimagining of the classic 15 puzzle. At the same time, the game will not let even the most inquisitive minds get bored.

Expand TD is a tower defense roguelite. Explore the map between waves, build your defenses, and discover useful locations, strange encounters, hidden rewards, and dangerous threats on every run.

Outcasts of Orion is a Rogue-like Auto Battler. Choose a hero, recruit allies, and take on the toughest baddies in the Orion Sector! Tactically set up your units and then watch the battle. Unlock items, heroes, and artifacts to discover new synergies.

The further you go, the more the universe turns against you. Voyage Router is a navigation-driven roguelite strategy game where you explore dimensional oceans, chart optimal paths, and risk everything for a greater haul.

Hexfall is a planet-scale tower defense game where over 100,000 enemies attack at once. Mine the crust, wire the power and arm a hex world against an armada that fills the sky long before it comes down.

The Final Frontier is a game about star battles and meaning of freedom. It’s a fascinating journey through the endless, procedurally generated space in a universe where you struggle for freedom taking a role of the rebel leader.

A rogue-lite dice game in space! Build your ship as you explore randomly generated star systems, survive hostile encounters, and upgrade your colony ship for the next generation of chasers. Can you find a new home for your orphaned race amongst the stars?

Warpflux is a top-down action based resource management game. As the commander of Earth's colony ship and a fleet of autonomous drones, collect supplies and defend against hostile forces during a thousand year voyage to save humanity.

Test your wits as well as your ability to lead an expedition in this deep space dungeon-crawler. Hire the best heroes and villains of the galaxy. Find unknown planets in uncharted space. Start small, plan big and get a fleet of warships capable enough to rival most fearsome enemies.

Embark on 'Foxfire Mine,' a 2D roguelike digging quest. Unearth valuable gems, manage resources, and navigate strategic upgrades for survival. Every descent challenges your tactics and adaptability in a dynamic underground world.

Turn your armada into a rotating fortress, striking from every angle. A roguelite tower defense where spatial reads decide survival.

This "spaceship simulation roguelike-like" allows you to take your ship and crew on an adventure through a randomly generated galaxy filled with glory and bitter defeat.

Klondor is in grave danger of being overwhelmed, enter the Labyrinth, prepare your defences, defend your Mana Crystal and annihilate the incoming waves of enemy forces that pose a threat to the Kingdom.

Command your starship through a galaxy-spanning conspiracy in this real-time tactical roguelike. Manage power, shields, weapons and more. Featuring permadeath progression, seamless portal travel, and intense capital ship combat using Newtonian Physics with Damped Velocity.

A single-player space-strategy roguelite about reconquering a shattered empire across a procedurally generated galaxy. Plan fleet battles that unfold on your orders, and drive ground invasions front by front across the planet below. Every ship, crew, and army you lose is gone for good.

A real-time submarine management and survival game with tactical pause, where you manage crew, systems, and resources under constant pressure.

Explore an endless text-based universe filled with exotic planets, strange life forms, and ancient civilisations. Manage a crew of space explorers, upgrade their ship, and brave dangerous worlds to gather the data you need to reach the mysterious Gatebuilders.

BALLRENA is a physics-driven build-crafting auto-battler roguelite. Choose a Core, buy, rotate, and merge oddly shaped parts, then fit them into a tight 5×5 grid. Send your custom ball into the arena and watch every collision, weapon trigger, and chain reaction put your decisions to the test.

Build your space station, design your own ships, and explore relaxed sci-fi sectors in Astrosphere. Gather resources, research new technologies, and shape your journey through the cosmos at your own pace.

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

Heat Signature is a game from the developers of Gunpoint where you break into spaceships, make terrible mistakes, and think of clever ways out of them. You take a mission, fly to the target ship, sneak inside, and make clever use of your gadgets to distract, ambush and take out the crew.

Hexworld is a tactical auto-battle RTS where you control the traveling kingdom-island, manage your tiles, collect and upgrade buildings, crash into other islands and watch your precious giant golem inevitably fall off the cliff on his way to the front lines.

The fusion of deck-building roguelike and tower defense returns, bigger than ever! Build your deck with powerful new cards, unlock unique trinkets, and deploy enhanced towers to overcome relentless waves of enemies and new strategic challenges.

Wildpath is a single-player roguelite autobattler where you choose a Hero, bond with an animal Companion, recruit Wildfolk and build an army to conquer a branching path of battles and bosses.

A sci-fi dice-driven roguelike where your dice fuel both your abilities and your enemies’. You'll need strategy and luck to outwit dynamic foes, harness synergistic upgrades, and escape creeping galactic doom before Fate catches up.

One wrong jump ends the mission. Explore 76 real worlds, from Mercury to TRAPPIST-1e, built from NASA data and astronomical research. Manage scarce resources, survey distant worlds, and search for humanity's new home in a science-driven space roguelite where every run could be your last.

Select unique spaceship models and multiple talents from 80+ options. Explore the world map, complete missions for gold, and shop for items. Defeat foes, earn experience, and enhance your spaceship's modules. Forge your style and prove its strength.

These days, destroying planets has become one of the hottest forms of art in the universe. The process is simple. Choose a meteor, attach some parts, and fire it at a planet. You can even choose your own judges. Would you like to join this world of art?

Intercept Course is a tactical space auto battler where you command a starship caught in a temporal rift while chasing a tech thief. Recruit a crew, survive with limited resources, and modify your starship to face rival factions stuck in their own conflicts across every corner of the multiverse.

Tower of Chaos is a unique combination of tactical auto battler and rogue-lite gameplay. Battle your way through the afterlife tower, manage your resources and relive the origins of your allies.

Build and upgrade a modular warship in this single-player roguelite. Command real-time battles, slow time to use abilities, and intercept incoming missiles. Unlock new starting ships and equipment between runs, and shape your crew's story through your choices.

Command an ancient starship and fight your way to the heart of a dying Empire. Fend off attacks from demented cultists, craven space pirates, and xenophobic Imperial soldiers. Discover powerful artifacts and use them to build your ship into a fearsome war engine.