Top similar games like Pathogen:

Take on the role of park manager and design the ultimate zoo for nature's greatest creations.

End humanity using disasters, plagues, and war. Spread chaos worldwide, combine catastrophic events, and stop them before they escape to the Ark.

A management sim where you run your own food shops, serving hungry locals while keeping a close eye on your resources. Grow or buy fresh ingredients locally. The competition is fierce and sabotage is always on the menu. Defend your business, and rise to become the food lord!

A vertical kingdom in the sky! Plan your ascent from the harsh Sand Zone, rising layer by layer as you and your Towertizens stand together against looming disasters. Build trade ports and vertical supply networks. Perform Rituals to shape miracles, and witness the prosperity of this rising nation.

Bleak Frontier is a strategy / city builder game set in a frozen wasteland in the far future, 4087 AD. As the chosen leader of the first permanent settlement in almost a century, you must guide the last survivors of the human race towards an uncertain future. Welcome to the Bleak Frontier.

Fight against huge hordes of geometric amalgamations with BOTH towers and allied defenders to stop them from breaking your CORE! Travel to barren deserts, hostile wastelands in this fast-paced tower-defence game.

Innovative yet familiar real-time strategy game in development. Grand-scale RTS game played on maps/planets of any 3D shape. It emphasizes strategy, base building, logistics, and reduces micro-management of individual units.

Do you like Tower Defense games with Strategy elements? Well, look no further! We've got exactly what you're looking for! Get ready to defend your settlement from enemies using a huge arsenal of towers!

Keep it cool or raise the heat in this first-person, online, control point, party game with up to 8 players. The hot-tempered Gelava (Jellies) will crank up the reactor’s heat, while the stone-cold Koizo (Fish) scramble to cool it down. Which team are you picking?

Develop your computer empire, control costs, and increase profits. Decide whether to develop hardware in-house or purchase it, and whether to prioritize cost-effectiveness or pursue higher profits. The choices are all up to you.

Battle in a post-apocalyptic future as the Ironclad Union or the Timberfolk Clan. Collect scrap, build weapons, dominate maps, and shape development in Early Access. Lead your faction to victory in Scrapmen's evolving warzone!

Recovery Syndicate is a prequel to Abeyance, in which you are the leader of one of the factions trying to reconstruct the economy of the galaxy. You must build and manage your colony's resources carefully, while watching out for rival factions who are also vying for supremacy.

Build and govern a growing city where prosperity, population growth, and social control must remain in balance. Expand districts, manage infrastructure, enact policies, and maintain stability in this city-building strategy simulation.

A factory automation incremental game at the end of the universe. Start crafting by hand, automate production, and build the Chronoforge to escape.

Polyion is a world management game where you can create and manage your own world and its resources. Place buildings, manage your resources, keep your population happy and create a thriving world.

City Builder Pro lets you unleash your inner ruler—design your dream base, prepare for epic battles, and feel the thrill of watching your city grow and dominate. Build smart, strike hard, and rise to power!

A strategy survival game made for beginners, by a beginner indie developer. Try to keep a small village alive in a world where time moves fast. Clear land, build houses and barns, set up fields, plant crops, and manage your resources carefully.

Build infrastructure to connect the expanding world to the internet! Having a working strategy and great management is key to winning your competition in this capitalist environment.

Pillazon is an MMO virtual business simulation game where you work as the CEO of a new company. Your mission is to create your own website and build the world's extensive drug empire!

Build mechas, form mecha teams, and command them to fight.

In this real time strategy city builder game you will help humanity in reaching beyond earth by establishing a permanent and thriving settlement in the asteroid belt. Settling in space comes with enormous challenges and dangers, which you will have to guide your people through

Play as S.C.R.A.P., an autonomous recycling robot, deployed to clean abandoned planets in this short incremental game. Destroy debris, collect scraps and convert it into usable resources. Optimize your systems through short, repeatable deployments.

Take on the challenge of managing these Little Renters and their needs. Keep them happy with the right decoration and set your rent prices to maximize profits! Stay alert as Thieves, Squatters, Fires, Sick Renters and Broken Decorations can cause you to Fail!

Build an intricate prison, hire the best staff, and pamper your prisoners to create the perfect rehabilitation facility in Prison Tycoon: Under New Management

The epic story of evolution, technology, humanity, and dinosaurs is yours to tap.

Project: C.E.L.L. is a retro-terminal sci-fi roguelike management sim where you engineer a living cell for a corporation chasing immortality. Run simulations, build organelles, manage resources, and stop cascading failures. How long can you keep the experiment alive?

Cities Virtual Reality is a VR city builder. You have a wide range of tools that you can use to build up your city! Play in a relaxing sandbox or play the campaign for a more intense experience.

Rule the state in this political strategy simulatior by interacting with characters and with the map. Each of your decisions will necessarily entail a result. The game raises topical problems of the modern world, politics and humanity as a whole.

Double Envelopment is a real-time strategy game where you are a general in charge of conducting an invasion of foreign countries, using a mix of grand strategy, operational artistry, and tactical decision-making to capture enemy cities and infrastructure, and lead your army to inevitable victory!

Estate Empire is a multiplayer strategic game inspired by classic board games. Compete against your friends and develop your own strategy to win, and try to dismantle your friend's empire. Invest in the same street as your friends, use your cards or become the mayor to create new laws against them.

Craft bio-weapons, master lethal science, and unleash global annihilation. Experiment. Fail. Adapt. Evolve. Repeat until humankind falls.

Become the billionaire you always mocked! Collect humans like trading cards, exploit their productivity, and compete in The Excess Index - where morally bankrupt capitalism is the only way to win. Own everything. Question nothing.

Plentiful is a nature sandbox. You shape the land and everything responds—water, plants, animals, and your people. Learn how this world works. Your tribe’s survival depends on it.

The technologically advanced humanity starts looking for other planets to conquer. Now that the Earth is depleted of its resources, we're looking for them elsewhere. The Universe is open for us now - and it cannot hide any secrets. So how will you conquer it?

Space 4X game with the ability to build factories, extract resources, with characters, internal and external markets ... Take part in the discussion of the game, share your vision)