Top similar games like Machines vs Monsters:

A tower-defense game with roguelite elements on fully explorable mini planets! Travel the galaxy of Vyrosa, land on planets, and defend your drilling equipment while mining fuel to continue your journey throughout the galaxy!

Drop Order is a dark sci-fi tactical tower defense where every turret placement shapes both your firepower and the enemy's route. Build synergistic defenses, create deadly mazes, and survive alien hordes with cards and hands-on drone combat.

The fusion of deck-building roguelike and tower defense returns, bigger than ever! Build your deck with powerful new cards, unlock unique trinkets, and deploy enhanced towers to overcome relentless waves of enemies and new strategic challenges.

Scrap Bastion is a strategy tower defense game where you manage your city, equipping it to survive the waves of mutant creatures, testing your planning and decision making capacities at every turn. Watch out, as time is crucial to win!

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

BAFTA award winning fleet-based RTS meets rogue-lite. In Distant Star: Revenant Fleet, build your fleet of up to 5 ships from a choice of 8 classes and traverse a randomly generated galaxy to defeat the Erebus Platform. NOW AVAILABLE ON MAC AND LINUX

A last-stand auto-battler on a dead magic world. Choose your heroes, upgrade their abilities, and try to hold on one more night.

Build, Upgrade, and then Move your Towers in this unique twist on the Tower Defence genre. With Rogue-Lite mechanics every run offers new strategies, and every death unlocks new upgrades. Grow. Evolve. Destroy the Robots!

We fused deck-building roguelikes and tower defenses in a way never seen before - deploy your towers, collect valuable trinkets and cast powerful spells to defend yourself against the Salkoth!

A Roguelike Tower Defense in space with missions to conquer. Can you hold against the spreading alien bosses? Build and upgrade towers against the corruption. Choose your technologies and warpspeed your way to victory.

Hold the line in a neon sci-fi siege. Deploy and upgrade 15 distinct towers, expose every enemy's weakness, and survive 50 escalating waves and relentless boss assaults. Every threat has a counter — find it before your base falls.

Qubicks is where tower defense meets roguelike as you venture across procedurally generated levels where you strategically position towers, balancing immediate survival with long-term growth. Upgrade your towers and heroes to adapt to difficult waves and ensure victory against alien inhabitants.

A top-down twin-stick shooter roguelite blending frenetic spaceship combat with deep base-building and tower defense. Fight through hostile territory, scavenge hardware, upgrade your ship, then build up your station to further empower your runs... as long as you can defend it. Godspeed, Commander.

Go down. Get stronger. Come back alive. Mine the mountain. Defend your shuttle. Adapt or get overrun.

Dive from your deep-sea station, vacuum the seabed for rare ore and haul it home before the next wave hits. Upgrade everything, choose your weapons and hold the line against the creatures of the abyss. Then go deeper for the Abyssal Core.

Towerbloom is a pathless roguelite tower defense with reactive gameplay. Employ countless outlandish strategies and supercharge your towers by hovering over them to vanquish enemies.

Amidst powerful alien empires, you are among the first humans in this corner of the procedurally generated galaxy. Trade and explore. With no combat, your success hinges on mastering complex alien economies and navigating intricate politics. Can you carve out a place for humanity in the cosmos?

Build esoteric towers. Combine conspiracy cards. Defend your mind. A psychedelic tower-defense roguelite where choices from the Akashik Records reshape your strategy. Spend Gnosis, extend the maze, and hold back the psychic invasion for as long as you can.

Beware Planet Earth! is a beguiling mix of classic tower defense and time management coming to PC via Steam for the first time. Save your cows from the Martian invasion by building an effective defense using towers, traps and objects, and also by firing your Zapper directly at the invading force of little green men!

ULTRAMASSIVE is a rogue-like deckbuilding game in a sci-fi setting. Embark on a journey towards the center of the galaxy, craft unique decks, fight hostile aliens, upgrade your space ship and face the unknown.

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

A roguelike tower defense where every draft permanently mutates your build. Stack modifiers, trigger massive Surge events, and watch your defenses evolve into unstable, compounding systems that fight in ways you didn’t design.

Defend your Core in an endless tower defense where every decision matters. Build too slow and you’re overrun. Build too fast and chaos breaks your defenses.

A single-player space-strategy roguelite about reconquering a shattered empire across a procedurally generated galaxy. Plan fleet battles that unfold on your orders, and drive ground invasions front by front across the planet below. Every ship, crew, and army you lose is gone for good.

Build your mobile outpost and combine over 20 weapons with 100+ items to create unique builds. Grow stronger against endless enemy hordes, conquer new planets, and experience the thrill of evolving from desperate survival to overwhelming firepower.

Transistor Defense is a strategic tower defense game where players must fend off the onslaught of a rogue sentient AI determined to overtake the network.

Build your defenses and face the tide. Hivetide is a mix of tower defense and real-time strategy where each bullet counts.

Bumper Blitz TD redefines tower defense with gravity-powered physics and dynamic gameplay. Build, upgrade, and bounce enemies away in this thrilling fusion of strategy and action!

Hold a mining outpost on an alien world while thousands of insects pour through the rock tunnels like a flood. Place towers on the high ground, aim their firing arcs, and spend the biomass from every run, won or lost, on upgrades that let you hold a little longer next time.

A strategic tower defense game where your arsenal evolves across time. Build base defenses and experiment by merging towers together to discover powerful new units. Manage your resources carefully, adapt your tactics, and survive enemy waves from the Stone Age to the far future.

The Fermi Paradox is a choice-driven sci-fi narrative strategy game in which your decisions in one corner of the galaxy can upend entire civilizations in another. Guide species through millennia and help them explore the vastness of space, make contact and, perhaps, create harmony.

MERGE blocks to get ammo... BLAST the alien horde... and BUILD the ultimate fighting drone! Not gonna lie, this game is a PARTY!

Sci-fi rogue-like mining/tower defense game. Mine through a procedurally generated world to discover artifacts. Defend your spaceship from waves of enemies. Discover and spend resources to improve your mining and spaceships combat ability.

Reclamation of Xanthros is a unique Tower-Defense Roguelike. Xeno have taken over the planet Xanthros and you must save it by defeating their Matriarch. Battle across a wide range of biomes with a changing assortment of Towers, Upgrades, and Artifacts. Features a unique turret building mechanic.

Space Year 2899. As the new Operations Chief of Japan's Space Facility Defense Office, protect orbital colonies from debris, space lifeforms and drone fleets. Build and upgrade defenses on 10 orbits with different routes, and reshape your tactics with 130+ research projects.

Skyward Bastion is a roguelite tower defense game set on floating islands. Build and upgrade your defenses, unlock new strategic possibilities, and adapt your run to procedurally expanding maps.