Top similar games like Orbital Defense 2899:

Totally Defenceless is a wave-based tower defence game. You will need to protect your energy cores from the invading alien bugs by strategically constructing a maze of towers to alter their path to your advantage.

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

Customize your Ships, Upgrade your fleet, and Command your way to victory in this ruthless rogue-lite tower defense/real time strategy hybrid. Take on an enemy that learns from your moves and adjusts its own path. Do you have what it takes to persevere?

Freely place a 15-chassis defense network, break visible enemy layers, and time Flux Gates, Protocol choices, commander abilities, and Overdrive across a 20-mission neon tower defense campaign.

Apocalypseed is a 2D real-time strategy game where you are the invasion. Devour humans to harvest flesh, build and strengthen an army of alien plants, and evolve your creatures into new forms with unique abilities. Crush the human resistance as it deploys increasingly dangerous threats to stop you.

TAVU is a PvE RTS game with a tactical combat system. Build your bases and defend them against waves of enemy attacks. Upgrade your units and destroy enemy bases to gain new territories and resources.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

A last-stand auto-battler on a dead magic world. Choose your heroes, upgrade their abilities, and try to hold on one more night.

Command your forces to victory in this intense tower defense experience! Strategically deploy your defenses to fortify your position and funnel the enemies through intricate mazes. Carefully allocate your resources and adapt your tactics to counter waves of relentless enemy drones!

Power the Unknown is a strategy game where you build a base on an unexplored planet and defend it from swarms of hostile bugs. Mine resources and generate enough energy to power your ever-growing base.

Command massive space battles where thousands of ships clash in real time. Build your fleet, choose a doctrine, reinforce the battlefront, unleash commander abilities, and adapt as unexpected events turn the tide of war in this mashup of strategy and auto-battler.

Build, Upgrade, and then Move your Towers in this unique twist on the Tower Defence genre. With Rogue-Lite mechanics every run offers new strategies, and every death unlocks new upgrades. Grow. Evolve. Destroy the Robots!

We've traveled to the past to conquer these fertile lands. Now, you must defend them from the blood cult intent on taking it for themselves. Be careful though: from where their blood is spilled, ancient magicks empower whomever is still alive.

A sci-fi tower defense where you design enemy routes and build defenses on alien planets. Combine 16 weapons, hold off counterattacks, and advance through a four-planet campaign. Research new gear, face wall-breakers and bosses, or try Endless Mode, seeded expeditions and the map editor.

A Roguelike Tower Defense in space with missions to conquer. Can you hold against the spreading alien bosses? Build and upgrade towers against the corruption. Choose your technologies and warpspeed your way to victory.

Space Base is an action-packed tower defence game, where you aim to protect your planets from the incoming forces of enemy ships and aliens by any means necessary. Build up your defences as stronger and stronger waves of enemies arrive to reach the highest score possible.

A minimalist sci-fi tower defense. Buy soldiers and upgrade them, defeat waves of enemies, hold your lines.

You’re not the ship—you’re a fragile prospector with a jetpack. Haul gold, deploy robots and defend your operation from meteor storms, aliens and pirates. Gear up between expeditions—but mine fast: a rival can take the claim while you’re still alive.

Tower defense / Roguelike / Sci-Fi / Pixel Art game with boomer games aesthetics. Mine resources and shoot those disgusting aliens right in their faces. Unlock new technology, develop new strategies and explore the planet. A modern old-school Pixel Art experience with the vibe of 90s classics.

Hold a mining outpost on an alien world while thousands of insects pour through the rock tunnels like a flood. Place towers on the high ground, aim their firing arcs, and spend the biomass from every run, won or lost, on upgrades that let you hold a little longer next time.

Solar Defense is a Military Sci-Fi inspired Tower Defense game focused heavily on strategy and decision making. Defend key locations and repel the Pilakarr forces back to their home world to end their attack and bring an end to this war.

Refactor is a hard-core tower defense game that combines modular building, route planning, and element composition.

Noble Armada: Lost Worlds is a moddable real-time strategy PC title based on the Noble Armada miniatures game. Set in the Fading Suns Universe, the five Royal Houses dominate human space as they battle each other for control of the greatest resource... humanity itself.

Defend the last citadel on a dying alien world. Summon a gacha collection of bio-engineered defense towers, forge a custom loadout, and conquer three modes, story-driven Chronicle, roguelite Contracts, and 1v1 PvP Ascension. Tower defense meets deck-building meta-progression.

A planetary tower defense where enemies attack across land, air, and space. Build layered defenses, manage resources, and survive an escalating alien invasion.

A pixelated 2.5D RTS meets tower defense as you battle mutated ants in a short campaign. Build walls, place turrets, and hold the line to reclaim Earth's surface in this tactical fight for survival where placement of everything matters.

An RTS where your units only take orders inside your radio network. Build relays to push the signal out and keep them alive, because the enemy goes for them first. Four maps, a hundred waves each.

Thousands of rift creatures. One base. Aim every turret's line of fire, then take the main cannon into your own hands. Take down five bosses across 15 maps, grow stronger between runs, and climb the global leaderboard in Endless. Build and share your own maps on the Workshop.

Alpha One is a top-down action, 4X-lite strategy game. Each action level is a turn in a strategic conflict as you race to collect resources, acquire upgrades, expand territory and build defenses. All to find a way home!

2D space shooter and turret defense come together to create the Planetary Defense System this world needs! Shoot down asteroids and aliens and survive the bosses in this arcade like game featuring customizable satellites, projectiles, and upgradable Cannon and Planet Shield systems.

Starfall Defenders is a classic tower defense game that features unique towers and enemies. It also has an in-game shop system that allows players to purchase better towers, upgrade existing ones, and buy special items like the Atom Bomb, Splash Bomb, and Air Supply.

Von Neumann Project is about a self replicating probe as it charts the galaxies, peacefully of course. Mine, build, expand, and explore in this sci-fi RTS. Remember to have as little impact on your surroundings as possible and protect yourself at all costs.

The hungry Gooper swarm threatens intergalactic peace. Stop them! Build towers around planets and take control over their orbits. Spin them with all you’ve attached! Collect new towers, powers and upgrades to beat the onslaught of goopers and save the galaxy in this colorful Tower Defense Roguelite!