Top similar games like Nexus Defenders:

The Rift is a tower defense game with elements of RPG gameplay that will appeal to players of all skill levels. Enemies from an alternate universe are attacking and it's up to the player to stop them by strategically building defensive towers.

The Echoes of Mars is a voxel-style tower defence game. Defend your research base on Mars from ancient creatures by strategically placing towers and using advanced tech.

Sci-fi tower defense meets ARPG-like hero combat. Build towers then fight alongside them with your hero as you battle through a campaign to uncover the fate of a colonization effort on a distant planet.

A single-player sci-fi strategy game set in a future where humankind has made the first leap to a distant star system

"In 'Random Core Defense,' acquire and enhance cores using limited resources to withstand relentless enemy onslaughts. Defeat powerful bosses and test your strategy to survive until the very end!"

Defense Grid: The Awakening is a unique spin on tower defense gameplay that will appeal to players of all skill levels. A horde of enemies is invading, and it's up to the player to stop them by strategically building fortification towers around their base.

Build towers, shape enemy paths, and defend your outpost from endless waves. Survive escalating threats, destroy falling asteroid hazards, and push your defenses to their limits in Endless Mode.

TechDev Tycoon is a technology company management simulator where you will be at the helm of your own technology business. Create all kinds of tech, cryptocurrencies, AI and OS, expand production, compete with competitors and explore new technologies to become the industry leader.

TAVU is a PvE RTS game with a tactical combat system. Build your bases and defend them against waves of enemy attacks. Upgrade your units and destroy enemy bases to gain new territories and resources.

A strategic and action-packed base survival game where you mine crystals, build units, and defend your base against waves of UFOs. Defeat enemies, gather resources, and unlock new planets to expand your defenses. Are you ready to conquer the galaxy?

Bite size colossal battle! Build an army in minutes as infantry upgrade with orbital drops into war machines! Then combine those machines to form the giant Mantlet mech! All while bullet hell rages! In a transhuman future, command Mantlet One to secure New Terra!

Classic Tower Defense meets space exploration. Build turrets on mining platforms, harvest enemies to build more defenses, and mine Dark Energy to travel the stars. As a sentient AI, you must upgrade your tech, scan planets, and find a new home for humanity before Earth fades away.

Join in on the next gold rush and become a prospector in space. In this unique tower defense you can set up and reposition towers for maximum efficiency and adapt to the environment.

Robowars is back on Steam! Fight off troops of droids for freedom and honor in our classical tower defense game. Lead the forces of the Solar Union to protect the peaceful planet of Praymos from the aggressive Trade Confederation.

A classic tower defense game set in space! Build and upgrade towers, defend your portal from waves of alien invaders, and outsmart evolving threats across handcrafted and procedural maps.

Defend your tower for as long as you can from the aliens invading your space! Level up, earn money and new units, and strategically place them in the grid!

A strategy game that blends base-building, war-chess-style progression, and otherworld exploration. In a world beset by internal and external crises, you are called to command a modern army through a portal, repel escalating threats, and seize vital resources.

Star Trek: Prelude is a space-based game that builds defense towers on earth to defend against alien invaders called Black Ember.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

Zero Bugs Given is a tower defense / roguelike game designed with the ambition of making every run different from the others. Every wave, a pair of bonus and malus will force you to adapt in the best way you can. Build your defense and try survive as long as you can!

A strategic space tower-defense game. Enemies detect, warn, and try to bypass defenses, forcing you to adapt. Combine diverse towers and face unique maps for varied battles. With tense sci-fi atmosphere, it delivers a fresh experience beyond traditional tower defense.

By Placing the turrets, Save Humanity from AI!

Strategy, timing and fortune: Novel and immersive tower defense game experience!

Playroom Invasion TD invites you to an exciting tower defense adventure set in a nursery filled with toy characters and towers. Take part in fun and tactical battles against evil toys and monsters trying to take over your room which is full of towers with different features.

Tower defense adventure where you recruit heroes and use them to take down the corruption.

The hungry Gooper swarm threatens intergalactic peace. Stop them! Build towers around planets and take control over their orbits. Spin them with all you’ve attached! Collect new towers, powers and upgrades to beat the onslaught of goopers and save the galaxy in this colorful Tower Defense Roguelite!

Temporal Titans is a Tower-Defense game with Time Travel. Send mechs back to previous waves to prevent your defeat, and protect your salvage team from the monstrous Grell as you scavenge the ruins of a lost earth. Rewind, rethink, and reclaim the future!

Expedition: Shadow World is a tactical game about an expedition sent to a distant planet to extract energy resources. Command a group of five troopers in real-time battles with a tactical pause and discover the mystery of the planet.

Edge of Extinction is a real-time strategy game focused on tactical unit control, faction identity, and large-scale conflict. Command armies across unstable voxel-based terrain, deploy formations, manage resources, and fight for survival as six rival factions are forced into war. Wishlist now!

Molten Armor is an action tower defense game with a non-linear story in sci-fi setting! Command defenses and stop hordes of enemies! Fight on land, sea and in the skies!Decisions taken in the heat of battle will change the course of the war.

Expansion is a sci-fi Action RTS where deck-building strategy meets fast-paced VR duels — battle AI or challenge real players.

In Vermin Control, you will enter a thrilling sci-fi tower defense world filled with strategic combat and high tension. Operate a versatile unit capable of both melee combat and construction, deploy and manage 9 unique devices, and protect key facilities from relentless vermin assaults.

A strategic tower-defense where you control powerfull drones. Unlock new tower and use specific technologies to defend your base on Thukothea!

Ifectra is a strategy game set in 2124 on the distant planet Emevera III, ruled by the Maxploit Corporation, where an epidemic of a yet unknown virus broke out. Your goal as the corporation security commander is to evacuate as many healthy people as possible and to eliminate infected individuals.