Top similar games like Microbial Mayhem:

A Fantasy Rogue-Like game with Paper thin graphics. Cut through waves of enemies and collect their souls to increase your power! Encounter a variety of enemies and events as you make your way through the DARK.

Last warrior of the Herbheim's clan, it's your duty to defend the last family mine

After the Earth exploded, the fate of the Earth is in your hands. By creatively building your own spaceship, you'll fight your way through space against pirates. On your journey you will meet many different life forms, some with good, others with bad intentions.

An action-adventure game, Relic has a unique storyline and environment with a pixel art style.

Pixel Fortress is a retro-inspired tower defense game packed with fast-paced real-time strategy. Build your defenses, command powerful abilities, and unleash devastating energy blasts to hold off relentless enemy waves. Can you master the battlefield?

Build your own towers from modular units, adapt mid battle, and master custom defenses in this Build-a-Tower Defense.

Scrap Bastion is a strategy tower defense game where you manage your city, equipping it to survive the waves of mutant creatures, testing your planning and decision making capacities at every turn. Watch out, as time is crucial to win!

Heroes Rally is a casual strategy tower defense game. Build towers with different characteristics and command heroes to repel all the enemies. Go and develop a your unique and powerful strategy!

Lone Howl is a rogue-like survival game where you control a one-eyed wolf facing increasing waves of enemies in a dark, mystical environment. Customize abilities, fight for survival, and adapt your strategy to overcome ever-growing challenges.

Lighark is a top-down action-adventure game where the protagonist pilots a spaceship, traversing through various wondrous planets and engaging in a revenge battle against the three factions of the galaxy. However, all of this is part of a larger conspiracy.

Explore the mysterious islands of Bridgelands, fight dangerous creatures, gather resources, and craft powerful gear. Discover hidden secrets, upgrade your tools, and dive into fast-paced battles across ever-changing islands. An action-packed adventure full of exploration and combat awaits.

Stranded on an infected world, one survivor against a rising tide of alien bugs. A top-down survivors roguelite where every enemy is a single pixel and the whole swarm is on screen... a million of them. Build your loadout, hold the line, reach extraction.

In this single-player roguelike, control an army of RECLAIMERS through a dangerous procedurally generated world. Recruit troops, collect resources, and craft upgrades to advance your army to fight orcs, trolls, and more monsters. Defeat enemies in battle & fight the Orc King!

Vox Siege is a an Action-RPG Tower Defence game. Where you play as a hero who build towers and use hero abilities to help defend Vox on their journey to close all dark portals that is wrecking their land Fiora.

A tactical defense game where you build the battlefield itself. Lure enemies through your maze using traps, towers, and godly powers.

Command your elven army and defend mystical lands from sea serpents, evil sorcerers, and wave after wave of gnoll tribesman, all with the help of brand-spankin’ new towers, heroes, and spells to fend off every last baddie.

Gather resources, upgrade your equipment, and strengthen your base with up to 4 players. When night falls, fend off waves of monsters and protect the precious Mana Stone from destruction.

Command a party of stalwart dwarves and delve Deep, Deep into their shattered kingdom to reclaim it from the ork and goblin invaders. Crawl, explore, and battle through dungeons using tactics and skills. Reclaim ancient dwarven artifacts to bolster the power and abilities of your party.

Summonsters is a roguelike auto-battler game where you buy summons and combine artifacts to survive against oncoming enemies. Utilize summons that fight on your behalf to defeat bosses and elites. To ensure survival, strategically combine artifacts to forge powerful legendary artifacts.

Last Hope is a combat-focused survival game where you will unlock new areas and weapons throughout your playtime to better equip you for fighting the increasingly harder nightly waves of enemies.

Survivor of the Journey is a survival game with rogue-like elements Survive in countless fantasy monsters Grow faster than the enemy that comes and knock them down Survive to the end and defeat the boss. Failed? Use your stuff to be strong. Can't you? Let's try our luck this time.

Hellish Scrub is a 2D top-down action-adventure where you must clean the underworld and defeat filth-loving demons by using their own trash against them. Get to scrubbing to earn your escape back to Earth!

In this top-down game you must think creatively to speed through waves of enemies, while staying alive. You are a samurai and to restore peace to the lands of Yarbil you must defeat the Trials of Yarbil.

You are the last living organism in the galaxy. Adrift and alone in a cold dark world you must scavenge for resources to keep your ship running, and arm your ship to prepare for the swarms arrival. 

Compete in ranked PvP tower defense, survive infinite dimension loops, or defend alongside a friend in online co-op. Build powerful turret combinations, adapt to ever-changing enemy paths, and climb a global ELO ladder.

This is a tower defence game that emphasizes decision making and strategy rather than fast reactions. Every choice you make impacts your overall progress, encouraging players to think carefully about how to prioritize their upgrades.

A build-focused tower defense where you craft powerful synergies, experiment with items, and push your strategy through short, highly replayable runs.

Tribes and Monsters is a survivor-like game where you can choose a tribe and become the leader of your own army. Try to collect materials in worlds inhabited by vicious monsters. Craft, upgrade, and enhance your tribe's base to unlock more features, stronger weapons, pets and so much more!

Join Q on a quest to challenge the Giants of the world in a fast-paced ARPG with a heavy focus on crafting, experimentation, and complete build freedom. You are what you wear; craft powerful gear, create unique builds, explore dangerous biomes, and carve your own path through relentless combat.

Feline Survivor is a rogue-lite game that combines classic Monopoly and Backgammon.You'll travels different planets, defeat countless monsters, and build the perfect map loop and weapon combos in this game of luck and tactics, until you finally find the secret treasure guarded by the monsters.

Embark on an alchemical journey in this vibrant 2D adventure! Craft unique monsters, engage in turn-based battles, and liberate the region. A fusion of exploration, crafting, and thrilling combat awaits in Fusion Nexus: Alchemic Evolution.

Defeat enemies in this cozy arena by strategically building your action loop!

Craft equipment, Recruit heroes, , and Explore dangerous lands. Command and defend your castle in this immersive 2D strategy game. Face challenging waves of enemies as you shape the fate of your kingdom. Unleash your strategic prowess and forge your legacy in this epic fantasy adventure.

Spectral Realm is a top-down tower defense Rogue game, where players need to play the role of an astronaut who has just landed on a different planet to block a constant stream of attacking native creatures and continuously strengthen themselves with the gems contained within their bodies.