Top similar games like Xenomycology:

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

Project Astra Dominium is a Tower Defense game with Basebuilding and Automation elements. Build up your base to become a supply hub for Earth's desperately needed materials, gather resources while defending against an unknown alien threat and improve your tower's and AI capabilities.

Build defenses to protect your mining sites from the hostile native alien species. Explore the planet and discover the true reasons you've been sent here for. A true old school pixel-art experience.

A Roguelike Tower Defense in space with missions to conquer. Can you hold against the spreading alien bosses? Build and upgrade towers against the corruption. Choose your technologies and warpspeed your way to victory.

The Rebel Space Admiral is an idler/ clicker game about space exploration with battles, trade, base building, planet invasions and science research. Fight your way through hundreds of star systems, meet aliens, find powerful artifacts and defeat an ancient evil before it purges the galaxy.

You are isolated on a small meteor and need to build a fire to escape before being destroyed by aliens. Use your limited space to create machines and obtain more and more resources. Enjoy this mix of puzzles, tower defense and incremental gameplay.

"In 'Random Core Defense,' acquire and enhance cores using limited resources to withstand relentless enemy onslaughts. Defeat powerful bosses and test your strategy to survive until the very end!"

Fly around, mine resources, expand your ship, build weapons and fight off aliens!

Build & defend a small remote mining base on Taichin XI from the alien hordes. Deploy defenses, upgrade your turrets and get ready for the nightfall. The Unearthened is a classic Idle Tower Defense game where you build towers and prepare for the invasion.

A strategic tower-defense where you control powerfull drones. Unlock new tower and use specific technologies to defend your base on Thukothea!

Keyclash is a tower defense roguelike about building on keyboard keys and surviving as long as possible.

Refactor is a hard-core tower defense game that combines modular building, route planning, and element composition.

Build your factory by day, then fight relentless hordes by night in this unique blend of factory-building and rogue-like mayhem. Gather resources and upgrade your arsenal with Magic, Guns and Tesla Coils?!

Inspired by modern science fiction! A modern real-time war game, the screen is in the style of realism, the fast-paced attack effect is easy to fatigue, easy to use and simple to operate, mainly in the traditional style

Scrap Bastion is a strategy tower defense game where you manage your city, equipping it to survive the waves of mutant creatures, testing your planning and decision making capacities at every turn. Watch out, as time is crucial to win!

Invader TD is a side scroller tower defense, where the player is in the role of an alien race with the purpose of infecting and dominating the earth, you must protect yourself from the attacks of the humans, who are trying to destroy you.

2D space shooter and turret defense come together to create the Planetary Defense System this world needs! Shoot down asteroids and aliens and survive the bosses in this arcade like game featuring customizable satellites, projectiles, and upgradable Cannon and Planet Shield systems.

Defend your castle from the attacks of the night creatures. Collect coins, interact with the elements of the game, discover, explore, learn and survive for 30 days or try again.

Bestion is a game that combines Roguelike tower defense elements with automated factory construction. Players are required to construct their own factory on a planet and protect the kernel from monster attacks.

Jishin, is a tower defense game where the ground is anything but stable. As waves of relentless enemies surge towards your base, you'll not only need to strategically build towers, but also adapt to the ever-shifting battlefield.

Build, Upgrade, and then Move your Towers in this unique twist on the Tower Defence genre. With Rogue-Lite mechanics every run offers new strategies, and every death unlocks new upgrades. Grow. Evolve. Destroy the Robots!

Get ready for an epic pixel art showdown ! Dive into the heart of tower defense chaos as you battle against scrumptious calorie-packed enemies, all on massive, sprawling maps. With an extensive arsenal of towers at your disposal, it's time to defend against the ultimate sweet tooth invasion!

The ultimate mash-up of Real-time Strategy and Tower Defense!

Mow down the alien hordes, scout for resources and survive. Dreadnought is a mix of Action Tower Defense Survival and Shoot 'Em Up Bullet Hell where you control the ships turrets & defend against waves of enemies. Choose your weapons, upgrade your ship & brace yourself, the horde is coming.

A rogue-like sci-fi Tower Defense strategy game with infinite replayability!

In a world where a robot revolution failed, the last humans search for a way to survive and escape. Beacon of Neyda is a side-scroller strategy game where you have to survive waves of enemies while creating and upgrading your base. Build where you want - Defend what you can.

Two kingdoms in battle against each other, the king Bennevert called for the legendary mighty mercenaries to defend strategic posts in dangerous lands in the battlefield. Are you prepared to be a mercenary?

"Touch Your Eyes" is a game born in the 2023 CiGA Gamejam. It is primarily a puzzle game with a gameplay style similar to pushing boxes, featuring multiple levels with special mechanics. We will continue to develop this game, and during this process, we welcome everyone to join our Discord and QQ communities to share your...

Build your towers, plan your efforts, watch out for changing paths and strike back against the alien invaders in this challenging tower defense game!

Build your defense base to repel alien invaders. Atahion is a strategy and tactical defense game in which you have to extract resources, build defense towers and use bonuses to complete the mission.

The ultimate space capital ship combat compendium is the evolution of hard core space combat sims. The only game of its kind currently in existence.