Top similar games like Main Sequence:

The Universe is yours. SpaceCraft is an online space exploration and building game. Explore a vast galaxy of solar systems and planets, mine and craft resources, design and build ships, automate planetary bases and interplanetary logistics, trade and cooperate.

Yuri’s Resolve is a single-player factory-building game set in Mars' orbit. Salvage wreckage, mine Phobos, construct manufacturing systems, and forge a path back home. Operate from the immersive cockpit of your ship as Yuri’s Resolve delivers a bold, innovative take on the factory building genre.

Factory Trashcension is a first-person open-world factory creation and optimization game with unlimited possibilities. Play with your friends and design efficient factories to TRASHCEND without worries and explore a v a p o r w a v e inspired universe!

Build floating automated rigs in a volatile gas giant. Extract elements, synthesize compounds, and descend through atmospheric layers in this sci-fi systems-builder focused on chemistry, engineering, and survival.

The ultimate space capital ship combat compendium is the evolution of hard core space combat sims. The only game of its kind currently in existence.

Astrocraft is a simulation game about building and managing your own space station. You mine resources, construct buildings, install machinery and equipment, sell goods to space travelers, and hire workers to automate all the operations.

Techtonica is a first-person factory automation game with a gripping mystery about mining your way out from the depths of an alien planet. Explore bioluminescent caves, mold destructible terrain, construct a massive subterranean factory. Dig your way toward answers & discover the secrets of Calyx.

A base-building and automation game about restoring a ruined planet. Mine resources, build factories, deploy AI drones, and revive a living world.

You were deep in uncharted space on a research mission. Disaster struck. Together with your friends, explore a mysterious asteroid field and mine whatever resources possible to build what you need to survive.

Factory management and sandbox base building in zero-g environment. Survive, expand and then dominate space industrial market. Build large scale resource processing plant completely from nothing.

Set on small procedurally generated planets, PoliPlanet is a unique first-person city building game. Discover new planets, gather resources, craft, explore, and build.

Explore endless Universe and create the most efficient constellation of colonies. Build conveyor systems to automate production. Take care of Astronauts and their needs! Establish new colonies as part of intergalactic simulation.

Embark on a journey of survival, crafting, and automation in this free prologue introducing one of the planets you can transform in Eden Crafters – an upcoming open-world game that challenges you, alone or with friends, to turn a hostile planet into a habitable haven for humanity.

Craft your workshop as an alchemist!‌ Harness arcane devices to automate crafting. Sell alchemical goods, fulfill commissions, and rise to become a renowned alchemy magnate. ‌Multiplayer Supported!‌ Invite master designers to (ahem) contribute their expertise—let them optimize your production lines!

Ensure the moon is safe for man's inevitable lunar habitat. Drive and interact as a Lunar Rover with crashed ships, the natural resources and explore the nearby landscape to determine the suitability!

Go to the Moon to explore its harsh nature and mysterious anomalies. Build your own lunar base, craft equipment, extract valuable resources and make many discoveries. Overcome the challenges of extreme lunar conditions, an oxygen-free atmosphere and much more unknown...

Take over an abandoned space station and manage your own ore mine. Cut through the asteroid with your laser, sell ore, and create an automated network of robot helpers to maximize your profit.

Take the helm as a new Station Commander and exploit an alien star system in this stunning space-station factory automation game. Amass resources and construct starships using increasingly advanced manufacturing and expand your station in a hostile universe.

Welcome to this innovative sci-fi open-world! As the last survivor of humanity, build a home on a wild alien planet. Reignite civilization—from primal survival to advanced energy systems. Use the Planetary Control Module to reshape the world, uncover human secrets, and journey back to Earth.

Untethered is a space survival-sandbox set in our own cosmic backyard. Explore zero-gravity environments, build and operate realistic space stations, and fight to stay alive in the unforgiving realm of deep space.

After a century in cryosleep you find yourself stranded amidst the ruins of mankind’s first interstellar colony. Explore derelict ships and stations and harvest raw resources in search of air, fuel and other equipment. Or loot and pillage what you need from other survivors. The choice is yours!

Create an automated system that terraforms a planet with an army of drones. Craft and build bases, set up a weather monitoring system, prepare to survive different types of storms, and take control of the climate and biomes!

Build ships from scrap and fly them in a gritty, realistic space sim. Venture solo or team up. Hunt for parts, haul vital resources, and keep your space agency afloat.

Advanced Space Flight, Combat, Trading, and Exploration Simulation. Set in a vast explorable universe, Evochron Legacy offers freeform gameplay with many diverse objectives and paths to choose from.

Construct, maintain, manage and upgrade the fleet of your space robots in this sandbox crafter. Build the base, gather resources and automate to succeed in your mission in a unique robotic spacesim.

LithoBreak is a survival factory-builder grounded in real physics and engineering. Build and automate a lunar colony, explore in first-person, and survive constant orbital threats – all while you Play with Science

Play as an astronaut on our moon in the future. Your task is to prepare the moon for future colonies by terraforming. Collect resources, explore procedurally generated caves, build buildings and create a second world for you and our earth.

Satisfactory is a first-person open-world factory building game with a dash of exploration and combat. Play alone or with friends, explore an alien planet, create multi-story factories, and enter conveyor belt heaven!

Command a space-faring empire in Sins of a Solar Empire: Rebellion, the new stand-alone expansion that combines 4X depth with real-time strategy gameplay.

As head of an interplanetary corporation, your goal is to extract resources from across the solar system and bring them home faster and cheaper than your competitors. Construct trade depots and colonies. Build rockets and spaceports. Master realistic orbital mechanics and maximize profits.

Kardashev is a first-person, space set, procedural open world, factory building game. Your primary goal is to ascend the Kardashev Scale.

Design, build, and optimize intricate, space-efficient factories in a unique grid-based puzzle system. Master complex supply chains and dominate a living interstellar economy to build your corporate empire. Conquer the cosmos alone or with friends.

Build the most efficient intergalactic factory in space simulation strategy game Dyson Sphere Program! Harness the power of stars, collect resources, plan and design production lines and develop your interstellar factory from a small space workshop to a galaxy-wide industrial empire.

Play as Agent 8085, the most advanced mining AI sent to asteroid 8085 Pinsky. Extract resources, upgrade your systems, and complete missions that affect the future of humanity. Your choices matter: promote unity, extinction, remain neutral. A sci-fi strategy game where your decisions have impact.

As a specially trained explorer in "Deep Crafter", you'll gather resources, design production lines, automate everything, and explore this vast, ocean-covered planet to uncover its secrets.

The Last Starship is a 2D space construction game where you design and upgrade your starship. Choose your path: pirate hunter, miner, engineer, spacebus driver, and more, whilst exploring vibrant star systems. Enjoy a growing sandbox world, with regular free updates. Your cosmic adventure awaits!