Top similar games like Main Sequence:

Factory Trashcension is a first-person open-world factory creation and optimization game with unlimited possibilities. Play with your friends and design efficient factories to TRASHCEND without worries and explore a v a p o r w a v e inspired universe!

The Universe is yours. SpaceCraft is an online space exploration and building game. Explore a vast galaxy of solar systems and planets, mine and craft resources, design and build ships, automate planetary bases and interplanetary logistics, trade and cooperate.

Yuri’s Resolve is a single-player factory-building game set in Mars' orbit. Salvage wreckage, mine Phobos, construct manufacturing systems, and forge a path back home. Operate from the immersive cockpit of your ship as Yuri’s Resolve delivers a bold, innovative take on the factory building genre.

You were deep in uncharted space on a research mission. Disaster struck. Together with your friends, explore a mysterious asteroid field and mine whatever resources possible to build what you need to survive.

Go to the Moon to explore its harsh nature and mysterious anomalies. Build your own lunar base, craft equipment, extract valuable resources and make many discoveries. Overcome the challenges of extreme lunar conditions, an oxygen-free atmosphere and much more unknown...

The ultimate space capital ship combat compendium is the evolution of hard core space combat sims. The only game of its kind currently in existence.

Embark on a journey of survival, crafting, and automation in this free prologue introducing one of the planets you can transform in Eden Crafters – an upcoming open-world game that challenges you, alone or with friends, to turn a hostile planet into a habitable haven for humanity.

Play as an astronaut on our moon in the future. Your task is to prepare the moon for future colonies by terraforming. Collect resources, explore procedurally generated caves, build buildings and create a second world for you and our earth.

Satisfactory is a first-person open-world factory building game with a dash of exploration and combat. Play alone or with friends, explore an alien planet, create multi-story factories, and enter conveyor belt heaven!

Techtonica is a first-person factory automation game with a gripping mystery about mining your way out from the depths of an alien planet. Explore bioluminescent caves, mold destructible terrain, construct a massive subterranean factory. Dig your way toward answers & discover the secrets of Calyx.

Factory management and sandbox base building in zero-g environment. Survive, expand and then dominate space industrial market. Build large scale resource processing plant completely from nothing.

After a century in cryosleep you find yourself stranded amidst the ruins of mankind’s first interstellar colony. Explore derelict ships and stations and harvest raw resources in search of air, fuel and other equipment. Or loot and pillage what you need from other survivors. The choice is yours!

Interact with strange new worlds in a unique and tactile way, molding the environment itself as if it were clay in your hands. Build your base, master resource management, automate your production lines, and more as you unravel the mysteries of the universe, alone or with friends.

Set on small procedurally generated planets, PoliPlanet is a unique first-person city building game. Discover new planets, gather resources, craft, explore, and build.

Stranded on a hostile alien world, you must gather resources, craft tools, and automate production to survive. Build a base, fend off deadly wildlife, and uncover ancient secrets in this immersive sci-fi survival adventure. Will you conquer the planet or succumb to its perils?

A space survival open world terraforming crafting game, designed for 1 to 10 players. Alter the ecosystem of an inhospitable planet to render it habitable for humanity. Survive, gather resources, and build your base. Then, generate oxygen, warmth, and pressure to create a brand new biosphere.

Build floating automated rigs in a volatile gas giant. Extract elements, synthesize compounds, and descend through atmospheric layers in this sci-fi systems-builder focused on chemistry, engineering, and survival.

Take the helm as a new Station Commander and exploit an alien star system in this stunning space-station factory automation game. Amass resources and construct starships using increasingly advanced manufacturing and expand your station in a hostile universe.

Astrocraft is a simulation game about building and managing your own space station. You mine resources, construct buildings, install machinery and equipment, sell goods to space travelers, and hire workers to automate all the operations.

Untethered is a space survival-sandbox set in our own cosmic backyard. Explore zero-gravity environments, build and operate realistic space stations, and fight to stay alive in the unforgiving realm of deep space.

You have officially joined the elite team of "Star Wipers"! Your mission? Cleaning! Alongside your trusted crew, you will embark on exciting expeditions to abandoned space stations, ruined restaurants in the cosmos, and unexplored planets.

StarRupture is a first-person open world base-building game with advanced combat and tons of exploration. Play alone or in a group on this sublime and ever-changing planet, extract and manage resources, create your complex industrial system and fight off hordes of alien monsters.

Build your ship, defend against drone waves and explore hundreds of sectors filled with stations, asteroids and planets with lots of POIs. The ship systems can be controlled via consoles with several hundred buttons. Craft equipment and blocks, loot the POIs and disabled drones.

Mine. Build. Survive. Engineer your way through the cosmos in this 2D space engineering sandbox!

Create an automated system that terraforms a planet with an army of drones. Craft and build bases, set up a weather monitoring system, prepare to survive different types of storms, and take control of the climate and biomes!

Craft your workshop as an alchemist!‌ Harness arcane devices to automate crafting. Sell alchemical goods, fulfill commissions, and rise to become a renowned alchemy magnate. ‌Multiplayer Supported!‌ Invite master designers to (ahem) contribute their expertise—let them optimize your production lines!

Raft™ throws you and your friends into an epic oceanic adventure! Alone or together, players battle to survive a perilous voyage across a vast sea! Gather debris, scavenge reefs and build your own floating home, but be wary of the man-eating sharks!

Command a space-faring empire in Sins of a Solar Empire: Rebellion, the new stand-alone expansion that combines 4X depth with real-time strategy gameplay.

Astrometica is a space exploration and base-building survival game. After a catastrophic event, explore vast space, gather resources, build bases, and uncover cosmic mysteries. Use advanced technology, craft tools, and discover new blueprints to survive and thrive in the unknown.

Railborn is a survival game where you build your train piece by piece. Navigate a world entangled by branching tracks. Find rare plants to cultivate on your farms. Upgrade your train - manage its power systems, direct resource flow, and distribute water. Designed for 1 to 4 players.

A base-building and automation game about restoring a ruined planet. Mine resources, build factories, deploy AI drones, and revive a living world.

Construct, maintain, manage and upgrade the fleet of your space robots in this sandbox crafter. Build the base, gather resources and automate to succeed in your mission in a unique robotic spacesim.

LithoBreak is a survival factory-builder grounded in real physics and engineering. Build and automate a lunar colony, explore in first-person, and survive constant orbital threats – all while you Play with Science

As a specially trained explorer in "Deep Crafter", you'll gather resources, design production lines, automate everything, and explore this vast, ocean-covered planet to uncover its secrets.

Explore endless Universe and create the most efficient constellation of colonies. Build conveyor systems to automate production. Take care of Astronauts and their needs! Establish new colonies as part of intergalactic simulation.