Top similar games like Immune Commander:

Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy.

Command the immune system in an incremental auto-battler with a touch of roguelite. Build your army of cells, pick upgrades and defend six organs from real viruses, bacteria, fungi and parasites — from the gut to the brain.

The hungry Gooper swarm threatens intergalactic peace. Stop them! Build towers around planets and take control over their orbits. Spin them with all you’ve attached! Collect new towers, powers and upgrades to beat the onslaught of goopers and save the galaxy in this colorful Tower Defense Roguelite!

Plant towers, hold the Nexus. A pixel-art tower defense where population caps how wide you can build, gold and mana decide what you build with. Draft augments as you level, spend gems on a permanent power-up tree, and find out how long your walls hold.

"Fighting for Land" is a casual roguelite tower defense game that blends randomized card draws, randomized power-ups, and territory-coloring.

Tower Defense x Roguelite! Recruit Kids with branching Elite paths, use powerful Items, and gain randomized strategic Perks to defend your Fort against the Brats! Various challenging environments, Brats, and Bosses await you and the Kooky Kids.

BALL MACHINE is real-time strategy driven by pinball. Launch creature marbles, gather red, green, and blue paint energy, and buy units, cartridges, upgrades, structures, and tactical tools. Command the battlefield against the standard AI or asynchronous builds formed from your own past decisions.

Relaxing, casual single-Player Tower Defense Game for breaks in life.

After the Gugu Deity's blunder, monsters rained down. By day, explore the wild and fortify your defenses. When night falls, brace for relentless waves of monster onslaughts from all directions. Rally your wits and courage, fight alongside your leafy allies, and survive until sunrise!

Turn your armada into a rotating fortress, striking from every angle. A roguelite tower defense where spatial reads decide survival.

Build mazes, customize your deck and travel through time, in a nostalgic tower defense game with a minimalist feel and a rogue-lite twist. Only you can save the Tree of Life from the malevolent forces of The Corruption...

A build-focused tower defense where you craft powerful synergies, experiment with items, and push your strategy through short, highly replayable runs.

A dynamic low-poly Tower Defense. Command mobile squads and repel attacks from 4 factions. Collect gold from settlements during battle to craft equipment—the currency for hiring new troops. Defeat titanic bosses, upgrade your camp, and unlock elite tiers for your army!

Magic Mushroom Defense is a creative tower defense game where players defend their castle against magical mushrooms in 100 unique maze-like levels. Strategically place and upgrade towers, adapt to evolving enemies, and overcome challenging obstacles to protect your kingdom.[ /i]

Goblin Siege: Protect the Castle! is a tower-defense game where you will have to defend your castle from a siege of goblins. Recruit soldiers, plan your strategy, and have fun!

A roguelike tower defense where every run reshapes your strategy. Build your team of towers, combine more than 80 artifacts, and explore a pixel-art world while taking on ever tougher challenges and bosses.

Defend your turf against endless waves of grinning enemies! Pick from 6 unique smiley classes with their own abilities, build and upgrade turrets across multiple lanes, and take down ever-tougher bosses – a colorful tower-defense hybrid built for replayability.

The evil black wizard has installed a clone on your throne and exiled you from the kingdom. Come, Exile. The time has come to take your kingdom back! Once you learn the tactics, challenge your friends in one-on-one battles.

It’s time to fill the fridge with your friends, the Munchie, the chef, and Popo! Keep stuffing food into the fridge and prove that no one organizes better than you. All in this fun and stylish inventory management game!

Immerse yourself in the cozy, minimalist world of Slorbis: Tower Defense. Build towers with unique roles, buy modifiers of varying rarities, collect money, and face the unpredictability of procedurally generated maps as you defend the king from dark spirits.

A real-time line-battle roguelite. Spend rations to summon swordsmen, shields, archers and cavalry onto a single front, then break the enemy base. Pick relics and promotions at every fork to build a different army each run. Three commanders, three ultimates.

3D-realtime tower defense game with (rainbow-) UNICORNS!

Defend your castle from the orcish chavs, lure them into your traps and destroy them.

RTS, but the soldiers will act automatically: Each soldier has different characteristics/attribute values/action methods. Choose the appropriate soldiers and buildings according to the battlefield situation, and destroy the opponent's castle only through your strategy rather than operation!

"Indie game team of hardship and adversity. Make the best game ever!" You become the head of the indie game development team. Let's develop a game with the goal of GOTY, the best award in the game industry. Create a game through defense, run a team, and aim for the best award.

What if you took finance and tower defense, and added them together? Well, this is Oinkenomics, where you create pig towers to defend your piggy bank. Defend against the enemies of finance: bulls, bears, and the powerful black swan. And make sure to manage your stocks.

This is a 3D pigeon tower defense game that utilizes resources to build turrets and collaborates with heroes to block enemy attacks.

Fable Forts! TD: defend your fairy kingdom from stupid human invaders!

Do you like Tower Defense games with Strategy elements? Well, look no further! We've got exactly what you're looking for! Get ready to defend your settlement from enemies using a huge arsenal of towers!

Defender of the Kingdom: Tower Defense is a colorful medieval tower defense strategy game where orcs and their horde attacked the kingdom and now the fate of the kingdom is in your hands, defenders!

An ADORABLELY SQUISHY rougelite game~! Command your army of slimes using the power of overwhelming number of Slime to gather and claim resources! But be AWARE of the time, because if it runs out before your lil guys are home, then The Horsemen will come charging!

This is a tower defense game combined with flagship elements. In this game, you need to use the monster cards in your hand to repel the surging greedy adventurers and protect the dungeon's treasure. You need to use each card wisely, otherwise... you will be overwhelmed by endless monsters~

Experience realistic plant growth as you fight off waves of enemies with genetically upgraded weaponized plants. Customize your arsenal and conquer the garden in this unique tower defense rougelike

A tower defense game set in the village of Loinkham. Use towers and various interactable objects in the environment to protect your little oinkers and their assets! Each map offers something new to help you with your journey. Unlock new towers and maps as you play.

Reborn is a glorious, hardcore revival of the beloved lane-defense classic. As greedy Vikings march north in search of gold, the Troll Liberation Front rise to defend their lands. Far from a “place-and-wait” TD game, every second counts in this fierce, tactical fight.

This is a tricky puzzle game with cute little blobs, sparkly gems, 50 levels, and the ability to load and create custom levels. Benny The Blob features some difficult and headache-inducing levels that will challenge even the most experienced puzzle fans.