Top similar games like Petri: Microbe Swarm:

A roguelike tower defense game with a dash of deckbuilding. Choose a reward, improve your build, survive the next wave, repeat. Highly replayable, difficult, and addictive. You'll want just one more wave, just one more run!

A fusion of tower defense games and roguelike deckbuilders. Use your cards to build towers and to upgrade them in unique ways. Gain rewards to customize your deck, defense and playstyle. Break the shapes before they break you!

Real Physics, where every shot matters. Real pool with Roguelike progression with an expansive meta-progression. Create your build with powerful items and charms, adapt to every table, and earn your place in The Hustle. Or play it Old-school and enjoy the real physics and custom tuned opponents

BAFTA award winning fleet-based RTS meets rogue-lite. In Distant Star: Revenant Fleet, build your fleet of up to 5 ships from a choice of 8 classes and traverse a randomly generated galaxy to defeat the Erebus Platform. NOW AVAILABLE ON MAC AND LINUX

Meow Meow Invasion is an action-roguelike survival game where you adopt abandoned kitties to unlock powerful synergies. Become the invader and dive into intense bullet hell combat, blending fast-paced action with strategic survival for a fresh challenge every time you play!

Play the first deck of Shapebreaker for free. A fusion of tower defense games and roguelike deckbuilders. Use your cards to build towers and to upgrade them in unique ways. Gain rewards to customize your deck, defense and playstyle. Break the shapes before they break you!

Are you good enough to make your country overcome the pandemic? Try it out! You're the president of a new country, In 1/1/2020 a pandemic started and you have to manage the country balancing 8 constantly chaging statistics using isolation measures or budget investments.

Command the immune system in an incremental auto-battler with a touch of roguelite. Build your army of cells, pick upgrades and defend six organs from real viruses, bacteria, fungi and parasites — from the gut to the brain.

Three in a Rogue is a tactical turn-based three in a row roguelike. Cascade combos to fight monsters and explore a randomly generated dungeon.

A territory-control strategy game where you continuously expand against AI opponents. Master six doctrines, unlock upgrades, and dominate procedurally generated maps.

A pixel-art roguelite tower defense game. Monsters are swarming toward the village, and you play as the captain of a band of mercenaries, building towers, sending out guards and holding the line with skills and traps. Mix and match over 100 cards and treasures to shape a company that's truly yours.

A minimalist sci-fi tower defense. Buy soldiers and upgrade them, defeat waves of enemies, hold your lines.

Forgetting is a procedurally generated panel-solving puzzle game. Inspired by games like the Witness, but with each playthrough offering a new dungeon to explore, new puzzles to solve, and new mechanics to learn.

A maze-building tower defense against hordes of thousands. Raise walls, build 15 kinds of defenses, pick a card every wave and unlock a 562-upgrade skill tree. Slow-motion missiles, a boss every wave and endless waves: how far can you go?

Connect by color or value. Chain combos. Craft builds. Outsmart 35+ special rules that twist the game. A roguelite tile-connecting strategy game where every match feeds a scoring engine you design. 120+ cores, items, and patches. No two runs play the same.

This is a strategy game that combines tower defense with Roguelike. Unlike traditional tower defense game, the towers in the game are vehicles that move along ‘loops’.You need to create defense loop and build battle trains to defend against enemy attacks.

A dark hex board. Shadow-crystal creatures march on your last lantern. Build no towers, build light. Aim emitters, bend beams with mirrors, and cross colors to unleash new effects. Every placement re-traces the whole board. A roguelite tower defense made of pure light.

An ADORABLELY SQUISHY rougelite game~! Command your army of slimes using the power of overwhelming number of Slime to gather and claim resources! But be AWARE of the time, because if it runs out before your lil guys are home, then The Horsemen will come charging!

Use ships to attack and destroy enemy space stations in real time.  Navigate through different randomly setup star maps to get to the exit and win.  It's a 2D single player space game that's massively replayable.

Fight your way up The Golden Caravan Casino in this noir Roguelite where Poker Battles decide your fate. Play bold Hands, gamble for powerful Trinkets and pull daring Tricks to shift the odds in your favor.

Stack blocks into a defence and let the attackers wear themselves out ricocheting through it. Survive fifteen waves, then switch sides and break into the layout you just built. Bank what you earn, unlock new shapes and cards, and run it again.

TD Worlds is a dynamic, highly strategical game that challenges your skill. Build an impenetrable defense and get ready to plunge into a new, unknown world to uncover its secrets. Use Twitch integration and play with your viewers.

ULTRAMASSIVE is a rogue-like deckbuilding game in a sci-fi setting. Embark on a journey towards the center of the galaxy, craft unique decks, fight hostile aliens, upgrade your space ship and face the unknown.

Lucky Hand is a roguelike deckbuilding game where every card drawn shapes your fate. Build powerful decks, strategize against challenging enemies, and explore dangerous places. With each battle, unlock new cards to help you in your adventure!

Help Gibo to collect the King's taxes. Every season, roll dice to send Gibo in corresponding towns and collect their resources. In your downtime, buy dice and town upgrades to satisfy the ever-growing King's greed.

Solitaire roguelike. Enter flow state while chaining combos of cards. Build the perfect deck, find the broken synergies, forget what time it is.

Defend the Obsidian Tower in a roguelike tower defense on procedurally generated hex paths. Build crossbows, flamethrowers, Tesla coils and mortars, combine fire, poison, ice and lightning, draft run cards between waves, and spend banked XP on permanent upgrades.

ZERO_FILL is a minimalist logic puzzle game. Bring all numbers to zero: click on a square to reduce or increase its value, but be careful - it also affects its neighbors. Includes a campaign with 75 boards, a boards creator and infinite random boards generation.

Play as a kind-hearted god in a tiny world. Grow thriving forests, inspire mortals to stand strong, and unleash nature's fury to shield them from evil. One small miracle at a time.

Connect the dots, close the lines, obliterate everything caught inside: a real-time, wave-based roguelite. Between waves, expand a massive talent tree, procedurally generated every run.

The Rock Paper Scissors game where rules are meant to be broken. Pick an archetype and defeat your foes to become the ultimate champion. Make the crowd go wild at your unfair plays, buy bracelets that will help you get the upper hand, but be careful... Your opponents might be cheating too !

Neon Orbit is a 360° radial gravity puzzle roguelite. Rotate planets, slot blocks falling toward the core, and draft card synergies to break the rules of the game. Face boss anomalies, survive system collapse, and conquer the Multiverse Rift.

Dungeon Decks is a roguelike deckbuilding game where you create custom characters, craft unique decks, and recruit up to 4 allies. Collect powerful party buffs, battle monsters, and choose your own path in procedurally generated dungeons!

A Calamity of Grumpiness has descended upon Happy Meadows! Spread Happiness to a Grumpy world in this turn-based strategy game where each attempt creates a randomly generated challenge.

Sokobond is an elegantly designed puzzle game about chemistry. It's logical, minimalist, and beautiful - crafted with love and science.

You are a dendritic cell. Rally neutrophils, charge into bacteria, carry antigen to the lymph node and craft antibodies. A roguelike blend of RTS and tower defense that follows one patient's immune system from age 2 to 72 — built on real immunology.