Top similar games like Pathogen:

Take on the role of park manager and design the ultimate zoo for nature's greatest creations.

End humanity using disasters, plagues, and war. Spread chaos worldwide, combine catastrophic events, and stop them before they escape to the Ark.

A management sim where you run your own food shops, serving hungry locals while keeping a close eye on your resources. Grow or buy fresh ingredients locally. The competition is fierce and sabotage is always on the menu. Defend your business, and rise to become the food lord!

A vertical kingdom in the sky! Plan your ascent from the harsh Sand Zone, rising layer by layer as you and your Towertizens stand together against looming disasters. Build trade ports and vertical supply networks. Perform Rituals to shape miracles, and witness the prosperity of this rising nation.

Bleak Frontier is a strategy / city builder game set in a frozen wasteland in the far future, 4087 AD. As the chosen leader of the first permanent settlement in almost a century, you must guide the last survivors of the human race towards an uncertain future. Welcome to the Bleak Frontier.

Fight against huge hordes of geometric amalgamations with BOTH towers and allied defenders to stop them from breaking your CORE! Travel to barren deserts, hostile wastelands in this fast-paced tower-defence game.

Innovative yet familiar real-time strategy game in development. Grand-scale RTS game played on maps/planets of any 3D shape. It emphasizes strategy, base building, logistics, and reduces micro-management of individual units.

Do you like Tower Defense games with Strategy elements? Well, look no further! We've got exactly what you're looking for! Get ready to defend your settlement from enemies using a huge arsenal of towers!

Keep it cool or raise the heat in this first-person, online, control point, party game with up to 8 players. The hot-tempered Gelava (Jellies) will crank up the reactor’s heat, while the stone-cold Koizo (Fish) scramble to cool it down. Which team are you picking?

Scrapmen is a persistent faction war with arcade FPS combat, player-driven logistics, tactical coordination, base building, and homefront support. Fight, build, supply, farm, organise, and help your faction survive in a stylised wasteland war that continues after you log off.

Develop your computer empire, control costs, and increase profits. Decide whether to develop hardware in-house or purchase it, and whether to prioritize cost-effectiveness or pursue higher profits. The choices are all up to you.

Recovery Syndicate is a prequel to Abeyance, in which you are the leader of one of the factions trying to reconstruct the economy of the galaxy. You must build and manage your colony's resources carefully, while watching out for rival factions who are also vying for supremacy.

Polyion is a world management game where you can create and manage your own world and its resources. Place buildings, manage your resources, keep your population happy and create a thriving world.

Build and govern a growing city where prosperity, population growth, and social control must remain in balance. Expand districts, manage infrastructure, enact policies, and maintain stability in this city-building strategy simulation.

City Builder Pro lets you unleash your inner ruler—design your dream base, prepare for epic battles, and feel the thrill of watching your city grow and dominate. Build smart, strike hard, and rise to power!

Build infrastructure to connect the expanding world to the internet! Having a working strategy and great management is key to winning your competition in this capitalist environment.

Pillazon is an MMO virtual business simulation game where you work as the CEO of a new company. Your mission is to create your own website and build the world's extensive drug empire!

Build mechas, form mecha teams, and command them to fight.

In this real time strategy city builder game you will help humanity in reaching beyond earth by establishing a permanent and thriving settlement in the asteroid belt. Settling in space comes with enormous challenges and dangers, which you will have to guide your people through

Play as S.C.R.A.P., an autonomous recycling robot, deployed to clean abandoned planets in this short incremental game. Destroy debris, collect scraps and convert it into usable resources. Optimize your systems through short, repeatable deployments.

Take on the challenge of managing these Little Renters and their needs. Keep them happy with the right decoration and set your rent prices to maximize profits! Stay alert as Thieves, Squatters, Fires, Sick Renters and Broken Decorations can cause you to Fail!

Rule the state in this political strategy simulatior by interacting with characters and with the map. Each of your decisions will necessarily entail a result. The game raises topical problems of the modern world, politics and humanity as a whole.

Build an intricate prison, hire the best staff, and pamper your prisoners to create the perfect rehabilitation facility in Prison Tycoon: Under New Management

Biosphere-3 is a God-view Ecosystem Sandbox. Splice DNA to design species, watch them forge food webs and survival strategies. Raise volcanoes or glaciers to shape a dead planet. Unleash lightning, acid rain or hurricanes to steer evolution. Awaken as the creator — the last biosphere is yours.

The epic story of evolution, technology, humanity, and dinosaurs is yours to tap.

Cities Virtual Reality is a VR city builder. You have a wide range of tools that you can use to build up your city! Play in a relaxing sandbox or play the campaign for a more intense experience.

Double Envelopment is a real-time strategy game where you are a general in charge of conducting an invasion of foreign countries, using a mix of grand strategy, operational artistry, and tactical decision-making to capture enemy cities and infrastructure, and lead your army to inevitable victory!

Build your fortune in a living medieval kingdom. Establish shops, manage caravans, master a dynamic economy, and outmaneuver rival merchant houses in single-player or competitive multiplayer as you build the realm's greatest trading empire.

Estate Empire is a multiplayer strategic game inspired by classic board games. Compete against your friends and develop your own strategy to win, and try to dismantle your friend's empire. Invest in the same street as your friends, use your cards or become the mayor to create new laws against them.

The technologically advanced humanity starts looking for other planets to conquer. Now that the Earth is depleted of its resources, we're looking for them elsewhere. The Universe is open for us now - and it cannot hide any secrets. So how will you conquer it?

Space 4X game with the ability to build factories, extract resources, with characters, internal and external markets ... Take part in the discussion of the game, share your vision)

Craft bio-weapons, master lethal science, and unleash global annihilation. Experiment. Fail. Adapt. Evolve. Repeat until humankind falls.

Dive into a world of creation and discovery, where each element combines to form new ones. Experiment freely in this interactive sandbox. But be careful: every combination has its consequences..

Become the billionaire you always mocked! Collect humans like trading cards, exploit their productivity, and compete in The Excess Index - where morally bankrupt capitalism is the only way to win. Own everything. Question nothing.

Experience a mystical journey with the Mims in this strategic god-like adventure—build, grow, protect, and wield divine powers. Now it's completely free! Also check out our other story-rich fantasy game, The End of the Sun, where you become a tracker of mythical beings and unravel mysteries.