Top similar games like The Binding of Isaac, The Binding of Isaac: Rebirth:

Skelly Selest is a score-attack hack slash dash run 'n' gun-athon. Venture into the procedurally generated perdition depths of Hell to purge the evil taint of the Deamonica Netherlords and their fiendly followers.

Sealer of Dungeons is an action-shooter with Rogue-lite elements. Play Sealers on their journey, you will find great treasures and abilities to seal the unknown evil above. Gather precious loot, discover hidden secrets, and chat with merchants to get powerful items. Seal the dungeon, save the world!

Reynard is a mixture of procedurally generated action RPG and a Tower Defense genre with roguelike elements. It has been influenced by classics such as The Legend of Zelda and an indie classic - The Binding of Isaac.

Seedovia is a rogue-like dungeon crawler where you traverse room after room, fighting challenging monsters. Chain your weapons, collect game-changing passive upgrades, and equip items to create unique builds and become increasingly more powerful.

Screams Echo is a dark run-based roguelite. With fully procedural levels, unique items, and powerful synergies that transform every run beyond recognition, no two playthroughs ever feel the same. Experiment with builds and turn desperate survival into destructive chaos.

ScourgeBringer is a fast-paced free-moving roguelite platformer. Help Kyhra to explore the unknown and slash her way through ancient machines guarding the seal of her past, and maybe the redemption of humanity.

A rogue-like dungeon crawler where each playthrough offers a unique experience. Play as a small hero climbing a tower filled with deadly traps, cunning enemies, and powerful bosses. Face a dark curse threatening the world, uncover secrets, and collect upgrades in a constantly changing labyrinth.

Play as the titular Archer Hero in this procedurally generated roguelike, as he sets off to climb the mysterious tower that suddenly appeared one day. Conquer the numerous floors, defeat the monsters that lurk in the shadows and solve the puzzles of this enigmatic tower.

Ever dreamt of being a space potato? Now’s your chance! Space Gladiators is a 2D hand-drawn roguelite platformer following a bunch of captives fighting their way out of a planet prison. Defeat hordes of aliens in the gladiatorial arenas and earn your freedom!

Worm Slayer is a Fast-Paced Bullet Hell Roguelike where you must fight your way through the dungeon that is the Worm King's den to finally reach and then defeat the Worm King.

Never Split the Party is an ultra social rogue-like! You're one of four adventurers joining together to explore a procedurally generated dungeon, amass powerful upgrades, and cooperate with your fellow adventures to conquer and crush the evil dungeon champions!

Straimium Immortaly is a shmup roguelike dungeoncrawler. Explore the butts-hard procedurally generated Cubicus battling beasties, looting endless item and weapon upgrades and defeating huge boss meanies in your vengeful quest to eradicate the Queeni Emperess.

Happy hour has arrived! Become the NecroBouncer and toss out rowdy guests in a roguelike adventure through the nightclub dungeon. Raise the dead, discover hundreds of relics, ban enemies and gobble up their powers. It’s one hell of a good time!

Scarlett's Dungeon is a retro-inspired action RPG dungeon crawler with roguelite elements. Explore randomly generated dungeons, fight monsters, and collect loot in beautifully crafted pixel art reminiscent of the Game Boy Advance era. Test your skills as you dive deep into ever-changing challenges!

In Enlightenment, you play in a roguelike action-shooter with a fast-paced challenging journey deep into a underground complex called "the Ark". Players will be tested by large varieties of enemies in a procedurally-generated dungeon, and become stronger by learning from the inevitable deaths.

Eko and the Bewitched Lands is a randomly generated Action Adventure RPG with Rogue-like and Puzzle elements. Help Eko rescue the Princess from the Dark Queen. During your journey you will find different weapons, abilities and artifacts that will change the way you play.

Lab Remnants is a monochromatic roguelike full of secrets and challenges. Play as an artificially made creature and make your way through your own creators to escape from their crazy experiments.

The ROGUELITE that feels like a ROGUELIKE. Praised for its fantastically generated dungeons, real-time combat and surprising amount of content and depth. One of the BEST GAMES OF THE YEAR according to PC Gamer and VICE Waypoint.

In this fast-paced rogue-lite, your health points are your only resource: sacrifice them to acquire vampiric powers and devour your enemies to heal yourself! Beware: every drop of blood counts in this frantic race to defeat the apostles of the Cult of the Sun!

Helmet Head is an action-roguelike with a 2D souls-lite combat style. Build your strength on each run by finding weapons, helmets, upgrades and items in randomly generated environments, and use them in clever ways to defeat your foes! Death wipes the slate clean. Keep learning, never stop fighting!

Dodge enemies' attacks, activate lethal traps and customize your hero in StormEdge. Brace yourself for the dangerous Elemental Storms that will put your skills to the test!

Star of Providence is a top down action shooter with procedurally generated elements. Explore a large, abandoned facility in search of incredible power, fighting dangerous foes and gaining new weapons and upgrades as you progress.

Shapes & Shots is a Roguelite Shooter Bullet-hell, where you can control time as you make your way through a twisted and delusional universe. Your enemies will merge, creating infinite combinations to try to overwhelm you: only your skills, combined with upgrades you choose, can lead you to victory.

Dungreed is a 2D side-scrolling action game with 2D Rogue-LITE elements. You become an adventurer exploring a continuously evolving dungeon to prevent the town from being destroyed. Eliminate enemies, use a variety of weapons and magic, eat food, and defeat evil in the dungeon!

Dungeon Potato is a fast-paced, top-down action roguelike where your loadout shapes the story. Survive unpredictable encounters, forge unique builds, and battle through a perilous labyrinth. Will you rise as a servant of the Potato God or rebel against it?

Risk of Rain is an action platformer with roguelike elements. With permanent death as a primary feature, players will have to play their best to get as far as possible. Fight on a mysterious planet with randomly spawning enemies and bosses, either alone or with 3 friends in online co-op.

Live the life of space captain Flinthook! Armed with your mighty hookshot, your uncanny slow-motion powers and your trusty blasma pistol, plunder and fight your way through an infinite variety of randomly-assembled spaceships for treasure, loot and fame!

The Last Strand is randomly generated twin stick shooter. You will play a pirate trying to escape a boat and seek vengeance, fighting enemies, helping NPC, discovering secrets and finding items.

By night, delve deep into your subconscious and discover powerful artifacts to conquer your nightmares. By day, explore the city of Redhaven and build relationships to unlock the power of your dreams. DREAM. DIE. WAKE. REPEAT.

SURVIVE in a transforming arena against ALIEN OGRES in this ROGUELIKE BULLET-HELL 💥 MODIFY your gun, make smart upgrade decisions and master your spaceship's controls to conquer the OGRE CHAMBERS !

Rush Rover is a 2D top-down shooter game. Compared to other similar games of the genre, the shooting experience is closer to traditional shoot'em up games. It includes random map generation, unique weapons, lots of different enemies, exciting boss battles and a dynamic chiptune soundtrack.