Top similar games like Adverse Reaction:

The Roguelike Puzzle game where you play Rock Paper Scissors and smash high scores with a variety of flavored blocks. Buy and equip power blocks to help you increase your score and get to the next round. Watch out for hazard blocks that may deter your progress and end your run.

A match-3 × falling-block hybrid roguelike. Forge gems into tetrominoes on the left board, drop them to clear lines and strike on the right. Fight through a five-chapter dark-fantasy campaign with elemental counters, 100+ relics and one-life runs, or chase high scores in Endless mode.

Rule the board with chaotic card synergies in a high-tempo block-placement roguelite. Bend physics, reverse board collapses, and chain game-breaking combos. Dominate online PvP, Co-op, and a 100-level Campaign. Draw your cards. Break the game.

SHORTED is a puzzle roguelike deckbuilder about tracing same-color Packets into scoring shapes. Tune your deck, combine rule-bending Patches, and break through six hostile Firewalls.

Neon Orbit is a 360° radial gravity puzzle roguelite. Rotate planets, slot blocks falling toward the core, and draft card synergies to break the rules of the game. Face boss anomalies, survive system collapse, and conquer the Multiverse Rift.

A roguelike block-stacker where every piece tells a story. Build your deck, survive disasters, enter dimensions, and discover 65 unique blocks — each with its own rules. Easy to learn. Impossible to master. One more run?

A slot machine roguelike built on dirty tricks. Rig the reels to escape a cursed amusement park before it takes your soul.

A turn-based, tile-matching puzzle roguelike with deck building. Play cards to create pieces on the board, connect four or more blocks of the same element to trigger reactions, and deal damage to enemies. Play at your own pace, you decide which pieces fall next, see the numbers grow!

A Calamity of Grumpiness has descended upon Happy Meadows! Spread Happiness to a Grumpy world in this turn-based strategy game where each attempt creates a randomly generated challenge.

Dig Dig Boom is a strategic mining roguelite set in a fully destructible world where time moves only when you move. Dig, blast, explore and fight your way through procedurally generated caves using a wide selection of mining tools with unique effects.

Connect by color or value. Chain combos. Craft builds. Outsmart 35+ special rules that twist the game. A roguelite tile-connecting strategy game where every match feeds a scoring engine you design. 120+ cores, items, and patches. No two runs play the same.

A visceral reimagining of the Suika-style physics puzzler, rebuilt as a punishing dark fantasy roguelike deckbuilder. Awaken as forgotten deity of bounty, stripped of grandeur, now facing sunless barrens and monsters. To restore balance, you must grow. To grow, you must sacrifice.

Tetromino Atelier is a Tetris-inspired falling-block puzzle with two distinct visual styles, responsive controls, and a wide range of static and animated backgrounds. Rotate, place, clear lines, build combos, and chase a higher score at your own pace.

A roguelite minesweeper game where you use different tiles, flags and skills to clear multiple boards in a row!

A puzzle poker casual game. Move card pieces around and build up powerful combos to deal damage! Balance between risks and rewards. Plan your board, use consumables, upgrade to get new cards new passives to help you win! Try out new builds and see how far you can go!

Build game-breaking combos, stack absurd multipliers, and forge powerful synergies in this roguelite match-3 puzzle game. Customize your gem bag, collect scrolls, relics, and tools, and discover new ways to push your score higher every run.

Hathor's Peak is a roguelike solitaire, reach the needed score before being out of cards. Progress through the levels, some of which will be boss battles that impose special rules and require you to use your action cards wisely.

SudoCrawler is a game that combines Sudoku with Roguelite! If you are a lover of logic puzzles and are addicted to the "meat pigeon" fun of building genres and challenging the limits, hurry up and give it a try.

The Lemmings roguelike. Magic the Wandering is a puzzle platformer where you learn spells, discover powerful wizards, and build your party to guide them through the world.

Command a warband of monsters in Tetrabeasts,the explosive fusion of classic falling-block puzzles and tactical combat. Form deadly battle lines, clear rows to unleash devastating attacks on enemy castles, and survive relentless counterstrikes. Forge your army. Master the blocks. Conquer the realms.

Kev-Inn's Packaging Facility is a block-dropping strategy roguelike that involves scoring boxes on a grid. Use different combinations of boxes and items to up your score, and gain combo to earn even more points! Purchase wacky upgrades for boxes, and navigate around your limited inventory!

The puzzle roguelike that turns dominoes into a mind-bending spectacle! Move, manipulate, and match using absurd tile modifiers, game-changing artifacts, and unique starting loadouts for endless chaos and replayability.

MERGE blocks to get ammo... BLAST the alien horde... and BUILD the ultimate fighting drone! Not gonna lie, this game is a PARTY!

Stackflow is a hypnotically addictive strategic roguelike about the pure pleasure of fitting pieces perfectly. Discover unique blocks, create satisfying connections, and trigger explosive combos that release pure dopamine.

Rig the machine until it pays out wrong. Draw symbols from your bag across five reels, chain paylines, and slot circuit-board artifacts into combos the house never accounted for. A roguelike deckbuilder about the arithmetic of very bad odds.

The match-3 roguelike. Stack relics, shatter rules, and pull off outrageous combos, all inside a puzzle game that boots like a fever dream from 1995. Crunchy, retro, and dangerously easy to start. Impossible to stop.

CiniCross is a dark fantasy roguelite where nonogram puzzles meet dungeon crawling. Solve increasingly complex puzzles, choose your path through a branching dungeon, and bend the rules using powerful artifacts. Each room is a puzzle. Each boss, a deadly challenge.

PLINKOMANCY is a roguelite that turns a simple ball drop into explosive chaos. Hit pegs, rack up massive numbers, and unlock upgrades as you push the arcade cabinet to its limits. How far can you go before the machine pushes back?

Clear blocks and raid together. Up to 8 players team up online as Dealer, Tank, Healer or Support. Face bosses that reshape the board and choose traits to build your strategy.

Myriad is a star themed 2D falling block rogue-lite puzzle game. Gaze the stars in the night sky and clear the board. Fit bonus blocks into your grid to make unique builds and score incredibly powerful line clears or just plain destroy the board as you see fit. How you play is up to you!

Minesweeper, but the mines fight back. Descend an endless shaft where the numbers lie, monsters burrow, and one wrong dig can end the run. Recruit 28 companions, hoard relics, and outsmart the Mole Queen. Survival is solvable by logic — going deeper is the gamble.

Control an acolyte of Dracula through the mazeburg, collecting villagers and avoiding the hunters to break the score, customize power ups to trigger your combos and become the hunter, transform Chompburg into a point making machine and discover dopamine blasting synergies!

Fight your way up Olympus in a match-3 roguelite. Match runes to strike and heal, cast spells and claim relics, and find the weakness every foe is hiding. Nine realms, seven demigods, one life per run.

Master an addictive arcade falling-block puzzle game with roguelite progression. Unlock powerful card-based upgrades, unleash spectacular combos, conquer handcrafted worlds, and create your own levels.

A roguelike deckbuilder where poker hands are scored on a grid, not played from a hand. Link neighboring cards across a 4x4 grid into pairs, straights and flushes, then slide, swap and delete cards to bypass hazards that block the paths you need.

Zero Bugs Given is a tower defense / roguelike game designed with the ambition of making every run different from the others. Every wave, a pair of bonus and malus will force you to adapt in the best way you can. Build your defense and try survive as long as you can!