Top similar games like Xenomycology:

We've traveled to the past to conquer these fertile lands. Now, you must defend them from the blood cult intent on taking it for themselves. Be careful though: from where their blood is spilled, ancient magicks empower whomever is still alive.

Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!

Creeper World 3 is what happens when cellular automata takes over a strategy simulation. Instead of discrete units that attack your base, a fluid-like substance spreads over the terraformable terrain. Your base, your weapons, your strategy... you must adapt them all.

Build towers and learn abilities to defend against swarms of hundreds of on-screen hostile alien creatures. Choose between sets of randomized upgrades that both upgrade you and the alien swarm. From enormous explosions to far-reaching flamethrowers, no two games are the same.

Project Astra Dominium is a Tower Defense game with Basebuilding and Automation elements. Build up your base to become a supply hub for Earth's desperately needed materials, gather resources while defending against an unknown alien threat and improve your tower's and AI capabilities.

Build, automate, and defend humanity's last factory on a dying industrial planet. Chain production lines, survive AUTON raids and dust storms, research lost technology, and uncover what silenced every factory before yours.

Tower defense / Roguelike / Sci-Fi / Pixel Art game with boomer games aesthetics. Mine resources and shoot those disgusting aliens right in their faces. Unlock new technology, develop new strategies and explore the planet. A modern old-school Pixel Art experience with the vibe of 90s classics.

A Roguelike Tower Defense in space with missions to conquer. Can you hold against the spreading alien bosses? Build and upgrade towers against the corruption. Choose your technologies and warpspeed your way to victory.

The Rebel Space Admiral is an idler/ clicker game about space exploration with battles, trade, base building, planet invasions and science research. Fight your way through hundreds of star systems, meet aliens, find powerful artifacts and defeat an ancient evil before it purges the galaxy.

A strategic tower-defense where you control powerfull drones. Unlock new tower and use specific technologies to defend your base on Thukothea!

"In 'Random Core Defense,' acquire and enhance cores using limited resources to withstand relentless enemy onslaughts. Defeat powerful bosses and test your strategy to survive until the very end!"

Fly around, mine resources, expand your ship, build weapons and fight off aliens!

Build & defend a small remote mining base on Taichin XI from the alien hordes. Deploy defenses, upgrade your turrets and get ready for the nightfall. The Unearthened is a classic Idle Tower Defense game where you build towers and prepare for the invasion.

A 2D pixel art tower defense game with unparalleled strategic depth. Deploy modules to redirect enemies, use tactical chips to command the battlefield, and upgrade towers with multi-branch modifications to protect humanity's vital Stellacore energy.

Refactor is a hard-core tower defense game that combines modular building, route planning, and element composition.

Keyclash is a simple tower defense roguelike about building on keyboard keys and surviving as long as possible.

Forge invincible defenses with lethal traps and devious machines, and crush relentless waves of adventurers in the ultimate tower defense showdown!

Solar Defense is a Military Sci-Fi inspired Tower Defense game focused heavily on strategy and decision making. Defend key locations and repel the Pilakarr forces back to their home world to end their attack and bring an end to this war.

Inspired by modern science fiction! A modern real-time war game, the screen is in the style of realism, the fast-paced attack effect is easy to fatigue, easy to use and simple to operate, mainly in the traditional style

Scrap Bastion is a strategy tower defense game where you manage your city, equipping it to survive the waves of mutant creatures, testing your planning and decision making capacities at every turn. Watch out, as time is crucial to win!

Invader TD is a side scroller tower defense, where the player is in the role of an alien race with the purpose of infecting and dominating the earth, you must protect yourself from the attacks of the humans, who are trying to destroy you.

Defend the last citadel on a dying alien world. Summon a gacha collection of bio-engineered defense towers, forge a custom loadout, and conquer three modes, story-driven Chronicle, roguelite Contracts, and 1v1 PvP Ascension. Tower defense meets deck-building meta-progression.

Loop Defense is a single-player sci-fi tower defense game. Build enemy routes with base walls, assemble a modular defense, manage limited loadouts, energy, and research, face armored, flying, carrier, and wall-breaker units across a star map, or challenge Endless Mode.

2D space shooter and turret defense come together to create the Planetary Defense System this world needs! Shoot down asteroids and aliens and survive the bosses in this arcade like game featuring customizable satellites, projectiles, and upgradable Cannon and Planet Shield systems.

A pixelated 2.5D RTS meets tower defense as you battle mutated ants in a short campaign. Build walls, place turrets, and hold the line to reclaim Earth's surface in this tactical fight for survival where placement of everything matters.

Defend your castle from the attacks of the night creatures. Collect coins, interact with the elements of the game, discover, explore, learn and survive for 30 days or try again.

Bestion is a game that combines Roguelike tower defense elements with automated factory construction. Players are required to construct their own factory on a planet and protect the kernel from monster attacks.

Jishin, is a tower defense game where the ground is anything but stable. As waves of enemies surge towards your base, you'll not only need to strategically build towers, but also adapt to the ever-shifting battlefield.

Tower Defense meets a Visual Novel narrative. Place an arsenal of towers to halt the invading enemy. Use special abilities such as napalm strikes, EMP blasts, and orbital lasers. A sci-fi space drama, filled with dialogue choices.

Build, Upgrade, and then Move your Towers in this unique twist on the Tower Defence genre. With Rogue-Lite mechanics every run offers new strategies, and every death unlocks new upgrades. Grow. Evolve. Destroy the Robots!

The ultimate mash-up of Real-time Strategy and Tower Defense!

Control your Hero to aid your Turrets and Traps in battle in this grim, dark Tower Defense & Action RPG with a scifi-grindhouse aesthetic. Create deadly weapon barrages and fuse together Bleed, Burn, Shock, Freeze, Stun and many more elements to annihilate your enemies.

Get ready for an epic pixel art showdown ! Dive into the heart of tower defense chaos as you battle against scrumptious calorie-packed enemies, all on massive, sprawling maps. With an extensive arsenal of towers at your disposal, it's time to defend against the ultimate sweet tooth invasion!